Anda di halaman 1dari 4

1048 Herald of Medicine Vol 29 No 8 August 2010

gene expression differs in subtypes of acute lymphoblastic methyltransgerase activity in three major Asian population
leukemia and influences methotrexated pharmacodynamics based study in Singapore [ J ] . Eur J Clin Pharmacol,
[ J] . J Clin Invest,2005,115(1) :110-117. 2008,64:373-379.
[11 ] CHU E, ALLEGRA C J, ANTIFOLATES Z, et al. Cancer [19] CHAUVENET A R,MADIN P,DEVIDAS M,et al. Anti
chemotherapy and biotherapy principle and practice [ M] . metabolite therapy for lesserrisk Blineage acute
Philadelphia:LippincotRaven,1996:109-148. lymphoblastic leukemia of childhood a report from
[12] PUI C H,RELLING M V,DOWING J R,et al. Acute ly children s Oncology Group Study [ J] . Blood, 2007, 110
mphoblastic leukemia[ J] . N Engl J Med,2004,350(15) : (1) :1105-1111.
1535-1548. [20] VEENMAN A J P,HAHLEN K,KAMPS W A,et al. High
[13] SCHRAPPE M, REITER A,LUDWING W D,et al. Imp cure rate with a modersately intensive treatment regimen in
roved outcome in childhood acute lymphoblastic leukemia nonhighrisk childhood acute lymphoblastic leukemia
despite reduced use of anthracyclines and cranial results of protocol ALL VI from the dutch childhood
radiotherapy: results of trial ALLBFM90, German leukemia study group[ J] . J Clin Oncol,1996,14(6) :911-
AustrianSwiss ALLBFM Study Group[ J] . Blood,2000,95 918.
(11) :3310-3322. [21] PEITER A, SCHARPPE M, LUDWIG W D, et al. Che
[14] . motherapy in 998 unselected childhood acute lymphoblastic
8 [ J] . ,2001,27 (4) :296 - leukemia patients,results and conclusion of the multicenter
297. trial,ALLBFM86[ J] . Blood,1994,84(9) :3122.
[15] KRYNETSKI E Y, TAI H L, YATCS C R, et al. Phar [22] ,. [ J] .
macogentics[ J] . Ann Rev Med,1996,6(1) :279. ,1993,31(5) :285-287.
[16] RELLING M V,HANCOCK M L,RIVERA G K,et al. J [23] INAMOCHI H, HIGASHIGAWA M, SHIMONO Y, et al.
Narl[ J] . Cancer Inst,1999, 91(3) :2001. Delayed cytotoxicity of 6mercaptopurine is compatible with
[17] WANG L, WEINSHILBOUM R. Thiopurine Smethyltran mitotic death caused by DNA damage due to incorporation
sferase pharmacogenetics insights, challenges and future of 6thioguanine into DNA as 6thioguanine nucleotide[ J] .
directions[ J] . Oncogene,2006,26(5) :520-522. J Exp Clin Cancer Res,1999,18(6) :417-424.
[18] KHAM S K, SOH C K, LIU T C, et al. Thiopurine S


,, , ,
( ,410128)
[ ] ( allicin) CH2 = CHCH2 SS( = O) CH2 CH = CH2 ,,
;,,
, ,

[ ] ;;;
[ ] R285 [ ] A [ ] 1004-0781(2010)08-1048-04

,, [1]
,, ( Allium sativum L. )
,,,
[ ] 2009-11-03 [ ] 2010-04-16
( allicin)
[ ] (1986 -) ,,,
,: :(0) ,,
13975884261,Email:xuxiaojiang1986@ 163. com [23] ,
[ ] (1969 -) ,,,,
: :0731 - 1
84673760,Email:xiaowenjun88@ sina. com 1721 ,
2010 8 29 8 1049

, [4] ,,
, ,
[5]

, ,
( MIC ) 1985 BLOCK [16]
( MBC ) 200 ~ 400 400 ~
1 600 mgmL ; MIC MBC
1
, pH10 ,
12. 5 ~ 25 25 ~ 50 mgmL 1 ROSS [6] ;
,
,, ;
SHADKCCHAN [7]
, 2vinyl( 4H) 1, 3
, dithiine 3vinyl(4H) 1,2dithiine ;
:, ,
CUTLER [8]
2. 2
30 ,,
,: JACOB [17] ,
,
,, , DNA
, ,
,, ,
[9] (SOS) , CAVALLITO [2]
, OGITA [18]
[10] ,
,, ROSS [6]
MIC50 MIC90 ,;MOSES
[11]
[19] GHANNOUM [20] ,L
,, ,
MIC Curtis [12]

RNA
, ,
2 COPPI [21] ,
, ,
, BAKRI [22]
,
[23] L
2. 1 CAVALLITO [2]
,
, ;
CH2 = CHCH2 SS ( = O) CH2 CH = CH2 , ;
[13]
RNA
, ARTHORSTOU ,
[14]
, ( alliin) , YOSHIDA [24]
, ,
[15]
,,:
,, ,
1050 Herald of Medicine Vol 29 No 8 August 2010

2. 3 ,
, ,:
OGITA [2526]
B ,
, :,,
, B , ;
B ,OGITA ,,
B( ) ;,
, ,
,,
,, ,
B , B [18]
,,
AN [27]
, ,
PEREZ ,
GIRALDO [28]
,,
,
2. 4

pH [ DOI] 10. 3870 / yydb. 2010. 08. 027
[28] ROSS [6] [ ]
[1] ,. 20 [ J] .
MOSES [19]
GHANNOUM [20]
,2006,22(2) :70-75.
,
[2] CAVALLITO C J,BAILEY J H. Allicin,the antibacterial
,,
principle of Allium sativum. I. Isolation, physical
properties, and antibacterial action [ J] . Am Chem Soc,
, 1944, 66(11) :1950-1951.
, [3] ADETUMBI M A,LAU B H. Allium sativum ( garlic)
, al antibiotic[ J] . Med Hypotheses,1983,12(3) :227-237.
3 [4 ] HANN G. History, folk medicine, and legendary uses of
COPPI [21]
garlic [ M ] / / KOCH HP, LAWSON LD. Garlic: the
science and therapeutic application of Allium sativum L.
HANN [4] > 60
and related species. Williams and Wilkins: Baltimore,
mgL 1 ,
1996:37-107.
,
[5] ,, ,.
, [ J] . ,2008,39(1) :108-110.
,, [6] ROSS Z M,O GARA E A, HILL D J,et al. Antimicrobial
, properties of garlic oil against human enteric bacteria:
,, evaluation of methodologies and comparisons with garlic oil
,, sulfides and garlic powder[ J] . Applied And Envir Onmental
, Microbiology, 2001,67(1) :475-480.
[7] SHADKCHAN Y,SHEMESH E,MIRELMAN D,et al. Eff
,
icacy of allicin,the reactive molecule of garlic,in inhibiting
,
Aspergillus spp in vitro, and in a murine model of
,
disseminated aspergillosis[ J] . J Antimicro Chem, 2004,53
(5) :832-836.
4 [8] CUTLER R R,WILSON P. Antibacterial activity of a new,
stable, aqueous extract of allicin against methicillin
,, resistant Staphylococcus aureus [ J] . British J Biome Sci,
2010 8 29 8 1051

2004,61(2) :1-4. [20] GHANNOUM M A. Studies on the anticandidal mode of


[9] ,,. action Allium sativum( garlic) [ J] . Gen Microbiol,1988,
[ J] . ,2008,28(2) :87-88. 134(11) :2917-2924.
[10] , ,,. [21] COPPI A, ABINIAN M, MIRELMAN D, et al. Antim
[ J] . , alarial activity of allicin, a biologically active compound
2005,15(12) :1339-1341. from garlic cloves[ J] . Antimicro Agents Chemoth, 2006,
[11] , . 50(5) :1731-1737.
[ J] . , [22] BAKRI I M, DOUGLAS C W. Inhibitory effect of garlic
2006,11(8) :925-928. extract on oral bacteria[ J] . Arch Oral Biol,2005,50(7) :
[12] CURTIS H,NOLL U,STORMANN J,et al. Broadspectrum 645-651.
activity of the volatile phytoanticipin allicin in extracts of [23] ,,,.
garlic ( Allium sativum L. ) against plant pathogenic [ J] . ,2004,31(2) :263-268.
bacteria, fungi and Oomycetes [ J ] . Physiol Mol Plant [24] YOSHIDA H,KATSUZAKI H, OHTA R, et al. Antimicr
Pathol,2004,65(2) :79-89. obial Activity of Thiosulfinates Isolated from OilMacerated
[13] ,LARRY D,LAWSON. A problem and it s cure in Garlic Extract [ J] . Biosci Biotechnol Biochem, 1999, 63
usage of allicin and other garlic terms[ J] . Acta Nutrimenta (3) :591-594.
Sinica,1999,21(3) :366-368. [25] OGITA A,FUJITA K,TANIGUCHI M,et al. Enhancement
[14] STOLL A, SEEBACK E. The enzymatiz dicomposition of of the fungicidal activity of amphotericin B by allicin, an
alliinase and the properties of alliinase [ J ] . Helo Chim allylsulfur compound from garlic, against the yeast
Acta, 1949,32:197-205. Saccharomyces cerevisiae as a model system [ J ] . Planta
[15] ,,,. Med,2006,72(13) :1247-1250.
[ J] . ,1996,6(1) :2-3. [26] OGITA A,FUJITA K,TANAKA T. Enhancement of the fu
[16] BLOCK E. The chemistry of garlic and onions[ J] . Sci Am, ngicidal activity of amphotericin B by allicin: effects on
1985,252(3) :94-99. intracellular ergosterol trafficking [ J] . Planta Med,2009,
[17] JACOB C. A scent of therapy: pharmacological implica 75(3) :222-226.
tions of natural products containing redoxactive sulfur [27] AN M M,SHEN H,CAO Y B,et al. Allicin enhances the
atoms[ J] . Nat Prod Rep,2006,23(6) :851-863. oxidative damage effect of amphotericin B against Candida
[18] OGITA A, NAGAO Y, FUJITA K,et al. Amplification of albicans[ J] . Int J Antimicrob Agents,2009,33 ( 3 ) :258 -
vacuoletargeting fungicidal activity of antibacterial 263.
antibiotic polymyxin B by allicin, an allyl sulfur compound [28] PEREZGIRALDO C, CRUZVILLALON G, S NCHEZSI
from garlic[ J] . J Antibiot ( Tokyo) ,2007,60 ( 8 ) :511 - LOS R, et al. In vitro activity of allicin against
518. Staphylococcus epidermidis and influence of subinhibitory
[19] MOSES A. Garlic ( Allinm sativum) inhibits lipid synthesis concentrations on biofilm formation[ J] . J Appl Microbiol,
by candida [ J ] . Antimicrob Agents Chemother, 1986, 30 2003,95(4) :709-711.
(3) :499-501.



( , 430030)

[ ] , ,
,
[ ] ;;
[ ] R287 [ ] A [ ] 1004-0781(2010)08-1051-03
6 844333

Anda mungkin juga menyukai