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viii Editors: Thiago Devesa Marquez and Davi Urgeiro Neto
will review potential therapeutics in SLE and reflect on where we stand, what we have
learned, and what may lie ahead.
Chapter V - A chronic disorder with unknown etiology, systemic lupus erythematosus
(SLE) is the most diverse autoimmune disorder with a relapsing and remitting course that
may affect any organ in the body. SLE has a broad spectrum of clinical presentations with
higher mortality than general population. These diverse clinical manifestations are mainly due
to SLE complex immunopathology in which B cells produce autoantibodies against mainly
intracellular auto antigen targets, and form complement fixing immune complex deposits
resulting in irreversible organ damage. More than one hundred autoantibodies have been
EBSCO Publishing : eBook Collection (EBSCOhost) - printed on 6/14/2017 3:15 PM via MARYVILLE UNIV
AN: 591939 ; Neto, Davi Urgeiro, Marquez, Thiago Devesa.; Lupus : Symptoms, Treatment and Potential Complications
Account: 096-810