Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-1: Basic principles of medicinal chemistry
Long Essay
1. Write a note on Cytochrome p-450 and monoaminooxygenase with specific emphasis on
its constitution and their role in biotransformation.
2. Discuss how the solubility and partition co-efficient influence the biological activity and
write a note on logp value.
3. Define biotransformation. Differentiate between phase I and phase II biotransformation.
With suitable examples explain the role of glucuronic acid and glycine in drug
metabolism.
4. What are conjugation reactions? Explain the role of these reactions in drug metabolism
with any two examples.
5. What is phase I metabolism? Explain the following phase I biotransformation with
suitable example a) oxidative b) reductive c) hydrolytic.
6. Explain oxidative biotransformation in detail and enumerate the factors affecting
biotransformation.
7. Explain the role of hydrogen bonding, protein binding and chelation in drug action.
8. Define and classify receptors. Explain drug receptor interaction with suitable examples
9. Explain any four physicochemical properties affecting biological activity of drug
molecules.
10. Explain role of Cytochrome P-450 in biotransformation. Discuss phase II drug
metabolism
Short Answer
1
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-2: Central nervous system depressants
Long Essay
1. Define sedative and hypnotics. Explain the SAR of barbiturates. Write the synthesis of
barbital.
2. With examples, classify barbiturates giving structure of atleast one in each class. write
the synthesis of methobarbital
3. Define the terms sedative & hypnotics. Explain the SAR of benzodiazepine. Outline the
synthesis of diazepam.
4. Explain the SAR of phenothiazines. Outline the synthesis of haloperidol and
chlorpromazine
5. Define and classify convulsions. Classify anticonvulsant agents with suitable examples
giving one structure from each class.
6. Define and classify general anaesthetics. Explain the mode of action and enumerate the
synthesis of halothane.
7. Discuss the common structural features of anticonvulsant agents. Explain the synthesis of
phensuximide and phenytoin sodium.
8. Differentiate between the terms sedative, hypnotic and tranquiliser and write the
synthesis of any one drug from each class.
9. a) What are skeletal muscle relaxants? Explain their medicinal application. Outline the
synthesis of chlorphenesin.
b) Explain the SAR of benzodiazepines
10. Outline the synthesis of glutethimide, phenytoin and alprazolam. Enumerate to which
class of drug do they belong and write their specific medicinal uses.
Short Answer
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15. Write the structure and uses of valproic acid and chloral hydrate
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-3: Adrenergic drugs
Short Essay
Short Answer:
1. Outline the synthesis of isoproterenol
2. Discuss non-selective β-blocker
3. What are β-adrenergic agonists? Give examples
4. Give the structure and medicinal uses of methyl dopa and naphazoline
5. Outline the synthesis of prazosin
6. Write the structure and medicinal uses of propranolol
7. What are β1-adrenergic blockers? Give examples.
8. Write the structure and medicinal uses of phenylephrine and clonidine.
9. Classify adrenergic receptors.
10. Write the name and structure of any two β-adrenergic agonist
11. What are adrenergic neuro transmitters.
12. Write a note on α1–adrenergic blockers
13. Write a note on α2–adrenergic blockers
3
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-4: Cholinergic drugs and related agents
Short Essay
1. Give the structure and therapeutic significance of any two irreversible cholinesterase
inhibitors.
2. What are cholinergic neurotransmitters? Explain the biosynthesis of acetyl choline
3. Write a note on neuromuscular blocking agents.
4. Give the synthesis of dicyclomine and tropicamide
5. Classify cholinergic agonist and give the synthesis of neostigmine
6. Write a note on cholinesterase inhibitors.
7. Discuss the SAR of cholinergic agonist
8. Write a note on cholinergic blockers.
9. Write a note on ganglionic blocking agents
10. Classify cholinergic blockers. Outline the synthesis of dicyclomine
11. Give the biosynthesis, metabolism and functions of acetyl choline
Short Answer
1. Write the structure and uses of any two cholinergic blocking agents
2. Give the specific uses of atropine and neostigmine
3. Write the structures of any two cholinesterase inhibitors
4. Mention the types of cholinergic receptors
5. Outline the synthesis of neostigmine
6. Outline the synthesis of dicyclomine
7. Write the structure and uses of any two ganglionic blocking agents
8. Write the structure and uses of any two neuromuscular blocking agents
9. Write the structure and uses of any two irreversible cholinesterase inhibitors
10. Outline the synthesis of tropicamide
11. Outline the functions of acetylcholine
12. Write the structure and uses of any two postganglionic blocking agents
13. Write the structure and mode of action of tubocurarine
14. Write the structure and uses of trimethophan and mecamylamine
15. Write the structure and uses of scopolamine and atropine
16. Write the structure and uses of benztropine and tropicamide
17. Write the structure and uses of carbachol and methacholine
18. Differentiate reversible and irreversible cholinesterase inhibitors
4
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-5: Local Anaesthetics
Short Essay
1. Define and classify local anaesthetic agents with examples. Outline the synthesis of
procaine
2. Explain the SAR of local anaesthetic agents with suitable example
3. Write the synthesis and uses of procaine and lidocaine
4. Classify local anaesthetic agents and explain their mechanism of action
5. Explain the mechanism of action of local anaesthetic agent and write the SAR of
lidocaine derivatives
6. Write the SAR of lidocaine derivatives and give the synthesis of procaine
7. Write the SAR of lidocaine derivatives and synthesis of lidocaine
8. Write the structure and uses of the following a) hexylcaine b) procainamide c)
Dimethisoquin d) prilocaine
9. Write the structure and uses of the following a) cyclomethicaine b) piperocaine c)
benzocaine d) dibucaine e) prilocaine
10. Define and classify local anaesthetic agent with examples. Outline the synthesis of
lidocaine
5
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-6: Histamine and antihistaminic agents
Short Essay
Short Answer:
1. What are histamine receptor? Give examples
2. Write the structure and uses of any two aminoalkyl ether derivatives
3. Write the structure and uses of any two H2 antagonists
4. Write the structure and uses of tripelenamine and pheniramine
5. What are gastric proton pump inhibitors. Give examples
6. Write the synthesis of cetrizine
7. Write the synthesis of chlorpheniramine
8. Write the structure and uses of cyclizine and trimeprazine
9. Write the structure and uses of promethazine and meclizine
10. What are antihistamininc agents? Give examples
11. Write the structure of any two piperazine derivatives as antihistaminic agents
12. Write the structure of any two phenothiazine derivatives as antihistaminic agents
13. Write the structure of any two piperazine derivatives as antihistaminic agents
14. Write the structure of any two propylamine derivatives as antihistaminic agents
15. Write the structure of any two ethylamine derivatives as antihistaminic agents
6
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-7: Analgesic agents
Short Essay
1. What are narcotic analgesics? Write the structure and uses of any four drugs.
2. What are narcotic antagonist? Write the structure and uses of any four drugs.
3. Define and classify NSAID’s. Write the structure of one drug from each class
4. Write the synthesis and uses of methadone and dextromethorphan
5. Outline the synthesis and uses of mefenamic acid and ibuprofen
6. Ouline the synthesis and uses of piroxicam and naproxen
7. Discuss on narcotic analgesics? Give the synthesis of methadone
8. Write a note on narcotic analgesics. Outline the synthesis of dextromethorphan
9. Outline the synthesis and uses of nimesulide and acetaminophen
10. Write a note on steroidal anti-inflammatory agents. Explain their medicinal merits and
demerits.
11. What are non-steroidal anti-inflammatory agents? Explain their mechanism of action
Short Answer
7
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-8: Structure and medical uses of important prostaglandins
Short Answer:
1. What are prostaglandins? Give examples
2. Write a note on the medicinal uses of prostaglandins
3. Write the structure and medicinal uses of any two prostaglandins
4. Give the structure and medicinal uses of PGE1 and PGE2
5. Give the structure and medicinal uses of prostaglandins PGF2A and PGE
6. Write the medicinal importance of prostaglandins
7. Give the name and structure of prostaglandins used in labour pain
8. What are thromboxanes? Give their medicinal uses
9. Classify prostaglandins with examples
10. Write the adverse effects of prostaglandins
11. What are prostaglandins? Name two examples used as abortefecents
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Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-9: Natural Products
Short Essay