Clozapine is everywhere

1. It is important to maximize the treatment of both psychosis and depression. There is suggestive
evidence that both first- and second-generation antipsychotic medications may reduce the risk
of suicide. However, clozapine is the most extensively studied and has been shown to have the
greatest therapeutic effect on suicidal behavior, possibly reducing the suicide rate by as much as
75%–85%. For these reasons, clozapine should be preferentially considered for patients with a
history of chronic and persistent suicidal ideation or behaviors.
2. Limit setting and behavioral approaches have been employed for the management of persistently violent
patients (432, 436). Antipsychotic medications remain the mainstay of management
(421, 437), with good evidence for clozapine in particular