DRUG/ THERAPEUTIC STUDY FORM

Generic Indication Contraindication Side Effects Adverse Drug-drug interaction Nursing Responsibilities
Name Effects
Omeprazole Short-term contraindicated Increased risk Anaphylaxis, Increased risk of •Give medication before meals,
treatment of active in patients with of Clostridium pancreatitis, hypomagnesaemia w/ preferably in the morning for once-
Brand Names benign gastric ulcer, known difficile-associated Stevens- diuretics. daily dosing. If necessary, also give an
Prilosec active duodenal hypersensitivity diarrhoea (CDAD) Johnson antacid, as prescribed.
ulcer, erosive to any and osteoporosis- syndrome, May increase INR and
Dose esophagitis (EE), component of related fractures. erythema prothrombin time w/ •If needed, open capsule and
symptomatic GERD. the formulation. Headache, rash, multiforme warfarin. Increased risk sprinkle the granules on applesauce
40 mg OD Hypersensitivity pruritus, dizziness, and toxic of digoxin-induced or yogurt or mix with water or acidic
Route reactions may fatigue, cough, epidermal cardiotoxic effects. fruit juice, such as apple or cranberry
Intravenous include back or abdominal necrolysis. juice. Give immediately.
anaphylaxis, pain, arthralgia and May increase plasma
anaphylactic myalgia, urticaria, concentration •To give drug via NG tube, mix
Mechanism of
shock, dry mouth, benzodiazepines (e.g. granules in acidic juice because
Action
angioedema, photosensitivity, diazepam), enteric coating dissolves in alkaline
Omeprazole is a
bronchospasm, bullous eruption, clarithromycin and pH.
substituted
interstitial fever, angioedema, methotrexate.
benzimidazole gastric
nephritis, and bronchospasm, •Because drug can interfere with
antisecretory agent
urticaria anaphylaxis, Decreased absorption absorption of vitamin B12, monitor
and is also known as
somnolence, of itraconazole, for anemia.
PPI. It blocks the final
aggression and ketoconazole,
step in gastric acid
vertigo, insomnia, posaconazole, •Be aware that long-term use of
secretion by specific
reversible dasatinib, iron salts. medication may increase the risk of
inhibition of
confusional states, gastric carcinoma.
H+/K+ ATPase enzyme
depression, May prolong
system present on
agitation, elimination of
the secretory surface
hallucination. diazepam, cilostazol,
of the gastric parietal
phenytoin and
cell. Both basal and
ciclosporin.
stimulated acid are
inhibited.
May reduce the
antiplatelet effect of
clopidogrel.
 Generic Indication Contraindication Side Effects Adverse Effects Drug-drug Nursing Responsibilities
Name interaction
Paracetamol Mild to - Decreased Thrombocytopenia, Stevens-Johnson May reduce serum -Check that the patient is not taking
moderate pain kidney function. leucopenia, syndrome, toxic levels w/ any other medication containing
and fever. pancytopenia, epidermal anticonvulsants paracetamol.
Brand Names neutropenia, necrolysis, acute (e.g. phenytoin,
- Decreased liver
Aeknil function. agranulocytosis, generalised barbiturates, - For children who may refuse
pain and burning exanthematous carbamazepine). medicine off a spoon try using a
- Alcohol sensation at inj pustulosis, acute medicine syringe to squirt liquid
Dose
dependence. site. Rarely, renal tubular May enhance the slowly into the side of the child’s
150mg as needed hypotension and necrosis and anticoagulant mouth or use soluble paracetamol
tachycardia. hepatotoxicity. effect of warfarin mixed with a drink.
and other
Route coumarins w/ - Some children may be happy to take
prolonged use. one paracetamol product but dislike
Intravenous the taste of another.
Accelerated
Mechanism of Action absorption w/
- There are no known harmful effects
metoclopramide
Paracetamol exhibits when used during pregnancy.
and domperidone.
analgesic action by
peripheral blockage of - Small amounts may pass into breast
May increase
pain impulse generation. milk. However, there are no known
serum levels w/
It produces antipyresis by harmful effects when used by
probenecid. May
inhibiting the breastfeeding mothers.
increase serum
hypothalamic heat- levels of
regulating centre. Its chloramphenicol. - Alcohol increases the risk of liver
weak anti-inflammatory damage that can occur if an overdose
activity is related to May reduce of paracetamol is taken. The hazards
inhibition of absorption w/ of paracetamol overdose are greater
prostaglandin synthesis in colestyramine w/in in persistent heavy drinkers and in
the CNS. 1 hr of admin. May people with alcoholic liver disease.
cause severe
hypothermia w/ - Evaluate therapeutic response.
phenothiazine.
 NURSING CARE PLAN
GOALS AND
ASSESSMENT DIAGNOSIS INTERVENTION RATIONALE EVALUATION
OBJECTIVES