The Role of Allergy

Desensitization in Autism

Darin Ingels, ND, MT(ASCP)

New England Family Health Associates
2425 Post Road, Suite 100
Southport, CT 06890
203-254-9957
nefha@nefha.com

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 Vaccines in 1974
•  2 mos: DTP, OPV
•  4 mos: DTP, OPV
•  6 mos: DTP, OPV
•  1 yo: Measles, PPD (TB)
•  1-12 yo: Rubella, Mumps
•  1 1/2 yo: DTP, OPV
•  4-6 yo: DTP, OPV
14 vaccines
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 Vaccines in 2009
•  "Birth: Hep B
•  2 mos: DTaP, Hib, Hep B, IPV, PCV, Rota
•  4 mos: DTaP, Hib, Hep B, IPV, PCV, Rota
•  6 mos: DTaP, Hib, Hep B, IPV, PCV, Flu, Rota
•  12 mos: Hep B, Hib, IPV, MMR, Varicella, PCV,
Hep A
•  15-18 mos: DTaP, Hep A
•  4-6 yrs: DTap, IPV, MMR, Varicella, MCV
34 vaccines
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 Vaccines: A Numbers Game
Infectious Disease Cases per year
1.  Measles < 35
2.  Mumps 250 (>6500 in 2006)
3.  Rubella <10 cases total since 2001
4.  Hepatitis B (HBV) 300,000-500,000
5.  H. influenzae (Hib) 25
6.  Diphtheria <1
7.  Tetanus <6
8.  Pertussis (Whooping 26,000 (In 2005, 38/39 deaths
cough) in infants , 6 mos)
9.  Polio 0 (last case in 1979)
10.  Menigococcus 1400-2800
11.  Pneumococcus 400 (96% of severe Dz from
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non-vaccine strains) 3"
 Vaccines: Hidden Ingredients
•  Mercury
•  Aluminum
•  Chicken serum
•  Bovine serum
•  Human serum albumin
•  Formaldehyde/Formalin
•  Antibiotics
•  Soy
•  Yeast
•  MSG (MMRV-ProQuad, VZV)
•  Insect cell protein (HPV)
http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/
excipient-table-2.pdf
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 Vaccines: Thimerosal-Free
•  "Hep B: Recombivax HB, Engerix-B
•  Rotavirus: Rotateq
•  DTaP: Infanrix, Daptacel, Adacel, Boostrix
•  Hib: ActHIB, OmniHIB, PedvaxHIB
•  PCV: Prevnar
•  Polio: IPOL
•  MMR: MMR-II
•  Hep A: Havrix, Vaqta
•  Flu: Fluzone (Thimerosal-free), FluMist
(Intranasal)
•  Varicella: Varivax#$$%"&'()*"+*,-./0"#&" 5"
Do Vaccines Predispose to Allergy?
Dermal testing of vaccines for children at high risk of allergies.
Sugai K, et al.
Department of Pediatrics, Yokohama City University, Fukuura 3-9, Yokohama, Kanagawa 239-0004, Japan. kazgoto@be.mbn.or.jp

Vaccinations for children with allergic diseases often need to be postponed or terminated because of the presumed risk of an immediate-
type allergic reaction such as anaphylaxis. A new skin test protocol for predicting allergic reactions using the vaccine itself and the
following stepwise vaccination method were developed and tested. Intradermal tests using 1:10 and 1:100 diluted measles vaccine
indicated that the former was superior to the latter because a positive reaction against 1:10 diluted vaccine was found in
28.6% of 49 patients with severe allergic diseases including bronchial asthma, atopic dermatitis, food
allergies and allergies to two or more allergens with high levels of IgE, as compared with the reaction against 1:100
diluted vaccine in 10.2% of the patients. Patients negative for 1:10 skin tests were safe from the following full-dose vaccine shots. Three
patients showed very strong local reactions against measles vaccine, and avoided receiving the following full-dose shot. Positive
reactions to skin tests of 1:10 diluted vaccine were found in 11 patients, who were given stepwise vaccinations. Three patients had
adverse reactions, and two of them had been negative for 1:100 skin tests. In the case of influenza vaccine, skin tests were again more
sensitive to 1:10 than to 1:100 diluted vaccine, because 3 out of 14 patients with positive reactions showed immediate-type adverse
reactions against the following stepwise vaccinations, and 1 of them was negative for the 1:100 skin test. Moreover, the results of the skin
prick test (undiluted vaccine) and the intradermal skin test (1:10 diluted vaccine) indicated that the latter was more useful in both cases of
measles (54 patients) and influenza vaccine (69 patients). Overall, the skin test using 1:10 diluted vaccine was the more suitable for
predicting an immediate-type reaction to measles and influenza vaccinations. Patients having negative 1:10 skin tests can be expected to
show no adverse reactions to the remaining injections and even the positive subjects will complete the course of vaccine doses by the
stepwise method.

Vaccine. 2007 Apr 30;25(17):3454-63. Epub 2007 Jan 11.

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Do Vaccines Predispose to Allergy?
Is infant immunization a risk factor for childhood asthma or allergy?
Kemp T, et al.
Department of Medicine, Wellington School of Medicine, New Zealand.

The Christchurch Health and Development Study comprises 1,265 children born in 1977. The 23
children who received no diphtheria/pertussis/tetanus (DPT) and polio immunizations
had no recorded asthma episodes or consultations for asthma or other allergic illness
before age 10 years; in the immunized children, 23.1% had asthma episodes, 22.5%
asthma consultations, and 30.0% consultations for other allergic illness. Similar differences
were observed at ages 5 and 16 years. These findings do not appear to be due to differential use of health
services (although this possibility cannot be excluded) or con-founding by ethnicity, socioeconomic status,
parental atopy, or parental smoking.

Epidemiology. 1997 Nov;8(6):678-80.

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Do Vaccines Predispose to Allergy?"
Do early childhood immunizations influence the development of atopy and do they cause allergic reactions?
Gruber C, Nilsson L, Bjorksten B
Department of Pediatric Pneumology and Immunology, Charité - Humboldt University, Berlin, Germany.

Concerns about allergic side-effects of vaccines and about a possible promotion of allergic diseases contribute to
incomplete vaccination rates in childhood. This article reviews the current understanding of these issues. There is
evidence that pertussis and diphtheria/tetanus antigens elicit immunoglobulin E (IgE) antibody
formation as part of the immune response. In murine models, pertussis toxin is an effective adjuvant for IgE
formation against simultaneously administered antigens. In children, however, sensitization to unrelated antigens or
development of allergic diseases do not seem to be augmented. In contrast, bacille Calmette-Guérin (BCG) and
measles vaccination have been proposed as suppressors of allergy because of their T helper 1 (Th1)-fostering
properties. In the murine system, BCG inhibits allergic sensitization and airway hyper-reactivity. Some
epidemiological studies in humans suggest an inhibitory effect of tuberculosis on allergy. BCG vaccination in
children, however, has no or merely a marginal suppressive effect on atopy. Other vaccine components such as
egg proteins, gelatin, and antibiotics are a potential hazard to children with severe clinical reactions
to these allergens. These rare children should be vaccinated under special precautions. In conclusion, vaccination
programs do not explain the increasing prevalence of allergic diseases, but individual children may uncommonly
develop an allergic reaction to a vaccine. The risks of not vaccinating children, however, far outweigh the risk for
allergy. Therefore, childhood vaccination remains an essential part of child health programs and should not be
withheld, even from children predisposed for allergy.

Pediatr Allergy Immunol. 2001 Dec;12(6):296-311.

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Do Vaccines Predispose to Allergy?"

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 Who has allergies?
•  According to the American Academy of Allergy,
Asthma and Immunology, more than 50 million
people in the U.S. have some form of allergy.
•  Allergic diseases affect more than 20% of the
population.
•  Allergies are the 6th leading cause of chronic disease
in the U.S.
•  Since “allergy” has a strict definition, the number of
people with hypersensitivity is likely much higher.
•  There is a higher likelihood of growing into an
allergy than growing out of one. Allergy symptoms
can occur at any age.
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 What is Allergy?
•  Allergy is defined as a “harmful, increased susceptibility to a
specific substance”, also known as hypersensitivity.

•  Typically used to describe type I or immediate hypersensitivity

reactions, mediated by IgE, but may include types II, III and
IV hypersensitivity.

•  However, this definition does not encompass the breadth of

immune reactions to substances.

•  Anyone presenting with recurrent infections or multiple

endocrine dysfunction should be evaluated for allergies.

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 Common Allergens
•  House dust mites
•  Pollen (trees, grasses and weeds)
•  Mold
•  Animal danders (cat, dog, rabbit, etc.)
•  Insects
•  Foods: milk, egg, peanuts, wheat, soy, tree nuts
•  Food components: histamine, tyramine, MSG,
phenolics

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Weapons of Mass Destruction

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 Less Common Allergens

•  Food dyes, especially tartrazine (yellow #5)

•  Chemicals: perfume, formaldehyde, phenol,
petroleum, preservatives, tobacco smoke (think
about your local mall with all new products)
•  Medications
•  Hormones, neurotransmitters? Do some of the
body’s proteins stimulate immune reactions?
•  Vaccines and their components?
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 Classification of Hypersensitivity
Adapted from Johansson SGO et al. Allergy 2001;56:813-24

Hypersensitivity

Allergic hypersensitivity Nonallergic hypersensitivity

(Immunologic mechanism defined) (Immunologic mechanism excluded)

IgE mediated Non-IgE mediated

Atopic T-cell
Non-atopic
Classic allergy (contact dermatitis, Celiac disease)

Insect sting Eosinophillic reactions

Parasites/Infection IgG-mediated
(allergic alveolitis, food allergies?)

Drugs
Idiosyncratic

Others
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 Classification of Hypersensitivity
Adapted from Johansson SGO et al. Allergy 2001;56:813-24

Hypersensitivity

Allergic hypersensitivity
Nonallergic hypersensitivity
(Immunologic mechanism(Immunologic
defined) mechanism excluded)

Enzymatic Food Intolerance

Pharmacologic Reactions
Psychological Reactions
(i.e. Lactose intolerance)
(i.e. caffeine)(i.e. aversions to foods)
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 Classical Allergy Symptoms

•  Allergic rhinitis (hayfever)

•  Sinusitis
•  Allergic conjunctivitis
•  Otitis media/Otitis interna
•  Asthma
•  Eczema
•  Contact dermatitis
•  Hives (urticaria)
•  Gastroenteritis

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Other conditions that may suggest allergy
•  Arthritis •  GERD
•  Autism (ASD) •  Glaucoma
•  Bladder infections •  Hypertension
•  Candidiasis •  Hypoglycemia
•  Canker sores •  Hypothyroidism
•  Celiac disease •  IBS
•  Chronic infections •  Inflammatory Bowel Dz
•  Colic •  Irregular menses
•  Constipation •  Migraine headaches
•  Depression •  Obesity
•  Diarrhea •  PMS
•  Fatigue (Chronic) •  Psoriasis
•  Gallbladder attacks •  Ulcers
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Allergic Shiners

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Allergic “Salute”

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Dennie’s Lines

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 Diagnosis of Allergies
Skin Tests: Blood Tests:
•  Total IgE
•  Prick Test •  RAST: Specific IgE
•  Scratch Test •  IgG4 tests (foods)
•  IgA (selective IgA
•  Patch Test deficiency)
•  Intradermal injections
Blood tests limited to IgE/IgG4
reactions, so will miss all non-
allergic and non-IgE
hypersensitivities

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 Diagnosis of Allergies
•  Provocation/Neutralization: Intradermal method of
using serial 1:5 dilutions to provoke symptoms with
one dilution and turning the symptoms off with the
neutralizing dose. Used for foods.
•  Serial endpoint titration (SET): Used for inhalants.
•  *Esoteric Testing: Electrodermal screening (EDS),
kinesiology, NAET.
* These methods are not FDA approved as diagnostic
methods, but may provide insight into one’s allergies.

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 Electrodermal Screening (EDS)
•  Developed by Reinhold Voll, MD in the
early 1950’s
•  The electric current passing through
acupuncture points differs from random
places on the skin
•  In 1994, Dr. Alfred Gillman discovered
cells communicate electrically before they
communicate biochemically
•  This means we can use the body’s
electrical patterns to detect changes in
tissue
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 Advantages of Electrodermal
Screening (EDS)
1.  Non-invasive! No needles, scratching, injections
2.  Ability to assess sensitivities in a short time period
Conventional: 4-6 foods in an hour
EDS: 100 foods in 15 minutes
3.  Ability to assess for allergens/sensitivities that may
not be possible through conventional means
(chemicals, hormones, neurotransmitters, etc.)
4.  More sensitive than conventional methods. May
detect subtle sensitivities or allergies

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Sublingual Immunotherapy (SLIT)
•  Treatment concept same as injection; different route
of administration. Allergy drops taken under tongue
and then swallowed. Can also be applied on the skin.
•  Used in Europe more widely than in U.S. More than
30 years of clinical use.
•  Proven safety record. No risk of anaphylaxis. Safe to
use with children.
•  Can use same diagnostic techniques to determine
neutralizing dose (endpoint).
•  More than 600 published clinical trials showing SLIT
effective in treating inhalant and food allergies.
Potential to treat other allergies/sensitivities
(chemicals, autoimmune conditions)?
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Sublingual Immunotherapy (SLIT)"
What can be treated with SLIT?
1.  Food allergies/sensitivities
2.  Molds
3.  Pollens (trees, grasses, weeds)
4.  Dust and dust mites
5.  Animal danders (cat, dog, horse, etc.)

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Sublingual Immunotherapy (SLIT)"
What can be treated with SLIT?
6.  Chemicals: Formaldehyde, phenol, benzene,
toluene, perfume, newsprint, etc.
7.  Hormones: Cortisol, T3, T4; this can be
significant in adrenal stress
8.  Neurotransmitters: Serotonin, dopamine, GABA,
norpepinephrine, epinephrine; think about
medicines/supplements that increase these
substances. Would you eat a peanut if you were
allergic to it?
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Sublingual Immunotherapy (SLIT): Is
It Effective?"
Studies show SLIT is effective 75-90% of the
time. The effectiveness of the treatment is
based on quality of antigen, dose of antigen
and duration of treatment. This is equal or
superior to conventional injection
immunotherapy.
The duration of treatment can be short (6 months
for food) up to many years (mold, pollens).

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 Advantages of Sublingual
Immunotherapy (SLIT)
1.  Non-invasive. Drops are administered under
the tongue or on the wrist. No needles or
injections.
2.  Excellent safety record.
3.  No weekly doctor’s visits to get treatment.
Able to administer at home.
4.  More control over dose. Treatment can be
easily tailored to response.
5.  More effective than conventional
immunotherapy?
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 Classical Homeopathy
•  Founded by Samuel Hahnemann, MD in 1796
•  Treatment principle based on Law of Similars or
“like cures like”
•  Substances derived from plants, minerals, animals
and other sources are potentized (dilution and
secussion) to make specific remedies and their
potencies
•  ‘X’ dilutions are serially 1:10 dilutions; ‘C’
dilutions are serially 1:100 dilutions
•  Anything beyond 12C or 24X is not likely to
contain any of its original substance
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Classical Homeopathy

You must look past the

autism to see the
individual…

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 Theory of Miasms"
•  Psora: “The mother of all diseases”. Weakness,
low energy, anxiety, fears, skin problems
(itchy), coldness, clear discharges
•  Sycosis: High energy (night owl), impatient,
impulsive, jealous, extremes, high fevers,
spasms, green/yellow discharges
•  Syphilis: High energy, destructive, aggressive,
isolated, secrecy, suspicious, deformity, bloody
discharges

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 Miasmatic Prescribing
•  The remedy prescribed should match the
miasmatic quality of the person.
•  Miasms are inherited or acquired. They form
the foundations of health and illness.
•  If you understand the miasmatic qualities of a
person, you can predict what types of illnesses
they may be susceptible to.
•  Even if the wrong remedy is selected, but if it
is the right miasm, you are likely to see
positive results.
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 How Does It All Fit?

Drug therapy SLIT Homeopathy

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Its never too late to undo the damage…

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