2003
Y IDE AMERICAN ACADEMY OF ANTI-AGING MEDICINE
R U
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&
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DI OU
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Anti-Aging
IN THIS ISSUE:
Classifieds 79
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Anti-Aging:
Continues as Global Phenomenon
British novelist Doris Lessing Cutting-edge diagnostic technologies such as Electron Beam
(b. 1919), making reference to the Tomography, brain mapping, full-body CT scanning, and wellness-
popularization of science fiction in oriented laboratory testing for very early detection and screening for
the 1970s, remarked: aging-related diseases have made their debuts at A4M scientific
What a phenomenon it has been— conferences. Today, experts predict that similar and yet even newer
exploding out of nowhere, digital technologies will drive vigorous growth and diversification in
unexpectedly of course, as always these types of diagnostics in the coming years [Market Data Enterprises].
happens when the human mind is Most recently valued at $30 billion annually [“Dateline NBC,” March 21,
being forced to expand; this time 2001], the anti-aging marketplace is expected to grow to $41.94 billion
starwards, galaxy-wise, and who in 2006, reflecting a robust average annual rate (AAGR) of 9% [“Drugs
knows where next. and Cosmetics for Aging Boomers,” Business Communications Company, Inc., 2002]. The anti-aging
A decade ago, anti-aging marketplace, a spinoff of the establishment of the anti-aging medical
medicine was labeled by some as movement by the A4M a decade ago, has blossomed because it is a
science fiction. Ten years later, market that is demographics-driven, and immune to external
many of the insights of anti-aging variables such as the economy and politics.
pioneering researchers and clinicians It is through the momentum of the individual clinical and
have become science fact. research efforts of our 12,000 members in 70 nations that A4M can
Multivitamin, multimineral supplementation. Dr. Ranjit achieve a world in which we all enjoy prolonged lifespans, absent of
Chandra and colleagures from Memorial University (Newfoundland) disease and disability, instead filled with productivity and vitality. We
demonstrated that a nutrient supplement with modest amounts of 18 remind you to maintain your A4M membership in current and good
vitamins, minerals, and trace elements caused “significant standing – or join if you have not done so already, and reap the many
improvement in short-term memory, problem-solving ability, membership benefits at your avail. Anti-Aging Board Certification
abstract thinking, and attention.” Additionally, the multi-vitamin, will position you as part of the Elite Core of the anti-aging
multi-mineral supplement improved immunity. Further, infection- movement. And as prolific publishers of authoritative texts in this
related illness in those taking the supplement occurred at less than specialty, we encourage you to expand your anti-aging library to
half the rate (23 days/year) compared to those who took placebo (48 include our latest publications.
days/year). Most compelling was the cost-effectiveness and simplicity In its first decade, A4M has achieved a rapid and broad
of a nutritional supplement to prevent or delay illness and functional international acceptance and adoption of anti-aging medicine (see
decline in the elderly. Dr. Chandra calculated that for every $1 US centerfold, pages 40-41). The creation of A4M and the anti-aging
spent on the supplement, $28 US would be saved in healthcare costs. medical movement unleashed an unexpected global phenomenon
Today, thirty-three percent (33%) of adults take supplements on the that will take us, as Ms. Lessing’s lesson suggests, “who knows where
specific advice of their doctor [Harris Interactive survey, 2001.] next.” Be there to see what’s around the corner.
Antioxidant supplementation. Dr. Denham Harnam, geriatric Dr. Ronald M. Klatz
expert at the University of Nebraska Medical Center, established the President, American Academy of Anti-Aging Medicine
free radical theory of aging in 1954. Forty years later, during which
his theory was often “ridiculed by the medical community” [Northwest
Indiana Times, June 30, 2003], he was the recipient of A4M’s Infinity Award, the
Dr. Robert Goldman
highest honor bestowed in for outstanding anti-aging discoveries. To Chairman, American Academy of
A4M, his premise was simple, elegant, and sensible: that free radical Anti-Aging Medicine
scavengers such as Vitamins C and E and other antioxidant
The American Academy of Anti-Aging Medicine (“A4M”) is a non-profit medical society dedicated to the advancement of
supplements, could decelerate free radical production, and, in doing technology to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the
so, stave off premature death. Contemporary scientists have now human aging process. A4M is also dedicated to educating physicians, scientists, and members of the public on anti-aging issues.
discovered links between free radicals and diseases such as cancer, A4M believes that the disabilities associated with normal aging are caused by physiological dysfunction which in many cases are
ameliorable to medical treatment, such that the human life span can be increased, and the quality of one’s life improved as one
cardiovascular disease, stroke, and Alzheimer’s Disease. Today, grows chronologically older. A4M seeks to disseminate information concerning innovative science and research as well as treatment
Vitamins A, beta-carotene, C, E, and the mineral selenium are now modalities designed to prolong the human life span. Anti-Aging Medicine is based on the scientific principles of responsible medical
commonly recommended by physicians, both anti-aging and others, care consistent with those of other healthcare specialties. Although A4M seeks to disseminate information on many types of
medical treatments, it does not promote or endorse any specific treatment nor does it sell or endorse any commercial product.
as a good preventive measure.
© Copyright 2003. The American Academy of current A4M members and to other qualified individuals. and/or other media], number of reprint instances), and
Anti-Aging Medicine. All rights reserved. ISSN 1533- To subscribe, submit your full name, professional indicate a contact name with telephone, facsimile, and
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Encouraging Current Trends in the United States. Four years ago, the
same group documented the first sustained
worldwide by 2020. The report’s co-editor
and Director of Cancer Services at the
In the United States, cancer ranks as the
second leading cause of death, responsible decline in cancer death rates. This trend was University of New South Wales (Australia),
for 23% of all deaths. One in four the first notable reversal from continual and Dr. Bernard Stewart, urges “Governments,
Americans – 1,500 every day – will succumb sometimes sizeable increases in cancer rates physicians, and health educators at all levels
to cancer-related death. Cancers of the lung, that had been occurring since the 1930s, [to] do much more to help people to …
bronchus, colon, and rectum account for when nationwide record keeping on deaths avoid preventable cancers.”
was implemented.
more than half of the total cancer deaths Cutting-Edge Diagnostics
among men and women. Figure 1 displays Complacency Discouraged
the most common cancers occurring in men The number of cancer cases is expected & Spinoff Therapies
and women, and the death rates, in 2002. to increase because of the growth and aging When Richard Nixon declared war on
In the jointly released “Annual Report to of the population in the coming decades. cancer in 1971, most scientists and
the Nation on the Status of Cancer” (2002) Warned NCI Director Dr. Andrew von researchers considered it to be a relatively
by the US National Cancer Institute (NCI), Eschenbach, “The continuing decline in the simple disease. For over three decades, and
the American Cancer Society (ACS), the rate of cancer deaths once again affirms the not until Human Genome Project (HGP)
North American Association of Central progress we’ve made against cancer, but the was well underway, the complexities of
Cancer Registries (NAACCR), and divisions report also highlights the need for an cancer eluded the world’s top experts in the
of the Centers for Disease Control & acceleration of research as the population of field. Cancer, as we now know, is the result
Prevention (CDC), it was reported that the US ages.” The singlemost important of certain, specific genetic mutations
death rates for all cancers was on the decline risk factor for cancer is age. Cancer rises to combining together simultaneously. Some
become the #1 cause of mutations are triggered endogenously, while
death for women age 40-59 others are of exogenous origin. Because the
(killing nearly 50,000 in 33,000 genes identically present in each of
1999), and is the #1 killer our cells are active in different combinations
among both men and and at different times during a single second,
women in the age bracket it is remarkable that the frequency of a gene
60-79 (300,000 deaths in mutating and multiplying to spread to other
1999). cells happens far less often than statistics
Estimates NAACCR, “If would dictate.
Dr. Ward Dean has written extensively on the biology of aging and is perhaps best known for his pioneering work on developing means to measure the
physiological and biochemical effects of aging as well as developing revolutionary nutritional and pharmacological protocols to delay aging and ameliorate age-
related diseases. Dr. Dean is a graduate of the US Military Academy at West Point. He is presently the Director of Research and Development for Vitamin
Research Products (www.vrp.com).
4 Anti-Aging Medical News • FALL 2003
Mitochondrial Function and Bio-Energetics
Continued from page 4
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Introduction
Evidence indicates that aging is
coupled to an accumulation of errors in
DNA that arise due to strand breakage,
DNA replication errors, or
dysfunctional DNA repair mechanisms.
Naturally occurring background
radiation is a pervasive mutagen known
to adversely affect DNA. Deuterium
oxide is also pervasive and adversely
affects DNA.
Deuterium is present in the Earth’s
surface waters at a concentration of 155
parts per million. At this low level it is
generally thought to have no effect.
However, over long periods of time
low levels of deuterium could play a
role, especially when coupled with
radiation and other mutagens that lead
to DNA damage.
As a consequence and over time,
Figure 1. Possible link between DNA errors and cancer rates3
through the mechanism of increased
hydrogen bonding strength, deuterium
may disrupt DNA repair enzymes and
slow the rate of DNA replication,
exposing it to a greater chance of
corruption.
Studies with deuterium depleted
water (DDW) in Hungary and
Romania show beneficial effects from
consuming DDW. The elimination of
deuterium from the diet may protect
DNA and slow the aging process.
Aging & DNA
The maximum lifespan that an
organism can achieve is tied to its
DNA.1 DNA is damaged by free
radicals produced by radiation,
mutagens, and normal metabolic
processes.
Figure 2. Two mechanisms of strand breakage linked to ionizing radiation
Continued on page 14
Kirk B. Goodall is currently a Senior Member of Technical Staff with the NASA Jet Propulsion Laboratory. He holds a Bachelor’s
degree in Physics from Harvard University and a Masters degree in Aeronautics & Astronautics from the Massachusetts Institute of
Technology. For the past four years he has pursued anti-aging medicine as an independent research effort. A more detailed presentation
of his research is available at: http://geocities.com/kgoodall2001/anti-aging.
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FALL 2003 • Anti-Aging Medical News 9
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10 Anti-Aging Medical News • FALL 2003
Mitochondrial Function and Bio-Energetics
Continued from page 8 Dr. Salvatore Pepe of the Alfred Thiamine (Vitamin B1)
flow, and increases glucose uptake. Hospital Cardiac Surgical Research Unit Large doses of thiamine (vitamin B1)
Furthermore, (R)-alpha lipoic acid in Melbourne, Australia, reported similar have been used to stimulate NADH,
appears to be about ten times more potent findings. Dr. Pepe demonstrated that an which then augments oxidative
than the more commonly available form omega-3 rich diet directly increases phosphorylation at Complex I. Doses of
of lipoic acid. The researchers further mitochondrial membrane cardiolipin 300 mg/day in patients with chronic
concluded that (R)-alpha lipoic acid concentrations, increases the ratio of external ophthalmoplegia (CPEO),
supplementation may be a safe and mitochondrial membrane omega-3 to resulted in normalization of blood levels
effective means to improve general omega-6, and increases tolerance of the of lactate and pyruvate.14
metabolic activity and increase heart to ischemia and reperfusion.12
antioxidant status.
Niacinamide (Vitamin B3) Riboflavin (Vitamin B2)
Riboflavin (vitamin B2) functions as
Omega Three Fatty Acids Drs. Christopher Driver and Angela a cofactor in Complex I and II.
Mitochondrial calcium levels Georgiou of the National Aging Riboflavin in a dose of 100 mg/day
increase and mitochondrial membrane Research Institute in Australia tested the improved exercise capacity in a patient
cardiolipin content decreases with aging. efficacy of niacinamide to re-energize the with a mitochondrial myopathy due to a
Scientists at the National Institute on bioenergy system of old fruit flies. After Complex I dysfunction.15
Aging found that omega-3 fatty acids administering niacinamide (250 mcg/ml
from fish oils are cardio-protective in of water) to the flies, they determined Exercise
aging animals, in that they minimized the that niacinamide ameliorated age-related Elderly subjects tend to use more
increase in mitochondrial calcium changes in bioenergy and extended the glucose and less fat during exercise than
content, prevented the decrease in lifespan of the flies by 15 percent.13 young subjects. However, endurance
cardiolipin content, and increased levels training increases muscle respiratory
of phosphatidylcholine.11 Continued on page 12
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FALL 2003 • Anti-Aging Medical News 21
ISSUE 2, 2003
M CARE
A REPORT FROM THE M EDICAL C OMMITTEE FOR A GING R ESEARCH AND E D U C AT I O N
SCIENTIFIC EDITORIAL
BOARD
Executive Editor
Dr. Ronald M. Klatz (USA)
Pres.-American Academy of Anti-Aging Medicine
Lifespan Literature Scan
Managing Editor
Domino-Effect Japan’s Elderly
Dr. Robert M. Goldman (USA)
Pres.-National Academy of Sports Medicine in Financial Set New Image
Chair- American Academy of Anti-Aging Medicine
Associate Editor Woes as of Aging
Catherine Cebula (USA)
Director-LEXCORE Research Program Australia Ages Japan is aging at a rapid rate never
before or currently experienced by any
Few Australians have a personal
Scientific Editorial Advisory Board other nation. An estimated 1 in 4
Juan Marcos Becerro MD, PhD (Spain)
financial plan in-place, as almost 80%
citizens will be age 65+ by the year
Olympic Medical Committee Spain (Ret.) of that nation’s population is estimated
Denise Bruner, MD (USA) Former President 2020. Japan’s more notable seniors now
to have an annual income at retirement
American Society of Bariatric Physicians
include Yuichiro Miura, age 70, who
Anongnuth Chiangpradit, MD (Thailand) of just $12,000. Warn investment
Bumrungrad Hospital first won fame as the first person to ski
experts, this will place an extreme
Brian Corrigan, MD, PhD (Australia) down the South Col of Mount Everest
Australian Olympic Committee (Ret.) burden on the government, since most
Eduardo De Rose, MD, PhD (Brazil) President in 1970, becoming the oldest person to
retiring Australians will have to seek
International Federation of Sports Medicine successfully ascend the 29,035-foot
Setsuya Fujita, MD, PhD (Japan) Director public pension. So far, financial
Louis Pasteur Medical Research Institute mountain straddling the border
planners have had a “hard sell” in
Rafael Santonja Gomez, PharmD (Spain) between Nepal and China in late May
Spanish Olympic Committee convincing working Australians to
2003. To commemorate the occasion,
Dato Harnam, MD, PhD (Malaysia) President commit to investment options.
Allergy and Immunology Medical Association Mr. Miura remarked, “I want to cheer
Thierry Hertoghe, MD (Belgium) Amongst upper-income Australians a
up Japan’s graying society as you can do
European Academy of Longevity Medicine survey revealed that financial matters
Vernon Howard, PhD (USA) something even at age 70.”
Harvard University (Ret.) were their #1 cause of stress in their reported by Taipei Times, June 3, 2003
Michael Klentze, MD, PhD (Switzerland) President personal lives. As a result, many
European Center for Aging Research and Education
employees and employers are losing on-
Stanley Kornhauser, PhD (USA) Director
National Institute for Electromedical Information the-job productivity. Applying US
Japan’s Innovative
Seung-Yup Ku, MD, PhD (Korea)
Seoul National University
research data to the Australian Import-Export
investment industry suggests that
Edward Lichten, MD (USA)
Wayne State College of Medicine
worker productivity could improve by
Proposal
Jean Monro, MB (United Kingdom) In initial meetings between Japan
Breakspear Hospital, England as much as 30% if employees learned to
João Francisco Marques Neto MD, PhD (Brazil) President, become financially savvy. and the Philippines, officials agreed to
SOBRAO
reported by The Weekend Australian, July 12, 2003 consider a proposal to issue visas to
Avni Sali, MD, PhD (Australia)
Swinburne University Graduate School of Medicine
Steve Sinatra, MD (USA) Continued on next page
University of Connecticut School of Medicine
Robert Tien, MD, MPH (Taiwan)
Duke University School of Medicine (Tenured)
Fredrick Vagnini, MD (USA)
Cornell University School of Medicine
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IMPORTANT: The American Academy of Anti-Aging Medicine (A4M) is a non-profit medical organization dedicated to the advancement of technology to detect, prevent,
and treat aging related diseases and to promote research into methods to retard and optimize the human aging process. A4M is dedicated to educating physicians,
scientists, health practitioners, and the general public in anti-aging issues and promote awareness thereof. Although A4M seeks to disseminate information on many
types of medical treatments, it does not promote or endorse any specific treatment nor does it sell or endorse any commercial product or service.
Deuterium Studies
In the last ten years, studies have
been performed in Hungary and
Romania, countries in which low-cost
deuterium depleted water is available.
Radiation and Low Level
Deuterium Studies on Mice
in Romania
In a study by Bild, mice were fed
DDW-30 for a 15 days period and
exposed to sub-lethal radiation (8.5
Grays).9 The control group was fed tap
water. The test group had a survival
rate of 61% while the control group’s
survival rate was 25%. The test group
also maintained normal white blood
deuterium depleted water (DDW) to endangering life occurred. We did not
cell and red blood cell platelet counts.
treat cancer over the last ten years. experience any deterioration in blood
DDW Trials on Cancer He reports that: “After the counts, irritation of the mucous
Patients in Hungary consumption of more than 10 tons of membrane, nausea, headache, etc., that
Dd-water [DDW], no event
Gabor Somlyai has successfully used Continued on page 31
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“Contact Us” form at the A4M’s Special Information Center for Publishing and Media Outreach, at www.a4minfo.net/vmag.
IMPORTANT: The American Academy of Anti-Aging Medicine (A4M) is a non-profit medical organization dedicated to the advancement of technology to detect, prevent,
and treat aging related diseases and to promote research into methods to retard and optimize the human aging process. A4M is dedicated to educating physicians,
scientists, health practitioners, and the general public in anti-aging issues and promote awareness thereof. Although A4M seeks to disseminate information on many
types of medical treatments, it does not promote or endorse any specific treatment nor does it sell or endorse any commercial product or service.
used to irrigate their crops. Based but it does not directly repair DNA. 1964, Vol 41, No. 3, 680-689
5 Cuma M and S Scheiner, “Influence of Isotopic Substitution on
upon geography and altitude we can It remains undetermined, given Strength of Hydrogen Bonds of Common Organic Groups”, J
Physical Organic Chemistry, Vol. 10, 383-395, 1997
infer that the deuterium content of the present scientific knowledge, whether 6 Griffiths TR, “The Possible Roles of Deuterium in the
Hunza region is at or below 133 ppm.11 DDW consumption will “rejuvenate” Initiation and Propagation of Aging and Other Biological
Mechanisms and Processes,” Proceedings of the Second International
the body, but it may become a new Conference on Stable Isotopes, October 20-23, 1975 Oak Brook
Illinois
therapeutic approach or intervention
Concluding Remarks that may assist in protecting cells and
7 Wood RD, Mitchell M, Sgouros J, and Lindahl T, “Human
DNA Repair Genes,” Science, Vol. 291, 1284-1289, February 16,
2001
Deuterium depleted water (DDW) tissues of the body, enabling them to 8 Levine, AJ, “p53 the Cellular Gatekeeper for Growth and
does not change its chemical function more efficiently. It is the Division,” Cell, Vol. 88, 323-331, February 7, 1997
9 Bild W, Stefanescu I, Haulica I, Lupusoru C, Titescu G,
composition when digested and has a author’s hope that future studies Iliescu R, Nastasa V., “Research Concerning the Radioprotective
and Immunostimulating Effects of Deuterium-depleted Water,”
direct effect at the cellular level. comparing deuterium in the drinking Romanian J of Physiology, 1999 Jul-Dec; 36(3-4): 205-18
Consumption of DDW can waters of inhabited and developed 10 Somlyai G, The Biological Effects of Deuterium Depletion, HYD
Ltd., 2001
conceivably protect DNA from damage environments versus that of lesser 11 Wushiki H, Deuterium Content of Stream Waters of Glacier
Origin in the Himalayas, Glaciological Expedition of Nepal,
and assist DNA repair mechanisms, developed and sparsely populated Contribution No. 37, 40-42, 1977
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