Journalof Psychiatry
(1988),
152,799—806
The psychiatric state of 483 women was examined antenatally and at 3, 6, and 12
months postpartum. Comprehensive assessments were made of all women antenatally
and of subgroups of the full sample postnatally. Psychiatric state was assessed using
the G,eneralHealth Questionnaire, the Present State Examination and the Montgomery
and Asberg Depression Rating Scale. In terms of PSE criteria, the point prevalence
of non-psychotic psychiatric disorder antenatally was found to be 6.0%; and postnatally
it was estimated to be 8.7% at 3 months, 8.8% at 6 months and 5.2% at 12 months
after delivery. These prevalence rates were compared to the rate in a general population
sample of non-puerperal women and found to be no greater. In a subgroup of the full
sample, the incidence of psychiatric disorder in the year following delivery was
estimated to be 15.1 %, which is close to a figure previously reported for women in the
community. The onset of psychiatric disturbance was soon after delivery in most
instances; and, for the majority, the episode of disturbance lasted for 3 months or less.
The distribution of PSECatego classes and syndromes among the antenatal and postnatal
samples were found to be similar to those in the non-puerperal comparison sample. Thus,
the prevalence, incidence, and nature of non-psychotic psychiatric disorder in the 12
months following delivery do not appear to distinguish it from such disorders arising at
other times.
In recent years there has been considerable interest Since Pitt's (1968) seminal paper, a number of
in non-psychotic psychiatric disorders in the puer studies have been reported in which standardised
perium. Early studies of depression in the puerperium methods of assessment were used. Widely varying
suffered from a number of methodological limita prevalence rates have emerged. Studies using self
tions. Some relied on the judgements of general report questionnaires have reported the rate of mild
practitioners about the presence of depression, to severe depressive symptoms to be 13% (Manly
without any clear operational criteria or standardised et a!, 1982) using the Beck Depression Inventory
procedures (Ryle, 1961; Tod, 1964; Blair eta!, 1970; (Beck eta!, 1961); and 22% (Hayworth et a!, 1980)
Dalton, 1971). Thus there was considerable variation using the Zung Depression Scale (Zung, 1965).
in the diagnostic criteria employed. In addition, since Similar variability exists in studies which employed
standardised procedures of assessment were rarely standardised interview methods of assessment. For
used, a systematic account of phenomenology was example, O'Hara eta! (1984) found a prevalence rate
not provided. Interpretation of the findings of this of 12% for major or minor depression 2 months after
early work is further compromised by the use of delivery using an interview adapted from the Schedule
small and non-random samples, variation in the for Affective Disorders and Schizophrenia (Endicott
timing of assessment after delivery, and the absence & Spitzer, 1978); and Paykel et a! (1980) found a
of comparative data. prevalence rate of 20010for mild clinical depression
An early study which sought to overcome some 6 weeks after delivery using the Raskin Three Area
of these difficulties was reported by Pitt (1968). In Depression Scale (Raskin eta!, 1970). Three British
a prospective study of a large random sample studies which used the Standardised Psychiatric
assessed by questionnaire and interview, the inci Interview (Goldberg eta!, 1970) found the prevalence
dence of depression in the 6—8weeks after delivery rate of psychiatric disorder to be 13% 3—5months
was found to be 10.8°lo.This rate Pitt reported to postpartum (Cox et a!, 1982), 16% 6 weeks after
be approximately six times greater than expected. He childbirth (Watson et a!, 1984), and 17% 3 months
also noted that the depressions were ‘¿atypical' in postpartum (Kumar & Robson, 1984). A problem
nature, in that other neurotic symptoms, such as in interpreting these findings is that no comparative
anxiety and irritability, were prominent. data have been provided which would allow a
799
800 COOPER ET AL
judgement of whether these figures represent an for the present study, a subset of women was selected using
elevated rate of psychiatric disorder. A further the following criteria: (a) age 16—40
years; (b) not currently
limitation of these studies is their relatively small pregnant; and (c) no pregnancy or delivery in the previous
sample size. This makes it difficult to examine the 12months. Thus a comparison sample of 313 non-puerperal
phenomenological features of identified psychiatric women was derived. Surtees et al (1983) not only used the
same definition of psychiatric disorder as was used in the
disorders and their duration and course. present study (PSE ID@5), but also the same occupational
The difficulties in interpreting the findings of classification system for establishing social class (Goldthorpe
studies concerned with the nature and frequency of & Hope, 1974).The puerperalsampleand thenon-puerperal
psychiatric disorder in the puerperium can only be comparison sample were very similar with respect to mean
overcome by a large prospective survey of pregnant age (27.2 and 28.8 years respectively),parity (4301oand 49°lo
women. Ideally, such a survey should be conducted primiparious respectively), and social class (39°loof both
with the women assessed up to 12 months after samples being working class).
delivery, to enable course and duration to be
established. This is important because it has been Measures
suggested that the rate of psychiatric disorder may Antenatally a structured interview was administered to all
be high both early and late in the postpartum year women to establish background and demographic variables,
(Kendell et a!, 1976); and because it has been gynaecological and obstetric history, attitude to the current
suggested that many of the psychiatric disorders pregnancy, psychiatric history, psychosexual functioning,
arising after childbirth run a chronic course (Pitt, and the level of social and material resources. The
1968). A study was conducted to meet these occurrence of stressful life events and the presence of
objectives. The principal aims were to establish the chronic social difficulties during the preceding 12 months
prevalence and incidence of psychiatric disorder in was assessed using the Interview for Recent Life Events
(Paykel et al, 1969; Paykel, 1983). Psychiatric state was
the year following delivery; to determine the onset
assessedusing the 60-itemGeneral Health Questionnaire
and course of these disorders; and to describe their (GHQ; Goldberg, 1972),the Present State Examination
clinical features. (PSE; Winget al, 1974),and the Montgomeryand Asberg
DepressionRatingScale(MADRS;Montgomery&Asberg,
Method 1979). At the postnatal interviews the main measures were
re-administered.Full obstetricdata wereobtained for each
Sample
woman from the computerised Oxford Obstetric Data
System. All the interviewers had extensive experience using
The sample was recruited from the appointments diary of the PSE in previous studies. Reliability was ensured by
the antenatal clinic of the John Radcliffe Hospital in holding regular meetings of all the raters where tape
Oxford, and from the delivery booking diary of the General recordedPSE interviewswereplayedand problematicitems
Practitioner Unit at the same hospital. Women were discussed.
included if they resided in Oxford City and were expected
to deliver during the 9-month recruitment period. Every
Procedure
secondwomanidentifiedwasapproachedfor interviewonce
consent from her general practitioner had been obtained. The aims of the study required that a large sample be
The women then received a letter from the research team examined. However, interviewing all women on all
and were interviewed in their homes. The antenatal postnatal occasions would have involved considerable
interview took place on average 6 weeks before each redundancy. Therefore, after certain groups had been
woman's expected date of delivery. There were 630 women extracted (see below), a two-stage sampling procedure was
initially selected for the study. Of these, 52 declined to used postnatally, with all the women screened periodically
participate; general practitioners asked for 7 to be excluded; using the GHQ, and all ‘¿probable
cases' (GHQ@ 12) then
51 were excluded because they were soon to move out of interviewed using the PSE.
the area and 23 because of their difficulties with the English The sample was initially assessed in the last trimester of
language; 9 women were contacted too late to be inter pregnancy and then re-assessed on three occasions in the
viewed; and 5 had a miscarriage. This left a final sample year following delivery: at 3,6, and 12 months postpartum.
of 483. Table I illustratesthe overallinterviewingscheme.The full
A comparison sample was provided for this study by Dr sample was interviewed antenatally. Three months after
Paul Surtees of the MRC Unit for Epidemiological Studies delivery, a ‘¿random
sample' of 112(i.e. 23°lo
of the original
inPsychiatry
inEdinburgh.Thissamplewas derivedfrom 483) was approached for interview, of whom 6 (5.4°lo)either
a community sample of Edinburgh women (Surtees et al, refused or could not be contacted and the rest (n = 106) were
1983). A random sample of 576 women was interviewed interviewed. The remaining 371 women were sent the
and psychiatric disorder was assessed using both Present 60-item GHQ. Of these questionnaires, 354 (95%) were
State Examination Index of Definition (PSE ID) criteria returned satisfactorily completed: 13 women had moved
and the ResearchDiagnosticCriteria (RDC; Spitzeret al, and were not traced in time and 4 wished to be excluded
1978). For the purposes of deriving a comparison sample from the study. Of the 354 who returned the GHQ, 90
PSYCHIATRIC DISORDERAFTER CHILDBIRTH 801
TABLE I
Interview scheme
AntenatalPostnatal3
monthsGroups months6 months12
interviewedFull sampleRandom sample sample
All GHQ probable All GHQ probable All GHQ probable
cases cases cases
Subsample of GHQ —¿ Subsample of GHQ
probable non-cases— probable non-cases
3-month PSE casesRandom
3- and 6-month PSE
casesTotal
ofinterviews483243107225
number
monthsGeneralsamplepostnatal
Antenatal3 months6 months12
sample'postnatal'postnatal'population2samplesample(n=483)(n=460)(n=442)(n=462)(n=313)Index
%Number%Definition1273
ofNumber %Number %Number %Number
was available. The proportion of those with an ID of 5 or 15 (l8°lo)of the 84 GHQ ‘¿probable
cases' were found to
more in the general population was not significantly be PSE ‘¿cases'
at interview.From the false negativerate
different from that in the antenatal puerperal sample of the GHQ, it can be estimated that 14 of the 327 GHQ
(@2@3.60,d.f.=l). ‘¿probable
non-cases' were PSE ‘¿cases'.
The estimated point
prevalence rate at 6 months postpartum was therefore 8.801o
Postnatal (i.e. 39 out of 442), which again is no different from that
At each of the three postnatal assessments, the point in the general population sample (,@2 0.1, d.f. = 1).
prevalence of psychiatric disorder was estimated. These
Twelve months postnatal. One year after delivery, four
estimates were derived from three sources: (a) the number
groups were interviewed (see Table I). In the subsample of
of PSE ‘¿cases'
among the GHQ ‘¿probablecases'; (b) the
45 GHQ ‘¿probable
non-cases' interviewed there were no
estimated number of PSE ‘¿cases'
among the GHQ ‘¿probable
non-cases' (calculated from the established false negative
PSE ‘¿cases'.
Extrapolations were made from the other
amongthe ‘¿randominterviewed
rate);and (c)the numberof PSE ‘¿cases' groups, as at 3 and 6 months, and the estimated
sample' (at 3 and 12 months). point prevalence at 12 months was found to be 5.2% (i.e.
24 out of 462). This is a significantly lower rate than that
Three months postnatal. Among the random sample of found in the general population sample (x@=14.9, d.f. =1,
106 subjects interviewed, eight (7.5%) were PSE ‘¿cases'. P<0.OOl).
Among the 89 GHQ ‘¿probable
cases' interviewed, 21 (24%)
were PSE ‘¿cases'.
Finally, among the 48 GHQ ‘¿probable Incidence of psychiatricdisorder
non-cases' interviewed,two were PSE ‘¿cases'.
The latter
figure represents a false negative rate for the GHQ of 4.2%. The two-stage sampling procedure does not allow an
From this rate an estimatecan be derivedof a further nine estimate of the annual incidence of psychiatric disorder
PSE ‘¿cases'
amongthe 216GHQ ‘¿probable non-cases'who from the full sample. The inception rate of psychiatric
were not interviewed.The PSE data from the 48 GHQ disorder in the year following delivery was therefore
‘¿probable
non-cases' were used to provide an estimate of examined among the randomly selected group of 112
the Index of Definition distribution for the full 264 GHQ womenassessedantenatally.At 3 months postpartum, 106
‘¿probable
non-cases', and this estimate contributed to the women(95¾)were assessedby interview;and 102(9l01o)
distribution shown in Table II. Therefore, the estimated were seen again 12 months postpartum. At the 6-month
point prevalence at 3 months postpartum was 8.7% (i.e. postpartum assessment, those identified by the GHQ as
40 out of 460), which is no different from the point ‘¿probable
cases' were also interviewed. A ‘¿case'
of new onset
prevalence for the general population sample (x2= 0.2, 3 monthspostpartumwasdefmedas a ‘¿case'
whohad been
d.f.=l). a ‘¿non-case'
antenatally. Sixmonths postpartum, a ‘¿case'
of newonset wasdefinedas a ‘¿case'
who had been a ‘¿non
Six months postnatal. Of the 31 women who had been case' 3 months postpartum. Twelve months postpartum,
found to be PSE ‘¿cases'
at the 3-month postnatal interview, a ‘¿case'
of newonset wasdefinedas a ‘¿case'
who had been
8 of the 24 who were assessed remained ‘¿cases'
at 6 months; a ‘¿non-case'
at both the 3-monthand 6-monthpostpartum
PSYCHIATRIC DISORDERAFTER CHILDBIRTH 803
TABLE III
Distributions of the postnatal PSE ‘¿cases'
by PSE Catego
25 class (%)‘
S
20
a PSE Catego
o class3 months months months population2
10
=31)N (n =31)6 (n =23)12 (n =23)General
(n
0
o
HHHHHH@
i
@Hfl
2 3 4 5 6
Months postpa'tum
7 8 9 10 11
Neuroticdepression29484842R
Retardeddepression26432626A
Anxiety3992632MMania330000
FIG. 1 Time of onset of postpartum psychiatric disorder (n = 55).
Obsessions3000
assessments. The proportion of ‘¿cases'
of new onset at each
of the threepostpartumassessmentswasfoundto be 7.7%, 1. The proportions are based on the Catego classes of subjects
positively identified at each assessment as a PSE ‘¿case'.
5.2°loand 2.2°lo
respectively.On this basis, the annual 2. Derived from Surtees et a! (1983).
incidence can be estimated as 15.101o. 3. This patient was not suffering from mania. The clinical diagnosis
was one of depression with occasional periods of elevated mood.
The rating of 1 on PSE symptom 41 (expansive mood and ideation)
Onset and duration of psychiatric disorder produced a certainty rating of + for syndrome 12 (HM —¿
hypomania) and thus a Catego class of M.
At each assessmentan estimatewasmade of the onset and
duration of any episode of identified psychiatric disturbance
arisingafterdelivery.
There were 53 women positively
identified postnatally as a ‘¿case'
on the PSE, and two of each occasion the identified ‘¿cases'in the puerperal
thesehad two separate onsets. As can be seenfrom Fig. 1, samplewerevirtually
all
ofdepression
oranxiety;
andthis
nearlyhalfthe identifiedcaseshad an onsetwithin3 months was also the case in the comparative general population
of delivery;and onlya quarter had an onsetbetween6 and sample. There were no significant differencesbetween
12monthspostpartum.Thedurationof identifieddisorders the puerperal sample and the general population sample
is shown in Fig. 2. It is apparent that two-thirds of the cases when the proportions within different Catego classes
had a duration of 3 months or less. were compared. In particular, the puerperal sample had
similar proportions of depressed cases to the comparison
Nature of psychiatric disorder group at 3 months (X2=0.6l,d.f.
= 1),6 months
(X2=2.99, d.f.= 1) and 12 months (x@=O.04, d.f.= 1)
The nature of the psychiatric disorders identified at each postpartum.
of the four assessmentswas examined by means of the Table IV shows the distribution of PSE ‘¿cases'
by
distribution of the PSE ‘¿cases'
by PSE Catego class and PSE syndromes at each assessment,togetherwith the
syndrome. comparable available data from the generalpopulation
Table III shows the distribution by Catego class of the sample. It can be seen that in the great majority of the
PSE ‘¿cases'
identified at each assessmentand the ‘¿cases' postnatal PSE ‘¿cases'the syndromes were the non
in the general population sample. It can be seen that on specific neurotic syndromes of worrying (WO), tension
(TE), and irritability (IT); and the specific neurotic
syndrome of simple depression (SD). When the frequency
of individual syndromes was compared for the post
30 natal ‘¿cases'
and the ‘¿cases'
in the comparison group,
no significant differences were found for any of the
25
I
syndromes for the 3-month and 12-month postnatal data.
20 A few differences did exist between the comparison group
and the 6-month postnatal ‘¿cases': among the puerperal
: 15 group, a greater proportion of cases had simple depression
a (@=4.l3, d.f.=l, P<0.0l) and loss of interest and
5 10
concentration (x@= 13.2, d.f. =1, P<0.001); and a smaller
@
5
0
1 2 3
H@I@
4 5 6
Months
7 8 9 10 11 12
proportion had generalised anxiety (x2on5.24, d.f. on1,
P<0.05)
P<0.05).
the low
and
These
rate
situational
of
syndromal
Catego
anxiety
differences
class A
(x@= 5.6,
in
simply
the
d.f. = 1,
reflect
6-month
postpartum sample shown in Table III; and the
FIG. 2 Duration of postpartum psychiatric disorder (n = 55). corresponding relatively high proportion of classes N
S psychiatrically disturbed at 12 months postpartum. and R.
804 COOPER ET AL
TABLE IV
Distributions of the postnatal PSE ‘¿cases'
by PSE syndromes (¾)'
PSE syndrome3 monthsGeneralpostnatalpostnatalpostnatalpopulation2‘cases'‘cases'‘cases'(n
months6 months12
depression771008777ONObsessional
symptoms1344GAGeneral
anxiety55174852SASituational
anxiety61355771HMHypomania300—DEDepersonalisation6134—EDPathological
guilt45617058IRIdeas
reference39262229TETension77917877LELack
of
energy35484832WOWorry9010010081ITIrritability81967077SUSocial
of
unease71577071ICLoss
concentration61916139HYHypochondriasis34410ODSomatic
of interest and
features of depression58787864
1. The proportions are based on the syndromes of women positively identified at each assessment as PSE ‘¿cases'.
2. Derived from Surtees et a! (1983).
3. Data not available in comparable form.
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9Correspondence: Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ
Non-psychotic psychiatric disorder after childbirth. A prospective
study of prevalence, incidence, course and nature.
P J Cooper, E A Campbell, A Day, H Kennerley and A Bond
BJP 1988, 152:799-806.
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