Osteoporosis natural history

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti,
M.B.B.S. [2]

Overview
Osteoporosis can be complicated by the development of fractures. The prognosis is generally good
and mortality from the disease will depend on the the type of fracture. The major type of fractures
contributing to mortality in these patients are vertebral fractures and hip fractures.

Natural History
The symptoms of the disease typically develop in the sixth decade of life. The risk of getting
osteoporosis increases proportionately with age. DXA bone densitometry is recommended every 2–
3 years as a screening tool. The outcome is usually good with appropriate and timely usage of
medications and with calcium and / or vitamin Dsupplementation. Persons who are elderly, who are
taking medications which deplete calcium, who are thin or of caucasian or asian race and female,
are at higher risk for osteoporosis. Having osteopenia, which is decreased mineral bone density, is
also a risk factor for osteoporosis.

Complications
Disease can be complicated by the development of:

 Fractures - the hip and the vertebrae are among the most frequent sites of fracture
Pathologic fractures

 DVT - a deep vein thrombosis can develop from prolonged immobility.

 Kyphosis (Dowager's hump)
 Restrictive lung disease
 Apart from risk of death and other complications, osteoporotic fractures are associated with a
reduced quality of life due to immobility, and emotional problems may also arise as a
consequence of this.[1]
 Drug side-effects:
 Bisphosphonates - esophagitis, osteonecrosis of the jaw, bone pain, muscle pain etc.,
 Raloxifene - thromboembolism, aggravates hot flashes, nausea, weight
gain, depression, insomnia, leg cramps, rash
  Teriparitide - orthostatic hypotension, asthenia, nausea, leg cramps, hypercalcemia (if taken
along with corticosteroids, thiazide diuretics, and calcium supplementation), must not be
given to patients with Paget's disease or a history of osteosarcoma or chondrosarcoma
 Nasal calcitonin-salmon - bronchospasm, rhinitis, epistaxis, arthralgias

Prognosis
 The prognosis of the disease is good if the decrease in bone mass density is identified early,
and the appropriate anti-osteoporotic medications are started.
 DVT caused by prolonged immobility from hip fractures is associated with a poorer prognosis
among patients with disease.
 The lifetime fracture risk in caucasian women is Hip fractures per 1000 patient-years[2]
18% for hip fractures, 16% for spine fractures,
and 16% for wrist fractures. In men the same WHO category Age 50-64 Age > 64 Overall
fractures account for 6%, 5%, and 3% Normal 5.3 9.4 6.6
respectively.
Osteopenia 11.4 19.6 15.7
 More than half of all women, and one third of all
men, have osteoporotic fractures in their Osteoporosis 22.4 46.6 40.6
lifetime.
 Men have a higher mortality from fractures
when compared to women.
 The 6-month mortality rate following hip fracture is approximately 13.5%.
 Vertebral fractures, while having a smaller impact on mortality than hip fractures, can lead to
severe chronic pain of neurogenic origin which is difficult to treat, as well as postural deformity.

References
1. Jump up↑ Brenneman SK, Barrett-Connor E, Sajjan S, Markson LE, Siris ES (2006). "Impact
of recent fracture on health-related quality of life in postmenopausal women". J. Bone Miner.
Res. 21 (6): 809–16. PMID 16753011. doi:10.1359/jbmr.060301.
2. Jump up↑ Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD (2007). "Low bone
mineral density and fracture burden in postmenopausal women". CMAJ. 177(6): 575–
80. PMID 17846439. doi:10.1503/cmaj.070234.
.