By: Like Wu, Xiaojuan Wang, Freda Peng, Bo Cheng, Susan Chu
The patient is 8-year-old boy. He was presented with language, mental, behavioral and
human communication disorders for the past 5 years. He was diagnosed as Autism. He
was born full-term with normal delivery. He was hyperactive, upset, agitated, impaired
language development and was unable to communicate with others when he was 2 years
old.
Physical examination: he was stable, Skin and mucous membrane were with no yellow
stain or petechia. His heart and lung were normal. He was alert, his comprehension,
judgment, attention and adaptability were bad. He was hyperactive, upset, unquiet,
soliloquize and he couldn’t answer questions. He could count from 1-10. He couldn’t
cooperate with the memory, calculation ability, or orientation examinations. He seldom
had eye contact with others. He couldn’t cooperate with the cranial nerves, sensation
and coordinated movement during examinations. The muscle power of four limbs was at
level 5, his muscle tension was normal. The tendon reflex decreased. The pathological
sign was negative. All of the laboratory examination and accessory examinations were
normal. He was diagnosed as” Autism”.
Treatment target: increase the number of normal neural stem cells (NSCs) in the brain,
switch on neural development, repair and regenerate the nerves. Increase the brain
function, improve the patient’s cognitive function and communication skills.
Treatment procedure and results:
We gave the patient 4 times neural stem cells (NSCs) and 4 times mesenchymal stem
cells (MSCs) implantation treatment. The stem cells were activated in the patient’s body
to repair the damaged nerves. Together with nourishment of the neurons, improve
circulation, regulating the immune, daily rehabilitation training was incorporated. After
the treatment, the patient was stable, developed a good spirit and mood. He seldom gets
upset and he developed more concentration. He could see movies or listen to music by
himself, and the duration was increased to between 30-40 minutes than before. He
speaks more with family members. He could answer questions and gained more
vocabulary. He could say a sentence which is made up of 6 words. His learning skill was
better. The memory, calculation ability, orientation, comprehension and attention were
better. He had more eye contact with others. His nerves, sensation, coordinated
movement examinations and meningeal irritation sign examination cooperation degree
was better.
Case analysis:
Autism is also called autistic disorder, it is one subtype of the catholicity eccyliosis. Male
patients were more than female as observed. This disease onset at early infancy. The
cardinal symptoms: various degrees of speech disturbance, human communication
disorders, less interesting or mechanic behavior. Around 3/4 young patients
accompanied with visible mental retardation. The main pathogen was unclear, it may be:
heredity, perinatal period factors, abnormal immune system or imbalance of various
neuroendocrine and neurotransmitter function. The patient had this disease from very
young, the pathogen was unclear, and his symptoms were: abnormal mind and
behaviors, cognitive disorder, bad communication skills and excitement.
There are a lot of methods to treat autism, but most of them lack medical evidences and
there is no best treatment plan. Our center uses advanced NSCs transplantation
technique to treats patients with autism. The NSCs is used together with MSCs to make
the imbedded NSCs increase the number of brain and spinal cord nerve cells, promotes
nerve differentiation and growth to improve his cognition and mental. This technique
was used in this patient and he recovered well and not only his cognition and mental, his
self-care ability and social skills were improved also. This provided relief of mental stress
and daily burden to his relatives. This brings hope to patients with this disease.
Research under our direction, the treatment result was satisfactory. During retrospective
experiment on animals, we found the same program had made great advances in nerve
precursor cell’s structure, migration, cortical tissue, neuron differentiation and
connection. For example: a small group of neurons migration lag in specific area or
appear in ectopia area of the patient, could result in mental hypoevolutism, epilepsy or
speech impediment. This can be fixed with implantation of nerve precursor cell. The
shape and structure of cortex can be normal. The safety of this treatment was confirmed
in many medical literatures. But each patient need complicated clinical technology
supporting, because the brain was controlled by gene in the development process, for
example: when we use the NSCs to correct neuron developmental deviation and
abnormality, neuron development need growth factors’ participation. It also need
immunological surveillance. Over growth nerve will be controlled by immune system,
only in that way can we get good result. All the processes need to be controlled by
experienced clinician and complicated clinical technology.
http://www.wumedicalcenter.com/article/CaseAnalysis/420156101155.html?gclid=Cj0KE
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V8zM68aJQAutMaAk_H8P8HAQ
Examen físico: Esta estable, su piel y membrana mucosa eran sin mancha amarilla o
petechia.
Su corazón y pulmones eran normales. Estaba alerta, su comprensión, juicio, atención, y
capacidad de adaptarse eran malas. El era hiperactivo, molesto y no podía responder a
las preguntas. Podía contar de 1 a 10, no podía cooperar con la memoria, con los cálculos
y exámenes de orientación, rara vez tenía contacto visual con los demás. El no podía
cooperar con los nervios craneales, sensación ni con el movimiento durante exámenes.
La energía del musculo de 4 miembros llego al nivel 5, la tensión muscular era normal. El
reflejo del tendón disminuyo. El signo patológico fue negativo. Todos los exámenes de
laboratorio dieron normales. Fue diagnosticado como autista.
Objetivo del tratamiento: Se incrementa el número de células madres neurales normales
en el cerebro, reparar y regenerar los nervios. Aumentar la función del cerebro, mejorar
la capacidad de comunicación y la función cognitiva del paciente.