Volkan Gürel, Ph.D.

Calle de Fuencarral, numero 137 1Co +1(34) 675 340 629 (ES)
Madrid, Madrid 28004 +1(401) 699 3215 (USA)
volkan.mgurel@gmail.com

PROFESSIONAL EXPERINCE

Scientist, Beech Tree Laboratories, Inc., Providence, RI USA 2008 – Present

 Analyzing and interpreting genomics/proteomics study results by coupling them with genomic
database and data analysis softwares
 Conducting preclinical and rodent studies, experienced in dose finding toxicology experiments
with various novel compounds and biologicals
 Preparing reports to support investigational new drug (IND) applications
 Managing purchasing, recruiting, and day-to-day operation of preclinical laboratory
 Writing peer-reviewed journal articles, institutional animal care and use committee (IACUC)
proposals, and collaborative grant applications to seek state and federal funding
 Providing internship opportunities and academic guidance; training, supervising students from
University of Rhode Island (URI) and Brown University
 Serving as course director for Environmental Health and Disease (BIOL182) at Brown
University, with lecture topics including various concepts in toxicology such as absorption,
distribution, metabolism and elimination (ADME), target organ toxicity, nanotoxicology and case
studies involving environmental disasters

ACADEMIC EXPERINCE

Brown University, Providence, RI 2004 - 2008

Postdoctoral Research Associate
Investigated the involvement of DNA mismatch repair in cisplatin-induced senescence and apoptosis
pathways. Also, explored hypoxia induced resistance to chemotherapy, genotoxicity and cytotoxicity
induced by small molecules and several heavy metals including Cr (III) or (VI), Ni, Co, and metal
containing carbon nanotubes.

University of North Dakota, Grand Forks, ND 2003 - 2004

Postdoctoral Fellow
Studied heavy metal induced carcinogenesis in the context of metallothionein genes and protein
expression profiles. Lead a research project to transform a normal human breast cell line by heavy
metal exposure, and developing a rodent models to transplant transformed breast cells in mammary
gland. This project resulted in continuing support by NIH and series of publications that were
instrumental in understanding heavy metal induced carcinogenesis.

University of West Virginia, Morgantown, WV 2000 - 2003

Graduate Research/Teaching Assistant
Investigation of mRNA and protein expression profiles of several isoforms of heavy metal-binding
proteins, Metallothioniens (MTs), and their potential significance in diagnosis and prognosis of
breast cancer tumors.

University of California, Davis, CA 1996 - 1998

Graduate Research/Teaching Assistant
Investigation of nucelogenesis in primary and metastatic tumors induced by v-src

EDUCATION

Boston College 2012

Clinical Research Certificate

West Virginia University – Morgantown, WV 2003

PhD, Developmental Biology and Genetics
University of California – Davis, CA 1998
MS, Avian Sciences
University of Ankara- Ankara 1994
B.S, Animal Sciences

PUBLICATIONS

 Gurel V, Lins J, Lambert K, Davis MG, Elinoff V, McMichael J. (2017). Initial double-blind,
randomized, parallel, placebo-controlled, multicenter clinical trial to asses safety and efficacy of
serotonin/histamine combination for the symptomatic improvement of urinary incontinence
(submitted to International Journal of Urology)

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 Mamber SW, Lins J, Gurel V, Hutcheson DP, Pinedo P, Bechtol D, Krakowka S, Henderson RF,
Cummins JM. Veterinary Immunology and Immunopathology. 2016 Apr;172:64-71. Low-dose
oral interferon modulates expression of inflammatory and autoimmune genes in cattle.

 Song QX, Balog B, Lin D, Jiang HH, Gurel V, Spaulding J, Tobacyk J, McMichael J, Damaser
MS. Journal of Neurourology and Urodynamics. 2016 Aug;35(6):703-10. Combination
Histamine and Serotonin Treatment Improves Stress Urinary Incontinence.

 Gurel V, Lins J, Lamber K, Lazauski J, Spaulding J, McMichael J. Dose-Response. 2015 Nov

11;13(4):1559325815616351. Serotonin and Histamine Therapy Increases Tetanic Forces of
Myoblasts, Reduces Muscle Injury, and Improves Grip Strength Performance of Dmdmdx Mice.

 Gurel V, Lambert K, Page AE, Loynachan AT, Huges K, Timoney JF, Fettinger M, Horohov
DW, McMichael J. Veterinary Microbiology. 2013 Jun;37(2):145-54. Streptolysin-O/Antibiotic
Adjunct Therapy Modulates Site Specific Expression of Extracellular Matrix and Inflammatory
Genes in Lungs of Rhodococcus equi Infected Foals.

 Mamber SW, Gurel V, Rhodes R, McMichael J. Dose-Response. 2011 Volume 9, Number 4,

554-578. Effects of Streptolysine O on Extracellular Matrix Gene Expression in Normal Human
Epidermal Kerotiocytes.

 McGeary JE, Gurel V, Knopik VS, Spaulding J, McMichael J. Neuropeptides. 2011

Oct;45(5):317-22. Effect of Nerve Growth Factor (NGF), Fluoxetine, and Amyitriptyline on Gene
Expression Profiles in Rat Brain.

 Hall EH*, Gurel V*, Dahlberg AE, McMichael J, Brautigan DL. Cellular Signaling. 2011
Dec;23(12):1972-7. Inhibition of human breast cancer Matrigel invasion by streptolysine O
activation of the EGF receptor ErbB1.

 Zecevic A, Menard H, Gurel V, Hagan E, DeCaro R, Zhitkovich A. Cell Cycle. 2009 Sep
1;8(17):2769-78. WRN helicase promotes repair of DNA double-strand breaks caused by aberrant
mismatch repair of chromium-DNA adducts.

 Reynolds MF, Peterson-Roth EC, Bespalov IA, Johnston T, Gurel V, Menard HL, Zhitkovich A.
Cancer Research. 2009 Feb 1;69(3):1071-9.Rapid DNA double-strand breaks resulting from
processing of Cr-DNA cross-links by both MutS dimers.

 Branko R, Chung AP, Johnston T, Gurel V, Morais P, Zhitkovich A. Journal of Bacteriology.

2008 Nov;190(21):6996-7003. Chromate-Inducible chrBACF Operon from Transposable Element
TnOtChr Confers Resistance to Chromium (VI) and Superoxide.

 Liu X, Gurel V, Morris D, Murray D, Zhitkovich A, Kane AB, Hurt RH. Advance Materials.
2007 Oct 19 (19) 2790-2796.Bioavailability of Nickel in Single-Wall Carbon Nanotubes.

 Zhou XD, Sens MA, Garrett SH, Somji S, Park S, Gurel V, Sens DA. Toxicological Sciences.
2006 Oct 93(2):322-30. Enhanced Expression of Metallothionein Isoform 3 Protein in Tumor
Heterotransplants Derived from As3+ and Cd2+ Transformed Human Urothelial Cells.

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 Gurel V, Sens DA, Somji S, Garrett SH, Weiland T, Sens MA. Toxicological Sciences. 2005
June 85(2):906-15. Post-Transcriptional Regulation of Metallothionein Isoform 1 and 2
Expression in the Human Breast and the MCF-10A cell Line.

 Somji S, Garrett SH, Sens MA, Gurel V and Sens DA. Toxicological Sciences. 2004 Aug
80(2):358-66. Expression of Metallothionein Isoform 3 (MT-3) Determines the Choice Between
Apoptotic or Necrotic Cell Death in Cd2+ Exposed Human Proximal Tubules Cells.

 Sens DA, Park S., Gurel V, Sens MA, Garrett SH, Somji S. Toxicological Sciences. 2004 May
79(1):56-63. Inorganic Cadmium- and Arsenite-Induced Malignant Transformation of Human
Bladder Urothelial Cells.

 Gurel V, Sens DA, Somji S,Garrett S, Nath J and Sens MA. Breast Cancer Research and
Treatment. 2003 Jul 80(2):181-91. Stable Transfection and Overexpression of Metallothionein
Isoform 3 Inhibits the Growth of MCF-7 and Hs578 T Cells but not that of T-47D or MDA-MB-
231 Cells.

 Sens DA, Rossi MR, Garrett SH, Park S, Gurel V, Sens MA, Nath J and Somji S. Metallothionein
Isoform 1 and 2 Gene Expression in a Human Urotelial Cell Line (UROtsa) Exposed to CdCl 2 and
NaAsO2. Journal of Toxicology and Environmental Health A. 2003 Nov 14; 66 (21):2031-46.

 Somji S, Sens MA, Garrett SH, Gurel V, Todd JH, Sens DA. Toxicology Letters. 2002 Jul 21:
133(2-3):241-254. Expression of hsp90 in the Human Kidney and Proximal Tubule Cells Exposed
to Heat, Sodium Arsenite and Cadmium Chloride.

PROFESSIONAL AFFILIATIONS

 Society of Toxicology

REFERENCES

1-Scientific Director-IdiPaz
Eduardo López-Collazo, Ph.D
elopezc@salud.madrid.org
Telephone: +34 91 727 75 76
28046 Madrid – Spain

2-Director of Business Development-BeechTree Labs Inc.

Thomas Hatch, MBA
thatch@beechtreelabs.com
Telephone: +01 859 494 3216
02905 Providence, Rhode Island-USA

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3-Assistant Professor of Biology- Brown University
Molecular Biology, Cell Biology and Biochemistry
Christoph_Schorl@brown.edu
Telephone: +01 401 863 2875
02912 Providence, Rhode Island-USA

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