Abstracts / Atherosclerosis 252 (2016) e1ee196
(40%) in group A had an ejection fraction <50% versus 8 of 24 patients
(33%) in group B . The number of patients with an ejection fraction <50%
was significantly reduced in group A compared with group B at 1 and 3
months after PCI, i.e. 11% versus 16% (p ¼ 0.046) at 1 month and 4% versus
16% (p ¼ 0.017) at 3 months.
Conclusions: NAC, appears to minimize myocardial reperfusion injury
during PCI and improves global and regional wall motion at 1 and 3
months after PCI.
EAS16-0154, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE,
PERIPHERAL VASCULAR DISEASE.
RELATIONSHIP BETWEEN LIPID DISORDERS AND SEVERITY AND
NATURE OF CORONARY ARTERY LESIONS IN MALE PATIENTS WITH
CORONARY ARTERY DISEASE
V. Kashtalap 1, O. Barbarash 2, O. Hryachkova 3, A. Novitskaya 4. 1 Research
Institute for Complex Issues of Cardiovascular Diseases - Russian Acade,
Polyvascular atherosclerosis pathophysiology laboratory, Kemerovo, Russia;
2
Research Institute for Complex Issues of Cardiovascular Diseases - Russian
Acade, Director, Kemerovo, Russia; 3 Research Institute for Complex Issues
of Cardiovascular Diseases - Russian Acade, Laboratory of cells technology,
Kemerovo, Russia; 4 Research Institute for Complex Issues of Cardiovascular
Diseases - Russian Acade, Cardilogy department, Kemerovo, Russia
Objectives: To study the relationship between lipid disorders and the
severity and nature of coronary lesions in patients with coronary artery
disease.
Methods: 119 consecutive male patients admitted to the clinic with veri-
fied stable coronary artery disease were included in the study. The median
of patients age was 61 (55.5; 66.0) years. All patients underwent coronary
angiography with the severity assessment of coronary atherosclerosis ac-
cording to the number of diseased vessels and the SYNTAX score, and
multislice computed tomography with the quantitative calcium scoring
index (CACS) calculation according to the Agatston method. The parame-
ters of lipid profile (total cholesterol and fractions) were measured in all
patients. All patients received statins.
Results: The comparative analysis of lipid profile and number of the
damaged coronary arteries was revealed the patients with three-vessels
damage of coronary arteries the high-density lipoprotein cholesterol
(HDL-C) level was significant lower than in patients with one - and two-
vessel damages. There was weak contradictory positive correlation be-
tween HDL-C level and CACS index. There were no significant relationships
between the parameters of lipid profile (total cholesterol and its fractions)
and the severity of coronary lesions, assessed by the number of affected
arteries and by the SYNTAX score, as well as coronary artery calcium
scoring.
Conclusions: The further search for biomarkers in patients with coronary
artery disease with statin therapy, that reflect the severity of atheroscle-
rosis and coronary calcification, is required because the traditional pa-
rameters of lipid profile have restrictions for the assessment of
cardiovascular risk in these patients.
EAS16-0768, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE,
PERIPHERAL VASCULAR DISEASE.
PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS OF HYPERTHYROID
RAT HEART DURING ISCHEMIA REPERFUSION
C.R. Revnic 1, C. Pena 2, F. Revnic 2, A.S. Nica 3, S. Prada 2, G.
Prada 4. 1 Bucharest, Romania; 2 NIGG Ana Aslan, Biology of Aging,
Bucharest, Romania; 3 UMF Carol Davila, Rehabilitation, Bucharest,
Romania; 4 UMF Carol Davila, Gerontology, Bucharest, Romania
Objectives: The aim of this study was to evaluate physiological parameters
of cardiac contractility in rat heart with hyperthiroid condition exper-
imentaly induced with T3
Methods: Our study has been done on 10 male Wistar rats treated with
T3(i.p. injections 4.5mg/kg body weight) for 4 weeks.Rat hearts have been
e185
excised and mounted in a Langendorf retrograde perfussion system and
perfused for 30 minutes with Krebs-Henseleit buffer(stabilization period),
and then applying 30 minutes ischemia followed by 60 minutes reperfu-
sion at 37C,pH 7.6 supplimented with 10mM glucose.Left ventricular
developed pressure(LVDP),heart rate(H.R.) and coronary flow(C.F.) have
been measured. Another objective of our study was evaluation of
biochemical parameters of cardiac metabolism in hyperthyroid rat heart
i.e.: LDH,CK,SOD,GSH,GGT,plasma cholesterol, and total lipids
Results: There is a decrease in coronary flow in hyperthyroid rat heart
versus controls.In both cases there is a decrease of this parameter during
reperfusion with lower values in controls and a tendency of reaching a
platau value. Hyperthyroidism is reflected by modification of plasma LDH 4
times higher than in controls accounting for an increase in plasma and
myocardial CK, but a decrease of SOD activity in myocardium may be in
part serves as energy support for accelerated metabolism and installing
oxidative stress at this level.There is a decrease in GGT and an increase in
total lipids.
Conclusions: Because of low levels of total plasma cholesterol and of
absence of a significant modification of lipid peroxides,hyperthyroid rat
heart is not a target for the atherogenic factors present in other forms of
arterial hyperthension.
EAS16-1019, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE,
PERIPHERAL VASCULAR DISEASE.
ACUTE ARTERIAL OCCLUSION OF APPARENTLY HEALTHY ARTERIES e A
CONCLUSIVE EXPLANATION USING FRACTAL PHYSICS
D. Tesloianu 1, M. Agop 2, I. Nedelciuc 3. 1 Clinical Emergency Hospital “Sf.
Spiridon” Iasi, Cardiology, Iasi, Romania; 2 GH. Asachi Technical University
Iasi, Physics, Iasi, Romania; 3 Institute of Cardiovascular Disease Iasi,
Interventional Cardiology, Iasi, Romania
Objectives: The acute arterial occlusion of an artery that has no significant
preexistent lesions usually leads to dramatic consequences. In the present
paper, we propose the scale e relativity approach to analyze the blood flow
dynamics.
Methods: We prove through mathematical modeling that the blocking of
the lumen of an absolutely healthy artery can happen as a result of the
“stopping effect”, in the conditions of a normal sanguine circulation. This
happens due to the fact that blood is a complex non-Newtonian fluid,
travelling into the complex structure of the arterial system, with nonlinear
particle dynamics. In this context the hypothesis according to which blood
entities move on continuous yet non-differentiable curves (and particu-
larly on fractal curves) becomes natural and moreover, lacking any con-
tradictions. Analyzing these types of dynamic implies a scale-relativity
(SR) type of physics.
Results: Mathematical models prove the existence of the stopping effect in
a normal arterial portion, an effect which appears through the auto
structure of the normal sanguine flux. This happens in the absence of any
lesion of the arterial wall. Taking into consideration the temperature and
viscosity variations that define the normal functioning of the human body,
we can easily understand the described phenomenon.
Conclusions: The purpose theory does not want to annul the classic
modeling of the cracking of an atheroma plaque with major thrombosis
added in explaining the acute arterial occlusion, but we consider that the
mathematical modeling offers at least a thoroughly explained and hard to
contradict alternative.
EAS16-0010, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE,
PERIPHERAL VASCULAR DISEASE.
AUTOLYSIS IN CAD STEMI ANTEROSEPTOAPICOLATERAL WALL PATIENT,
A CASE REPORT
P. Sudjana, F. Nugraha, C. Achmad, A. Purnomowati, T. Aprami. Hasan
Sadikin Hospital, Cardiovascular, Bandung, Indonesia
Objectives: Autolysis is a mechanism to dispose the excessive blood clot in
our circulation. It is regulated by plasma protein called plasmin.Thrombus
e186 Abstracts / Atherosclerosis 252 (2016) e1ee196
autolysis in acute myocardial infarction can be recognized from the ECG
that shows premature ventricular contraction, accelerated ventricular
rhytm, and couplet that resembles the reperfusion rhytm. This case report
become important because served as a evidence of autolysis in STEMI
patient that well documented from the ECG and proved by angiography
that rarely been documented before
Methods: Our patient 51-years-old male came with chief complain of
typical angina onset 11 hours accompanied by diaphoresis and nausea
with no complication of the acute myocardial infarction. The risk factors
for coronary artery disease in this patient were dyslipidemia, smoking, and
family history with CAD. The ECG showed STEMI in anteroseptoapico-
lateral wall with evolution and VES unifocal frequent with episode of
couplet. While the patient being observed in the emergency room, the ECG
rhytm turned into accelerated idioventricular that latter assesed as
reperfusion rhytm that happen from autolysis mechanism in a patient that
hasn’t been given trombolytic therapy.
Results: This autolysis then confirmed by angiography that done the next
day which show multiple stenosis 80-90% in proximal-mid LAD from
which in STEMI patient the stenosis use to be 100%.
Conclusions: Autolysis doesn’t happen in all STEMI patient. There are
several factors that influence the incidence of autolysis such as the fre-
quency of physical exercise and endothelial dysfunction (caused by dia-
betes, smoking, hypertension).
EAS16-0326, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE,
PERIPHERAL VASCULAR DISEASE.
VENOUS THROMBOEMBOLISM AND CORONARY SYNDROME
A. Babets 1, A. KURIATA 2. 1 Dnipropetrovsk, Ukraine; 2 Dnipropetrovsk State
Madical Academy, Therapy, Dnipropetrovsk, Ukraine
Objectives: To evaluate the effectiveness of VT on developing and prog-
nosis of MI and CHD in general.
Methods: Group of 17 patients with deep DVT ,(20-76 years) . 1 patient
-congenital valvular heart disease, CHD 7pts , MI 2pts - hypertension
stage III 3pts, pericarditis 3 pts, atrial fibrillation 2 pts.-heart failure II A
1pts , II Be Class 3 pts. Patients with confirmed pulmonary embolism
divided into two groups: high and low risk. Among moderate risk factors
were observed: autoimmune diseases and blood transfusion (by 5.9%),
congestive heart (to 82.3%) and respiratory failure (in 17.6%), infection (in
76.4%), cancer stroke (by 5.9%), DVT (23.5% - a history in 64.7% - con-
nected with PE). Weak factors risks related: diabetes type 2 (5.9%), hy-
pertension (in 35.2%), old age (over 65 years - 17.6%), laparoscopic
surgery (5.9%), obesity ( 23.5%), pregnancy (11.7%), varicose veins in
history (at 17.6%).
Results: To assess the prognosis of patients with pulmonary embolism
using index PESI. On average age of the examined was 51,2 ± 8,7 years,
were 8 (47.0%) of men diagnosed 1 (5.9%) cancer; in 13 (76.4%) patients had
heart failure II A, 1 (5.9%) - II B, in 3 (17.6%) - and the extent of chronic lung
disease, heart rate  100, SBP <100 , BH> 30 - 5 (29.4%), temperature body
normally - in 12 (70.5%), mental status change (stupor) - in 1 (5.9%)
individuals.
Conclusions: DVT have a great effect on increasing risk of developing CHD
and found that DVT had high influence on developing MI.
EAS16-0702, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE,
PERIPHERAL VASCULAR DISEASE.
ASSOCIATION OF BASELINE APOLIPOPROTEIN B AND FRIEDEWALD
LDLC WITH LONG-TERM RE-INFARCTION IN HYPERTRIGLYCERIDEMIC
PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
M. Hermans 1, A. van der Laarse 2, M. Schalij 1, F. Romijn 2, N. Smit 2, Y. van
der Burgt 3, W. Jukema 1, C. Cobbaert 2. 1 Leiden University Medical Center,
Cardiology, Leiden, Netherlands; 2 Leiden University Medical Center, Clinical
Chemistry en Laboratory Medicine, Leiden, Netherlands; 3 Leiden University
Medical Center, Center for Proteomics & Metabolomics, Leiden, Netherlands
Objectives: Cardiovascular morbidity is associated with dyslipidaemia,
determined by serum lipids and lipoproteins. Conventional lipid profiling
lacks analytical accuracy, particularly in hypertriglyceridemic (HTG) pa-
tients. A quantitative proteomics assay was developed for detection and
quantification of six serum apolipoproteins, among them apolipoprotein
B100 (apoB), and qualitative apoE phenotyping. The total number of
atherogenic lipoprotein particles is reflected by serum apoB concentration.
This study aims to assess the value of quantitative serum apoB on long-
term re-infarction in HTG ST-elevated myocardial infarction (STEMI)
patients.
Methods: Patients with STEMI from the MISSION! Intervention Study in
2004-2005 were analyzed. Patients with previous statin use or >65 years
were excluded. The association between baseline serum apoB and long-
term re-infarction in HTG patients in comparison with LDLc according to
Friedewald (LDL-F) was investigated.
Results: In total, 55 (34%) of 161 included patients had triglyceride levels
>2.0 mmol/L. Corrected for sex, both LDL-F [HR 2.2 (CI 1.1-4.7) p-val-
ue¼0.04] and apoB [HR 1.3 (CI 1.0-1.8) p-value¼0.04] are associated with
long-term re-infarction in normal triglyceride (NTG) patients. In HTG pa-
tients, LDL-F was not associated with long-term re-infarction [HR 1.8 (CI
0.8-4.0) p-value¼0.13], whereas apoB association was borderline signifi-
cant [HR 1.3 (CI 1.0-1.7) p-value¼0.08].
Conclusions: Baseline quantitative serum apoB is associated with long-
term re-infarction in NTG and borderline significant in HTG STEMI pa-
tients. LDL-F is associated with long-term re-infarction in NTG STEMI pa-
tients only.
Ă
EAS16-0396, VASCULAR BIOLOGY: MYOCARDIAL INFARCTION, STROKE,
PERIPHERAL VASCULAR DISEASE.
CORRELATION OF HIGH-SENSITIVE CRP, CAROTID INTIMA-MEDIA
THICKNESS, AND THE CHRONIC KIDNEY DISEASE OF HEALTHY
RESIDENTS: RESULTS FROM THE KYUSHU AND OKINAWA
POPULATION STUDY (KOPS)
Y. Tanaka 1, M. Shimizu 1, N. Furusyo 1, Y. Kato 1, J. Hayashi 2. 1 Graduate
School of Medical Sciences- Kyushu University, Department of general
internal medicine, Fukuoka, Japan; 2 Kyushu General Internal Medicine
Center - Haradoi Hospital, Department of general internal medicine,
Fukuoka, Japan
Objectives: Chronic kidney disease (CKD) has been recognized as a risk
factor for cardiovascular disease. We previously reported that carotid
atherosclerosis was independently associated with the development of
CKD. This large-scale epidemiological study investigated whether or not
the relationship between carotid atherosclerosis and renal function is
modified by serum marker of inflammation.
Methods: Common carotid intima-media thickness (cIMT), serum high
sensitivity C-reactive protein (hsCRP), and the estimated glomerular
filtration rate (eGFR) were measured for 1,381 adult residents (mean age
58.3±8.7 years) of Kyushu, Japan, who attended free public physical ex-
aminations. CKD was defined as an eGFR <60 mL/min/1.73m2, and the
cutoff value for the high and low hsCRP groups was the top quintile (1.02
mg/L).
Results: The overall mean cIMT was 0.59±0.10 mm, and the prevalence of
CKD was 8.4%. The cIMT of the high hsCRP group was significantly higher