DAFTAR ISI

Hal.
LEMBAR PENGESAHAN......................................................................... ii
KATA PENGANTAR................................................................................... iii
DAFTAR ISI................................................................................................. v
DAFTAR TABEL......................................................................................... viii
DAFTAR GAMBAR.................................................................................... ix
BAB I PENDAHULUAN
1.1 Latar Belakang........................................................................... 1
1.2 Rumusan Masalah...................................................................... 4
1.3 Maksud dan Tujuan
1.3.1 Maksud ............................................................................ 4
1.3.2 Tujuan ............................................................................. 4
1.4 Manfaat Penelitian
1.4.1 Manfaat Akademik........................................................... 4
1.4.2 Manfaat Pelayanan Kesehatan/Kebijakan Kesehatan...... 5
1.4.3 Manfaat Masyarakat.......................................................... 5
BAB II TINJAUAN PUSTAKA
2.1 Konsep Demam Berdarah Dengue............................................. 6
2.1.1 Definisi Demam Berdarah Dengue.................................. 6
2.1.2 Epidemiologi.................................................................... 7
2.1.3 Insidensi........................................................................... 7
2.1.4 Etiologi............................................................................. 8
2.1.5 Patogenesis....................................................................... 9
2.1.5.1 Virulensi Virus.................................................... 9
2.1.5.2 Teori Immunopatologi........................................ 10
2.1.5.3 Teori Endotoksin................................................ 10
2.1.5.4 Teori Mediator.................................................... 11
2.1.5.5 Teori Apoptosis................................................... 11
2.1.5.6 Teori Endotel...................................................... 11

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 2.1.6 Manifestasi Klinik............................................................ 11
2.1.6.1 Demam Dengue.................................................. 11
2.1.6.2 Demam Berdarah Dengue.................................. 11
2.1.7 Diagnosis.......................................................................... 12
2.1.7.1 Demam Dengue.................................................. 12
2.1.7.2 Demam Berdarah Dengue.................................. 12
2.1.7.3 Dengue Shock Syndrome................................... 13
2.1.8 Derajat Klinis................................................................... 13
2.1.9 Patofisiologi..................................................................... 13
2.1.10 Pemeriksaan Penunjang dan Diagnostik.......................... 16
2.1.10.1 Uji Hemaglutinasi Inhibisi (HI)......................... 17
2.1.10.2 Uji Neutralisasi................................................... 17
2.1.10.3 Uji Elisa.............................................................. 17
2.1.10.4 Uji Serologis Rapid Test..................................... 19
2.2 Konsep Pemeriksaan Serologi dengan RDT.............................. 20
2.2.1 Prosedur Penggunaan Rapid Diagnostic Test.................. 20
2.2.2 Kegunaan Tes................................................................... 20
2.2.3 Prinsi Tes.......................................................................... 20
2.2.4 Interpretasi....................................................................... 21
2.2.4.1 IgM/IgG Negatip................................................ 21
2.2.4.2 IgM Positip......................................................... 21
2.2.4.3 IgG Positip.......................................................... 21
2.2.4.4 IgM/IgG Positip.................................................. 21
2.3 Kerangka Pemikiran................................................................... 22
BAB III SUBJEK DAN METODE PENELITIAN
3.1 Rancangan Penelitian................................................................. 24
3.2 Subjek Penelitian ........................................................................ 24
3.2.1 Kriteria Inklusi................................................................. 24
3.2.2 Kriteria Eksklusi.............................................................. 24
3.3 Cara Pengambilan Sampel.......................................................... 24
3.4 Variabel Penelitian...................................................................... 25

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 3.5 Definisi Operasional................................................................... 25
3.6 Instrumen Penelitian................................................................... 25
3.7 Prosedur Penelitian..................................................................... 26
3.8 Analisis Data.............................................................................. 27
3.9 Tempat Dan Waktu Penelitian.................................................... 28
3.10 Jadwal Penelitian....................................................................... 28
3.11 Alur Penelitian........................................................................... 29
DAFTAR PUSTAKA................................................................................... 30

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