PHP 2511

Applied Regression Analysis

Mondays and Wednesdays, 10:30 - 11:50

Instructor Adam J Sullivan

Address Brown School of Public Health, Brown University, Providence
Office 7th Floor, Room 717
Phone (401)863-1980
Mail adam sullivan@brown.edu

COURSE DESCRIPTION
This course provides a survey of regression techniques for outcomes common in public
health data including continuous, binary, count and survival data. Emphasis is on
developing a conceptual understanding of the application of these techniques to solving
problems, rather than to the numerical details. Extensive use of the computer will be
made for analysis of datasets.
This course is designed for graduate and advanced undergraduate students who will be
analyzing data with scientific colleagues and who want to develop a practical hands-on
toolkit and gain experience in distilling complex statistical information into formats
understandable to colleagues. Stata and R programming environments will be featured
within this course.

PREREQUISITES
Students should have courses in probability and statistical inference at the level of PHP
2510.

RECOMMENDED TEXTBOOKS
Sheather, Simon J, “A Modern Approach to Regression with R”, Springer ISBN:
9780387096087, (2009).
Vittinghoff, Eric; Glidden, David V ; Shiboski, Stephen C; McCullough, Charles E.,
“Regression Methods in Biostatistics, 2nd ed.”, Springer ISBN: 9781461413530, (2011).
Both these texts are available for Free Online from Brown Library

OTHER TEXTBOOKS
Kleinbaum, David G; Kupper, Lawrence L; Nizam, Azhar; Rosenberg, Eli S., “Applied
Regression Analysis and Other Multivariable Methods 5th Edition”, Brooks Cole ISBN:
9781285051086, (2014).
Kleinbaum, David G., “Survival Analysis: A Self Learning Text”, Springer ISBN:
9781441966469, (2012).
Kleinbaum, David G., “Logistic Regression: A Self Learning Text”, Springer ISBN:
9781441917423, (2010).
Hosmer, David W; Lemeshow, Stanley; Sturdivant, Rodney X. , “Applied Logistic
Regression, 3rd Edition”, Wiley ISBN: 9780470582473, (2013). Hosmer, David W;
Lemeshow, Stanley; May, Susanne., “Applied Survival Analysis: Regression Modeling of
Time to Event Data, 2nd Edition”, Wiley ISBN: 9780471754992, (2008).
Ramsey, Fred; Schafer, Dan, “The Statistical Sleuth: A Course in Methods of Data
Analysis, 3rd Edition”, Brooks/Cole ISBN: 9781133490678, (2013).

EVALUATION
Participants will be graded based on:

Participation & Quizzes 10%

Homework 30%
Midterm Exam 30%
Final Exam 30%
To receive full credit, all assignments must be submitted on Canvas by the due date.
 TENTATIVE SCHEDULE

Date Lecture Topic Reading

Jan. 27 1 Overview of Course, Basics VGSM 1.1 - 3.2
Feb. 1 2 Simple Linear Regression VGSM 3.3 - 3.4
Feb. 3 3 Linear Regression: Multiple Linear VGSM 4.1 - 4.2
Feb. 8 4 Linear Regression: Categorical Predictors, Confounding VGSM 4.3 - 4.4
Feb. 10 5 Linear Regression: Interaction VGSM 4.6
Feb. 15 6 Linear Regression: Model Assessment VGSM 4.7
Feb. 17 7 Linear Regression: Model Building
Feb. 22 No Class Long Weekend
Feb. 24 8 Logistic Regression: Single Predictor VGSM 5.1
Feb. 29 9 Logistic Regression: Multiple Predictor VGSM 5.2
Mar. 2 10 Logistic Regression: Model Fit VGSM 5.4
Mar. 7 11 Logistic Regression: Matched Studies VGSM 5.3
Mar. 9 12 Logistic Regression: Other types of Logistic Regression VGSM 5.5
Mar. 14 13 Logistic Regression: Model Building
Mar. 16 14 Poisson Regression
Mar. 21 15 Survival Analysis: Intro and Kaplan-Meier VGSM 3.5, 6.1
Mar. 23 16 Survival Analysis: Logrank, Comparing Survival Curves VGSM 3.5, 6.1
Mar. 28 & 30 Spring Recess
April 4 17 Survival Analysis: Regression Models Part 1 VGSM 6.2
April 6 18 Survival Analysis: Regression Models Part 2 VGSM 6.2
April 11 19 Survival Analysis: Time Dependent & Stratified Cox VGSM 6.3
April 13 20 Survival Analysis: Model Fit VGSM 6.4
April 18 21 Survival Analysis: Competing Risks VGSM 6.5
April 20 22 Survival Analysis: Model Building
April 25 23 Longitudinal Data: Repeated Measures VGSM 7.1
April 27 24 Longitudinal Data: Hierarchical, Longitudinal Data VGSM 7.2 - 7.3
May 2 26 Longitudinal Data: GEE VGSM 7.4
May 4 27 Longitudinal Data: Random Effects Models VGSM 7.5
May 9 28 Extra Class If Needed
OVERALL COURSE EXPECATIONS:
Students will be expected to do the following:

1. Attend all lectures and participate in class discussions.

2. Read assigned materials prior to coming to class and actively participate in class
discussions.

3. Complete and turn in all assignments on time. Solutions to homework must be

clearly written with appropriate tables and figures included. Computer output with
annotations will not be accepted.

4. Demonstrate an understanding on material on examinations.

OVERALL COURSE LEARNING OBJECTIVES

After successful completion of this course you will understand and be able to develop
and interpret regression models to describe how an outcome is related to one or more
predictor variables. In particular these include the following capabilities:

1. Recognize when data should be analyzed by regression

2. Plan an appropriate analysis

3. Analyze the data with the assistance of a computational program.

4. Coherently summarize results.

BROWN SCM/AM CORE COMPETENCIES
Primary Competencies

1. Identify and implement statistical techniques and models for analysis of data.

2. Acquire knowledge and skills in research methodologies to collaborate with sub-

stantive investigators.

3. Understand the advantages and disadvantages of randomized and non-randomized

studies to measure effects of interventions.

4. Apply programming skills to analyze data and develop simulation studies.

Refresher Competencies

1. Demonstrate a foundation in statistical theory and methods for standard designs

and analyses encountered with biomedical data.

2. Recognize key research designs and be able to assist in developing plans for their
implementation.

3. Attain proficiency in management, documentation of study data for use in practical

statistical analysis.

4. Formulate a public health question in statistical terms.

5. Develop proficiency in making oral, written and poster presentations of work to

statistical and non-statistical colleagues.

6. Review and evaluate the use of biostatistical methods in public health or biomedical
field of study.

7. Demonstrate proficiency in the language of the public health or biomedical field of

studies.
STUDENTS WITH SPECIAL NEEDS
Brown University is committed to full inclusion of all students. Students who, by nature of
a documented disability, require academic accommodations should contact the professor
during office hours. Students may also speak with Student and Employee Accessibility
Services at 401-863-9588 to discuss the process for requesting accommodations.