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DEGENERATION :

TGF B 1 >>

SMA >>

COLAGEN III >>

MICROTRAUMA

VASCULAR PROBLEM

HISTO; DISORIENT FIBER, METAPLASIA CHONDR, CALCIFIC, MYXOID HYALIN DEG, THINNED

SPUR IMPINGE

CAPS LAX OR CONTRACT

OVERUSE

SUBST P

SEROTONIN

GLUTAMAT

APOPTOSIS; PRDX5 >>

C JUN N-TERMINAL PROTEIN (JNK) >>

MMP 1 >>
HEALING : TENDON TO BONE

CYTOKINES :
TGFB
ILS
IGF
VEGF
PDGF
IL 4
IL 6

BMP;
BMP 2-7
BMP 12
BMP 14

MMP;
TIMP 1
TIMP 2
MMP 2

COLLAGEN
TYPE I

VASCULAR
IMAGING?
MSC;
GDF 8
FGF 4
COLLAGEN I

HEALING ; TENDON TO TENDON

mRNA ALFA 1 COLLAGEN TYPE 1