ABSTRAK

Ailani, Achmad fauzan. 2017. Pengaruh Pemberian Ekstrak Kulit Pisang Kepok (Musa
paradisiaca formatypica) terhadap Ketebalan Aorta Tikus Putih Galur Wistar
(Rattus norvegicus strain wistar) Model Aterosklerotik. Tugas Akhir, Fakultas
Kedokteran Universitas Muhammadiyah Malang. Pembimbing: : (I) Dian
Yuliartha L.* (2) Suharto. (**)
Latar Belakang : Aterosklerosis merupakan kontributor utama terhadap patogenesis
penyakit jantung koroner (PJK). Kulit pisang kepok (Musa paradisiaca formatypica)
mengandung senyawa flavonoid golongan katekin dan saponin yang berfungsi sebagai
antioksidan.
Tujuan : Membuktikan pengaruh ekstrak kulit pisang kepok (Musa paradisiaca
formatypica) terhadap ketebalan dinding aorta tikus putih jantan (Rattus norvegicus)
galur wistar model aterosklerosis.
Metode Penelitian : True experimental dengan post test only control group design.
Sampel dibagi dalam 4 kelompok, semua kelompok diberi diet tinggi kolesterol,
kelompok 1, 2, dan 3 diberi ekstrak kulit pisang kepok 20, 40, dan 80
(mg/200gBB/hari). Data dianalisis menggunakan uji normalitas, uji homogenitas, uji
ANOVA, uji bonferoni, dan uji regresi yang pengolahannya menggunakan SPSS 17.
Hasil Penelitian dan Pembahasan : Hasil uji one way anova didapatkan pengaruh
yang bermakna (p<0,000). Hasil uji post hoc didapatkan perbedaan yang bermakna
(p<0,05) pada tiap kelompok perlakuan. Hasil uji regresi linier didapatkan R2=0,79
(ekstrak kulit pisang kepok memberikan pengaruh sebanyak 79% sementara 21% lain
adalah faktor yang tidak diteliti). Flavonoid sebagai antioksidan dengan mendonorkan
ion hidrogen sehingga dapat menetralisir efek toksik dari radikal bebas. Saponin
mencegah miselisasi kolesterol selama pencernaan di usus halus, sehingga dapat
mengurangi tersedianya kolesterol untuk penyerapan ke enterosit.
Kesimpulan : Ekstrak kulit pisang kepok berpengaruh terhadap ketebalan dinding
aorta tikus putih jantan (Rattus norvegicus) galur wistar model aterosklerosis

Kata kunci : aterosklerosis, ekstrak kulit pisang kepok, flavonoid

*) Staf Pengajar Patologi Anatomi Fakultas Kedokteran UMM

**)) Staf Pengajar Radiologi Fakultas Kedokteran UMM
 ABSTRACT

Ailani, Achmad Fauzan. 2016. The Influence of Kepok Banana Peel Extract (Musa
paradisiaca formypica) on the aortic wall thickness in Atherosclerosis Model
of White Male Rats (Rattus norvegicus) Wistar Strain. Final Assignment,
Medical Faculty of Muhammadiyah Malang University, Advisors : (I) Dian
Yuliartha L.* (II) Suharto**

Background : Atherosclerosis is the main contributor to the pathogenesis of coronary

heart disease (CHD). The peel of kepok banana (Musa paradisiaca formatypica)
contain flavonoid compounds (katekin) and saponins which act as antioxidants.
Objective : To prove the effect of kepok banana (Musa paradisiaca formatypica) peel
extract against the thickness on the aortic wall in atherosclerosis model of white male
rats (Rattus norvegicus) wistar strain.
Methods : True Experimental with post-test control group design. The samples were
divided into 4 groups. All group was given a high-cholesterol diet, while group 1, 2,
and 3 were given kepok banana (Musa paradisiaca formatypica) peel extract as much
as 20, 40, and 80 (mg/200gBB/day). Statistical analysis consists of normality test,
homogeneity test, ANOVA test, Bonferoni test, and regression test in SPSS 17.
Result : One way ANOVA test results shows significant effect (p<0.00). Results of
post hoc test was found significant of differences (p<0.05) in each group of treatment.
The results of linear regression was obtained R2 = 0.79 (the kepok banana (Musa
paradisiaca fomratypica) peel extract influence as much as 79% while 21% refers on
the other factors that were not being studied). Flavonoids as antioxidant to donate
hydrogen ions to neutralize toxic effect of free radicals. Saponins prevent cholesterol
micelle formation in intestine.
Conclusion : kepok banana (Musa paradisiaca formatypica) peel extract influences
the thickness on the aortic wall in atherosclerosis model of white male rats (Rattus
norvegicus) wistar strain.

Keyword : atherosclerotic, kepok banana (Musa paradisiaca formatypica) peel extract,

flavonoid

*) Lecturer of Pathological Anatomy of Medical Faculty of Muhammadiyah Malang

University
**) Lecturer of Radiology of Medical Faculty of Muhammadiyah Malang University