The Leading Provider of Advanced Neurostimulation Products

Advanced Neurostimulation
The Magstim range of magnetic stimulation systems provide a variety of high quality solutions for
researchers and clinicians working within Neurology, Neuroscience, Psychiatry and Rehabilitation.
Magstim has substantial expertise in magnetic stimulation, and is a leader in the field, offering a wide
range of magnetic stimulators and stimulating coils to suit a variety of clinical and research
applications.

Non-invasive Neuromodulation
Magnetic stimulation is a non-invasive and painless method of stimulating human tissue using strong,
time varying magnetic fields to induce small currents in nerve tissue. These are able to stimulate
the human cortex, spinal roots and peripheral nerves.
Depending on the application a variety of output waveforms may be used to excite or inhibit nerve
response. These pulses can be either monophasic or biphasic, or a combination of the two.

This brochure is intended for users of TMS equipment outside of the USA.

a leader in the field of magnetic stimulation

Users of Magstim Transcranial Magnetic Stimulators in the USA please note:

Caution - Investigational Device. Federal (or United States law) limits device to investigational use.
 Magstim Magstim

Controlled
Magstim
Monophasic Trains
2002 & BiStim2
Systems- Monophasic
Magstimproduce
Magstim BiStim² offers the potentialsystems;
two monophasic to combine two
the Magstim Twocomponent
ISI optionsofoffer
clinical and research
maximum assessment techniques,
controllability:
Monophasic single pulse systems are favoured in neurological
Magstim
2002 and 200² unitswhich
BiStim2, to provide
are usedfullyextensively
programmable
within the including:
applications due to the accuracy of the stimulation and the low heat ● 1ms - 999ms in 1ms resolution
paired
fields of pulse stimulation
neurology through a single For
and neurophysiology. stimulating
accurate Triple Stimulation Technique
output. ● ● 1.0ms - 99.9ms in 0.1ms resolution
coil. The
single ability
pulse to changemonophasic
functionality, pulse intervals and to systems
waveform ● Resting Motor Threshold
Magstim
favoured 200
independently
are 2
for:control& the
BiStim
power 2level- Monophasic
of each Magstim BiStim² has the added advantage of being able to sum the
● Active Motor Threshold
Magstim producefortwo
●200²Neurological
allows monophasic
precise
research systems;
sub- and the Magstim2002
supra-threshold two single pulses provided by the Magstim 2002
● Central Conduction Time
and BiStim2, which
●conditioning are used
and test
Cortical mapping extensively
pulses.
and within the for
Thisresearch
brain is invaluable fields of
the stimulators to produce a single high power pulse equal to
● Motor Evoked Potential
neurology and neurophysiology. For accurate single pulse functionality, 113% of a single Magstim 200².
●investigation
Functionalofassessment
Inter-Cortical and Intra-Cortical
of central motor pathways ● Input-Output Curve
monophasic waveform systems are favoured for:
●Inhibition and Facilitation.
Early diagnosis, assessment and monitoring ● Cortical Silent Period
l Neurological research
of nervous diseases, such as Multiple
l The inter-stimulus
Cortical mapping and interval (ISI) of the two pulses is
brain research Magstim 200² offers complete flexibility and can be
Sclerosis and Motor Neurone Disease.
l adjustable using either
Functional assessment of the integral
central motorstimulator
pathways controls, interfaced with a wide range of commercially available
l remote
Early diagnosis, assessment and monitoring of nervous diseases,
Single control
pulsecoil or externally via triggering EMG systems. The monophasic waveform provides a high
such as Multiple Sclerosis and Motor
software offering complete user flexibility.Neurone Disease. degree of hemispheric accuracy, low noise and less coil
Magstim 200² provides users with the ability to elicit
Single pulsepotentials, quickly and easily, as a routine heating than other Trains
Controlled pulse waveforms.
cortical evoked
Magstim 200 provides users with the ability to elicit cortical
2
Magstim
The MagstimBiStim
2
offers the potential
200² is backward to combine
compatible with all two Magstim
Magstim
evoked potentials, quickly and easily, as a routine component of clinical 200 units to provide fully programmable paired pulse stimulation
2
stimulating coils.
and research assessment techniques, including: through a single stimulating coil. The ability to change pulse intervals
and to independently control the power level of each Magstim 2002
l Triple Stimulation Techniquev
allows for precise sub- and supra-threshold conditioning and test pulses.
l Resting Motor Threshold
This is invaluable for the investigation of Inter-Cortical and

a worldThemarket leader in the field of

l Active Motor Threshold Intra-Cortical Inhibition and Facilitation.
l Central Conduction Time inter-stimulus interval (ISI) of the two pulses is adjustable using
l Motor Evoked Potential
l Input-Output Curve
magnetic stimulation
either the integral stimulator controls, remote control coil or externally
via triggering software offering complete user flexibility.
l Cortical Silent Period Two ISI options offer maximum controllability:
l Motor Mapping l 1ms - 999ms in 1ms resolution
l 1.0ms - 99.9ms in 0.1ms resolution
Magstim 2002 offers complete flexibility and can be interfaced with BiStim2 has the added advantages of being able to sum the two
a wide range of commercially available EMG systems.The monophasic single pulses provided by the Magstim 2002 stimulators to produce
waveform provides a high degree of hemispheric accuracy, low noise a single high power pulse equal to 113% of a single Magstim 2002,
and less coil heating than other pulse waveforms. The Magstim 2002 is as well as having the functionality to connect two individual coils for
backward compatible with all Magstim stimulating coils, via the coil adaptor. interhemispheric stimulation.

Magstim Magstim Magstim Magstim

200² BiStim² Rapid² Rapid² Plus¹

Output Type Monophasic Monophasic Biphasic Biphasic

Twin Pulse
Maximum voltage 2.80kV 2.50kV* 1.67kV 1.67kV
Maximum repetition rates 30% 2.0s 2.0s Single PSU - 50Hz Dual PSU - 100Hz 100Hz

“
(230V configuration) 50% 3.0s 3.0s Single PSU - 30Hz Dual PSU - 50Hz 97Hz

Minimum Inter Stimulus Interval

100% 4.0s
N/A
4.0s
1.0ms
“
Single PSU - 15Hz Dual PSU - 25Hz
N/A
41Hz
N/A
Minimum Inter Train Interval N/A 4.0s 0.5s 0.5s

* Also available as 2.80kV

 Magstim

Magstim 2002
Biphasic & BiStim2 - Monophasic
Systems
Magstim produce two monophasic systems; the Magstim component of clinical and research assessment techniques,
Magstim Rapid2 - Biphasic
2002 and BiStim2, which are used extensively within the including:
Magstim Rapid2 repetitive Transcranial Magnetic Stimulation (rTMS) Magstim Rapid2 has a unique in built two channel EMG amplifier
fields of neurology and neurophysiology. For accurate ●withTriple Stimulation Technique
devices are highly effective non-invasive biphasic magnetic stimulators integral system acquisition software including latency and
single pulse
designed functionality,
to meet the exactingmonophasic waveform
needs of those involvedsystems
at all levels of Restingmeasurements.
●amplitude Motor Threshold
The dedicated touch screen user interface
are favoured for:
clinical and academic research. Highly efficient, short duration biphasic ●withActive Motor
internal Threshold
and external memory makes storage and retrieval
● Neurological
pulses research
makes it very well suited to bilateral cortical stimulation and is of results straightforward.
● Central Conduction Time Connecting the optional thermal printer
used in many different
● Cortical mapping and areas of brain
research, including:
research allows for the provision of hard copies.
● Motor Evoked Potential
●Rapid can be usedCurve
with other investigation tools such as fMRI, EMG,
2
● Functional
Cognitive assessmentviof- in
Neuroscience central motor pathways
the investigation of learningvii viii, Input-Output
● Early
memory ix
diagnosis,
, speechx
assessment
, hearing, and monitoring
visual, perception and functional connection EEG, tDCS, tACS and Image-guided TMS over a broad range of
● Cortical Silent Period
protocols and is fully compatible with existing Magstim coils through
of nervous xidiseases,
Psychiatry such as
- to influence Multiple
specific brain function within the Magstim 200²
customised offers complete flexibility and can be
hardware.
Sclerosis and
dorsolateral Motorcortex
prefrontal Neurone Disease.
interfaced with
Magstim Rapid a wide
2 range
Plus 1 of innovative
is an commercially availableto the
enhancement
Neurophysiology - used in the stimulation of the peripheral EMG
Rapidsystems.
2
Theonly
and is the monophasic
system ablewaveform provides ahigher
to offer a significantly high
Single pulse
and central nerve pathways degree of hemispheric accuracy, low noise and less coil is
repetition rate at stimulation output of 30% and higher. This
Magstim 200² provides users with the ability to elicit particularly
Rehabilitation - used in the promotion of muscle recovery heating thanuseful
otherinpulse
applications using protocols such as Theta Burstxii,
waveforms.
cortical
and evoked
the relief potentials,
of nerve spasticityquickly and easily, as a routine as the Magstim Rapid2 Plus1 is capable of up to 89% output at 50Hz.
The Magstim 200² is backward compatible with all Magstim
With the addition of a Plus1 module a single PSU Rapid2 can be easily
The Magstim Rapid2 range of repetitive stimulators has been stimulating coils.
upgraded to dual PSU performance, whereas the addition of the Plus1
developed to maintain a consistent pulse amplitude/frequency during
module to a dual PSU Rapid2 make high powered protocols feasible.
the delivery of stimulation trains through Single Pulse, Repetitive, Burst
and Session modes of operation. Rapid2 stimulators offer frequencies 100
Rapid2 Plus1
of up to 100Hz, with a 0.1Hz frequency resolution for the first 30Hz. 90
Dual PSU Rapid2
80 Single PSU Rapid2
(230v configurations)
70
Frequency (Hz)

60

50

40

30

Magstim Rapid2 is for single pulse 20

and repetitive stimulation 10

0
0 10 20 30 40 50 60 70 80 90 100
Power (%)

Magstim Rapid2 Performance

100

90

80

70
Frequency (Hz)

60

50

40

30

20

“
10

0
0 10 20 30 40 50 60 70 80 90 100
Power (%)

Rapid2 Plus1

Dual PSU Rapid2

Single PSU Rapid2
 Magstim

Magstim 2002 & BiStim2 - Monophasic

Magstim produce two monophasic systems; the Magstim component of clinical and research assessment techniques,
2002 and BiStim2, which are used extensively within the including:

An effective treatment where

fields of neurology and neurophysiology. For accurate ● Triple Stimulation Technique
single pulse functionality, monophasic waveform systems ● Resting Motor Threshold
are favoured for:
traditional medication has failed
● Active Motor Threshold
● Neurological research ● Central Conduction Time
● Cortical mapping and brain research ● Motor Evoked Potential
● Functional assessment of central motor pathways ● Input-Output Curve
As the original pioneers of TMS, Magstim are industry recognised
● Early diagnosis, assessment and monitoring ● Cortical Silent Period
as world leaders in diagnostic, research and therapy solutions.
of nervous diseases, such as Multiple
Magstim 200² offers complete flexibility and can be
rTMS (Repetitive
Sclerosis Transcranial
and Motor Neurone Disease. Magnetic Stimulation) is a treatment
interfaced with a wide range of commercially available
for patients that have not responded to pharmaceutical solutions - it is
Single pulse EMG systems. The monophasic waveform provides a high
estimated that up to 40% of patients do not benefit from, or cannot
degree of hemispheric accuracy, low noise and less coil
tolerate,
Magstim 200² antidepressant
provides users with medications – even after repeated
the ability to elicit attempts.
heating than other pulse waveforms.
Acortical
recent study
evoked has shown
potentials, quickly that rTMS
and easily, as ahas a 58% response rate and
routine
37% remission rate and has shown efficacy as a well-tolerated The Magstim 200² is backward compatible with all Magstim
therapeutic option . 1 stimulating coils.

Benefits of rTMS
● Treatment with rTMS has a fast onset of action with
significant patient improvement2
● Treatment is provided as an outpatient procedure
● Patients can return to normal activities
after treatment
● No anaesthesia or sedation required
● 20-30 treatments over 4-6 weeks
● 37.5 minute treatment time

Is rTMS right for you?

rTMS is a treatment that can be used as an adjunct with medication, or as a drug free treatment.
This therapy avoids the side effects associated with antidepressant medication.
rTMS is the future for depressed patients who are proving resistant to traditional
pharmaceutical solutions.

To request more information, please visit:

“
www.magstim.com/TMSclinical
email: TMSclinical@magstim.com or Tel: +44 (0) 1994 240798

1 Carpenter. L, et al: Transcranial Magnetic Stimulation (TMS) for major depression: a multisite, naturalistic, observational study of acute treatment outcomes
in clinical practice (2012)
2 Rossini. D, et al: Transcranial magnetic stimulation in treatment-resistant depressed patients: A double-blind, placebo-controlled trial (2005)
 Magstim

Magstim 2002 & BiStim2 - Monophasic

Stimulator Compatibility Regulatory
Magstim produce two monophasic systems; the Magstim component of clinical and research assessment techniques,
Part
2002 and BiStim2, which Coil
are used Description
extensively within the Application
including: 2002 Bistim2 Rapid2 CE Mark FDA
No. Clearance
fields of neurology and neurophysiology. For accurate ● Triple Stimulation Technique
single pulse functionality, monophasic waveform systems ● Resting Motor Threshold
are favoured for: 3192-00 90mm Standard Cortical
● Neurological research Single High Power Stimulation 3
● Active Motor Threshold
● Central Conduction Time
3 3 3 3
Coil Remote Cervical
● Cortical mapping and brain research
Control rootsMotor Evoked Potential
nerve ●
● Functional assessment of central motor pathways ● Input-Output Curve
Lumbosacral
● Early diagnosis, assessment and monitoring nerve ●
rootsCortical Silent Period
of nervous diseases, such as Multiple
Magstim 200² offers complete flexibility and can be
9784-00 Disease.
Sclerosis and Motor Neurone 90mm Coil Cortical
* Single High Power Stimulation 3 3 3 3
a wide range of commercially available
interfaced with 3
Single pulse Coil 1st generation EMG systems. The monophasic waveform provides a high
Cervical
nerve degree
roots of hemispheric accuracy, low noise and less coil
Magstim 200² provides users with the ability to elicit Lumbosacral
heating than other pulse waveforms.
cortical evoked potentials, quickly and easily, as a routine nerve roots
The Magstim 200² is backward compatible with all Magstim
stimulating coils.
1165-00 25mm Branding Iron Facial nerve
* Double Polyurethane Median nerve 3 3
Coil 1st generation Ulnar nerve
Somatosensory
evoked potentials
F-Wave and
reflexes

3190-00 70mm Remote Cortical

Double Coil Stimulation 3 3 3 3 3
Coil Spinal roots
Peripheral
nerves

3271-00 70mm Branding Iron Cortical

* Double Polyurethane Stimulation 3 3 3 3
Coil 1st generation Femoral nerve
Back and neck

3281-00
*
70mm Flat coil
Double Polyurethane
Cortical
Stimulation
3 3 3 3
Coil 1st generation Femoral nerve
Back and neck

Please refer to www.magstim.com for regular product updates.

* Requires coil adapter

“
 Magstim

Magstim 2002 & BiStim2 - Monophasic

Stimulator Compatibility Regulatory
Magstim produce two monophasic systems; the Magstim component of clinical and research assessment techniques,
2002 and BiStim2, which Part
are usedCoil
extensivelyDescription
within the Application
including: 2002 Bistim2 Rapid2 CE Mark FDA
No. Clearance
fields of neurology and neurophysiology. For accurate ● Triple Stimulation Technique
single pulse functionality, monophasic waveform systems ● Resting Motor Threshold
are favoured for: 4102-00 D702 High Cortical
● Neurological research Double Performance Stimulation 3
● Active Motor Threshold
● Central Conduction Time
3 3 3
Coil Double Coil Spinal Roots
● Cortical mapping and brain research ● Motor Evoked Potential
Peripheral
● Functional assessment of central motor pathways Nerves
● Input-Output Curve
● Early diagnosis, assessment and monitoring ● Cortical Silent Period
of nervous diseases, such as Multiple
Magstim 200² offers complete flexibility and can be
9902-00Disease.
110mm Cone Coil Central motor
Sclerosis and Motor Neurone
* Double 1st generation 3 3 3 3
interfaced with a wide range of commercially available
disorders
Single pulse Coil EMG
Spinal systems. The monophasic waveform provides a high
injuries
Urology
degree of hemispheric accuracy, low noise and less coil
Magstim 200² provides users with the ability to elicit
heating than other pulse waveforms.
cortical evoked potentials, quickly and easily, as a routine
The Magstim 200² is backward compatible with all Magstim
4150-00 Alpha stimulating coils.
Cortical
70mm
Alpha Coil
Stimulation 3 3 3 3
Double Spinal roots
Coil Peripheral
nerves

3530-00 70mm Air Cooled Power intensive

Double Coil protocols 3 3
Coil Long duration
protocols

3910-00 70mm Air Film Psychiatry

Double Coil Cognitive 3 3 3
Coil Neuroscience
Neurology
Neurophysiology
Rehabilitation

3950-00 70mm Identical to the Cortical

Double active coil (see Stimulation 3 3
Coil above) other than Cervical
(Placebo) the stimulating nerve roots
output. Suitable
Lumbosacral
for double-blind
nerve roots
trials

Please refer to www.magstim.com for regular product updates.

* Requires coil adapter

“
Magstim

Magstim 2002 & BiStim2 - Monophasic

Magstim produce two monophasic systems; the Magstim component of clinical and research assessment techniques,
2002 and BiStim2, which are used extensively within the including:
fields of neurology and
Distributor neurophysiology. For accurate
Information ● Triple Stimulation Technique
single pulse functionality, monophasic waveform systems ● Resting Motor Threshold
are favoured for: ● Active Motor Threshold
● Neurological research ● Central Conduction Time
● Cortical mapping and brain research ● Motor Evoked Potential
● Functional assessment of central motor pathways The Magstim CompanyCurve
● Input-Output Ltd
● Early diagnosis, assessment and monitoring Spring
●Gardens,
CorticalWhitland
Silent Period
of nervous diseases, such as Multiple Carmarthenshire,
Magstim 200²SA34
offers0HR
complete flexibility and can be
Sclerosis and Motor Neurone Disease. Wales, UK
interfaced with a wide range of commercially available
T: +44 (0)1994 240798
EMG systems. The monophasic waveform provides a high
Single pulse
E: sales@magstim.com
degree of hemispheric accuracy, low noise and less coil
Magstim 200² provides users with the ability to elicit
heating than other pulse waveforms.
www.magstim.com
cortical evoked potentials, quickly and easily, as a routine
The Magstim 200² is backward compatible with all Magstim
References
stimulating coils.

i Combining TMS and fMRI: From 'virtual lesions' to

functional-network accounts of cognition.
Ruff CC, Driver J, Bestmann S.
Cortex. 2008 Dec 6. [Epub ahead of print]

ii Combining TMS and EEG to study cognitive function and

cortico-cortico interactions.
Taylor PC, Walsh V, Eimer M.
Behav Brain Res. 2008 Aug 22;191(2):141-7. Epub 2008 Apr 1.

iii Mapping of the human visual cortex using image-guided

transcranial magnetic stimulation.
Fernandez, E., Alfaro, A., Tormos, J.M., Climent, R., Martinez, M., Vilanova, H.,
Walsh, V., and Pascual-Leone, A.
Brain Research Protocols 10:115-124, 2002.

iv Complementary localization and lateralization of orienting

and motor attention.
Rushworth, Matthew F.S., Ellison, Amanda, and Walsh, Vincent.
Nature Neuroscience, 4(6), June 2001.

v Triple stimulation technique (TST) in amyotrophic lateral

sclerosis
Leonid Komissarow, Jens D. Rollnik, Dessislava Bogdanova, Klaus Krampfl, F.
A. Khabirov, Andon Kossev, Reinhard Dengler and Johannes Bufler
Clinical Neurophysiology, Volume 115, Issue 2, Pages 356-360

vi Transcranial magnetic stimulation and cognitive

neuroscience
Vincent Walsh and Alan Cowey
Nature Reviews – Neuroscience, Volume 1, October 2000, 73-79

vii The Contribution of Primary Motor Cortex is Essential for

Probabilistic Implicit Sequence Learning: Evidence from Theta
Burst Magnetic Stimulation
Leonora Wilkinson, James T. Teo, Ignacio Obeso, John C. Rothwell and
Marjan Jahanshahi
Journal of Cognitive Neuroscience

viii Transcranialmagnetic stimulation can measure and

Users of Magstim Transcranial Magnetic Stimulators
modulate learning and memory
J Grafman E Wassermann
in the USA please note:
Neuropsychologia 37 (1999) 159-167
Caution - Investigational Device. Federal (or United
ix Contribution
of memory functions
of noninvasive cortical stimulation to the study
States law) limits device to investigational use.
A. Floela, L.G. Cohen
Brain Research Reviews 53 (2007) 250–259
All standard products carry the mark, comply with the Medical Device Directive
x Stimulating language: insights from TMS 93/42/EEC, and are manufactured under a Quality System certified to ISO 13485.
Joseph T. Devlin and Kate E. Watkins
Brain 130, (2007) 610–622 © 2012 The Magstim Company Limited. Magstim®, and Air FilmTM are registered
xi Applications of TMS to Therapy in Psychiatry. trademarks of The Magstim Company Limited.

“
Lisanby, Sarah H.; Kinnunen, Leann H.; Crupain, Michael J.
Journal of Clinical Neurophysiology. 19(4):344-360, August 2002. All specifications are subject to change. All material in this literature is produced in
xii Exploring Theta Burst Stimulation as an intervention to
good faith
improve motor recovery in chronic stroke
P. Talelli, R. Greenwood, J. Rothwell
Clinical Neurophysiology, Volume 118, Issue 2, Pages 333-342

This brochure is intended for users outside the USA