Diketahui :

1. Durasi Obat adalah 3 jam bisa dilihat dari awal kurva naik tepat saat MEC 4 mcg/mL pada jam pertama dan sampai

2 Ka = 2.303 x (-0.15) = 0.34545

Ke = 2.303 x (-0.45143) = 1.03964329
t1/2abs = 0.693/Ka = 2.0060790 jam
t1/2elim = 0.693/Ka = 0.6665747825872

(𝐷𝑂 𝑥 𝐹 𝑥 𝐾𝑎)/(𝐶�° (𝐾𝑎−𝐾𝑒))

Vd =

(3 𝑥 0.8 𝑥 −0.34545)/(3.6 (0.34545 −1.039643290))

0.82908/2.4990
95844

Vd = 0.331751982218
AUC = 1/2 x A x T = 1/2 x 10 x 6.7 = 33.5
Cltot = Vd x Ke = 16 x -1.03964329 = 16.63429264

Cara Berbeda
F = f x (1-ER)
f = seberapa diabsorbsi, absorbsi penuh dianggap 1
0.8 = 1 x (1-ER)
ER = 0.2

ER = CL/Q
Dianggap clearance hanya pada hepar,
jadi Q adalah liver blood flow yaiut 90 L/h
0.2 = CL/90
CL = 18
t1/2 = 0.7 x VD/CL
t1/2 = 0.7 x 16/18
t1/2 = 0.67
 Waktu (jam) Kadar Obat (mccg/mL)
1 3.5
2 6.7
3 4.9
4 3.6
5 2.6
6 1.8
7 1.2
8 0.8
9 0.5
10 0.3

/mL pada jam pertama dan sampai jam ke-4

SUMMARY OUTPUT

Regression Statistics
Multiple R 0.12970131
R Square 0.01682243
Adjusted R Square -0.474766355
Standard Error 1.813146436
Observations 4

ANOVA
df SS MS F Significance F
Regression 1 0.1125 0.1125 0.0342205323 0.8702986896
Residual 2 6.575 3.2875
Total 3 6.6875

Coefficients Standard Error t Stat P-value Lower 95%

Intercept 5.05 2.2206417991 2.2741173304 0.1508106343 -4.5046504988
X Variable 1 -0.15 0.810863737 -0.1849879248 0.8702986896 -3.6388650715
 Upper 95% Lower 95.0% Upper 95.0%
14.604650499 -4.504650499 14.6046504988
3.3388650715 -3.638865072 3.3388650715
SUMMARY OUTPUT

Regression Statistics
Multiple R 0.9713196329
R Square 0.9434618292
Adjusted R Square 0.9293272865
Standard Error 0.2311462122
Observations 6

ANOVA
df SS MS F
Regression 1 3.5662857143 3.5662857143 66.748663102
Residual 4 0.2137142857 0.0534285714
Total 5 3.78

Coefficients Standard Error t Stat P-value

Intercept 4.5857142857 0.4250170065 10.789484223 0.0004184833
X Variable 1 -0.4514285714 0.0552545132 -8.1699855019 0.0012220495
Significance F
0.0012220495

Lower 95% Upper 95% Lower 95.0% Upper 95.0%

3.4056778985 5.7657506729 3.4056778985 5.7657506729
-0.604839694 -0.298017449 -0.604839694 -0.2980174488