Aluminum Hydroxide Gel Magnesium Hydroxide
TACIDIN
350 mg / 150 mL per 5 mL Oral
Antacid
FORMULATION
Each sachet contains
Aluminum Hydroxide Gel…………………. 150 mL
Magnesium Hydroxide.……………………. 350mg
PHARMACOLOGIC CATEGORY
Antacid
PRODUCT DESCRIPTION
PHARMACODYNAMICS AND
PHARMACOKINETICS
Magnesium hydroxide and aluminum
hydroxide in the presence of hydrochloric acid
reacts in the stomach to form magnesium
chloride and water. Food or other factors may
decrease gastric emptying in which extends
the availability of aluminium hydroxide to
react and may increase the amount of
aluminium chloride formed.
INDICATION
Aluminium hydroxide is used as an antacid.
Orally, It is given in doses of up to about 1 g,
between meals and at bedtime. For adults,
500-1500 mg 3-6 times daily, between meals
and at bedtime. Magnesium hydroxide given in
orral liquid, 400 mg/5 mL, 800 mg/5 mL.. Take
1-3 h after meals and at bedtime when used as
an antacid. Shake well the suspension before
use.
DOSAGE AND MODE/ROUTE OF
ADMINISTRATION
Oral suspension
CONTRAINDICATION
Magnesium hydroxide when contraindicated
may cause appendicitis, ileus or intestinal
obstruction, severe renal impairment,
undiagnosed rectal bleeding. Aluminum
hydroxide may cause hypophosphatemia.
PRECAUTIONS
Antacids/laxatives should be used carefully
with person which has renal impairment and in
those with chronic diarrhea, GI disease, and
undiagnosed GI and rectal bleeding. Elderly
patients may be at increased risk of
constipation and fecal impaction. Adequate
hydration should be maintained. Pattern of
daily bowel activity and stool consistency and
serum aluminum, calcium, phosphate, and uric
acid levels should be monitored.
WARNINGS
Do not take other oral drugs within 1-2 h of
antacid administration.
PREGNANCY AND LACTATION
Renal failure, toxemia of pregnancy during 2 h
preceding delivery. Occasional use of
magnesium hydroxide for constipation is
generally considered compatible for pregnancy
and lactation.
INTERACTIONS
Magnesium hydroxide by alterations in gastric
pH and emptying, and by formation of
complexes that are not absorbed.
DRUGS: Ketoconazole, bisphosphonates,
fluoroquinolones, tetracycline, methenamine,
nitrofurantoins as may decrease the
absorption of these drugs. Calcium may
reverse the effects of magnesium for it is used
to treat magnesium toxicity. Digoxin may cause
changes in cardiac conduction if magnesium is
excessive or depleted. Herbal:
None
Food: None
ADVERSE DRUG REACTION
Effect that is dose-dependent may cause
diarrhea. Hypermagnesaemia may occur,
usually in patients with renal impairment.
OVERDOSAGE AND TREATMENT When
given in large doses, it may result to
magnesium toxicity which causes loss of deep
tendon reflexes, heart block, respiratory
paralysis, and cardiac arrest. Hypocalcemia
with tetany also may occur. The antidote for
toxicity is 10-20 mL 10% calcium chloride or
gluconate (5-10 mEq of calcium). Prolonged or
excessive use may cause hypophosphatemia,
in neonates or those with renal failure, may
produce aluminum toxicity encephalopathy
STORAGECONDITION
May refrigerate prior to use; do not freeze. In
an airtight container , at a temperature not
exceeding 30 °C.
NAME AND ADDRESS OF MANUFACTURER
Pharmaricx Laboratories Inc
Canlubang Industrial Estate, Cabuyao Laguna
ADR REPORTING STATEMENT
For suspectedd adverse drug reaction, report
to the FDA: www.fda.gov.ph
REGISTRATION NO: DR – XY080306