Please cite this article in press Awais Tariq et al.., Role of Octreotide in Upper Gastrointestinal Bleeding Due To
Liver Cirrhosis, Indo Am. J. P. Sci, 2018; 05(04).
patients were from Child-Pugh Class B and 10 after 48 hours. In relation to Child-Pugh Class A, in
patients were in Class C. In age group 51-65 years, 2 10 patients bleeding remained control, in 2 patients
patients were in Child-Pugh Class A, 9 were in Class bleeding continued after 24 hours and 1 patient
B and 18 patients were in Child-Pugh Class C. developed episode of re-bleeding. According to
Efficacy of Octreotide was shown in the form of child-pugh class B, in 13 patients bleeding remained
“bleeding controlled”, “bleeding continued” and “re- control, in 5 patients bleeding continued after 24
bleeding”. In 35 (56.45%) patients out of total 62 hours and 2 patients developed episode of re-bleeding.
bleeding was successfully controlled with continues In child-pugh class C, 10 patients had re-bleeding.
infusion of octreotide in 24 hours duration. In 14 Out of 62 patients 4 patient died. Out of 4 patients, 3
(22.58%) patients bleeding remained continue and in belong to Child-Pugh Class C and 1 from Class B.
13 patients there was episode of re-bleeding observed
In a study done by Baik et.al and Badaruddin AH 6. Sharara AI,Rockey DC. Gastroesophageal
et.al. Hemostasis achieved more frequent with variceal hemorrhage. N Engl J Med 2001;
octreotide than terlipressin [13,14]. In a comparative 345(9):669-81.
study between octreotide and vasopressin showed 7. Walker S, Kreichgauer HP, Bode JC.
control of bleeding 88% and 54% respectively Terlipressin vs. somatostatin in bleeding
[15,16]. Corley DA et.al. Found octreotide has better esophageal varices: a controlled, double-blind
control of re-bleeding than vasopressin and study. Hepatology 1992;15:1023-30.
terlipressin. A multicenter randomized trail 8. Pedretti G, Elia G, Calzetti C,Magnani
conducted in France showed that control of bleeding G,Fiacadorri F. Octreotide versus terlipressin in
with octreotide is 79% and terlipressin 59% [17-21]. acute variceal hemorrhage in liver cirrhosis.
But there are several studies that showed that there is Emergency control and prevention of early
no significant difference in the efficacy of different rebleeding. Clin Investig 1994;72:653-59.
treatment. 9. Feu F, Ruiz del Arbol L, Banares R, Planas R,
Bosch J. Double-blind randomized controlled
This study favors that octreotide play a handsome trial comparing terlipressin and somatostatin for
role in controlling upper gastrointestinal bleeding in acute variceal hemorrhage. Gastroenterology
cirrhotic patient, especially in patient with Child- 1996;111:1291-99.
Pugh class A. Endoscopy is the gold standard 10. 9, Zhou Y, Qiao L, Wu J, Hu H, Xu C:
treatment for upper gastrointestinal bleeding but in Comparison of the efficacy of octreotide,
our set up due to over burden of patients and lack of vasopressin, and omeprazole in the control of
emergency endoscopic procedures and skilled hand, acute bleeding in patients with portal
patient had to wait for 3-5 days for his turn. In such hypertensive gastropathy:
patients octreotide play important role for control of 11. a controlled study. J Gastroenterol Hepatol 2002,
bleeding, until the endoscopy is performed. 17:973- 979.
12. 10. Walker S, Kreichgauer HP, Bode JC.
Conflict of interest: Terlipressin (glypressin) versus somatostatin in
The authors declare no conflict of interest. the treatment of bleeding esophageal varices--
final report of a placebo-controlled, double-blind
CONCLUSION: study.Zeitschrift fur Gastroenterologie
Octreotide has good efficacy in treating upper 1996;34:692-98.
gastrointestinal bleeding in cases with liver cirrhosis 13. Clarke DL, McKune A, Thomson SR: Octreotide
and this is significantly better in cases with Child lowers gastric mucosal blood flow in normal and
Pugh Class A. portal hypertensive stomachs. Surg Endosc 2003,
17:1570-1572.
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