DAFTAR ISI

DAFTAR ISI .................................................................................. i

DAFTAR TABEL.......................................................................... iv
BAB I PENDAHULUAN ......................................................... 1
1.1 Latar Belakang ...................................................................... 1
1.2 Rumusan Masalah .................................................................. 2
1.3 Tujuan Penelitian ................................................................... 3
1.4 Kegunaan Penelitian............................................................... 3
1.5 Kerangka Pemikiran ............................................................... 3
1.6 Lokasi dan Waktu Penelitian ................................................. 4
BAB II TINJAUAN PUSTAKA................................................ 5
2.1 Tablet ....................................................................................... 5
2.1.1 Feformulasi pada Tablet ................................................. 5
2.1.2 Evaluasi Granul .............................................................. 7
2.1.3 Evaluasi Fisik Tablet ...................................................... 8
2.2 Tumbuhan Sambung Nyawa ................................................... 9
2.2.1 Klasifikasi....................................................................... 9
2.2.1 Morfologi ....................................................................... 10
2.2.2 Kandungan Kimia .......................................................... 11
2.6.3 Manfaat........................................................................... 11
2.3 Ekstraksi .................................................................................. 13
2.3.1 Ekstraksi Dingin ................................................................... 13
2.3.2 Ekstraksi Panas ..................................................................... 14
2.4 Diabetes Melitus ...................................................................... 15
2.4.1 Pengertian Diabetes Melitus........................................... 15
2.4.2 Epidemilogi .................................................................... 16

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 2.4.3 Klasifikasi Diabetes Melitus .......................................... 16

BAB III METODOLOGI PENELITIAN .................................. 18

3.1 Alat Dan Bahan ....................................................................... 18
3.1.1 Alat .................................................................................... 18
3.1.2 Bahan ................................................................................. 18
3.2 Determinasi ............................................................................. 18
3.3 Pembuatan Ekstrak Daun Sambung Nyawa ........................... 19
3.4 Skrining Fitokimia................................................................... 19
3.4.1 Flavonoid ........................................................................ 19
3.4.2 Tanin............................................................................... 20
3.4.3 Steroid dan Triterpenoid................................................. 20
3.4.4 Monoterpen dan Seskuiterpen ........................................ 20
3.5 Formulasi Tablet ..................................................................... 21
3.6 Evaluasi Granul ....................................................................... 21
3.6.1 Laju Alir dan Sudut Istirahat .......................................... 21
3.6.2 Indeks Kompresibilitas dan Rasion Hausner ................. 22
3.7 Evaluasi Tablet ........................................................................ 23
3.7.1 Penampilan Fisik ............................................................ 23
3.7.2 Keseragaman Ukuran ..................................................... 23
3.7.3 Keseragaman Bobot ....................................................... 24
3.7.4 Kekerasan Tablet ............................................................ 24
3.7.5 Keregasan Tablet ............................................................ 24
3.7.6 Waktu Pembasahan ........................................................ 25
3.7.7 Waktu Hancur ................................................................ 25
3.8 Uji Aktivitas Ekstrak Daun Sambung Nyawa ......................... 26
3.8.1 Subjek Penelitian .................................................................. 26
3.8.2 Pemberian Dosis ................................................................... 26

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 3.8.3 Perlakuan Hiperglikemia ...................................................... 26
3.8.4 Cara Pengukuran Kadar Glukosa Darah Mencit .................. 27
3.9 Analisa Data ............................................................................ 27
DAFTAR PUSTAKA .................................................................... 28

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 DAFTAR TABEL

Tabel 1.1 Kegiatan Penelitian .......................................................................... 4

Tabel 3.1 Formulasi Tablet .............................................................................. 23
Tabel 3.2 Hubungan Sudut Istilah dengan Sifat Alir ....................................... 25
Tabel 3.3 Kategori Indeks Komplesibilitas...................................................... 26
Tabel 3.4 Syarat Keseragaman Bobot .............................................................. 27

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