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ORIGINAL ARTICLE

Factors Predicting Inpatient Rehabilitation Length of Stay of


Acute Stroke Patients in Singapore
Woan Shin Tan, MSocSc, Bee Hoon Heng, MBBS, MSc (Public Health), FAMS,
Karen Sui-Geok Chua, MBBS, MRCP, FAMS, Kay Fei Chan, MBBS, MRCP, FAMS
ABSTRACT. Tan WS, Heng BH, Chua KS, Chan KF. Factors health care expenditure.2 Internationally, the social and eco-
predicting inpatient rehabilitation length of stay of acute stroke pa- nomic burden of stroke is expected to escalate given the tri-
tients in Singapore. Arch Phys Med Rehabil 2009;90:1202-7. pling of the number of older persons over the next 50 years.3
Objective: To determine the predictors of hospital length of Because the process of recovery is slow with up to two thirds
stay (LOS) of stroke patients at the point of admission. of stroke survivors remaining moderately or severely disabled
Design: A retrospective cohort study. 3 months after the stroke,4 rehabilitation should be commenced
Setting: An acute hospital rehabilitation center in Singapore. early to maximize their physical and functional outcomes5,6
Participants: Stroke patients (N⫽491) admitted between and to minimize the substantial social and economic burden7
March 2005 and December 2006. placed on caregivers of these patients.
Interventions: None. A key challenge to gaining timely access to rehabilitation
Main Outcome Measures: Rehabilitation LOS was calcu- programs is the availability of bed resources to accommodate
lated as the total number of rehabilitation days before dis- the patients. Recovery should not be compromised by the lack
charge. We measured the functional status of patients by using of rehabilitation resources. In this regard, it would be important
the Functional Independence Measure (FIM). for hospital administrators and health care systems to identify
Results: The median LOS was 29 days (mean ⫽ 30.8d). the prognostic variables for LOS to ensure the effective and
Independent clinical and sociodemographic characteristics efficient management of bed resources. The identification of
found to significantly predict rehabilitation LOS were FIM the accurate prediction of LOS is also useful in helping to set
motor score at admission, the presence of more than 3 comor- a target date for caregivers in their preparation of postdischarge
bid conditions at admission, living with nonimmediate relatives care.
before admission, and the hospital subsidy status of the patient. Stroke is the fourth leading cause of death in Singapore.8
In particular, the admission FIM motor score explained 43% of Over the last 2 decades, the number of hospital discharges in
the variation in LOS and decreased the LOS by approximately Singapore for cerebrovascular disorders increased from
1.1 days for each 1-point increase in score.
3,7329 to 8,74510 between 1986 and 2006. The incidence
Conclusion: Patients’ socioeconomic status and family
structure was found to influence LOS and should be considered rate of stroke has been reported to be 1.8/1,000 person years,11
in allocating resources and determining treatment need. The but this is set to rise with the unprecedented aging12,13 of the
extent of motor function of patients at admission is an impor- population over the next 2 decades. The number of Singapore
tant factor influencing rehabilitation LOS and is a useful tool residents aged 65 years or older is projected to triple from
for facilitating rehabilitation resource planning for stroke 305,600 (8.5%) in 2007 to 900,000 (18.7%) in 2030.14,15
patients. In view of the rising demand for stroke rehabilitation ser-
Key Words: Length of stay; Prognosis; Rehabilitation; vices, the use of health care resources in the rehabilitation
Stroke. setting needs to be optimized. Health care professionals gen-
© 2009 by the American Congress of Rehabilitation erally rely on clinical experience and analytic reasoning to
Medicine estimate the LOS of patients, which involves significant
amounts of either intuitive pattern recognition or intuitive
regression16 of clinical, functional, and socioeconomic factors.
TROKE CAUSED AN ESTIMATED 5.7 million deaths
S worldwide in 2005, and it was projected that, if the current
trend persists, over 50 million healthy life years will be lost
To improve the accuracy of LOS prediction, prognostic vari-
ables need to be translated into a statistical model.17 Although
a previous Singaporean study18 has examined the determinants
from stroke by 2015.1 It was estimated that stroke accounted
of rehabilitation LOS, it focused on identifying potentially
for 10% of all deaths worldwide in 1999, and expenditure on
cerebrovascular diseases ranged between 2% and 4% of total preventable medical and nonmedical factors determining LOS
in a subacute care setting. In this study, we sought to identify
LOS determinants in an acute inpatient rehabilitation setting by
examining variables that can be assessed at the time of admis-
From Health Services and Outcomes Research Department, National Healthcare sion and to determine their relative importance in predicting the
Group (Tan, Heng), Singapore; and Department of Rehabilitation Medicine, Tan Tock rehabilitation LOS for patients with acute stroke.
Seng Hospital (Chua, Chan), Singapore.
Presented in part to the National Healthcare Group Annual Scientific Congress,
November 10 –11, 2007, Singapore.
No commercial party having a direct financial interest in the results of the research
supporting this article has or will confer a benefit on the authors or on any organi-
zation with which the authors are associated. List of Abbreviations
Reprint requests to Woan Shin Tan, MSocSc, Health Services and Outcomes
Research Dept, National Healthcare Group, 6 Commonwealth Lane, #04-01/02 GMTI LOS length of stay
Building, Singapore 149547, e-mail: woan_shin_tan@nhg.com.sg. log logarithm
0003-9993/09/9007-00801$36.00/0 ln natural logarithm
doi:10.1016/j.apmr.2009.01.027

Arch Phys Med Rehabil Vol 90, July 2009


PREDICTING STROKE REHABILITATION LENGTH OF STAY, Tan 1203

METHODS atrial fibrillation, ischemic heart disease, myocardial infarction,


previous stroke, renal diseases, tumor, ulcer disease, asthma,
Setting and chronic obstructive pulmonary disease, and others were
This study involved a retrospective review of medical also extracted from the medical records.
records of acute stroke patients admitted to an inpatient reha- We recorded the acute LOS as the number of days spent in
bilitation center in Singapore between March 2005 and De- an inpatient hospital before admission to the rehabilitation
cember 2006. The 93-bedded center is a not-for-profit public center and computed the rehabilitation LOS by subtracting the
sector facility and is the largest acute inpatient rehabilitation date of admission to the rehabilitation center from the date that
unit in Singapore. Patients admitted were entered into a com- the patient is discharged to home, another hospital, or nursing
prehensive rehabilitation program managed by a multidisci- home.
plinary team led by a physiatrist working together with phys- The FIM28 was used to assess functional status at admission.
iotherapists, occupational therapists, speech therapists, nurse The multidisciplinary team assessed and scored the FIM within
clinicians, medical social workers, psychologists, and acupunc- 72 hours of admission and at weekly intervals when the team
turists. met to discuss patients’ rehabilitation progress and postdis-
Within the public sector, patients may choose to be admitted charge plans. All providers were trained and credentialed in
to single-bedded private (class A), 2-bedded semiprivate (class FIM scoring. It is a widely used functional assessment mea-
B1), or dormitory-styled subsidized (class B2 and C) wards. sure, which contains 13 items related to self-care, bowel and
Patients in class A pay the full cost, whereas patients in other bladder continence, mobility, and ambulation, and 5 items
ward classes enjoy subsidies ranging from 20% of the cost for related to communication, social functioning, and cognition.
class B1 rooms to 65% and 80% of the cost for the class B2 and Rating is conducted on a 7-level ordinal scale, ranging between
C rooms, respectively. 1 (totally dependent) and 7 (totally independent). Because
several studies29,30 have examined and confirmed the validity
Population of aggregating FIM items into motor and cognitive scores, we
Patients included in this retrospective study met the follow- summed up the first 13 items to develop the motor score and
ing criteria: (1) diagnosis of stroke, which was defined as an the last 5 items to develop the cognitive score. This resulted in
acute onset of neurologic deficit lasting more than 24 hours, of a motor FIM score range of 13 to 91 and a cognitive FIM score
cerebrovascular origin, and was confirmed by both clinical and range of 5 to 35.
radiographic means, and (2) stroke occurred within the 3
months preceding admission. We excluded patients with trau- Statistical Analysis
matic brain injuries and/or spontaneous subarachnoid hemor- We first performed univariate analyses to examine the rela-
rhages because of different etiology, prognostic factors, and tionship between rehabilitation LOS and each of the variables.
outcomes. Informed consent was waived by the National Because the distribution of LOS was nonnormal, the results of
Healthcare Group Institutional Review Board. the analysis were summarized by median values. We used the
Mann-Whitney U test or the Kruskal-Wallis test to assess the
Data Collection and Study Parameters differences among or between groups. Continuous variables
Three trained abstractors reviewed the medical records. Based were stratified using certain cutoff points for comparison.
on clinical judgment and predictors found to be significant in We applied a cutoff of 65 years for age and stratified the
literature,19-27 we extracted the following data from the case notes: acute hospital LOS based on its median value. The initial
demographics and preadmission living arrangements, stroke FIM motor score was categorized into 3 levels: (1) 13ⱕse-
type, site and side, comorbidity, hospital ward class, and acute vere disability⬍26, (2) 26ⱕ moderate disability ⬍65, and (3)
and rehabilitation LOS. Electronic medical data were extracted 65ⱕmild disabilityⱕ91 and the initial FIM cognitive score was
to derive information related to functional status at admission. similarly classified into (1) 5ⱕsevere disability⬍10, (2) 10ⱕ
Because the objective of this study was to predict LOS at moderate disability⬍25, and (3) 25ⱕmild disability ⱕ35.
admission, we included only factors present at admission. A multivariate linear regression model was used to select
The demographic characteristics included age, sex, and eth- variables that significantly predict rehabilitation LOS. A back-
nic group. Information regarding patients’ preadmission living ward selection procedure was used to select the covariates of
arrangement was based on documented genograms, which are the final model using P⬎.10 as the removal criterion. To avoid
pictorial representations of family trees recording information overfitting the model, only variables found to be significant
about the relationship between family members and living (P⬍.10) in the univariate analysis were included in the multi-
arrangements. In this study, we have classified living arrange- variate model. Because the rehabilitation LOS was positively
ments as living with only immediate family (parents, spouse, skewed, we logarithmically transformed the data to produce a
children, single siblings), living with nonimmediate family more normal distribution. To interpret the estimated coeffi-
(cousins, nephews, nieces, or siblings with a distinct family cients resulting from a linear regression on a nonlinearly trans-
nucleus of their own), living with others (unrelated persons), formed dependent variable (LOS), we had to back-transform
and living alone. the fitted values and multiplied it by a smearing factor,31 which
Diagnoses of stroke were made by admitting emergency is the mean of the antilog of the unstandardized residuals.
room physicians or neurologists or neurosurgeons and con- Outliers were not excluded if there was no evidence of a
firmed by neuroimaging (computed tomography or magnetic mistake. We used bivariate scatterplots to ascertain that the
resonance imaging brain scans) within 6 hours of acute admis- relationship between the explanatory variables and ln-LOS is
sion. Types of stroke lesions were broadly classified as either linear.
hemorrhagic or ischemic in nature. Brain lesions were classi- The independence of error terms was checked to ensure there
fied by cortical, subcortical, or brainstem groups and by the was no serial correlation. The variance inflation factor was
involved hemisphere (left, right, and bilateral). Patients’ history used to test for multicollinearity, residual plots, and histograms
of comorbid conditions such as hypertension, diabetes mellitus, were used to test for heteroscedasticity and normality. A prob-
hyperlipidemia, congestive heart failure, valvular heart disease, ability (P value) of less than .05 was considered to be statisti-

Arch Phys Med Rehabil Vol 90, July 2009


1204 PREDICTING STROKE REHABILITATION LENGTH OF STAY, Tan

Table 1: Demographic, Clinical and Functional Characteristics of motor and cognitive functions correspondingly (table 2). The
Rehabilitation Inpatients (Nⴝ491) mean acute and rehabilitation LOS were 14.2⫾11.4 (median,
Mean or Median or 25th–75th 11.0) and 30.8⫾16.3 (median, 29.0). Approximately 1 in 10
Characteristics Number of Percentage Percentile patients (91.4%) had at least 1 kind of comorbid condition.
Demographic characteristics Hypertension (79.2%), hyperlipidemia (54.8%), and diabetes
Age (y) 61.3 62.0 53–71 mellitus (36.1%) were the 3 most prevalent comorbid condi-
Sex, male 289 58.9 tions.
Ethnicity
Univariate Results
Chinese 405 82.5
Malay 45 9.2 We found that age, sex, ethnicity, and prestroke living ar-
Indian 24 4.9 rangement did not correlate significantly with median LOS.
Others 17 3.5 Although individual comorbid conditions were not signifi-
Prestroke living arrangement cantly associated with median LOS, having more than 3 co-
With immediate family 446 90.8 morbid conditions at admission was associated with a shorter
With nonimmediate family 15 3.1 LOS at 10% significance level (see table 2). Our findings
Alone 19 3.9 indicated a strong association between median LOS and the
Others 11 2.2 choice of hospital ward class, which also serves as a proxy for
Ward class socioeconomic status. The median rehabilitation LOS was also
Private (A, B1) 55 11.2 significantly longer for patients who had a longer acute hospital
Subsidized (B2, C) 436 88.8 stay (0 –11d vs ⱖ12d). Similar results were obtained when the
Comorbidity, any 449 91.4 data were analyzed with log transformation of LOS.
Hypertension 389 79.2 Among the clinical characteristics, the median LOS was
Hyperlipidemia 269 54.8 longer for patients diagnosed with hemorrhagic stroke and
Diabetes mellitus 177 36.1 inversely associated with both the FIM motor and cognitive
Previous stroke 90 18.4 scores. The site of the brain lesion and affected hemisphere
Ischemic heart disease 68 13.8 were not significantly associated with median LOS.
Atrial fibrillation 32 6.5
Congestive heart failure 11 2.2
Multivariate Results
Myocardial infarction 9 1.8 Table 3 shows that the significant factors predicting rehabil-
Valvular heart disease 6 1.2 itation LOS were the extent of patients’ dysfunction in physical
Clinical characteristics activity at admission (FIM motor score), ward class, prestroke
FIM motor score at admission 36.4 36.0 23–48 living arrangement, and medical comorbidity, with the fitted
FIM cognitive score at model explaining 46% of the variance in rehabilitation LOS.
admission 23.8 27.0 16–33 We ran diagnostic tests to ensure that assumptions of the
Type of stroke
Ischemic 345 70.3
Hemorrhagic 146 29.7 Table 2: Factors Significantly Associated With Rehabilitation LOS
Acute LOS (d) 14.2 11.0 7–17 by Univariate Analysis
Rehabilitation LOS (d) 30.8 29.0 21–38 N⫽491
Median
Characteristics No. % LOS (d) P*

Demographic characteristics
cally significant. All statistical tests were performed by using Ward class ⬍.001
the Statistical Package for Social Sciences, version 15.0.a Private (A, B1) 55 11.2 36
Subsidized (B2, C) 436 88.8 28
RESULTS Number of comorbid conditions .063
0–3 430 87.6 29
We retrieved a total of 525 case notes over a 21-month
⬎3 61 12.4 25
period from March 1, 2005, to December 31, 2006. We ex-
Clinical characteristics
cluded 3 patients diagnosed with traumatic intracerebral hem-
FIM motor score at admission ⬍.001
orrhage, 25 patients diagnosed with subarachnoid hemorrhage,
Severe: 13–25 140 28.5 40
and 2 patients with missing FIM scores at admission. Four
Moderate: 26–64 328 66.8 25
patients who were transferred to an acute care hospital during
Mild: 65–91 23 4.7 11
the period of rehabilitation stay were also excluded. In total, we
FIM cognitive score at admission ⬍.001
included 491 patients in the analysis.
Severe: 5–9 73 14.9 37
Patient Characteristics Moderate: 10–24 145 29.5 32
Mild: 25–35 273 55.6 25
As shown in table 1, the mean age of patients was 61.3 years
Type of stroke ⬍.001
(median; 62.0y), 58.9% were men, 82.5% were of Chinese
Ischemic 345 70.3 27
ethnicity, and 90.8% resided with their immediate family mem-
Hemorrhagic 146 29.7 31
bers. Of the patients, 70.3% were diagnosed with ischemic
Acute LOS (d) .001
stroke. Those choosing private or semiprivate wards were
0–11 267 54.4 27
11.2%. The mean motor and cognitive scores of the FIM at
ⱖ12 224 45.6 30
admission were 36.3⫾16.0 (median, 36.0) and 23.6⫾10.2 (me-
dian, 27.0), respectively. At admission, almost 95% and 44% *The Mann-Whitney U test or the Kruskal-Wallis test was used to
of the patients were moderately or severely impaired in their assess the differences between groups.

Arch Phys Med Rehabil Vol 90, July 2009


PREDICTING STROKE REHABILITATION LENGTH OF STAY, Tan 1205

Table 3: Multiple Regression Analysis Predicting Ln-LOS*


Coefficient (SE) ␤ 95% Confidence Interval P

FIM motor score at admission ⫺.022 (0.001) ⫺0.647 (⫺.024 to ⫺0.020) ⬍.001
Ward class
Subsidized *
Private 0.200 (0.059) 3.410 (0.085–0.309) .001
Prestroke living with nonimmediate family
No *
Yes 0.281 (0.106) 0.089 (0.074–0.489) .008
No. of comorbid conditions at admission, ⬎3
No *
Yes ⫺0.177 (0.055) ⫺0.107 (⫺0.284 to ⫺0.068) .001
(Constant) 4.088 (0.047) (3.993–4.176) ⬍.001

NOTE. N⫽491. Adjusted R2⫽0.455. R2 is the percentage of total variance explained by the model. The following variables, in addition to the
reported (significant) variables, were entered into the model: stroke type, acute LOS, and FIM cognitive score at admission.
*Reference category.

ordinary least squares regression model were not violated. We for stroke patients. A similar relationship has been found in
found the log-scale residuals to be homoscedastic, which im- studies performed in inpatient rehabilitation settings in the
plied that the ordinary least-squares estimates with the logged United Kingdom34 and the United States.22 A Taiwanese study
dependent variable were unbiased.32 The Durbin-Watson sta- performed by Chung et al33 found the ability of stroke patients
tistic was 1.988, indicating that the model met the assumption to engage in self-care activities to have a major impact on the
of independence of the residual. Multicollinearity was also not rehabilitation LOS. Although others35,36 have reported cogni-
detected because the variance inflation factor for all indepen- tive dysfunction to complicate the rehabilitation process and to
dent variables was close to 1.0. When the standardized resid- prolong LOS, poor cognitive status did not independently in-
uals were plotted against a theoretic normal distribution in a crease the LOS in this study. Table 4 shows that the LOS was
probability-probability plot, the points formed an approximate determined predominantly by the FIM motor score regardless
straight line, which indicated normality of the standardized of the severity of cognitive dysfunction at admission. However,
residuals. both motor and cognitive status of patients should be taken into
The strongest predictor, after adjustment, was FIM motor account in the planning of care and the setting of rehabilitation
score at admission, which explained 43% of the LOS variation. goals. When catering to patients who are more cognitively
The smearing estimator of the fitted model was calculated to be impaired, more specialized rehabilitation efforts need to be
1.0806. After back-transforming the fitted values and multiply- committed. This has impact on the rehabilitation manpower
ing it by the smearing estimator, we found a 1-point increase in needed particularly as the population ages.
the admission FIM motor score to be associated with a 1.1-day As with other studies, age,23-25 stroke type, and lesion
decrease in the mean rehabilitation LOS (P⬍.001). The choice characteristics24 were not found to significantly influence LOS.
of private wards corresponded to a 1.3-day increase in LOS, The current evidence regarding the influence of individual
whereas we found residing with nonimmediate family mem- comorbid conditions is equivocal. Similar to the findings in
bers to be associated with a 1.4-day increase in LOS. Having other studies,19,21,24 we did not find diabetes mellitus and heart
more than 3 comorbid conditions at admission was signifi- disease to be significant prognostic variables. In this study,
cantly associated with a reduction in LOS by 1.3 days. individual medical comorbid conditions did not independently
After entering FIM motor score at admission into the model, influence LOS, but patients with more than 3 conditions had
we found stroke type, acute LOS, and FIM cognitive score at shorter LOS. Similar findings also draw attention to medical
admission not to be significantly associated with ln-LOS. We comorbidity as an indicator for rehabilitation potential with a
found patients with hemorrhagic stroke to have lower mean higher degree of comorbidity found to be prognostic of poorer
FIM motor scores compared with those with ischemic stroke rehabilitation outcomes.37 If we calculate rehabilitation effec-
(32.8 vs 38.4, P⬍.001). The mean FIM motor score was also tiveness, defined as actual functional improvement divided by
higher for patients with acute LOS of 11 days or less compared potential improvement ([discharge FIM score ⫺ admission
with those with LOS 12 days and above (38.5 vs 33.5, FIM score]/[maximum achievable FIM score ⫺ admission FIM
P⬍.001). Hence, the variable FIM motor score adequately score]), we find the mean rehabilitation effectiveness for pa-
captured and explained the impact of hemorrhagic stroke and tients with more than 3 comorbid conditions to be significantly
acute LOS on rehabilitation LOS.
DISCUSSION Table 4: Mean Rehabilitation LOS by FIM Motor and FIM
Cognitive Scores
Stroke rehabilitation will become more important as the
population ages. Hospital administrators and rehabilitation pro- LOS (d)
fessionals who are responsible for ensuring an efficient deliv- FIM Motor Score at Admission
ery and accessibility of rehabilitation services will need to FIM Cognitive Score
anticipate the resource needs of different patients. There is at Admission 13–25 26–64 65–91
limited information regarding drivers of inpatient rehabilitation 5–9 44.1 28.3 13.0
resource use by stroke patients in an Asian context.18,21,33 10–24 42.6 28.4 15.7
We found the extent of independence in motor functions at 25–35 42.1 26.1 11.8
admission to be the strongest predictor of rehabilitation LOS

Arch Phys Med Rehabil Vol 90, July 2009


1206 PREDICTING STROKE REHABILITATION LENGTH OF STAY, Tan

lower than for those who did not (0.26 vs 0.32; P⫽.015). In the CONCLUSION
public health care sector in Singapore, even though health The objective of our study was to determine the relative
services are subsidized through general taxation, subsidized importance of variables that can be assessed at the time of
patients still pay between 20% and 80% of their inpatient ex- admission in predicting acute rehabilitation LOS. We found
penses. Although the national catastrophic insurance scheme, Me- patients’ socioeconomic status and family structure to influence
dishield, pays for part of the bill, up to 60% of a large hospital bill LOS, and they should be considered in allocating resources and
is still being paid for by patients.38 Hence, patients who were determining treatment need. The results further suggest the
unable to continue to make functional gains could be discharged FIM motor score at admission to be a strong predictor of the
earlier to minimize their financial burden. In addition, with duration of stay, although cognitive function was not found to
increasing tension between the demand for health services and be an independent predictor. Hence, the use of FIM tools could
the cost of providing them, clinicians may be implicitly be extended to other acute rehabilitation hospital units to fa-
rationing health care resources by allocating resources ac- cilitate better management of bed resources.
cording to the rate at which rehabilitation gains can be
reached. Nonetheless, the availability of the family to pro- Acknowledgments: We thank Wai Fung Chong, BN, MBA, for
vide postdischarge care and the employment of foreign her assistance during the data-collection phase of the study and the
staff of Tan Tock Seng Rehabilitation Center for their help and support
domestic helpers as untrained caregivers39 facilitated the in this study.
discharge of medically complex patients.
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