Hemolytic Uremic
Thrombolytics 3 0 0 4 1
Hematology Medbullets
Syndrome (HUS)
Team
MIXED
PLATELET/COAGULATION
DISORDERS Overview
Von Willebrand Disease
Thrombolytics
Disseminated Intravascular catalyze the
Coagulation (DIC)
formation of
Heparin-Induced endogenous
Thrombocytopenia (HIT)
plasmin from
HYPERCOAGULABLE
plasminogen
STATES precursor
plasmin is
Factor V Leiden
a serine
Prothrombin Gene protease
Mutation
that
Antithrombin III Deficiency degrades
Protein C/S Deficiency clots (thrombi)
Drugs
CANCER (SEE
tPA (alteplase)
ONCOLOGY)
streptokinase
HEME DISORDERS
urokinase
APSAC (anistreplase)
Heme Synthesis, Mechanism
Porphyrias, and Lead
Poisoning catalyze conversion of plasminogen to plasmin
cleaves fibrin clots
Methemoglobinemia
cleaves thrombin
Acute Intermittent clot-specificity
Porphyria
tPA is clot-specific
PHARMACOLOGY acts only on fibrin-bound
plasminogen
RBC/WBC streptokinase is not clot specific
depletes circulating
Transfusion
plasminogen, factor V,
Filgrastim / Sargramostim factor VIII
Erythropoietin ↑ PT, ↑ PTT, no change in platelet count
Clinical use
COAGULATION administer as early as possible following
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Toxicity
bleeding and intracerebral hemorrhage
contraindicated in patients with
history of bleeding, surgery,
hypertension
streptokinase may cause hypersensitivity
Hematology derived from β-hemolytic
streptococci
Antagonist
aminocaproic acid and tranexamic acid
inhibitor of fibrinolysis
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