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25/04/2018 USMLE Step 1 High Yield Topics

Step 1: High Yield Topics

The most critical topics to master in advance of the USMLE Step 1

High Yield Topics on Firecracker

For the USMLE Step 1
This page is intended to layout the highest-yield topics on Firecracker - while it
may serve as a guide to targeted subject and topic review during your dedicated
prep, it should not replace your daily Firecracker study plan in 'Today's To-Do's'.
Firecracker covers about 1200 topics for the USMLE Step 1. A 'topic' is
something like: Inguinal canal. Inguinal canal is a topic in the sub-subject of
the abdomen in the subject of anatomy, like so: Anatomy > Abdomen > Inguinal
canal. 1/13
25/04/2018 USMLE Step 1 High Yield Topics

In this grid, each topic in the right-most column is linked to that topic page inside
Firecracker. You must have a current Firecracker account to access these
pages, and once there you can review the topic, quiz yourself on questions
related to the topic, or mark the topic to add it to your Firecracker study plan. If
you don't yet have a study plan, create one here:

Subject Sub-subject Topic Name

Anatomy Upper Limb Brachial Plexus-Axillary Nerve

Anatomy Upper Limb Brachial Plexus

Anatomy Upper Limb Brachial Plexus-Musculocutaneous Nerve

Anatomy Upper Limb Brachial Plexus-Ulnar Nerve

Anatomy Upper Limb Brachial Plexus-Radial Nerve

Anatomy Upper Limb Brachial Plexus-Median Nerve

Anatomy Abdomen Abdominal Vasculature-The Celiac Trunk

Anatomy Lower Limb The Knee Joint

Anatomy Lower Limb Thigh: The Femoral Triangle

Anatomy Upper Limb Arm: Muscles

Anatomy Upper Limb Arm: Nerves

Anatomy Upper Limb Rotator Cu Muscles

Behavioral Science Biostatistics Number Needed to Treat or Harm

Behavioral Science Biostatistics Speci city, Sensitivity, PPV & NPV

Behavioral Science Biostatistics Absolute Risk Reduction

Behavioral Science Biostatistics Precision and Accuracy

Biochemistry Cellular Energy Glycogen Storage Diseases

Biochemistry Genetics Inheritance & Pedigree Analysis

Biochemistry Genetics Cystic Fibrosis

Biochemistry Genetics Trisomy 21

Cardiology Cardiology Anatomy Coronary Arteries

Cardiology Cardiology Pathology Diagnosis of MI

Cardiology Cardiology Pathology Hypertension

Cardiology Cardiology Pathology Ischemic Heart Disease 2/13
25/04/2018 USMLE Step 1 High Yield Topics

Cardiology Cardiology Pathology Angina Pectoris

Cardiology Cardiology Pathology Complications of MI

Cardiology Cardiology Physiology Heart Auscultation

Cardiology Cardiology Physiology EKG Tracings

Cardiology Cardiology Physiology Electrocardiogram

Cardiology Cardiology Anatomy Cardiac Anatomy

Cardiology Cardiology Anatomy Arteries

Cardiology Cardiology Anatomy Veins

Cardiology Cardiology Pathology Aortic Dissection

Cardiology Cardiology Pathology Types of Shock

Cardiology Cardiology Pathology Rheumatic Heart Disease

Cardiology Cardiology Pathology Endocarditis

Cardiology Cardiology Pathology Cardiac Tamponade

Cardiology Cardiology Pathology Ventricular Fibrillation

Cardiology Cardiology Pathology Congenital Heart Defects

Cardiology Cardiology Pathology Valvular Heart Disease

Cardiology Cardiology Pathology Morphologic Changes of Acute MI

Cardiology Cardiology Pathology Chronic Ischemic Heart Disease

Cardiology Cardiology Pathology MI & ACS

Cardiology Cardiology Pharmacology Antihypertension Drugs: Vasodilators

Cardiology Cardiology Pharmacology Congestive Heart Failure Therapy

Cardiology Cardiology Pharmacology Anginal Therapy

Cardiology Cardiology Pharmacology Class II Antiarrhythmics (& Beta Blockers)

Cardiology Cardiology Pharmacology Antihypertension Drugs: Sympatholytics

Cardiology Cardiology Pharmacology Class IV Antiarrhythmics

Cardiology Cardiology Pharmacology Hypolipidemic Drugs

Cardiology Cardiology Pharmacology Class III Antiarrhythmics

Cardiology Cardiology Pharmacology Class I Antiarrhythmics

Cardiology Cardiology Physiology Cardiac Output & Pressure Measurements

Cardiology Cardiology Physiology Starling Curve

Cardiology Cardiology Physiology Factors A ecting Cardiac Output

Dermatology Skin Pathology Basal Cell Carcinoma 3/13
25/04/2018 USMLE Step 1 High Yield Topics

Dermatology Skin Pathology Melanoma

Dermatology Skin Pathology Blistering Disorders

Dermatology Skin Pathology Squamous Cell Carcinoma

Embryology Organ Development Pharyngeal Arches

Pharyngeal Pouches, Grooves/Clefts, and

Embryology Organ Development

Endocrinology Endocrine Pancreas Type I Diabetes Mellitus

Endocrinology Endocrine Pancreas Diabetes Mellitus

Endocrinology Endocrine Pancreas Type II Diabetes Mellitus

Endocrinology Endocrine Pharmacology Diabetes Mellitus Pharmacology

Endocrinology Adrenals Cushing Syndrome

Endocrinology Adrenals Congenital Adrenal Hyperplasia

Endocrinology Adrenals Hyperaldosteronism

Endocrinology Adrenals Adrenocortical Insu ciency

Endocrinology Endocrine Pancreas Hormones of the Endocrine Pancreas

Endocrinology Endocrine Pharmacology Posterior Pituitary Pharmacology

Endocrinology Endocrine Pharmacology Anterior Pituitary Pharmacology

Endocrinology Endocrine Pharmacology Thyroid Pharmacology

Endocrinology Endocrine Pharmacology Adrenal Cortex Pharmacology

Endocrinology Endocrine Pharmacology Hypothalamic Pharmacology

Hypothalamic Pituitary
Endocrinology Hypothalamic-Pituitary Axis

Endocrinology Thyroid & Parathyroid Thyroid

Endocrinology Thyroid & Parathyroid Hyperthyroidism

Endocrinology Thyroid & Parathyroid Graves disease

Endocrinology Thyroid & Parathyroid Hashimoto thyroiditis

Endocrinology Thyroid & Parathyroid Hypothyroidism

Endocrinology Thyroid & Parathyroid Thyroid hormone

Endocrinology Thyroid & Parathyroid Parathyroid Gland

Endocrinology Thyroid & Parathyroid Hyperparathyroidism

Gastroenterology In ammatory Bowel Disease

Gastroenterology Gastroenterology Cirrhosis 4/13
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Gastroenterology Acute Appendicitis

Gastroenterology Anatomy
Gastroenterology Retroperitoneal Structures
& Histology

Gastroenterology Anatomy
Gastroenterology Abdominal Wall Layers
& Histology

Gastroenterology Chronic Mesenteric Ischemia

Gastroenterology Irritable Bowel Syndrome

Gastroenterology Pancreatic Adenocarcinoma

Gastroenterology Budd-Chiari Syndrome

Gastroenterology Alcoholic Liver Disease

Gastroenterology α1-Antitrypsin De ciency

Gastroenterology Hemochromatosis

Gastroenterology Carcinoid

Gastroenterology Hepatolenticular Degeneration (Wilson

Pathology Disease)

Gastroenterology Gastroesophageal Re ux Disease and

Pathology Esophageal Cancer

Gastroenterology Cholelithiasis and Cholecystitis

Gastroenterology Colorectal Cancer

Gastroenterology Familial Colorectal Cancer
Pathology 5/13
25/04/2018 USMLE Step 1 High Yield Topics

Gastroenterology Gastroenterology Protein and Lipid Digestion


Gastroenterology Pancreatic Secretions

Gastroenterology Bile

Hematology/Oncology Anemia Anemia (Overview)

Hematology/Oncology Anemia Sickle Cell Disease

Hematology/Oncology Anemia Anemia: Iron De ciency Anemia

Hematology/Oncology Anemia Anemia: Megaloblastic Anemias

Hematology/Oncology Anemia Anemia: Thalassemias

Hematology/Oncology Anemia Antiglobulin (Coombs) Tests

Anemia: Paroxysmal Nocturnal

Hematology/Oncology Anemia

Anemia: Intravascular vs. Extravascular

Hematology/Oncology Anemia

Hematology/Oncology Anemia Anemia: Sideroblastic Anemia

Hematology/Oncology Anemia Anemia (Di erential)

Hematology/Oncology Anemia Aplastic Anemia and Fanconi Anemia

Hematology/Oncology Anemia Anemia: The Anemia of Chronic Disease


Hematologic Disorders

Hematologic Disorders
Heme Synthesis and Porphyrias

Mixed Disorders of Hemostasis x

Hematology/Oncology Hematologic Malignancies Multiple Myeloma

Hematology/Oncology Hematologic Malignancies Lymphoma: Non-Hodgkin

Hematology/Oncology Hematologic Malignancies Lymphoma: Hodgkin

Hematology/Oncology Leukemia: Chronic Myelogenous Leukemia

Hematology/Oncology Warfarin (Coumadin®)

Hematology/Oncology Prednisone

Hematology/Oncology Fibrinolytic Agents
Pharmacology 6/13
25/04/2018 USMLE Step 1 High Yield Topics

Hematology/Oncology Hematology/Oncology Antineoplastic Antibiotics


Hematology/Oncology Imatinib

Streptococcus pneumoniae
Microbiology Bacteria

Microbiology Bacteria Staphylococcus aureus

Microbiology Viruses HIV (Retrovirus)

Microbiology Viruses Herpesviridae - EBV (Epstein-Barr virus)

Microbiology Viruses Hepadnavirus (Hepatitis B)

Microbiology Viruses Hepatitis C virus

Microbiology Viruses Hepatitis

Microbiology Antimicrobials HIV Drugs

Microbiology Antimicrobials Cephalosporins

Microbiology Antimicrobials Vancomycin

Microbiology Bacteria Bacillus cereus

Microbiology Bacteria Shigella

Microbiology Bacteria Mycobacterium tuberculosis

Microbiology Bacteria Haemophilus in uenzae

Microbiology Bacteria Helicobacter pylori

Microbiology Bacteria Vibrio spp.

Streptococcus agalactiae (GBS, Group B

Microbiology Bacteria

Microbiology Bacteria Staphylococcus epidermidis

Microbiology Bacteria Listeria monocytogenes

Microbiology Bacteria Escherichia coli

Microbiology Bacteria Klebsiella

Microbiology Bacteria Bordetella pertussis

Microbiology Bacteria Salmonella

Microbiology Bacteria Treponema pallidum

Microbiology Bacteria Streptococcus pyogenes (Grp A Strep, GAS)

Microbiology Bacteria Campylobacter jejuni

Microbiology Bacteria Clostridia 7/13
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Microbiology Bacteria Mycoplasma pneumoniae

Microbiology Bacteria Enterococci

Microbiology Bacteria Chlamydia trachomatis

Microbiology Bacteria Corynebacterium diphtheriae

Microbiology Bacteria Neisseria

Microbiology Bacteria Pseudomonas aeruginosa

Microbiology Fungi Aspergillus fumigatus

Microbiology Fungi Cryptococcus neoformans

Microbiology Fungi Candida albicans

Microbiology Laboratory Microbiology Gram-negative Bacteria

Microbiology Laboratory Microbiology Specialized Bacterial Structures

Microbiology Parasites Entamoeba histolytica

Microbiology Viruses Herpesviridae - VZV (Varicella-Zoster virus)

Microbiology Viruses Poxviruses

Microbiology Viruses Rhinovirus & Coronaviruses

Microbiology Viruses Herpesviridae - CMV (Cytomegalovirus)

Microbiology Viruses Rubella (German Measles)

Nephrology Nephrology Pathology Focal segmental glomerulosclerosis (FSGS)

Nephrology Nephrology Pathology Kidney Stones

Nephrology Nephrology Pathology Renal tubular acidosis

Nephrology Nephrology Pathology Chronic kidney disease

Nephrology Nephrology Pathology Alport syndrome

Nephritic syndrome-PSGN
Nephrology Nephrology Pathology
(poststreptococcal glomerulonephritis)

Nephrology Nephrology Pathology Nephritic syndrome-IgA nephropathy

Nephrology Nephrology Pathology Nephrotic syndrome & systemic etiologies

Nephrology Nephrology Pathology Infection of the Urinary Tract and Kidney

Nephritic syndrome-RPGN (rapidly

Nephrology Nephrology Pathology
progressive glomerulonephritis)

Nephrology Nephrology Pathology Acute Kidney Injury

Nephrotic syndrome-Membranous

Nephrology Nephrology Pathology nephropathy (membranous

glomerulopathy) 8/13
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Nephrology Nephrology Pathology ADPKD (autosomal-dominant (adult)

polycystic kidney disease)

ARPKD (autosomal-recessive (childhood)

Nephrology Nephrology Pathology
polycystic kidney disease)

Nephritic syndrome-MPGN

Nephrology Nephrology Pathology (membranoproliferative


Nephrology Nephrology Pharmacology Loop diuretics

Nephrology Nephrology Pharmacology Thiazide diuretics

Nephrology Nephrology Pharmacology Potassium-sparing diuretics

ACE inhibitors & Angiotensin II receptor

Nephrology Nephrology Pharmacology

Nephrology Nephrology Physiology Acid-Base Balance

Neurology Neuroanatomy Arteries of the Brainstem and Spinal Cord

Neurology Neuroanatomy Arteries of the Brain

Neurology Neurology Pathology Intracranial Hemorrhage

Neurology Neurology Pathology Parkinson disease

Neurology Neurology Pathology Huntington disease

Neurology Neurology Physiology Cranial Nerves

Neurology Neuroanatomy Visual System

Neurology Neurology Pathology Nonviral CNS Infections

Neurology Neurology Pathology Guillain-Barre syndrome

Neurology Neurology Pathology Headaches

Neurology Neurology Pathology Spinal Cord Lesions

Neurology Neurology Pathology Viral Infections of the CNS

Neurology Neurology Pathology Stroke

Neurology Neurology Pathology Alzheimer disease

Neurology Neurology Pathology Other Causes of Dementia

Neurology Neurology Pathology Adult Brain Tumors

Neurology Neurology Pathology Seizures

Neurology Neurology Pathology Hydrocephalus

Neurology Neurology Pathology Multiple Sclerosis

Neurology Neurology Pathology Amyotrophic lateral sclerosis 9/13
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Neurology Neurology Pharmacology Antiepileptics: Drugs of Choice

Neurology Neurology Pharmacology Benzodiazepines and Barbiturates

Neurology Neurology Physiology Motor Neuron Signs

Neurology Neurology Physiology CNS Neurotransmitters

Neurology Neurology Physiology Spinal Tract Anatomy and Functions

Neurology Neurology Physiology Spinal Cord

Neurology Neurology Physiology Aphasia

Neurology Neurology Physiology Cerebellum

Orthopedics & MG (Myasthenia Gravis) & LEMS (Lambert-

Autoimmune Pathology
Rheumatology Eaton Myasthenic Syndrome)

Orthopedics &
Autoimmune Pathology SLE (Systemic Lupus Erythematosus)

Orthopedics &
Autoimmune Pathology Infectious Arthritis

Orthopedics &
Autoimmune Pathology Sarcoidosis

Orthopedics &
Autoimmune Pathology RA (Rheumatoid Arthritis)

Orthopedics & Musculoskeletal

Smooth Muscle Contraction
Rheumatology Physiology

Orthopedics &
Skeletal Pathology Gout

Orthopedics &
Skeletal Pathology Osteomyelitis

Orthopedics &
Skeletal Pathology Malignant Primary Bone Tumors

Pathology Neoplasms Oncogenes and Associated Tumors

Pathology Neoplasms Tumor Suppressors and Associated Tumors

Pathology Neoplasms Paraneoplastic Syndromes

Pathology Neoplasms Benign Tumors

Pathology Neoplasms Tumor Markers

Pharmacology Agents β-Blockers

Pharmacology Agents Cholinergic Agents 10/13
25/04/2018 USMLE Step 1 High Yield Topics

Pharmacology Agents Direct Sympathomimetics

Pharmacology Agents α-Blockers

Pharmacology Agents Anticholinergics: Muscarinic Receptors

Pharmacology Pharmacology Physiology G Protein Signal Transduction

Pharmacology Toxicology CYP450 Interactions

Psychiatry Psychiatry Pathology Personality Disorders

Psychiatry Psychiatry Pharmacology Selective Serotonin Reuptake Inhibitors

Psychiatry Psychiatry Pharmacology Tricyclic Antidepressants (TCAs)

Psychiatry Psychiatry Pharmacology Monoamine Oxidase Inhibitors

Psychiatry Psychiatry Pharmacology Traditional Antipsychotics (Neuroleptics)

Pulmonology Pulmonology Pathology Lung Disease: Obstructive vs. Restrictive

Pulmonology Pulmonology Pathology Pneumonia

Pulmonology Pulmonology Pathology Lung Cancer: Squamous Cell Carcinoma

Pulmonology Pulmonology Pathology Lung Cancer: Overview

Pulmonology Pulmonology Pathology Lung Cancer: Small Cell Carcinoma

Pulmonology Pulmonology Pathology Obstructive Lung Disease: Asthma

Pulmonology Pulmonology Pathology Upper Respiratory Infections

Pulmonology Pulmonology Physiology Oxygen - hemoglobin dissociation curve

Reproductive Reproductive Pathology Breast Tumors: Malignant Carcinoma

Reproductive Reproductive Physiology Menstrual Cycle

Reproductive Reproductive Physiology Pregnancy



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