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from The New Yorker

July 8, 1996
ANNALS OF MEDICINE

Conquering the Coma


What does it take to save the life of a coma patient like the Central Park victim? Not a
miracle, as her family and doctor explain.

by Malcolm Gladwell

1. precipitously, a neurosurgeon other of her laughing and


removed a blood clot from her leaning through a doorway-
On the afternoon of right frontal cortex. A few just so people would know
Tuesday, June 4th, a young hours later, Urgent Four-as what she really looked like.
woman was taken by the trauma-unit staff named
ambulance from Central her, because she was the Urgent Four-or the Central
Park to New York Hospital, fourth unidentified trauma Park victim, as she became
on the Upper East Side. patient in the hospital at that known during the spate of
When she arrived in the time-was wheeled from the media attention that
emergency room, around operating room to an surrounded her case-came
four o'clock, she was in a intensive-care bed close to dying on two
coma, and she had no overlooking the East River. occasions. Each time, she
identification. Her head was, She had staples in her scalp fought back. On Wednesday,
in the words of one from the operation, and her June 12th, eight days after
physician, "the size of a chest and arms and fingers entering the hospital, she
pumpkin." She was bleeding were hooked up, via a maze of opened one blue eye. The
from her nose and her left intravenous lines and cables, mayor of New York,
ear. Her right eye was to monitors registering heart Rudolph Giuliani, was
swollen shut, and the bones rate, arterial blood pressure, paying one of his daily visits
above the eye were broken and blood-oxygen saturation. to her room at the time, and
and covered by a black-and- She had special inflatable she looked directly at him.
blue bruise. cuffs on her legs to prevent Several days later, she began
the formation of blood clots, tracking people with her one
Within minutes, she was put and splints on her ankles, good eye as they came in
on a ventilator and then since coma patients tend to and out of her room. She
given X-rays and a cat scan. point their toes. Four days began to frown and smile.
A small hole was drilled in later, after she was identified On June 19th, the
her skull and a slender and her parents and her two neurosurgeon supervising
silicone catheter inserted, to sisters arrived at her bedside, her care leaned over her bed,
drain cerebral spinal fluid one of the first things the pinched her to get her
and relieve the pressure family did was to put two attention, and asked, "Can
steadily building in her large pictures of her on the you open your mouth?" She
brain. At midnight, after wall above her bed-one of her opened her mouth. He said,
that pressure had risen holding her niece, and the "Is your name --?" She
nodded and mouthed her the police. The story also had an attempt to insure that
name. a hero, in Jam Ghajar, the you do not have to be ten
man who saved her life: a minutes away from one of
"I'm at the foot of her bed, young and handsome the best hospitals in the
her cheering squad," her neurosurgeon with an M.D. country in order to survive a
mother recalls. She is a and a Ph.D., a descendant of vicious beating. One of the
striking woman, with thick Iranian royalty who has an leaders of the movement, in
black hair and luminous athlete's walk, strong, fact, is the doctor who saved
eyes, and her voice grows beautiful hands, and ten Urgent Four's life, and he
animated with the memory. medical-device patents to his has held up the care she
" 'Go! Go! You're doing name. If this were the movies, received as an example of
great! Go!' And the doctor Ghajar would be played by what ought to be routine in
says, 'Do you want me to Andy Garcia. the treatment of brain
pinch her again?' And I'm injury. That makes the
yelling at her. I'm telling But the story of Urgent Four is lesson of the Central Park
her, 'Say no, get out of here, not the standard tale of the victim and her remarkable
go!' " triumph of medicine and the recovery exactly the opposite
human spirit. To think of this of the lesson of the heroic
And her daughter mouthed, as an episode of "E.R." is to medical dramas on
"Go." diminish it. The typical television. Recovery need
narratives of recovery are not be remarkable. The real
2. about exceptional people in medical miracle is the kind
exceptional circumstances, that can be repeated over
There is something and that is why the narratives and over again.
compelling about such are both irresistible and,
stories of medical recovery, finally, less than consoling. 3.
and something undeniably Brilliant doctors and new
moving about a young technology can work miracles. When Urgent Four was
woman fighting back from But what if your doctor isn't attacked in Central Park, her
the most devastating of brilliant and your hospital assailant smashed her
injuries. In the days doesn't have the newest forehead on the smooth,
following the Central Park technology? If the principal hard surface of the sidewalk
beating, the case assumed failing of the American with such force that the
national proportions as the medical system is that it bones above her right eye
police frantically worked to provides one standard of care were shattered. Then, as if
locate Urgent Four's family for the fortunate and another he didn't consider his task
and identify her attacker. for everyone else, the typical completed, he turned her
The victim turned out to be story of medical triumph ends over and began again,
a talented musician, a piano up as a kind of indictment, a pounding the back of her
teacher beloved by her reminder that miracles are head against the ground
students. Her alleged apportioned by privilege and hard enough to fracture her
assailant turned out to be a position. skull behind her left ear. The
strange and deeply ferocity-and the
disturbed unemployed The case of Urgent Four is thoroughness-of the attack
salesclerk, who veered off different. The profession that bruised the muscles between
into Eastern mysticism saved her life is in the midst of her scalp and her skull,
during his interrogation by an ambitious transformation, causing her scalp to swell.
What was more serious was Urgent Four's was at twenty, Auersperg, after a car
that in response to the which is high but not accident, thirteen years ago.
trauma her brain also began disastrous. A further rise, Most days, Ghajar drives
to swell, pressing up against however, would put her in the back and forth between the
the inside of her skull. In danger zone. At nine o'clock hospital and the institute,
any trauma patient, this Tuesday night, that is exactly juggling his research at
swelling, which increases what happened: Urgent Four's Aitken with a clinical
what is known as ICP abruptly surged into the schedule that keeps him on
intracranial pressure (ICP), fifties. call two weeks out of every
is the neurosurgeon's chief four. "Jam is completely
concern, because the The physician in charge of her committed--he's got a razor-
continuing rise in ICP makes case, Jam Ghajar, is, at forty- sharp focus," Sunny von
it harder and harder for the four, one of the country's Bülow's daughter, Ala
body to supply the brain leading neurotrauma Isham, told me. "He's
with an adequate amount of specialists. On his father's godfather to my son. I
blood. Upon autopsy, ninety side, he is descended from the always joke that we should
per cent of coma patients family that ruled Persia from carry little cards in our
show clear signs of stroke: the late seventeen-hundreds wallets saying that if
their brains quite literally until 1925, and his anything happens to us call
starved to death. grandfather on his mother's Jam Ghajar."
side was the Shah of Iran's
This is why when Urgent personal physician. Ghajar spent all day
Four was brought to the Neurosurgeons, Ghajar says, Tuesday, June 4th, at
New York Hospital-Cornell with a smile, are Jamaica Hospital. In the
Medical Center complex the "overachievers," and the evening, he returned to the
neurosurgical resident on description fits him perfectly. Aitken Neuroscience
duty inserted a catheter As a seventeen-year-old, he Institute, where a colleague,
through her skull to siphon was a volunteer at U.C.L.A's Michael Lavyne, told him of
off excess cerebral spinal Brain Research Institute. As a the young woman hovering
fluid. In cases of trauma, first-year resident at New near death across the street
this clear fluid, in which the York Hospital, he invented a at New York Hospital. At
brain floats, flows into a device--a tiny tripod to guide seven o'clock, Ghajar left his
cavity that is called the the insertion of ventricular office for the hospital. Two
ventricle, in the center of the catheters--that made the hours later, with Urgent
brain, and the hope was to cover of the Journal of Four's ICP at dangerous
empty the ventricle, Neurosurgery. Today, Ghajar levels, he ordered a second
reducing the pressure inside is the chief of neurosurgery at cat scan, which immediately
the skull. This is also why Jamaica Hospital, in Queens. identified the culprit: the
the trauma staff kept a very He is also the president of the bruise on her right frontal
close eye on the pressure Aitken Neuroscience Institute, cortex had given rise to a
gauge attached to that in Manhattan, a research massive clot. At midnight,
catheter during the first few group that grew out of the Ghajar drilled a small hole
hours after Urgent Four was double tragedy experienced by in her skull, cut out a chunk
admitted. According to the the children of Sunny von three inches in diameter
index used by neurologists, a Bülow, who lost not only their with a zip saw, and, he said,
healthy person's ICP is mother to coma but also their "this big brain hemorrhage
between zero and ten. father, Prince Alfred von
just came out-plop-like a big the next day, Thursday. By a also in New Jersey, using as
piece of black jelly." series of flukes, no one in her a guide the return address
family had even suspected on a letter Jane had written
But the task was only half that she was missing. Her to her sister. It was one-
finished. The rule of thumb older sister, whom I will call thirty Friday morning.
for a trauma patient is that Jane, had been with her the
the blood pressure has to be previous Saturday night, when "I got a call from the police,
kept at least seventy points she played in a concert. The which I didn't believe, of
higher than the ICP or the two sisters, who share a course," Jane said. She is a
flow of oxygen and nutrients birthday, spoke on the phone graceful woman, with
to the brain will be on Monday afternoon, and it shoulder- length black hair
impaired. Even after Urgent wasn't unusual for several and a hint of a Jersey accent.
Four's clot was removed, her days to pass between "I thought it was a prank
differential was only fifty conversations. Nor did the call, and I thought I was
points. At the same time, news of the attack, when it being stalked. They asked
however, her heart was became public, make much of me my name and if I had a
racing at a hundred and an impression on Jane: her sister with that name, and I
eighty beats per minute. car radio was broken, and, was almost rude to them on
This made raising her blood because she was busy with the phone, because I
pressure tricky. "We're work, she had no time to read thought it was someone
standing around her bed," the newspaper. Her parents, playing a joke on me. Then
Ghajar recalls. "It's four in meanwhile, were travelling in they referred to this
the morning. There's Dr. Utah, and were equally incident, and I had no idea
Fischer"-Eva Fischer, the oblivious. "It was the first what they were talking
group-care physician- vacation we'd ever taken about. At that point, my
"there's three surgical where we hadn't read a husband ran and got the
residents, there's myself, newspaper," her mother told newspaper, because he had
there's a chief resident from me. "Or watched the news." been following the story and
neurosurgery, and then two had seen the sketch. I got off
nurses, and we're all On Thursday, however, one of the phone and had to fight
standing around her trying Urgent Four's piano students collapsing. The captain
to figure out what the best showed up for her weekly probably sensed that. He
drug would be to reduce her lesson, and when her teacher said, 'Can you come? I'll
pulse and increase her blood didn't arrive the student send you an escort.' And
pressure at the same time." remembered seeing drawings then he called back a little
It took three hours-and two of the Central Park victim that while later and said, 'Would
different blood-pressure had been posted on buildings you be willing to ride in a
medicines-to get Urgent and mailboxes throughout helicopter to get here?' "
Four out of the danger zone. Manhattan, and she began to
It was 7 a.m. when Ghajar wonder. She called the police. At 3 a.m., she and her
left her bedside and began They searched the woman's husband landed in
neurosurgery rounds. apartment, on Fifty- seventh Manhattan. They were taken
Street, and learned her immediately by police car to
4. parents' address, in New the hospital, and there they
Jersey. Upon finding that they were greeted by Mayor
The identity of Urgent Four were away, the police Giuliani and Howard Safir,
did not become known until telephoned Jane, at her home, the police commissioner.
"They probably spent twenty I met with Urgent Four's want to wake up and know
minutes trying to let me family-her mother, father, and it's over-and it's not." The
understand what had older sister-in Jam Ghajar's mother seemed the most
happened and prepare me, office, on East Seventy-second shaken and most exhausted
and I ended up saying, Street, two days after she first of the three. At one point as
'Don't bother trying to began to speak. Her parents we talked, she accidentally
prepare me. It's not going to have been together for thirty- referred to her daughter in
work.' The anticipation was eight years, and have the easy the past tense, saying, "She
awful. And when I saw her, affection of the well-married. was-"
of course, the effect was The father, trim and gray-
indescribable." haired, is an engineer by "Is," Jane interrupted. "Is."
training, with the discipline
The next to arrive was the and plainspokenness 5.
family's youngest daughter, characteristic of that
who came by car with her profession. His wife is a Had Urgent Four been taken
husband later on Friday schoolteacher, intelligent and to a smaller hospital, or to
morning. At midnight articulate. They spoke with me any of the thousands of
Friday, the parents arrived. on the condition that the trauma centers in America
The police had tracked them personal details of their lives which do not specialize in
down by tracing their rental- be kept private, and they brain injuries, the chances
car registration and then confined their conversation to are that she would have
sending the Utah police details of the case which they been dead by the time any of
cruising through motel considered germane: their her family arrived. This is
parking lots in and around religious faith, their what trauma experts who
Zion National Park to spot admiration for Dr. Ghajar's are familiar with the case
the corresponding license medical team, their hopes for believe, and, of the many
plate. "At one point after their daughter's recovery. It lessons of the Central Park
they found us," her father was an intense and moving beating, it is the one that is
told me, "we drove through conversation. Over the past hardest to understand. It's
a town in Utah which had three weeks, the family has not, after all, as if Urgent
my mother's name. Both of fashioned a protective cocoon Four were suffering from a
us burst out crying. My for themselves, refusing to rare and difficult brain
mother was pretty close to read any of the press accounts tumor. Brain trauma is the
her. So we took that as an of Urgent Four's assailant, leading cause of death due
omen that she would be and barely leaving her to injury for Americans
looking over her." Jane said hospital room except to rest under forty-five, and results
that when she first saw the and eat. This was the first in the death of some sixty
patient at the hospital she time they had talked to the thousand people every year.
knew immediately she was outside world, and long-pent- Nor is it as if Urgent Four
her sister. But her father up feelings and thoughts came had been given some kind of
said that if he had not been out in a rush. daring experimental
told who she was he would therapy, available only at the
never have known her. "To "We went for days on two most exclusive research
me she was almost hours' sleep," her mother said. hospitals. The insertion of
unrecognizable," he said. "You don't feel as tired, the ventricular catheter is
because you're so wound up. something that all
You want it all to be over. You neurosurgeons are taught to
do in their first year of does reduce ICP, but it can Boston- Rochester study was
residency. CAT scanners are also end up reducing the flow not that the children of
in every hospital. The of blood to the brain, causing Boston were receiving
removal of Urgent Four's irreversible brain damage. considerably better care
blood clots was The most troubling finding, than their counterparts in
straightforward however, was that only a third upstate New York but,
neurosurgery. The raising of the trauma centers rather, that health care for
and monitoring of blood surveyed said that they children in Boston might
pressure are taught in routinely monitored ICP at all. well be needlessly expensive.
Nursing 101. Urgent Four In another hospital, the surge When it comes to brain
was treated according to in Urgent Four's ICP on injury, the stakes are a little
standards and protocols that Tuesday night which signalled higher. At the handful of
have been discussed in the the formation of a blood clot centers around the country
medical literature, outlined might not have been caught. specializing in brain trauma,
at conferences, and backed it is now not unusual for the
by every expert in the field. Such dramatic variations in mortality rates of coma
medical practice are hardly patients to run in the range
Yet the fact is that if she had confined to neurosurgery. It is of twenty per cent or less. At
been taken to a smaller not unusual for doctors in one trauma centers where brain
hospital or to any one of the community to perform injury is not a specialty,
thousands of trauma centers hysterectomies, say, at two or mortality rates for coma
in America which do not three times the rate of doctors patients are often twice that.
specialize in brain injuries in another town. Rates for "If I break my leg, I don't
she would have been treated some cardiac procedures care where I go," Randall
very differently. When differ around the country by Chesnut, a trauma specialist
Ghajar and five other as much as fifty per cent. at San Francisco General
researchers surveyed the Obstetrical specialists are Hospital, told me. "But, if I
country's trauma centers almost twice as likely to hit my head, I want to
five years ago, they found deliver children by cesarean choose my hospital."
that seventy-nine per cent of section as family physicians
the coma patients were are. In one classic study Part of the problem is that in
routinely given steroids, published seven years ago, a the field of neurosurgery it
despite the fact that steroids team of researchers found has been difficult to reach
have been shown repeatedly that children in Boston were hard, scientific conclusions
to be of no use-and possibly 3.8 times as likely to be about procedures and
of some harm-in reducing hospitalized for asthma as treatments. Physicians in
intracranial pressure. children in Rochester, New the field have long assumed,
Ninety-five per cent of the York; 6.1 times as likely to be for example, that blood clots
centers surveyed were hospitalized for accidental in the brain should be
relying as well on poisoning; and 2.6 times as removed as soon as possible.
hyperventilation, in which a likely to be hospitalized for But how could that
patient is made to breathe head injury. assumption ever be
more rapidly to reduce scientifically verified? Who
swelling-a technique that In most cases, however, the would ever agree to let a
specialists like Ghajar will concern about practice comatose family member lie
use only as a last resort. variation has focussed on the still with a mass of
Prolonged hyperventilation issue of cost. The point of the congealed blood in the brain
while a team of curious night. He practices primarily Three years ago, after a
researchers watched to see out of Jamaica Hospital, not neurosurgery meeting in
what happened? The the far more prestigious New Vancouver, Ghajar-along
complexity and mystery of York Hospital, because with Randall Chesnut and
the brain has, moreover, led Jamaica gets serious brain- Donald W. Marion, a brain-
to a culture that rewards trauma cases every second day trauma specialist at the
intuition, and has thus and New York might get one University of Pittsburgh-
convinced each only every second week. "If I decided to act. For help they
neurosurgeon that his own were operating and doing turned to the Brain Trauma
experience is as valid as disks and brain tumors, I'd be Foundation, which is the
anyone else's. Worse, brain making ten times as much," education arm of the brain-
injury is an area that is of no he says. In the entire country, trauma institute started by
more than passing interest there are probably no more Sunny von Bülow's children.
to many neurosurgeons. than two dozen The foundation gathered
Most neurosurgeons make neurosurgeons who, like some of the world's top
their living doing disk Ghajar, exclusively focus on brain-injury specialists
surgery and removing brain researching and treating brain together for eleven meetings
tumors. Trauma is an trauma. between the winter of 1994
afterthought. It doesn't pay and last summer. Four
particularly well, because Ghajar says that in talking to thousand scientific papers
many car-accident and other neurosurgeons he covering fourteen aspects of
shooting victims don't have sensed a certain resignation in brain- injury management
insurance. (Urgent Four treating brain injury-a feeling were reviewed. Peter C.
herself was without that the prognosis facing Quinn, the executive
insurance, and a public coma patients was so poor director of the Brain Trauma
collection has been made to that the neurosurgeon's role Foundation, who
help defray her medical was limited. "It wasn't that the coördinated the effort, says,
expenses.) Nor does it pose neurosurgeons were lazy," "Sometimes I felt I was in a
the kind of surgical Ghajar said. "It was just that courtroom drama, because
challenge that, say, an there was so much what they did was argue the
aneurysm or a tumor does. information out there that it evidence of the scientific
"It's something like-well, was confusing. When they got documents, and as soon as
you've got mashed-up young people in comas, half of someone said, 'It's been my
brains, and someone got hit the patients would die. And experience,' everyone would
by a car, and it's not really the half that lived would be say, 'Oh, no, that won't cut
very interesting," Ghajar severely disabled, so the it. We want to know what
says. "But brain tumors are neurosurgeon is saying, 'What the evidence is.' They would
kind of interesting. What's am I doing for these people? come in on a Friday and
happening with the DNA? Am I saving vegetables?' And work all day Saturday and
Why does a tumor develop?" that was honestly the feeling Sunday. They'd work a
that neurosurgeons had, twenty-hour weekend. It
Then, there are the hours, because the methods they was gruelling."
long and unpredictable, tied were trained in and were
to the rhythms of street using would produce that kind In March of this year, the
thugs and drunk drivers. of result." group produced a book-a
Ghajar, for example, blue three-ring binder with
routinely works through the fifteen bright-colored
chapter tabs-laying out the good a chance to survive as Monday, there was a
scientific evidence and state- she would in the middle of pounding on the door of our
of-the-art treatment in every New York City," I was told by room," the patient's father
phase of brain-trauma care. Jack Wilberger, Jr., who is an said. "We were wanted back
The guidelines represent the associate professor of on the floor, and we had to
first successful attempt by neurosurgery at the University make a decision within a
the neurosurgery of Pittsburgh Medical Center very few minutes on whether
community to come up with and a member of the they should operate. What
a standard treatment guidelines team. "That's what we were given was: If you
protocol, and if they are we're hoping for. To give don't operate, she might die.
adopted by anything close to everyone the same chance, to The other side of it was that
a majority of the country's give a everyone a level playing if they did operate it could
trauma centers they could field." save her life but with a
save more than ten decent likelihood that she
thousand lives a year. A copy 6. might be very badly
has now been sent to every impaired. So we and our two
neurosurgeon in the Urgent Four had one more daughters went back and
country. The Brain Trauma scare before she began her thrashed it out and we
Foundation has mailed the climb toward recovery. Late unanimously decided to go
guidelines to scientific Sunday night, her ICP began forward."
journals, hospitals, to rise again, back up into the
managed-care groups, and thirties. Ghajar, who was in It was by then one-thirty in
insurance companies, and Paris meeting with the World the morning. For four hours,
the neurosurgeons involved Health Organization about the the family waited, sleepless
with the project have been brain- trauma guidelines and and exhausted, terrified that
promoting their work at was calling in to the hospital they had made the wrong
medical meetings around residents for updates, began decision. At dawn, the
the country. This is why the to get worried. He booked a surgeon filling in for Ghajar,
story of the Central Park flight home. While he was in Michael Lavyne, emerged
victim does not end the way the air, Urgent Four's from the operating room. A
most medical dramas end, in condition worsened. A third miracle had happened, he
empty celebration of heroics cat scan was ordered, and it reported: as soon as an
and exceptionalism, but showed that she had incision was made, the clot
instead has become a developed a second clot-this had just popped out, all on
powerful symbol of the time on her left temporal lobe, its own. "They got lucky,"
campaign to reform in the place behind her ear Ghajar says.
neurosurgery. For where her attacker had
everything Jam Ghajar used banged the back of her head. From that point, Urgent
to save Urgent Four's life is This clot was far more serious Four's progress was steady.
in that binder. than the first, because the Her eye opened. Then she
temporal lobe is the seat of began to talk. The swelling
"What we are hoping is that comprehension, and to around her face receded.
if a woman gets hurt in the remove the clot might well Her ICP became normal.
middle of rural Wyoming, risk damaging Urgent Four's Soon she was sitting up. By
and there is a neurosurgeon ability both to speak and to last week, she was working
there and a hospital with an understand. "At about twelve- with a speech therapist, and
I.C.U., then she will have as thirty, quarter to one on Ghajar and her father had
begun driving around the spinal fluid and monitored his
New York area looking for a blood pressure, to make sure
good rehabilitation center. it was seventy points higher
than his ICP. Then, that
"Yesterday, she was looking evening-fourteen hours later-
at me, and I said, 'You know, the patient's condition
you had a bad accident, and worsened. "I had to go back in
your brain was bruised'-I'd and take out the
told everyone not to tell her hemorrhages," Ghajar said,
she was assaulted. 'Your and there was a note of
brain was bruised, and you exhaustion in his voice. He
are recovering.' She looked left the hospital at one o'clock
at me and she frowned. Her Wednesday morning.
eye went up with this 'Oh,
really?' look. And I said, 'Do "People want to personalize
you remember your this," Ghajar said. He was on
accident?' She shook her Seventy-second Street,
head. But it's too early. outside his office, walking
Sometimes they do." Ghajar back to New York Hospital to
went on, "We are very good visit Urgent Four. "I guess
at predicting outcome, in the that's human nature. They
sense of mortality, but we're want to say, 'It's Dr. Ghajar's
not good at predicting protocol. He's a wonderful
functional outcome, which is doctor.' But that's not it.
the constant question for These are standards
this patient. 'Is she going to developed according to the
be able to play the piano?' best available science. These
We still can't answer that are standards that everyone
question." can use."

In his first week back on call © 1997 Malcolm Gladwell


after the Urgent Four case,
Ghajar saw three new coma
patients. The latest was a
thirty- year-old man who
had barely survived a
serious car accident. He was
in worse shape than Urgent
Four had been, with a
hemorrhage on top of his
brain. He was admitted to
Jamaica Hospital on
Monday at 11 p.m., and
Ghajar operated from
midnight to 6 a.m. He
inserted a catheter in the
patient's skull to drain the

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