PROPOSAL SKRIPSI

EFEK PEMBERIAN VITAMIN C DAN ZINK TERHADAP JUMLAH

SPERMA MENCIT JANTAN BALB/C YANG TERPAPAR ASAP ROKOK

Yang diajukan Oleh :

Mokh. Syaifulloh Gondo Kusumo

J500100009

Telah disetujui oleh pembimbing untuk dilakukan seminar proposal skripsi

Surakarta,..................................2013

Pembimbing Utama Pembimbing Pendamping

dr. Retno Sintowati .M.Sc dr. Wulandari Berliani Putri

Kepala Biro Skripsi

dr. Muh. Shoim Dasuki, M.Kes

iv
 DAFTAR ISI

Halaman Judul .............................................................................................. i

Lembar Persetujuan ..................................................................................... ii
DAFTAR ISI ............................................................................................... iii
DAFTAR TABEL ........................................................................................ v
DAFTAR GAMBAR .................................................................................. vi
DAFTAR LAMPIRAN .............................................................................. vii
Pernyataan .................................................................................................viii
Kata Pengantar ............................................................................................ ix
ABSTRAK .................................................................................................. xi
ABSTRACK .............................................................................................. xii

Bab I Pendahuluan
A. Latar Belakang ........................................................................... 1
B. Rumusan Masalah ...................................................................... 3
C. Tujuan Penelitian ....................................................................... 3
D. Manfaat Penelitian ..................................................................... 3

Bab II Tinjauan Pustaka

A. Vitamin C ................................................................................... 5
B. Zinc ............................................................................................ 7
1. Sifat Kimia Zinc ................................................................... 8
2. Sifat Fisik Zinc ..................................................................... 9
C. Rokok ........................................................................................ 9
D. Spermatozoa ............................................................................. 13
1. Spermatozoa ...................................................................... 13
2. Motilitas Spermatozoa ...................................................... 17
3. Fungsi Hormonal Testis ..................................................... 18
E. Mencit ..................................................................................... 19
F. Kerangka Konsep .................................................................... 22

iii
 G. Hipotesis ................................................................................. 22

Bab III Metodologi Penelitian

A. Jenis Penelitian .............................................................................. 23
B. Tempat dan Waktu Penelitian ....................................................... 23
C. Subyek dan Obyek Penelitian ....................................................... 23
D. Teknik Sampling ............................................................................ 23
E. Estimasi Besar Sampel .................................................................. 24
F. Kriteria Retriksi ............................................................................ 24
G. Pengalokasian Subjek .................................................................... 24
H. Identifikasi Variabel ....................................................................... 25
I. Definisi Operasional ...................................................................... 26
J. Alat dan Bahan Penelitian ............................................................. 26
K. Perisiapan Penelitian ..................................................................... 27
L. Cara Penelitian .............................................................................. 28
M. Rencana Analisis Data ................................................................... 28
N. Skema Penelitian ............................................................................ 29
O. Jadwal Penelitian ........................................................................... 30

Bab IV Hasil dan Pembahasan

A. Hasil ............................................................................................... 31
1. Determinasi Hewan Uji ............................................................. 31
2. Analisis Data ............................................................................. 31
3. Hasil Analisis Statistik .............................................................. 32
B. Pembahasan .................................................................................... 36
Bab V Kesimpulan dan Saran
A. Kesimpulan .................................................................................... 40
B. Saran .............................................................................................. 40

DAFTAR PUSTAKA ................................................................................ 41

iv
iii