Suwi Muwowo

P-3/11AP
02/19/18
Annotations Week of February 19th

Citation: “Amyloid Plaques and Neurofibrillary Tangles.” BrightFocus Foundation, July 1, 2015.

This image represents a cross-section of the brain as seen from the front. The cross-

section on the left represents a normal brain and the one on the right represents a brain with

Alzheimer's disease. In Alzheimer's disease, there is an overall shrinkage of brain tissue. The

grooves or furrows in the brain, called sulci (plural of sulcus), are noticeably widened and there

is shrinkage of the gyri (plural of gyrus), the well-developed folds of the brain's outer layer. In

addition, the ventricles, or chambers within the brain that contain cerebrospinal fluid, are

noticeably enlarged. In the early stages of Alzheimer's disease, short-term memory begins to fade

(see box labeled 'memory') when the cells in the hippocampus, which is part of the limbic

system, degenerate. The image is very informative and allows viewers to understand the anatomy

of the brain easily. This image was first posted in 2015, but has since been updated in 2017,

showing the reliability of website as it keeps updates with new and ongoing research.
 Suwi Muwowo
P-3/11AP
02/19/18
Annotations Week of February 19th

Citation: “My Site.” Accessed February 13, 2018. http://alzheimdisease.weebly.com/.

This image represents the differences between the normal brain and the Alzheimer’s

brain. The viewer is able to see: the Alzheimer's tissue has fewer nerve cells and synapses than a

healthy brain, it also had plaques, which are abnormal clusters of protein fragments built up

between nerve cells, the dead and dying nerve cells contain tangles which are twisted strands of

another protein, the Alzheimer's brain has less neurons, the Alzheimer's brain is more shrunk in

size. With this, symptoms are memory loss, language disability, and thinking and reasoning

disability. Since, this information comes from a non-credited person’s personal website, the

information presented is questionable. The creator of this website should add more info on the

origin of the information they are presenting. However, the pictures used are quite informative

and accurate.