1206236331
Pembimbing:
FAKULTAS KEDOKTERAN
PROGRAM PENDIDIKAN DOKTER SPESIALIS
KEDOKTERAN OKUPASI
JAKARTA
2013
CHAPTER I
INTRODUCTION
LITERATUR REVIEW
REVIEW
7 Journal articles have been reviewed :
6 Messenger RNA expression and genetic polymorphisms of cell cycle control genes
and chromosomal aberrations in Chinese vinyl chloride monomer-exposed workers.
Y.L, Qiu et al: p53 mRNA expression of VCM-low- and high-exposure groups was
significantly lower than that of nonexposed group (P < 0.001), but p21 mRNA expression
of the two VCM-exposed groups was significantly higher than that of the nonexposed
group (P < 0.001). This study did not find the relationship between chromosomal
aberrations, genotypes, and the expression of p53, p21, and CCND1. Conclution:
Messenger RNA expressions of p53 and p21 are changed with VCM-exposure status.6
CHAPTER III
DISCUSSION
The study of biological markers dercribe that vinyl chloride biomonitoring marker are
Excretion of VC metabolites (e.g., thiodiglycolic acid), genetic assays (e.g., chromosomal
abnormalities or micronucleus assay), levels of enzymes (e.g., in liver function tests), von
Willebrand factor, and serum oncoproteins (p21 and p53) and/or their antibodies as
biomarkers of VC-induced effects.
1. TJ Cheng et al. Urinary thiodiglycolic acid levels for vinyl chloride monomer-exposed
polyvinyl chloride workers. J Occup Environ Med.2001. 43(11):934-8.
2. Jennifer Schindler et al. The effect of genetic polymorphisms in the vinyl chloride metabolic
pathway on mutagenic risk. J Hum Genet. 2007. 52:448–455
4. Attarchi Mir Saeed et al. Evaluation of liver enzyme levels in workers exposed to vinyl
chloride vapors in a petrochemical complex. Journal of Occupational Medicine and
Toxicology 2007. 2:6
6. Y.L. Qiu et al. Messenger RNA expression and genetic polymorphisms of cell cycle control
genes and chromosomal aberrations in Chinese vinyl chloride monomer-exposed workers.
J Occup Environ Med .2011 Dec;53(12):1442-6.