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Preventing Primary

Cesarean Sections: Intrapartum Care


Tekoa L. King, CNM, MPH

Some intrapartum care practices promote vaginal birth, whereas others may increase the
risk for cesarean section. Electronic fetal monitoring and use of the Friedman graph to plot
and monitor labor progress are associated with increasing the cesarean section rate.
Continuous one-to-one support and midwifery management are associated with lower
cesarean section rates. This article reviews the evidence that links specific intrapartum
care practices to cesarean section. Strategies that can be implemented in the current social
and cultural setting of obstetrics today are recommended.
Semin Perinatol 36:357-364 © 2012 Elsevier Inc. All rights reserved.

KEYWORDS fetal heart rate monitoring, intrapartum care, midwifery, primary cesarean section

M ore than 4 million women give birth in the United


States each year and slightly more than one-third of
these women give birth by cesarean section.1 The rate of
contrast, midwifery management and continuous support
during labor are associated with lower cesarean section rates
in both observational and randomized controlled trials
cesarean section rose from 21% in 1996 to 32.9% in 2009, (RCTs).7-9 Labor support practices, such as encouraging oral
and today, it is the most common surgical procedure per- fluids, frequent ambulation, avoiding an epidural, and phys-
formed in the United States.1,2 Because cesarean births are iological management of the second stage, have been pro-
associated with short-term and long-term adverse health ef- moted as interventions that could lower the cesarean section
fects for the mother and infant, strategies that effectively rate; however, studies evaluating some of these specific inter-
lower the incidence of this procedure are urgently needed.3-6 ventions have had conflicting results. Thus, there is a plethora of
To lower the total cesarean section rate, which is the sum of intrapartum care practices that could influence the rate of cesar-
all repeat and primary procedures, decreasing the number of ean section either singly or in concert. Identification of the most
primary cesarean sections is a critical first step. This article frequent indications for a primary cesarean section in low-risk
reviews intrapartum management for nulliparous women at women sheds some light on where to look first.10,11
term with a singleton fetus in vertex presentation (NTSV) Barber et al11 analyzed the indications for 10,757 women
because this is the population in which the cesarean section who had cesarean sections performed between 2003 and
rate varies widely. Recommendations for care practices that
2009 in one large academic hospital. They found that fetal
promote vaginal birth are presented.
intolerance of labor (32%) and arrest of labor (18%) ac-
counted for 50% of the increase in the primary cesarean rate.
Background: Indications for Similarly, Main et al10 analyzed the rates and indications for
Intrapartum Cesarean Section cesarean sections in California, which is where 1 of every 8
infants born in the USA is born. These authors looked spe-
Several labor management practices are associated with an cifically at the NTSV cesarean section rate that was 28.1%
increased cesarean section rate, including, but not limited to, overall with regional variation that ranged from 21.5% to
early admission, diagnosis of the active phase of labor at 3-4 33.5% and hospital variation that ranged from 10% to 50%.
cm dilatation, and continuous electronic fetal monitoring. In Fetal intolerance of labor and arrest of labor accounted for
40%-50% of all cesarean sections, and they exhibited the
largest regional and interhospital variability.
Department of Obstetrics, Gynecology and Reproductive Sciences, Univer- Wide variability in practice is a well-known marker for
sity of California San Francisco, San Francisco, CA.
Address reprint requests to Tekoa L. King, CNM, MPH, Department of
medical practices that are underused in some settings and
Obstetrics, Gynecology and Reproductive Sciences, University of Cali- overused in others.12,13 In fact, the inverse relationship be-
fornia San Francisco, San Francisco, CA. E-mail: tking@acnm.org tween quality health care and variation in practice has been

0146-0005/12/$-see front matter © 2012 Elsevier Inc. All rights reserved. 357
http://dx.doi.org/10.1053/j.semperi.2012.04.020
358 T.L. King

well documented.14 Thus, the diagnosis of fetal intolerance of There was no standard terminology shared by the different
labor and the management of dystocia are the 2 key areas study designs so even the definition of late decelerations was
where application of evidence-based strategies may have the different from 1 study to the next. In addition, the studies
most impact in lowering the rate of primary cesarean section. differed in their inclusion criteria. Some included women at
The third variable that affects intrapartum cesarean section term only and others included preterm gestations.
rates is the influence of the provider. Recently Chen et al22 used US birth certificate data from
2004 to compare outcomes in women who had EFM in labor
vs those who were monitored via IA. The analysis included
Fetal Intolerance of Labor women who were 24-44 weeks’ gestation. They excluded
Approximately 20%-30% of all NTSV cesareans are per- stillbirths, infants with congenital anomalies, and women
formed for fetal intolerance of labor.10 Continuous electronic who had repeat cesarean sections. A higher cesarean section
fetal heart rate monitoring (EFM) is the norm for ⬎90% of rate was found in the EFM group versus the IA group (2.8%
women who give birth in the United States.15 Nevertheless, vs 1.5%, respectively; relative risk [RR] ⫽ 1.81, 95% confi-
the efficacy of EFM has not been proven. dence interval [CI] ⫽ 1.74-1.88). However, early neonatal
mortality (infant death at ⬍6 days) for women who were
ⱖ37 weeks’ gestation was lower in the EFM group (0.2% for
The Evidence for EFM EFM vs 0.3% for IA; RR ⫽ 0.65, 95% CI ⫽ 0.47-0.90).
The story of EFM is well known.16 In brief, EFM was adopted Neonatal seizures were less common in women who had
into clinical practice in the 1960s and 1970s before being obstetrical disorders, chronic medical conditions, or a pre-
assessed in randomized trials. The beliefs that variant fetal term birth if monitored with EFM (0.7/1000 live births vs
heart rate (FHR) patterns reflect fetal hypoxemia and that 1.1/1000 live births), but the incidence of neonatal seizures
EFM could identify the fetus with impending asphyxia early in women who were low risk were not different when com-
enough to intervene were compelling, and this technology pared by monitoring modality (0.5/1000 live births vs 0.5/
was rapidly embraced. The first studies of EFM compared 1000 live births).
outcomes in settings before and after the introduction of Because 89% of the women in the Chen analysis experi-
intrapartum monitoring and found that women who had enced EFM in labor, the numbers in the comparison groups
continuous EFM during labor had fewer intrapartum still- were markedly different. Additionally, much of the data re-
births.17 It is important to note that a reduction in intrapar- corded on birth certificates have been shown to be unreliable.
tum stillbirth is still a true benefit of EFM. Thus, it is not clear if inherent bias in the data source benefits
The initial RCTs were conducted in the 1970s and 1980s. one monitoring modality or neither. Perhaps most impor-
They found that EFM was associated with higher rates of tantly, intrapartum hypoxia is only one of many etiologies of
cesarean section without a concomitant improvement in early neonatal mortality. The results of this most recent study
newborn outcomes.18 A Cochrane meta-analysis, which was do not inform the debate about using EFM versus IA for
last updated in 2006, compared 13 RCTs of continuous EFM low-risk women at term. In the end, the question of superi-
with intermittent auscultation (IA) and confirmed higher ce- ority of EFM versus IA has not been solved, and a randomized
sarean section rates but no improvement in Apgar scores, trial of sufficient power is unlikely to be completed given the
perinatal mortality or rates of cerebral palsy in infants born to resources that would be needed to conduct this study.
women in the continuous EFM.19 EFM is associated with a Today, EFM is often used as the poster child for a medical
50% reduction in the incidence of early neonatal seizures, technology that was accepted in clinical practice despite hav-
but there were no differences between the EFM and IA ing no documented benefits,23,24 and the argument that EFM
groups in the rate of cerebral palsy when the infants with should be discarded frequently appears in the obstetrical lit-
newborn seizures were reexamined at 4 years of age.20 erature.21,25 However, changing a practice that is currently
These results are frequently cited because the evidence that standard of care is very difficult.26 Therefore, using current
shows EFM increases the cesarean section rate without a research findings to replace or alter the protocols used for
concomitant improvement in newborn outcomes.21 On intrapartum fetal monitoring in monitored women who are
closer examination, there are multiple study design differ- low risk for fetal acidemia at the onset of labor is more likely
ences and problems that should disallow generalizing the to be successful than a whole-scale change in practice.
results of these RCTs and meta-analysis to women in labor
today for either recommending its use or recommending that
it not be used. The RCTs included in the meta-analysis were FHR Monitoring Modalities That
all conducted between 1976 and 1994, which makes them may Lower the Cesarean Section Rate
⬎20 years old.19 The majority of these studies were con- In the last decade, FHR research demonstrated that an um-
ducted before the importance of FHR variability because an bilical artery pH value of ⬍7.0 reflects an increased risk for
indicator of fetal hypoxemia was known; thus, the decision to hypoxic ischemic encephalopathy, and those FHR patterns
do a cesarean section for fetal distress was made on the basis that are most associated with low umbilical artery pH values
of decelerations with or without a diminution in baseline were identified.27 Standardization in clinical practice also im-
variability. Many of the studies used fetal scalp sampling as an proved. In 2005-2006, the relevant professional associations
auxiliary test, which is rarely used today in the United States. all endorsed use of a standard terminology for FHR charac-
Preventing primary cesarean sections 359

Figure 1 Algorithm for interpreting fetal heart rate patterns. (Color version of figure is available online.) © Tekoa King.

teristics. In 2008, the workshop on FHR monitoring jointly academic center. Available institutional resources are a criti-
sponsored by the National Institute of Child Health and Hu- cal factor in making the decision about watching and waiting
man Development and the American College of Obstetricians versus intervention. Institutional protocols for managing
and Gynecologists recommended a 3-tier system for interpre- FHR patterns will work best if they are developed by a mul-
tation of FHR patterns,28 and in 2010, American College of tidisciplinary team composed of all the key players, including
Obstetricians and Gynecologists published a practice bulletin nursing, midwifery, obstetrics, anesthesia, and administra-
that includes additional recommendations which results in a tion.37 Resultant cesarean section rates for nonreassuring fetal
four-tier system.29 In addition, there is a rapidly increasing status will always need to be risk adjusted for hospital level
body of evidence about the relationship between specific characteristics.
FHR patterns and fetal/newborn acidemia that if imple-
mented into practice, may help lower the primary cesarean IA Protocols
section rate.30,31 IA protocols could be established in settings that have the
resources to offer women this modality. Maternal and new-
5-Tier System for FHR Interpretation born outcomes in women who give birth at home or in free-
The practice change that is most likely to have a positive standing birth centers are cared for with intermittent moni-
impact on reducing the cesarean section rate is more refined toring through labor. Large observational studies of these
interpretation of FHR patterns and institutionally developed settings have documented lower cesarean section rates and
protocols for management of abnormal FHR patterns. The similar or improved newborn outcomes when compared
2008 National Institute of Child Health and Human Devel- with women with similar demographic characteristics who
opment FHR workshop recommended that FHR patterns be give birth in hospitals and monitored with continuous
divided into 3 categories for interpretation on the basis of EFM.9,38 These cohort studies can at best detect an associa-
their association with fetal acidemia: I, normal; II, indetermi- tion between the type of intrapartum care and newborn out-
nate; and III, abnormal.28 The FHR patterns in category I and comes. However, the results have been markedly consistent
category III are well-established markers for a nonacademic across different populations and when the analysis controls
fetus and a fetus with a significant risk for acidemia, respec- for possible confounders.39 It is important to note that posi-
tively.32,33 Category II includes a heterogenous group of pat- tive newborn outcomes in settings that use IA only occur
terns that vary with regard to their association with fetal when the staff understands how to use IA, the institution has
acidemia, which makes this category difficult to use in clini- a workforce that allows the continuous presence of a nurse or
cal practice. However, there appears to be a dose-response midwife for women in active labor, and there is a policy and
relationship between time spent in category II during the last process in place for moving to EFM when abnormalities on IA
2 hours before birth and an increased risk for lower Apgar are detected.40
scores and neonatal intensive care unit admission.33 Recent
studies of a 5-tier system that subdivides category II have FHR Monitoring
shown that the 5-tier system more accurately reflects fetal in the Latent Phase of Labor
acid– base status.34-36 A simplified graphic for FHR interpre- A brief FHR tracing is often obtained on admission to rule out
tation adapted from the 5-tier system is presented in Figure 1. variant patterns that might require additional evaluation.
Standardized management protocols must be considered However, a meta-analysis of 4 RCTs that measured the out-
with caution. The response to a specific FHR pattern in an comes of low-risk women who had an admission test and
out-of-hospital birthing center or level 1 hospital that does those who were evaluated via IA (n ⫽ 13,000) found no
not have in-house obstetrical or anesthesia coverage may difference in newborn outcomes and an increase in cesarean
have to be more conservative than the response in a tertiary sections in the women how had the admission test (RR ⫽
360 T.L. King

Table 1 Normal Labor Progress in Nulliparous Women at Term in Spontaneous Labor


Active Phase
Author N Hours, Mean (2SD) Key Findings Clinical Implications
Friedman46 500 2.5 (12) Frequent use of opioids, caudal The Friedman curve should not
anesthesia, oxytocin, and be used to monitor labor
forceps different from today progress
Peisner and Rosen52 1060 <50% in active labor Do not make the diagnosis of
by 4 cm, 74% in active labor until at least 5
active labor by 5 cm cm
Zhang et al50 26,838 4.4 (16.7) Active phase not entered until Do not make the diagnosis of
5-6 cm. Speed of cervical active labor until at least 5-6
dilation progressively cm
accelerates
Kilpatrick and Laros53 2302 8.1 (16.6) no analgesia, Length of first and second Cervical dilation in active phase
10.2 (19) conduction stages are longer in women of labor in women with
analgesia* with conduction anesthesia conduction analgesia may
take 0.5-1 hour longer than
women who do not have
conduction analgesia
Albers et al54 1513 7.7 (19.4) Length of active phase of labor Racial differences in labor
was longer in Hispanic and length need to be explored in
American Indian women more detail. Individual
when compared with non- institutions can determine
Hispanic white women normal time frames for their
setting
Albers55 2511 7.7 (17.5)* Midwifery-managed care. Use of IA and ambulation
43.7% used EFM, 61% during active labor in women
women were ambulatory in without analgesia may
labor. EFM and ambulation shorten length of the first
were associated with longer stage of labor
labors
Zhang et al49 1329 5.5 (13.7)† Marked interindividual Allow at least 2 hours between
variability in cm at which each increment of cervical
active phase starts (3-5 cm). dilation before 7 cm
Time interval of no change
>2 hours not uncommon
before 7 cm
Jones and Larson56 120 6.2 (13.4) Hispanic population
Neal et al48 7009 6 (13.4) Systematic review included Allow at least 2 hours between
studies of women with each increment of cervical
analgesia and oxytocin dilation in late active phase of
augmentation; slowest labor
normal rate of cervical
dilation approximates 0.5-0.6
cm/h
EFM, electronic fetal monitoring; IA, intermittent auscultation.
*First stage of labor as defined by patient history.
†90th percentile.

1.20, 95% CI ⫽ 1.00-1.44).41 Although this is a statistically during the latent phase may help mitigate the cesarean sec-
significant finding, it is difficult to justify not using EFM on tion rate in this population.
admission to screen for the rare FHR pattern that indicates an
increased risk for fetal acidemia given the current medicole-
gal climate in the United States. Nonetheless, women who are Labor Management Practices
admitted in latent labor are more likely to have a cesarean That Improve Vaginal Birth Rates
section than women who are admitted in active labor,42 and
there are no professional guidelines that recommend EFM for Dystocia is the leading cause of primary cesarean sections
women who are in latent labor. Therefore, a shift from con- today, accounting for approximately half of those performed
tinuous EFM and bed rest to encouraging ambulation and during labor.43 Dystocia also accounts for the greatest varia-
maintaining comfort for women who require hospital care tion in institutional cesarean rates.44,45 A brief review, the
Preventing primary cesarean sections 361

Figure 2 Partograph for low-risk, nulliparous women with spontaneous labor onset. Reprinted with permission from
Neal and Lowe.57 (Color version of figure is available online.)

indications for failure to progress and intrapartum care prac- dilation is used to assess labor progression. (2) In nulliparous
tices that are associated with lower rates of cesarean section, women, 90% of women will have a linear dilation rate of at
informs recommendations for changes in intrapartum man- least 0.5 cm/h. (3) Cervical dilation accelerates progressively
agement. throughout active labor. (4) The time between each centime-
ter of dilatation is more variable in early active labor than it is
Failure to Progress in Labor in late active labor. The partogram includes a dystocia line
Dystocia is vaguely defined as slow or abnormal progression that incorporates these 4 principles and additionally assumes
of labor. For decades, progress in labor has been measured to any ⬎4-hour delay in dilation after 5 cm is an indication for
determine the statistical limits of normal via use of a time intervention.57 The results of clinical research using the Neal
versus dilatation graph created by Emanual Friedman in and Lowe partogram are anticipated. Until an improved labor
1955.46 Friedman followed the progress of 500 primigravid graph is clinically available, discarding the Friedman curve
women to determine the mean, median, range, and standard and incorporating the key summary points listed in Table
deviation of the first stage of labor. He divided the resulting 242,45,58-66 are recommended when making clinical decisions
sigmoid curve into the latent, active and transition phases about labor progress.
“for purposes of mathematical simplification . . . ”p569.46 Un-
fortunately, the intrapartum courses that informed the Fried- Intrapartum Care Practices
man graph are not an accurate reflection of labor progress That Lower the Cesarean Section Rate
today.47-50 Even more interesting is that they were probably Delayed admission until the onset of active labor, continuous
not an accurate depiction of labor in 1955. supportive care, avoiding epidural analgesia, supporting ad-
Recent investigations have identified and corrected some equate hydration, use of upright positions, and less use of
of the problems inherent in Friedman’s work.48,51 Zhang et amniotomy and oxytocin during labor all have some biologic
al50 repeated the analysis of labor progress using data from plausibility for facilitating vaginal birth via support for phys-
the National Collaborative Perinatal Project. Using a repeated iological labor. Although there is some evidence for use of
measures analysis, they found that the latent phase of labor each of these practices, only continuous one-to-one support
lasted longer than Friedman detected and that a deceleration during labor has been shown to confer a statistically signifi-
phase did not occur. It is important to note that the data for cant advantage.58 Table 2 summarizes the key findings from
this analysis came from a large prospective study of women studies of labor practices that may be associated with a lower
who gave birth between 1955 and 1966, when intrapartum cesarean section rate.42,58-66 It is important to note that these
management was similar to the management experienced by management strategies are most often studied individually,
the women in Friedman’s sample. Table 1 presents the results which disallows assessment of any potentiating effect they
of contemporary studies on labor progress in primigravid may have on each other when offered in aggregate. To date,
women at term and summarizes the key findings.46,47-50,52-56 only studies of midwifery care have indirectly assessed intra-
From a clinical perspective, it is clear that continued use of partum management that includes all these care practices as a
the Friedman curve to determine the limits of normal is re- comprehensive model of care.
sulting in iatrogenic intervention and overusage of cesarean
section.
A Labor Curve for the Future
The Role of the Provider
Neal and Lowe57 recently developed a partogram (Fig. 2) Many years of prospective and retrospective observational
based on the following principles culled from an extensive studies have consistently found midwifery care associated
review of the current research on labor progress: (1) Active with a lower cesarean section rate when compared with phy-
labor must be accurately diagnosed before the rate of cervical sician-only management.9,38,67,68 There are 2 interrelated cri-
362 T.L. King

Table 2 Individual Intrapartum Care Practices that Promote Vaginal Birth in Women at Term in Spontaneous Labor
Management Practice Key Findings Clinical Implications
Admit in active labor Retrospective studies found admission after active labor Avoid admitting women in latent
is established results in less intervention and lower labor and/or avoid EFM and
cesarean sections.42,45 bed rest in women who are
One RCT of 209 women found a trend for fewer admitted in latent labor
cesareans (7.6% in delayed admission group vs 10.6%
in early admission group; OR ⴝ 0.70, 95% CI ⴝ 0.27-
0.81).58
Ambulation and upright Upright positions and freedom of movement are Ambulation in active labor may
positions associated with less perceived pain, shorter labor, shorten labor duration
improved uterine contractility, and increased patient
satisfaction.59,60
Trend toward lower cesarean section rates that is not
statistically significant
Continuous labor support Continuous support provided by a nonmedical person Continuous one-to-one support
reduces cesarean section rate (16 trials, n ⴝ 13,391; during labor
RR ⴝ 0.91, 95% CI ⴝ 0.83-99)60,61
Epidural vs The association between epidural analgesia and cesarean Encourage nonpharmacologic
nonpharmacologic section is controversial, and most studies have methods of pain relief for
methods of pain control significant crossover or statistically significant results women who are interested in
that may not be clinically significant.62,63 avoiding epidural analgesia
RCTs that have found no association primarily use active
management of labor protocols. It is possible that
active management mitigates the effect of epidural
analgesia on cesarean section rates.64,65
Oral hydration and nutrition 125 cc/h vs 250 cc/h is associated with shorter labors, Encourage oral fluid and
less use of oxytocin, and a trend toward fewer nutrition in labor
cesarean sections.66
OR, odds ratio; RCT, randomized controlled trial; RR, relative risk.

tiques of this body of literature as a whole. First, most of the in the RCTs, which were largely conducted in Europe. Intrapar-
research on midwifery has included nonrandomized com- tum management with regard to the indications for cesarean
parison groups, which suggests selection bias may slant the section cannot be directly generalized to intrapartum care in the
results in favor of midwifery care. To address this issue, many United States.
of these studies applied logistic regression models and/or The research methodology questions about midwifery care
specific selection criteria to comparison groups that ac- may remain unsolved. It is not clear if women who chose
counted for confounders. In clinical practice, midwives in the midwives are inherently at lower risk for having a cesarean
United States care for a larger proportion of underserved section in some intangible way that has not been measured,
women when compared with the case mix of obstetricians. or if the midwifery model of care lowers cesarean section
This is a population that has been noted to have a higher a rates to a greater extent than has been measured given mid-
priori risk for cesarean section.7,69,70 wives have a higher proportion of women in their caseload
Secondly, women cared for by midwives who require a cesar- who are at risk for cesarean section secondary to racial or
ean section are referred to a collaborating physician, which may socioeconomic disadvantage. Of more importance is the
result in the cesarean section being attributed to the physician overall consistency of findings that midwifery care is associ-
versus the midwife. Thus, only studies that include an intention- ated with positive obstetrical outcomes that include higher
to-treat analysis can address this problem. Hatem et al8 did con- vaginal delivery rates. Increased use of midwives in the
duct a meta-analysis of RCTs that evaluated outcomes by inten- United States is recommended.
tion-to-treat and did not detect a difference in cesarean section
rates when midwifery care was compared with physician-only
care (11 trials, n ⫽ 11,897, RR ⫽ 0.96, 95%CI ⫽ 0.87-1.06).
Conclusions
The meta-analysis did find that midwifery care was associated The cesarean section rate for low-risk women at term is al-
with improved outcomes in most other indices, including more most twice as high as it should be. Many of the medical
spontaneous vaginal births (9 trials, n ⫽ 10,926, RR ⫽ 1.04, reasons for this crisis have been identified, including elective
95% CI ⫽ 1.06-1.04). Despite the repute of the Cochrane meta- induction, early admission, EFM, and a graphic standard for
analysis process, these RCT results and the subsequent meta- labor progress that is outdated and inappropriate. A multi-
analysis present an incomplete picture of midwifery care out- pronged reality-based approach is going to be necessary to
comes. Several different models of midwifery care were included effect a positive change in the primary cesarean section rate.
Preventing primary cesarean sections 363

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