NSG-426 Pharmacology II

Chapter 57: Drugs That Are Cell Cycle-Nonspecific

1. A 39-year-old woman is receiving doxorubicin for the treatment of cancer. After each treatment,
the patient has acute nausea and vomiting accompanied by a slightly increased heart rate. The
nurse will advise her to
A) perform relaxation techniques after the treatments.
B) make an appointment for cardiac function tests.
C) take the drug only at bedtime.
D) perform light exercise after administration of the drug.

2. A 51-year-old female patient has been receiving doxorubicin (Adriamycin) for metastatic breast
cancer. Her medical record indicates she has cardiomyopathy and a cumulative dose of 300
mg/m2 of doxorubicin. Which of the following measures would help limit the severity of the
cardiomyopathy in this patient?
A) A reduced dose
B) A single large dose instead of multiple doses
C) The use of dexrazoxane in conjunction with doxorubicin
D) Meticulous monitoring during drug administration

3. A 57-year-old male patient who has been prescribed doxorubicin for small-cell lung cancer is
advised by the nurse to avoid taking aspirin or drugs that contain aspirin because it may
A) cause extravasation injury.
B) promote bleeding.
C) cause a radiation recall reaction.
D) cause acute nausea and vomiting.

4. A male patient has been on long-term bicalutamide (Casodex) therapy. In order to assess
adverse effects of the drug therapy, the nurse will closely monitor which of the following?
A) Visual function
B) Blood counts
C) Pap test results
D) Liver function

5. A patient receiving high-dose cisplatin therapy exhibits symptoms of hypomagnesemia. Which

of the following should the nurse suggest to help offset the magnesium losses from the cisplatin
therapy?
A) Consuming dairy products
B) Consuming chocolates
C) Drinking 2 to 3 liters of fluid a day
D) Consuming potassium-rich foods

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 6. A nurse has been assigned to a 55-year-old woman who has a malignant brain tumor. The
patient is receiving her first dose of carmustine. It will be critical for the nurse to observe for
which of the following?
A) Nausea and vomiting
B) Respiratory difficulty
C) Inability to drink fluids for 6 hours
D) Reddish urine

7. A 62-year-old patient taking tamoxifen exhibits increased bone and tumor pain along with a
local disease flare. The nurse interprets this as an indication of which of the following?
A) A hypersensitivity reaction
B) The tumor responding to treatment
C) Nephrotoxic effects of tamoxifen
D) Cardiomyopathy

8. Intravenous carmustine has been prescribed for a patient with cancer. The nurse should help
relieve the discomfort of pain and burning during the infusion by
A) slowing the infusion.
B) decreasing the volume used for dilution.
C) decreasing the total volume of the primary IV infusion.
D) administering a dose of 2 units of bleomycin before carmustine.

9. A nurse is providing patient education to a 35-year-old woman who has been prescribed
cyclophosphamide therapy. When discussing possible hair loss, the nurse will advise the patient
to
A) seek chemical treatment.
B) brush her hair vigorously to stimulate growth.
C) use strong shampoo to maintain hair length.
D) see a wig specialist.

10. A female patient is taking oral cyclophosphamide therapy for breast cancer. Because of possible
adverse effects of the drug, the nurse will instruct the patient to do which of the following?
A) Drink a lot of water
B) Limit fluid intake
C) Take the medication at bedtime
D) Increase the protein in her diet

11. A 54-year-old received a diagnosis of breast cancer several weeks ago and her current treatment
regimen includes tamoxifen, a cell cycleñnonspecific antineoplastic drug. Which of the
following is a characteristic of a cell cycleñnonspecific drug?
A) The drug is effective regardless of whether a cancerous cell is proliferating.
B) The drug is capable of inducing cell division and subsequent mutations of cancerous
cells.
C) The drug is readily able to distinguish between normal body cells and malignant cells.
D) The drug induces an abnormal cell cycle that results in cancerous cell death.

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12. A patient with a recent diagnosis of chronic myelogenous leukemia (CML) is discussing
treatment options with his care team. What aspect of the patient's condition would contraindicate
the use of cyclophosphamide for the treatment of leukemia?
A) The patient has a diagnosis of type 2 diabetes and takes oral antihyperglycemics.
B) The patient has had a history of nonadherence to medical treatment.
C) The patient's bone marrow function is significantly depressed.
D) The patient has decreased renal function.

13. An elderly man has been admitted to a residential care facility and the nurse has conducted a
medication reconciliation. The man has taken numerous drugs in the past, including a course of
bicalutamide (Casodex) several years earlier. The nurse recognizes this drug as being an
antiandrogen and is consequently justified in presuming that the man has a history of what
disease?
A) Lymphoma
B) Lung cancer
C) Skin cancer
D) Prostate cancer

14. An adult patient who has been diagnosed with a rectal tumor is scheduled to begin treatment
with cisplatin. The nurse has conducted patient teaching about the possibility of nausea and
vomiting. In order to reduce the patient's risk of severe nausea, the nurse should
A) place the patient on a low-residue diet.
B) ensure that the patient is NPO from midnight prior to receiving the drug.
C) administer a combination of antiemetics prior to the administration of the drug.
D) encourage the patient to request antiemetics if the nausea becomes unbearable.

15. A patient with non-Hodgkin's lymphoma (NHL) will be starting a course of doxorubicin shortly.
When planning this patient's care, what nursing diagnosis should the nurse prioritize?
A) Risk for Infection related to suppressed bone marrow function
B) Risk for Impaired Skin integrity related to cytotoxic effects of doxorubicin
C) Risk for Imbalanced Nutrition: More Than Body Requirements related to metabolic
effects of doxorubicin
D) Risk for Ineffective Airway Clearance related to decreased neurological function

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