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This review discusses the non-motor symptoms of Parkinson's disease (PD), which are common but often under-recognized and untreated. Some key points:
- Non-motor symptoms include depression, apathy, sleep disorders, and erectile dysfunction. They occur across all stages of PD and greatly impact quality of life.
- Dopaminergic pathways in the brain that are disrupted in PD mediate several non-motor symptoms. Imaging studies show dopamine dysfunction in areas linked to sleep, autonomic function, and neuroendocrine issues.
- While non-dopaminergic treatments have been studied, this review focuses on evidence that non-motor symptoms may be treatable through dopaminergic strategies like dopamine agonists
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Risk Factors for Non-motor Symptoms in Parkinson’s Disease
This review discusses the non-motor symptoms of Parkinson's disease (PD), which are common but often under-recognized and untreated. Some key points:
- Non-motor symptoms include depression…