Product Identifier
Product name Meguiar's A22 - Deep Crystal Carnauba Wax
Synonyms Product Code: A22
Other means of
Not Available
identification
Relevant identified uses of the substance or mixture and uses advised against
The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere developing. Before starting
Relevant identified uses consider control of exposure by mechanical ventilation.
Wax emulsion
HAZARDOUS CHEMICAL. NON-DANGEROUS GOODS. According to the WHS Regulations and the ADG Code.
Classification [1] Skin Corrosion/Irritation Category 2, Specific target organ toxicity - single exposure Category 3 (narcotic effects), Aspiration Hazard Category 1
Legend: 1. Classified by Chemwatch; 2. Classification drawn from HSIS ; 3. Classification drawn from EC Directive 1272/2008 - Annex VI
Label elements
Hazard statement(s)
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H304 May be fatal if swallowed and enters airways.
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Substances
See section below for composition of Mixtures
Mixtures
CAS No %[weight] Name
64742-48-9. 10-25 naphtha petroleum, heavy, hydrotreated
Not Available 5-10 polymer blend proprietary
9007-48-1 1-5 polyglycerol oleate
66402-68-4 1-5 kaolin, calcined
63148-62-9 1-5 polydimethylsiloxane
8007-43-0 1-5 sorbitan sesquioleate
64742-46-7. 1-5 distillates, petroleum, middle, hydrotreated
7732-18-5 45-65 water
Any material aspirated during vomiting may produce lung injury. Therefore emesis should not be induced mechanically or pharmacologically. Mechanical means should be used if it is considered
necessary to evacuate the stomach contents; these include gastric lavage after endotracheal intubation. If spontaneous vomiting has occurred after ingestion, the patient should be monitored for
difficult breathing, as adverse effects of aspiration into the lungs may be delayed up to 48 hours.
For acute or short term repeated exposures to petroleum distillates or related hydrocarbons:
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Primary threat to life, from pure petroleum distillate ingestion and/or inhalation, is respiratory failure.
Patients should be quickly evaluated for signs of respiratory distress (e.g. cyanosis, tachypnoea, intercostal retraction, obtundation) and given oxygen. Patients with inadequate tidal volumes or
poor arterial blood gases (pO2 50 mm Hg) should be intubated.
Arrhythmias complicate some hydrocarbon ingestion and/or inhalation and electrocardiographic evidence of myocardial injury has been reported; intravenous lines and cardiac monitors should
be established in obviously symptomatic patients. The lungs excrete inhaled solvents, so that hyperventilation improves clearance.
A chest x-ray should be taken immediately after stabilisation of breathing and circulation to document aspiration and detect the presence of pneumothorax.
Epinephrine (adrenalin) is not recommended for treatment of bronchospasm because of potential myocardial sensitisation to catecholamines. Inhaled cardioselective bronchodilators (e.g.
Alupent, Salbutamol) are the preferred agents, with aminophylline a second choice.
Lavage is indicated in patients who require decontamination; ensure use of cuffed endotracheal tube in adult patients. [Ellenhorn and Barceloux: Medical Toxicology]
Treat symptomatically.
Extinguishing media
The product contains a substantial proportion of water, therefore there are no restrictions on the type of extinguishing media which may be used. Choice of extinguishing media should take into
account surrounding areas.
Though the material is non-combustible, evaporation of water from the mixture, caused by the heat of nearby fire, may produce floating layers of combustible substances.
In such an event consider:
foam.
dry chemical powder.
carbon dioxide.
Environmental precautions
See section 12
SORBENT
RANK APPLICATION COLLECTION LIMITATIONS
TYPE
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Meguiar's A22 - Deep Crystal Carnauba Wax
Legend
DGC: Not effective where ground cover is dense
R; Not reusable
I: Not incinerable
P: Effectiveness reduced when rainy
RT:Not effective where terrain is rugged
SS: Not for use within environmentally sensitive sites
W: Effectiveness reduced when windy
Reference: Sorbents for Liquid Hazardous Substance Cleanup and Control;
R.W Melvold et al: Pollution Technology Review No. 150: Noyes Data Corporation 1988
Moderate hazard.
Clear area of personnel and move upwind.
Alert Fire Brigade and tell them location and nature of hazard.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water course.
No smoking, naked lights or ignition sources.
Increase ventilation.
Stop leak if safe to do so.
Contain spill with sand, earth or vermiculite.
Collect recoverable product into labelled containers for recycling.
Absorb remaining product with sand, earth or vermiculite.
Collect solid residues and seal in labelled drums for disposal.
Wash area and prevent runoff into drains.
If contamination of drains or waterways occurs, advise emergency services.
Control parameters
EMERGENCY LIMITS
Ingredient Material name TEEL-1 TEEL-2 TEEL-3
naphtha petroleum, heavy,
Naphtha, hydrotreated heavy; (Isopar L-rev 2) 171 ppm 171 ppm 570 ppm
hydrotreated
polydimethylsiloxane Dimethyl siloxane; (Dimethylpolysiloxane; Syltherm XLT; Syltherm 800; Silicone 360) 1.5 mg/m3 16 mg/m3 990 mg/m3
distillates, petroleum, middle,
Hydrotreated middle distillate (Petroleum base oil) 0.23 mg/m3 2.5 mg/m3 15 mg/m3
hydrotreated
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Meguiar's A22 - Deep Crystal Carnauba Wax
MATERIAL DATA
Sensory irritants are chemicals that produce temporary and undesirable side-effects on the eyes, nose or throat. Historically occupational exposure standards for these irritants have been based on
observation of workers' responses to various airborne concentrations. Present day expectations require that nearly every individual should be protected against even minor sensory irritation and
exposure standards are established using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no-observable-effect-levels (NOEL) are used to determine these limits where
human results are unavailable. An additional approach, typically used by the TLV committee (USA) in determining respiratory standards for this group of chemicals, has been to assign ceiling
values (TLV C) to rapidly acting irritants and to assign short-term exposure limits (TLV STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints combine to
warrant such a limit. In contrast the MAK Commission (Germany) uses a five-category system based on intensive odour, local irritation, and elimination half-life. However this system is being
replaced to be consistent with the European Union (EU) Scientific Committee for Occupational Exposure Limits (SCOEL); this is more closely allied to that of the USA.
OSHA (USA) concluded that exposure to sensory irritants can:
cause inflammation
cause increased susceptibility to other irritants and infectious agents
lead to permanent injury or dysfunction
permit greater absorption of hazardous substances and
acclimate the worker to the irritant warning properties of these substances thus increasing the risk of overexposure.
NOTE M: The classification as a carcinogen need not apply if it can be shown that the substance contains less than 0.005% w/w benzo[a]pyrene (EINECS No 200-028-5). This note applies only to
certain complex oil-derived substances in Annex IV.
European Union (EU) List of harmonised classification and labelling hazardous substances, Table 3.1, Annex VI, Regulation (EC) No 1272/2008 (CLP) - up to
the latest ATP
NOTE N: The classification as a carcinogen need not apply if the full refining history is known and it can be shown that the substance from which it is produced is not a carcinogen. This note
applies only to certain complex oil-derived substances in Annex VI.
European Union (EU) List of harmonised classification and labelling hazardous substances, Table 3.1, Annex VI, Regulation (EC) No 1272/2008 (CLP) - up to
the latest ATP
NOTE P: The classification as a carcinogen need not apply if it can be shown that the substance contains less than 0.01% w/w benzene (EINECS No 200-753-7). Note E shall also apply when the
substance is classified as a carcinogen. This note applies only to certain complex oil-derived substances in Annex VI.
European Union (EU) List of harmonised classification and labelling hazardous substances, Table 3.1, Annex VI, Regulation (EC) No 1272/2008 (CLP) - up to
the latest ATP
Exposure controls
Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed engineering controls can be highly
effective in protecting workers and will typically be independent of worker interactions to provide this high level of protection.
The basic types of engineering controls are:
Process controls which involve changing the way a job activity or process is done to reduce the risk.
Enclosure and/or isolation of emission source which keeps a selected hazard "physically" away from the worker and ventilation that strategically "adds" and
"removes" air in the work environment. Ventilation can remove or dilute an air contaminant if designed properly. The design of a ventilation system must match
the particular process and chemical or contaminant in use.
Employers may need to use multiple types of controls to prevent employee overexposure.
General exhaust is adequate under normal operating conditions. Local exhaust ventilation may be required in specific circumstances. If risk of overexposure
exists, wear approved respirator. Correct fit is essential to obtain adequate protection. Provide adequate ventilation in warehouse or closed storage areas. Air
contaminants generated in the workplace possess varying "escape" velocities which, in turn, determine the "capture velocities" of fresh circulating air required
to effectively remove the contaminant.
Simple theory shows that air velocity falls rapidly with distance away from the opening of a simple extraction pipe. Velocity generally decreases with the square
of distance from the extraction point (in simple cases). Therefore the air speed at the extraction point should be adjusted, accordingly, after reference to
distance from the contaminating source. The air velocity at the extraction fan, for example, should be a minimum of 1-2 m/s (200-400 f/min) for extraction of
solvents generated in a tank 2 meters distant from the extraction point. Other mechanical considerations, producing performance deficits within the extraction
apparatus, make it essential that theoretical air velocities are multiplied by factors of 10 or more when extraction systems are installed or used.
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Personal protection
NEOPRENE A A-PAPR-AUS /
up to 10 x ES A-AUS P2 -
Class 1 P2
VITON A
A-AUS / Class 1
NATURAL RUBBER C up to 50 x ES - -
P2
PVA C up to 100 x ES - A-2 P2 A-PAPR-2 P2 ^
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Partition coefficient
Odour Not Available Not Available
n-octanol / water
Auto-ignition temperature
Odour threshold Not Available Not Available
(°C)
Decomposition
pH (as supplied) Not Available Not Available
temperature
Melting point / freezing
Not Available Viscosity (cSt) Not Available
point (°C)
Initial boiling point and
199 Molecular weight (g/mol) Not Applicable
boiling range (°C)
Flash point (°C) >93 (PMCC) Taste Not Available
Evaporation rate <1 Explosive properties Not Available
Flammability Not Applicable Oxidising properties Not Available
Surface Tension (dyn/cm or
Upper Explosive Limit (%) Not Available Not Available
mN/m)
Lower Explosive Limit (%) Not Available Volatile Component (%vol) 16 (VOC)
Vapour pressure (kPa) Not Available Gas group Not Available
Solubility in water (g/L) Partly Miscible pH as a solution (1%) Not Available
Vapour density (Air = 1) >1 VOC g/L Not Available
High inhaled concentrations of mixed hydrocarbons may produce narcosis characterised by nausea, vomiting and lightheadedness. Inhalation of aerosols may
produce severe pulmonary oedema, pneumonitis and pulmonary haemorrhage. Inhalation of petroleum hydrocarbons consisting substantially of low molecular
weight species (typically C2-C12) may produce irritation of mucous membranes, incoordination, giddiness, nausea, vertigo, confusion, headache, appetite
Inhaled
loss, drowsiness, tremors and anaesthetic stupor. Massive exposures may produce central nervous system depression with sudden collapse and deep coma;
fatalities have been recorded. Irritation of the brain and/or apnoeic anoxia may produce convulsions. Although recovery following overexposure is generally
complete, cerebral micro-haemorrhage of focal post-inflammatory scarring may produce epileptiform seizures some months after the exposure. Pulmonary
episodes may include chemical pneumonitis with oedema and haemorrhage. The lighter hydrocarbons may produce kidney and neurotoxic effects. Pulmonary
irritancy increases with carbon chain length for paraffins and olefins. Alkenes produce pulmonary oedema at high concentrations. Liquid paraffins may produce
anaesthesia and depressant actions leading to weakness, dizziness, slow and shallow respiration, unconsciousness, convulsions and death. C5-7 paraffins
may also produce polyneuropathy. Aromatic hydrocarbons accumulate in lipid rich tissues (typically the brain, spinal cord and peripheral nerves) and may
produce functional impairment manifested by nonspecific symptoms such as nausea, weakness, fatigue and vertigo; severe exposures may produce inebriation
or unconsciousness. Many of the petroleum hydrocarbons are cardiac sensitisers and may cause ventricular fibrillations.
Central nervous system (CNS) depression may include nonspecific discomfort, symptoms of giddiness, headache, dizziness, nausea, anaesthetic effects,
slowed reaction time, slurred speech and may progress to unconsciousness. Serious poisonings may result in respiratory depression and may be fatal.
The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere developing. Before starting
consider control of exposure by mechanical ventilation.
Swallowing of the liquid may cause aspiration of vomit into the lungs with the risk of haemorrhaging, pulmonary oedema, progressing to chemical pneumonitis;
serious consequences may result.
Signs and symptoms of chemical (aspiration) pneumonitis may include coughing, gasping, choking, burning of the mouth, difficult breathing, and bluish
coloured skin (cyanosis).
Accidental ingestion of the material may be damaging to the health of the individual.
Ingestion Ingestion of petroleum hydrocarbons may produce irritation of the pharynx, oesophagus, stomach and small intestine with oedema and mucosal ulceration
resulting; symptoms include a burning sensation in the mouth and throat. Large amounts may produce narcosis with nausea and vomiting, weakness or
dizziness, slow and shallow respiration, swelling of the abdomen, unconsciousness and convulsions. Myocardial injury may produce arrhythmias, ventricular
fibrillation and electrocardiographic changes. Central nervous system depression may also occur. Light aromatic hydrocarbons produce a warm, sharp,
tingling sensation on contact with taste buds and may anaesthetise the tongue. Aspiration into the lungs may produce coughing, gagging and a chemical
pneumonitis with pulmonary oedema and haemorrhage.
Repeated exposure may cause skin cracking, flaking or drying following normal handling and use.
Skin Contact Open cuts, abraded or irritated skin should not be exposed to this material
The material may accentuate any pre-existing dermatitis condition
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Limited evidence exists, or practical experience suggests, that the material may cause eye irritation in a substantial number of individuals and/or is expected to
produce significant ocular lesions which are present twenty-four hours or more after instillation into the eye(s) of experimental animals. Repeated or prolonged
eye contact may cause inflammation characterised by temporary redness (similar to windburn) of the conjunctiva (conjunctivitis); temporary impairment of vision
and/or other transient eye damage/ulceration may occur.
Eye Some nonionic surfactants may produce a localised anaesthetic effect on the cornea; this may effectively eliminate the warning discomfort produced by other
substances and lead to corneal injury. Irritant effects range from minimal to severe dependent on the nature of the surfactant, its concentration and the duration
of contact. Pain and corneal damage represent the most severe manifestation of irritation.
Petroleum hydrocarbons may produce pain after direct contact with the eyes. Slight, but transient disturbances of the corneal epithelium may also result. The
aromatic fraction may produce irritation and lachrymation.
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.
Repeated or prolonged exposure to mixed hydrocarbons may produce narcosis with dizziness, weakness, irritability, concentration and/or memory loss, tremor
in the fingers and tongue, vertigo, olfactory disorders, constriction of visual field, paraesthesias of the extremities, weight loss and anaemia and degenerative
changes in the liver and kidney. Chronic exposure by petroleum workers, to the lighter hydrocarbons, has been associated with visual disturbances, damage to
the central nervous system, peripheral neuropathies (including numbness and paraesthesias), psychological and neurophysiological deficits, bone marrow
Chronic toxicities (including hypoplasia possibly due to benzene) and hepatic and renal involvement. Chronic dermal exposure to petroleum hydrocarbons may result in
defatting which produces localised dermatoses. Surface cracking and erosion may also increase susceptibility to infection by microorganisms. One
epidemiological study of petroleum refinery workers has reported elevations in standard mortality ratios for skin cancer along with a dose-response relationship
indicating an association between routine workplace exposure to petroleum or one of its constituents and skin cancer, particularly melanoma. Other studies have
been unable to confirm this finding.
Chronic solvent inhalation exposures may result in nervous system impairment and liver and blood changes. [PATTYS]
TOXICITY IRRITATION
[1] [CCINFO-Shell]
naphtha petroleum, heavy, Dermal (rabbit) LD50: >1900 mg/kg
hydrotreated [1] [EXXON]
Oral (rat) LD50: >4500 mg/kg
None reported
TOXICITY IRRITATION
polyglycerol oleate
Not Available Not Available
TOXICITY IRRITATION
kaolin, calcined
Oral (rat) LD50: >2000 mg/kg [1] Not Available
TOXICITY IRRITATION
[2] Eye (rabbit): 100 mg/1h - mild
polydimethylsiloxane Dermal (rabbit) LD50: >2000 mg/kg
[2]
Oral (rat) LD50: >17000 mg/kg
TOXICITY IRRITATION
sorbitan sesquioleate Not Available Eye (rabbit): 3 mg mild
Skin (rabbit): 0.45 mg mild
TOXICITY IRRITATION
distillates, petroleum,
Dermal (rabbit) LD50: >2000 mg/kg [1] [CCINFO-Shell]
middle, hydrotreated
[1] None reported [EXXON]
Oral (rat) LD50: >5000 mg/kg
TOXICITY IRRITATION
water
[2] Not Available
Oral (rat) LD50: >90000 mg/kg
Legend: 1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2.* Value obtained from manufacturer's SDS. Unless otherwise specified data
extracted from RTECS - Register of Toxic Effect of chemical Substances
for petroleum:
This product contains benzene which is known to cause acute myeloid leukaemia and n-hexane which has been shown to metabolize to compounds which are
neuropathic.
This product contains toluene. There are indications from animal studies that prolonged exposure to high concentrations of toluene may lead to hearing loss.
This product contains ethyl benzene and naphthalene from which there is evidence of tumours in rodents
Carcinogenicity: Inhalation exposure to mice causes liver tumours, which are not considered relevant to humans. Inhalation exposure to rats causes kidney
tumours which are not considered relevant to humans.
Mutagenicity: There is a large database of mutagenicity studies on gasoline and gasoline blending streams, which use a wide variety of endpoints and give
NAPHTHA PETROLEUM, predominantly negative results. All in vivo studies in animals and recent studies in exposed humans (e.g. petrol service station attendants) have shown negative
HEAVY, HYDROTREATED results in mutagenicity assays.
Reproductive Toxicity: Repeated exposure of pregnant rats to high concentrations of toluene (around or exceeding 1000 ppm) can cause developmental
effects, such as lower birth weight and developmental neurotoxicity, on the foetus. However, in a two-generation reproductive study in rats exposed to gasoline
vapour condensate, no adverse effects on the foetus were observed.
Human Effects: Prolonged/ repeated contact may cause defatting of the skin which can lead to dermatitis and may make the skin more susceptible to irritation
and penetration by other materials.
Lifetime exposure of rodents to gasoline produces carcinogenicity although the relevance to humans has been questioned. Gasoline induces kidney cancer in
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male rats as a consequence of accumulation of the alpha2-microglobulin protein in hyaline droplets in the male (but not female) rat kidney. Such abnormal
accumulation represents lysosomal overload and leads to chronic renal tubular cell degeneration, accumulation of cell debris, mineralisation of renal medullary
tubules and necrosis. A sustained regenerative proliferation occurs in epithelial cells with subsequent neoplastic transformation with continued exposure. The
alpha2-microglobulin is produced under the influence of hormonal controls in male rats but not in females and, more importantly, not in humans.
For Group E aliphatic esters (polyol esters):
According to a classification scheme described by the American Chemistry Council' Aliphatic Esters Panel, Group E substances are esters of monoacids,
mainly common fatty acids, and trihydroxy or polyhydroxyalcohols or polyols, such as pentaerythritol (PE), 2-ethyl-2-(hydroxymethyl)- 1,3-propanediol or
trimethylolpropane (TMP), and dipentaerythritol (diPE). The Group E substances often are referred to as "polyol esters" The polyol esters are unique in their
chemical characteristics since they lack beta-tertiary hydrogen atoms, thus leading to stability against oxidation and elimination. The fatty acids often range
from C5-C10 to as high as C18 (e.g., oleic, stearic, isostearic, tall oil fatty acids) in carbon number and generally are derived from naturally occurring
sources. Group E esters may have multiple ester linkages and may include mixed esters derived from different carbon-length fatty acid mixtures. The lack of
beta-tertiary hydrogen atoms in the structure of the polyol esters makes them characteristically and chemically stable against oxidation and elimination in
comparison to other ester classes or groups. For these reasons, trimethylolpropane (TMP) and pentaerythritol (PE) esters with fatty acids of C5 to C10
carbon-chain length have applications as synthetic lubricants for passenger car motor oil and military and civilian jet engines. TMP and PE esters of C18
acids (e.g., isostearic and oleic acids) also have found use in synthetic lubricant applications, including refrigeration lubricants and hydraulic fluids. Because
of their higher thermal stability characteristics, they also find use in a variety of high temperature applications such as industrial oven chain oils, high
temperature greases, fire resistant transformer coolants and turbine engines
Polyol esters that are extensively esterified also have greater polarity, less volatility and enhanced lubricity characteristics. Acute toxicity: Depending on the
degree of esterification, the polyol esters can be resistant or slow towards chemical or enzymatic hydrolysis (i.e., esterase or lipases) as a result of steric
hindrance. PE and diPE esters that are capable of being enzymatically hydrolyzed will generate pentaerythritol or dipentaerythritol, and the corresponding fatty
acids which, for most of the Group E esters, are comprised mainly of oleic, linoleic and stearic acids as well as the fatty acids in the C5-10 carbon-length.
Similarly, TMP esters can undergo metabolism to yield trimethylolpropane (2-ethyl-2-hydroxymethyl-1,3-propanediol) and fatty acid constituents. Pentaerythritol
and trimethylolpropane have been reported to have a low order of toxicity The acute oral LD50 for these substances was greater than 2000 mg/kg indicating a
relatively low order of toxicity. The similarity in the low order of toxicity for these substances is consistent with their similar chemical structure and
physicochemical properties
Repeat dose toxicity: Polyol esters are generally well tolerated by rats in 28-day oral toxicity studies. NOAEL for these substances was 1000 mg/kg/day in
Sprague-Dawley rats. The TMP ester of heptanoic and octanoic acid did not produce signs of overt systemic toxicity at any dose levels tested (i.e., 100, 300,
and 1000 mg/kg/day). There were no treatment-related clinical in-life, functional observation battery, or gross postmortem findings. There were no treatment
POLYGLYCEROL OLEATE
related mortality, and no adverse effects on body weight, food consumption, clinical laboratory parameters, or organ weights. However, there were increased
numbers of hyaline droplets in the proximal cortical tubular epithelium of the 300 and 1000 mg/kg/day in male rats. Based on these findings (hyaline droplets),
the NOAEL for this polyol ester
was established at 100 mg/kg/day for male rats. Hyaline droplet formation observed in the male kidneys is believed to be a sex/species condition specific to only
male rats, which has little relevance to humans.
The results from these repeated dose dermal toxicity studies suggest that polyol esters exhibit a low order of toxicity following repeated application. This may be
attributable to similarities in their chemical structures, physicochemical properties, and common metabolic pathways (i.e., esters can be enzymatically
hydrolyzed to the corresponding polyalcohol and the corresponding fatty acids) The polyol, hexanedioic acid, mixed esters with decanoic acid, heptanoic acid,
octanoic acid and PE, was applied to the skin of groups of 10 (male and female) rats for five days a week for four (4) weeks at dose levels of 0, 125, 500 and
2000 mg/kg/day. Treated animals exhibited no signs indicative of systemic toxicity. No visible signs of irritation were observed a treatment sites.
Microscopically, treated skin (viz., greater than or equal to 500 mg/kg/day) exhibited a dose-related increased incidence and severity of hyperplasia and
hyperkeratosis of the epidermis and sebaceous gland hyperplasia. These effects were reversible. None of the minor changes in haematology and serum
chemistry parameters were considered biologically significant. High dose females (2000 mg/kg/day) exhibited a significant increase in relative adrenal and
brain weights when compared to the controls. These differences were attributed to the lower final body weight of the female animals. The NOAEL in this study
for systemic toxicity was established as 500 mg /kg/day and 125 mg/kg/day for skin irritation.
Reproductive and developmental toxicity: Since metabolism of the polyol esters can occur, leading to the generation of the corresponding fatty acids and
the polyol alcohol (such as pentaerthyritol, trimethylolpropane, and dipentaerythritol), the issue of whether these metabolites may pose any potential
reproductive/developmental toxicity concerns is important.. However, the polyol alcohols such as pentaerthyritol, trimethylolpropane, and dipentaerythritol, would
be expected to undergo further metabolism, conjugation and excretion in the urine. Available evidence indicates that these ester hydrolysates (i.e., hydrolysis
products), primarily fatty acids (e.g., heptanoic, octanoic, and decanoic acids) and secondarily the polyol alcohols should exhibit a low order of reproductive
toxicity. it can be concluded that this group of high molecular weight polyol esters should not produce profound reproductive effects in rodents.
Genotoxicity: Polyols tested for genetic activity in the Salmonella assay, have been found to be inactive. Several polyol esters have been adequately tested for
chromosomal mutation in the in vitro mammalian chromosome aberration assay, and all were inactive. Two TMP esters were also tested for in vivo
chromosomal aberration in rats, and both demonstrated no activity. Thus, it is unlikely that these substances are chromosomal mutagens.
For siloxanes:
Effects which based on the reviewed literature do not seem to be problematic are acute toxicity, irritant effects, sensitization and genotoxicity.
Some studies indicate that some of the siloxanes may have endocrine disrupting properties, and reproductive effects have caused concern about the possible
effects of the siloxanes on humans and the environment.
Only few siloxanes are described in the literature with regard to health effects, and it is therefore not possible to make broad conclusions and comparisons of
the toxicity related to short-chained linear and cyclic siloxanes based on the present evaluation. Data are primarily found on the cyclic siloxanes D4
(octamethylcyclotetrasiloxane)
and D5 (decamethylcyclopentasiloxane) and the short-linear HMDS (hexamethyldisiloxane).
These three siloxanes have a relatively low order of acute toxicity by oral, dermal and inhalatory routes and do not require classification for this effect.
They are not found to be irritating to skin or eyes and are also not found sensitizing by skin contact. Data on respiratory sensitization have not been identified.
Subacute and subchronic toxicity studies show that the liver is the main target organ for D4 which also induces liver cell enzymes. This enzyme induction
contributes to the elimination of the substance from the tissues. Primary target organ for D5 exposure by inhalation is the lung. D5 has an enzyme induction
profile similar to that of D4. Subacute and subchronic inhalation of HMDS affect in particular the lungs and kidneys in rats.
None of the investigated siloxanes show any signs of genotoxic effects in vitro or in vivo. Preliminary results indicate that D5 has a potential carcinogenic
effect.
POLYDIMETHYLSILOXANE D4 is considered to impair fertility in rats by inhalation and is classified as a substance toxic to reproduction in category 3 with the risk phrase R62 ('Possible
risk of impaired fertility').
The results of a study to screen for oestrogen activity indicate that D4 has very weak oestrogenic and antioestrogenic activity and is a partial agonist (enhances
the effect of the estrogen). It is not uncommon for compounds that are weakly
oestrogenic to also have antioestrogenic properties. Comparison of the oestrogenic potency of D4 relative to ethinyloestradiol (steroid hormone) indicates that
D4 is 585,000 times less potent than ethinyloestradiol in the rat stain Sprague- Dawley and 3.7 million times less potent than ethinyloestradiol in the Fisher-344
rat strain. Because of the lack of effects on other endpoints designated to assess oestrogenicity, the oestrogenicity as mode of action for the D4 reproductive
effects has been questioned. An indirect mode of action causing a delay of the LH (luteinising hormone) surge necessary for optimal timing of ovulation has
been suggested as the mechanism.
Based on the reviewed information, the critical effects of the siloxanes are impaired fertility (D4) and potential carcinogenic effects (uterine tumours in
females). Furthermore there seem to be some effects on various organs following
repeated exposures, the liver (D4), kidney (HMDS) and lung (D5 and HMDS) being the target organs.
A possible oestrogenic effect contributing to the reproductive toxicity of D4 is debated. There seems however to be some indication that this toxicity may be
caused by another mechanism than oestrogen activity
No toxic response noted during 90 day subchronic inhalation toxicity studies The no observable effect level is 450 mg/m3. Non-irritating and non-sensitising in
human patch test. [Xerox]*
The material may cause skin irritation after prolonged or repeated exposure and may produce a contact dermatitis (nonallergic). This form of dermatitis is often
SORBITAN SESQUIOLEATE characterised by skin redness (erythema) and swelling epidermis. Histologically there may be intercellular oedema of the spongy layer (spongiosis) and
intracellular oedema of the epidermis.
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Toxicity
Ingredient Endpoint Test Duration (hr) Species Value Source
naphtha petroleum, heavy,
EC50 96 Algae or other aquatic plants 64mg/L 2
hydrotreated
kaolin, calcined LC50 96 Fish 0.078-0.108mg/L 2
kaolin, calcined EC50 48 Crustacea 1.5mg/L 2
kaolin, calcined EC50 96 Algae or other aquatic plants 0.024mg/L 2
kaolin, calcined NOEC 72 Algae or other aquatic plants >=0.004mg/L 2
polydimethylsiloxane LC50 96 Fish 3.16mg/L 4
sorbitan sesquioleate LC50 96 Fish >100mg/L 2
distillates, petroleum,
NOEC 48 Crustacea =10mg/L 1
middle, hydrotreated
water EC50 384 Crustacea 199.179mg/L 3
water EC50 96 Algae or other aquatic plants 8768.874mg/L 3
water LC50 96 Fish 897.520mg/L 3
Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity 3. EPIWIN Suite V3.12 -
Legend: Aquatic Toxicity Data (Estimated) 4. US EPA, Ecotox database - Aquatic Toxicity Data 5. ECETOC Aquatic Hazard Assessment Data 6. NITE (Japan) -
Bioconcentration Data 7. METI (Japan) - Bioconcentration Data 8. Vendor Data
For surfactants:
Environmental fate:
Octanol/water partition coefficients cannot easily be determined for surfactants because one part of the molecule is hydrophilic and the other part is hydrophobic. Consequently they tend to
accumulate at the interface and are not extracted into one or other of the liquid phases. As a result surfactants are expected to transfer slowly, for example, from water into the flesh of fish. During
this process, readily biodegradable surfactants are expected to be metabolised rapidly during the process of bioaccumulation. This was emphasised by the OECD Expert Group stating that
chemicals are not to be considered to show bioaccumulation potential if they are readily biodegradable.
Several anionic and nonionic surfactants have been investigated to evaluate their potential to bioconcentrate in fish. BCF values (BCF - bioconcentration factor) ranging from 1 to 350 were found.
These are absolute maximum values, resulting from the radiolabelling technique used. In all these studies, substantial oxidative metabolism was found resulting in the highest radioactivity in the
gall bladder. This indicates liver transformation of the parent compound and biliary excretion of the metabolised compounds, so that "real" bioconcentration is overstated. After correction it can be
expected that "real" parent BCF values are one order of magnitude less than those indicated above, i.e. "real" BCF is <100. Therefore the usual data used for classification by EU directives to
determine whether a substance is "Dangerous to the "Environment" has little bearing on whether the use of the surfactant is environmentally acceptable.
Ecotoxicity:
Surfactant should be considered to be toxic (EC50 and LC50 values of < 10 mg/L) to aquatic species under conditions that allow contact of the chemicals with the organisms. The water solubility of
the chemicals does not impact the toxicity except as it relates to the ability to conduct tests appropriately to obtain exposure of the test species. The acute aquatic toxicity generally is considered to
be related to the effects of the surfactant properties on the organism and not to direct chemical toxicity
For hydrocarbons:
Environmental fate:
The lower molecular weight hydrocarbons are expected to form a "slick" on the surface of waters after release in calm sea conditions. This is expected to evaporate and enter the atmosphere where
it will be degraded through reaction with hydroxy radicals.
Some hydrocarbon will become associated with benthic sediments, and it is likely to be spread over a fairly wide area of sea floor. Marine sediments may be either aerobic or anaerobic. The
material, in probability, is biodegradable, under aerobic conditions (isomerised olefins and alkenes show variable results). Evidence also suggests that the hydrocarbons may be degradable under
anaerobic conditions although such degradation in benthic sediments may be a relatively slow process.
Under aerobic conditions hydrocarbons degrade to water and carbon dioxide, while under anaerobic processes they produce water, methane and carbon dioxide.
Alkenes have low log octanol/water partition coefficients (Kow) of about 1 and estimated bioconcentration factors (BCF) of about 10; aromatics have intermediate values (log Kow values of 2-3 and
BCF values of 20-200), while C5 and greater alkanes have fairly high values (log Kow values of about 3-4.5 and BCF values of 100-1,500
The estimated volatilisation half-lives for alkanes and benzene, toluene, ethylbenzene, xylene (BTEX) components were predicted as 7 days in ponds, 1.5 days in rivers, and 6 days in lakes. The
volatilisation rate of naphthalene and its substituted derivatives were estimated to be slower.
Indigenous microbes found in many natural settings (e.g., soils, groundwater, ponds) have been shown to be capable of degrading organic compounds. Unlike other fate processes that disperse
contaminants in the environment, biodegradation can eliminate the contaminants without transferring them across media.
The final products of microbial degradation are carbon dioxide, water, and microbial biomass. The rate of hydrocarbon degradation depends on the chemical composition of the product released to
the environment as well as site-specific environmental factors. Generally the straight chain hydrocarbons and the aromatics are degraded more readily than the highly branched aliphatic
compounds. The n-alkanes, n-alkyl aromatics, and the aromatics in the C10-C22 range are the most readily biodegradable; n-alkanes, n-alkyl aromatics, and aromatics in the C5-C9 range are
biodegradable at low concentrations by some microorganisms, but are generally preferentially removed by volatilisation and thus are unavailable in most environments; n-alkanes in the C1-C4
ranges are biodegradable only by a narrow range of specialised hydrocarbon degraders; and n-alkanes, n-alkyl aromatics, and aromatics above C22 are generally not available to degrading
microorganisms. Hydrocarbons with condensed ring structures, such as PAHs with four or more rings, have been shown to be relatively resistant to biodegradation. PAHs with only 2 or 3 rings
(e.g., naphthalene, anthracene) are more easily biodegraded. In almost all cases, the presence of oxygen is essential for effective biodegradation of oil. The ideal pH range to promote
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biodegradation is close to neutral (6-8). For most species, the optimal pH is slightly alkaline, that is, greater than 7.
All biological transformations are affected by temperature. Generally, as the temperature increases, biological activity tends to increase up to a temperature where enzyme denaturation occurs.
Atmospheric fate: Alkanes, isoalkanes, and cycloalkanes have half-lives on the order of 1-10 days, whereas alkenes, cycloalkenes, and substituted benzenes have half-lives of 1 day or less.
Photochemical oxidation products include aldehydes, hydroxy compounds, nitro compounds, and peroxyacyl nitrates. Alkenes, certain substituted aromatics, and naphthalene are potentially
susceptible to direct photolysis.
Ecotoxicity:
Hydrocarbons are hydrophobic (high log Kow and low water solubility). Such substances produce toxicity in aquatic organisms by a mechanism referred to as "non-polar narcosis" or "baseline"
toxicity. The hydrophobicity increases and water solubility decreases with increasing carbon number for a particular class of hydrocarbon. Substances with the same carbon number show
increased hydrophobicity and decreased solubility with increasing saturation. Quantitative structure activity relationships (QSAR), relating both solubility and toxicity to Kow predict that the water
solubility of single chemical substances decreases more rapidly with increasing Kow than does the acute toxicity.
Based on test results, as well as theoretical considerations, the potential for bioaccumulation may be high. Toxic effects are often observed in species such as blue mussel, daphnia, freshwater
green algae, marine copepods and amphipods.
The values of log Kow for individual hydrocarbons increase with increasing carbon number within homologous series of generic types. Quantitative structure activity relationships (QSAR), relating
log Kow values of single hydrocarbons to toxicity, show that water solubility decreases more rapidly with increasing Kow than does the concentration causing effects. This relationship varies
somewhat with species of hydrocarbon, but it follows that there is a log Kow limit for hydrocarbons, above which, they will not exhibit acute toxicity; this limit is at a log Kow value of about 4 to 5. It
has been confirmed experimentally that for fish and invertebrates, paraffinic hydrocarbons with a carbon number of 10 or higher (log Kow >5) show no acute toxicity and that alkylbenzenes with a
carbon number of 14 or greater (log Kow >5) similarly show no acute toxicity.
QSAR equations for chronic toxicity also suggest that there should be a point where hydrocarbons with high log Kow values become so insoluble in water that they will not cause chronic toxicity,
that is, that there is also a solubility cut-off for chronic toxicity. Thus, paraffinic hydrocarbons with carbon numbers of greater than 14 (log Kow >7.3) should show no measurable chronic toxicity.
Experimental support for this cut-off is demonstrated by chronic toxicity studies on lubricant base oils and one “heavy” solvent grade (substances composed of paraffins of C20 and greater) which
show no effects after exposures to concentrations well above solubility.
The initial criteria for classification of substances as dangerous to the aquatic environment are based upon acute toxicity data in fish, daphnids and algae. However, for substances that have low
solubility and show no acute toxicity, the possibility of a long-term or chronic hazard to the environment is recognised in the R53 phrase or so-called "safety net". The R53 assignment for possible
long-term harm is a surrogate for chronic toxicity test results and is triggered by substances that are both bioaccumulative and persistent. The indicators of bioaccumulation and persistence are
taken as a BCF > 100 (or log Kow > 3 if no BCF data) and lack of ready biodegradability. For low solubility substances which have direct chronic toxicity data demonstrating no chronic toxicity at 1
mg/L or higher, these data take precedence such that no classification for long term toxicity is required.
Drinking Water Standards: hydrocarbon total: 10 ug/l (UK max.).
DO NOT discharge into sewer or waterways.
Bioaccumulative potential
Ingredient Bioaccumulation
water LOW (LogKOW = -1.38)
Mobility in soil
Ingredient Mobility
water LOW (KOC = 14.3)
Labels Required
Marine Pollutant NO
HAZCHEM Not Applicable
Air transport (ICAO-IATA / DGR): NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS
Sea transport (IMDG-Code / GGVSee): NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS
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Not Applicable
Safety, health and environmental regulations / legislation specific for the substance or mixture
Other information
Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by the Chemwatch Classification committee using
available literature references.
A list of reference resources used to assist the committee may be found at:
www.chemwatch.net
The SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks in the workplace or other
settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, frequency of use and current or available engineering controls must be considered.
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end of SDS