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This document summarizes a drug study of the antibiotic Co-trimoxazole. It is used to treat uncomplicated UTIs caused by susceptible bacteria as well as acute otitis media in children. It works by inhibiting nucleic acid and protein synthesis in bacteria. Common side effects include rash, fever, nausea and vomiting. Nursing responsibilities include performing culture/sensitivity tests before use, protecting tablets from light, arranging blood counts during therapy, and discontinuing the drug if blood elements are reduced.
This document summarizes a drug study of the antibiotic Co-trimoxazole. It is used to treat uncomplicated UTIs caused by susceptible bacteria as well as acute otitis media in children. It works by inhibiting nucleic acid and protein synthesis in bacteria. Common side effects include rash, fever, nausea and vomiting. Nursing responsibilities include performing culture/sensitivity tests before use, protecting tablets from light, arranging blood counts during therapy, and discontinuing the drug if blood elements are reduced.
This document summarizes a drug study of the antibiotic Co-trimoxazole. It is used to treat uncomplicated UTIs caused by susceptible bacteria as well as acute otitis media in children. It works by inhibiting nucleic acid and protein synthesis in bacteria. Common side effects include rash, fever, nausea and vomiting. Nursing responsibilities include performing culture/sensitivity tests before use, protecting tablets from light, arranging blood counts during therapy, and discontinuing the drug if blood elements are reduced.
FREQUENCY (prescribed and INDICATION MECHANISM OF ADVERSE REACTIONS recommended) ACTION (by system) Uncomplicated Trimethoprim inhibits the Side Effects UTIs caused by Tablets – 100, 200 mg susceptible strains synthesis of nucleic acids Rash of Escherichia and proteins in Pruritus coli, Proteus susceptible bacteria; the Fever mirabilis, Klebsiella bacterial enzyme Epigastric distress pneumoniae, Entero bacter species, and involved in this reaction Nausea coagulase- is more readily inhibited Vomiting negative Staphyloco than the mammalian ccusspecies, including S. enzyme. Saprophyticus. Sulfamethoxazole acts as Treatment of acute a false-substrate inhibitor otitis media due to of dihydropteroate susceptible strains of S. synthetase. Sulfonamides Pneumoniae and Ha such as sulfamethoxazole emophilus are analogues of p- influenzae in aminobenzoic acid children. NURSING RESPONSIBILITIES CONTRAINDICATION/S Unlabeled uses: (PABA) and (at areleast 10) With dapsone for competitive inhibitors of Contraindicated with allergy to treatment of initial the enzyme; inhibiting trimethoprim and sulfamethoxazole, Perform episodes of culture and sensitivity tests before beginning drug Pneumocystis the production of pregnancy (teratogenic in pre-clinical therapy. jiroveci (carinii) dihydropteroic acid. studies), megaloblastic anemia due Protect the 200mg tablets from exposure to light. pneumonia in to folate deficiency. Arrange patients who canfor regular, periodic blood counts during therapy. Use cautiously with hepatic Discontinue tolerate co- drug and consult with physician if any significant trimoxazole; reduction in any formed blood element occurs. or renal impairment, treatment and lactation. prevention of traveller’s diarrhea.