Bio3200: Human Physiology F2010

3 credits
MW3-4:20pm
Gen Lectures 100

Mark F.A. VanBerkum

5178 Biological Sciences Building
577-5554
mvb@wayne.edu
Description and Objective: To understand the basic principles of human
physiology. Major organ systems will be covered emphasizing the structure and
function AND regulation = PHYSIOLOGY

Basic cell biology & biochemistry very helpful – reviewed in first few chapters.
Represent baseline knowledge you are expected to have via prerequisites =
Bio1510/2600.

Bio3070*

Bio1510
Bio2600

Bio3100*
Bio32000
Text:

The text is REQUIRED reading.

students are responsible for ALL material

even if NOT specifically covered in class.

The text chosen is: Human Physiology: An

Integrated Approach with Interactive
Physiology, Fifth Edition by Dee Unglaub
Silverthorn [IBSN: 0321559398].

Fourth edition: Ok I think – BUT no guarantee

Communication:
Office hours: M & W: 1:30 to 2:30 pm
T 1-2 pm [ but NOT always]
You may also e-mail for a mutually convenient appointment.
answer only an ODD question or two via e-mail; if complicated find me
I do NOT reply to notes repeating announcements or found on BB

Class Web Site: Go to Pipeline and Blackboard [http://blackboard.wayne.edu/]

to access the class web site for most class handouts (syllabus, lecture notes
etc), which will be available as PDF files.

CHECK this site often, as I will try to upload a PDF file of my PowerPoint slides
before each class.

I also anticipate using an overhead or tablet so come prepared to take notes.

Attendance: Class attendance is mandatory for an exam day (see dates
below): failure to write an exam results in a zero (0). I strongly recommend
that you attend all classes to augment your own reading of the text and to
catch a glimpse of how I think/emphasize selected topics.

Timeliness: On exams dates do NOT arrive late!! You will not be allowed to
take the exam if you arrive after the first student has finished the exam and left
the room (and some students finish in less than 15 min). Assuming you sit for
the exam, no additional time will be provided.

Religious Conflicts: Tell me NOW – i.e. by Sept. 8, 2010

i.e. look at ALL exam dates now. No make-up exams will be given unless you
have notified me in writing by the above date.

ADD/DROP POLICY: I follow all university policies on adding or dropping this

class. Contact Mrs. Hunter, Biology Advisor for help in this area.
Individuals with Disabilities: Register with Student Disability Services (SDS)
for coordination of your academic accommodations, then co-ordinate with me.

UNEXPECTED UNIVERSITY CLOSURES: will hear via:

1. the University Newsline (313) 577-5345 *
2. WSU Homepage (www.wayne.edu) *
3. WSU Pipeline (www.pipeline.wayne.edu) *
4. WDET-FM (Public Radio 101.9)
5. by other local radio and television stations

If the University is officially closed on an exam day, the exam will be held on the
next regularly scheduled class day.

Any specific issue not covered by this syllabus will be resolved using University
policies.

Disputes that cannot be resolved following the guidelines present in this syllabus will
be resolved by following the guidelines of the University “Student Due Process”.
 GRADING: EXAM DATES:
4 class exams, and a cumulative final exam. Plus
25 ‘bonus’ clicker points Wed. Sept. 22, 2010
EXAM DATES: will NOT change, content may Mon. Oct. 18, 2010
NO MAKE-UP EXAMS will be given as you drop Wed. Nov. 10, 2010
lowest, if don’t write = zero
multiple choice with problem solving and reasoning.
Mon. Dec. 6, 2010
Old exams on Blackboard, NOT section 3
Final: FRIDAY Dec.
The FINAL Exam is CUMULATIVE, worth 200 points
17, 2010 AT 1:20 pm
scheduled FRIDAY Dec. 17 starting at 1:20 am (NOTE TIME AND DAY).
DO NOT be late, as no extra time is provided.
Make-up exam: REQUIRE documented reason (e.g. illness, or family emergency)
signed by a non-family professional person (e.g. doctor, police officer, funeral director
etc.):
travel plans will NOT be used as a reason to take a make up.
Without a note you do NOT write a make up AND you get a zero
a make-up exam may not occur until January.
Grade Calculation:
93-100% A
A letter grade is calculated after total score normalized
(averaged) to the score of the second highest
90-92 A-
student. 86-89 B+
82-85 B
This number converted to percentage and assigned a
letter grade according to the table at right.
80-81 B-
76-79 C+
72-75 C
Exam I 100 points top 3 scores
Exam II 100 points = 300 points
70-71 C-
Exam III 100 points 67-69 D+
Exam IV 100 points 63-66 D
Final Ex = 200 points
TOTAL = 500 points
60-62 D-
+ clicker bonus points 25 59 or less F
Clicker Bonus Points:
starts for points AFTER Exam 1 (although Qs will be
used sooner)

25 points for voluntary/optional use

added to exam scores
if answer 90% of all questions asked = 25 points, pro-
rated accordingly

ONLY accept answers received by my computer

because you are here.

If I see multiple clickers in use – all will be confiscated

– and returned to students during office hours – ALL
students involved will LOSE any chance for bonus
points and any funds spent on getting them.

Questions?
Physiology
= INTEGRATION & Homeostasis between body systems

Internal and External environments.

It is ALL about homeostasis

Input Signal

Controller

Output
Signal

Figure 1-4
Concept Mapping = Flow
Charts

allows you to create a basic

structure that lets you “hang”
the details onto

Figure 1-5b
Read & understand the section on graphs and how to “read” them (i.e. convert
them into a sentence describing the relationship between dependent and
independent variables -- the text is full of them!
Table 1-2
 Cell Communication: Recap from 2600
Signal Transduction - conversion of one type of signal to another

ions

+ a fifth one - “autocrine” --

self-regulation, feedback to
self
Figure 6-2 - Overview
Figure 6-1 - Overview
Signal transduction:
conversion of an extracellular signal
to intracellular signal
ligand

2600:
In Bio2600: we used
concept of

hydrophilic
(= lipophobic)

vs

hydrophobic
(= lipophilic)

Figure 6-4 (2 of 3)
general types of membrane receptors:

Figure 6-5
2600

review Protein Kinase A and C cascades

Figure 6-6
Ligand-Receptor interaction: key communication step
  KINETICS:
  degrees of specificity
  saturation
  maximum conductance rate

  regulated (gated)
  inhibitable (biologically &/or
pharmacologically)

Agonist and Antagonists

see pgs. 40-45 for review

on protein interactions
and kinetics
Tyrosine kinase signaling

Figure 6-10
Homeostasis: maintain a relatively stable environment

need to detect environment, assess if

OK from either direction, and have
mechanism to fix

= variety of CONTROL SYSTEMS

Canon’s Postulates:
1. nervous system plays role in
organism fitness
2. tonic control is often used
- set at a mid-point so can go UP & DOWN

3. Antagonistic control -- positive and

negative feedback loops regulate
activity
4. ligand and receptor specificity
endocrine – one hormone,
many receptors = differential response
Figure 6-19
Control mechanism – two phases:

Response loop: Afferent

and integration
center

Feedback loop: Efferent

Figure 6-23
tonic control of blood vessel
diameter

Antagonist control of heart rate

Homeostasis:
Multiple levels of control LOCAL vs Reflex control:

Figure 6-22
means body must “integrate” information

and often it oscillates near a set point but not exactly on it as

you get feedback fromboth sides of the set point. (over shoot/
undershoot)
Figure 6-26
Control systems
•  vary in specificity, speed and duration
•  simple to complex,
•  mixed endocrine & neuronal loops
•  every connection point is an integration point
(i.e. cell has to make a decision to do something or not)
as we cover chp 7
think about these
chain of events

Figure 6-31 - Overview