Mechanism of Fever
PGE2:
Can occur as a result of hematogenous or
1) Maintains PDA lymphatic seeding from a distant site or
2) Stimulates Pain
3) Increases temperature set point spread from an adjacent site.
4) Increases Uterine Tone Inflammation os psoas muscle causes pain
when the his is extended (psoas sign)
PGI2:
1) Inhibits Platelet aggregation s/s: Fever, back or flank pain, inguinal mass,
2) Decreases Uterine Tone
difficulty walking
Risk factors: Diabetes, IV drug use, HIV
Osteomyelitis
Children:
Caused transient bacteremia
metaphysis
Adults:
Cause by open wound bactermia
Epiphysis
Pterion where the frontal, parietal, temporal and sphenoid bones meet in the skull.
Pterion fractures:
Ferritin
TIBC
Factors that ↑ EPO production
hypoxemia (↓PO2)
severe anemia
left shift O2 binding curve
high altitude
↓ SaO2 (carbon
monoxide/methemoglobinemia)
Pathological (ectopic):
Renal cell carcinoma &Hepatocellular carcinoma
Packed red blood cells/whole blood transfusions contain citrate citrate is a calcium chelator
hypocalcemia parasthesis