Povidone-Iodine Solution

(10%), I
1. Formulations
No. 1 No. 2
PVP-Iodine 30/06 (BASF) .............................10.0 g 10.0 g
Lutrol F 127 [1] ...................................................– 0.3 g
Lutrol E 400 [1] ...................................................– 0.5 g
Citric acid 0.1 molar solution ........................43.6 g 43.2 g
Na2HPO4 · 12H2O 0.2 molar solution ..........46.4 g 46.0 g
2. Manufacturing
Dissolve the PVP-Iodine (and Lutrol F 127) in the mixture of the buffer
solutions (and Lutrol E 400).
3. Properties of the solutions
Brown clear solutions having a low viscosity and pH of about 4.5.
4. Chemical stability
Formulation No. 1 (20–25 °C, 1 year)
0 Month 6 Months 12 Months
Available iodine 100% 100% 96%
pH 4.4 4.1 4.4
Formulation No. 2 (52 °C, 14 days)
Loss of available iodine 6.3%
BASF Pharma

Povidone-Iodine Solution
(10%), II
1. Formulation
I. PVP-Iodine 30/06 (BASF) ......................10.00 g
II. Texapon K 12 (Henkel) ............................0.03 g
III. Sodium biphosphate (Na2HPO4) .............0.14 g
Sodium citrate........................................0.03 g
Sodium hydroxyde solution, 1 molar ........2.08 g
Glycerol .................................................1.00 g
Water...................................................86.42 g
2. Manufacturing
Dissolve Texapon K 12 (II) in solution III and add slowly PVP-Iodine to the
well stirred solution.
3. Properties of the solution
Brown transparent liquid having a pH of 4.5.
4. Chemical stability
After production After 14 days/52 °C
pH ...............................................4.5 3.5
Available iodine .......................1.08% 1.03%
Loss of iodine ..................................– 4.6%
BASF

Povidone-Iodine Teat-Dip Solution

for Cattles (3%)
1. Formulation
PVP-Iodine 30/06 (BASF) ........................3.00 g
Glycerol .................................................8.00 g
Glacial acetic acid ..................................0.80 g
Sodium hydroxide solution, 50%.............0.35 g
Water ..............................................ad 100.0 g
2. Manufacturing
Mix all liquid components and dissolve PVP-Iodine.
3. Properties of the solution
Brown transparent liquid having a pH of 4.3.
4. Chemical

Povidone-Iodine Mastitis Cream for Cattles

(10%)
1. Formulation
I. PVP-Iodine 30/06 (BASF) ...........................10 g
II. Liquid paraffin ...........................................10 g
Vaseline ....................................................10 g
Cetylstearyl alcohol.................................5 – 8 g
Cremophor A 6 [1].......................................2 g
Cremophor A 25 [1] .....................................2 g
III. Propylene glycol Pharma [1].........................5 g
Water .................................................53 – 56 g
2. Manufacturing
Dissolve PVP-Iodine I in the solvents III. Mix the components II by
heating, stir the solution I/III in the molten mixture II and cool by stirring.
3. Stability (52 °C, 14 days)
The cream is physically stable and shows no loss of iodine.
BASF

Povidone-Iodine Gels
(10%)
1. Formulations
No. 1 No. 2
I. PVP-Iodine 30/06 (BASF) ........................10.0 g 10.0 g
Sodium chloride .............................................– 1.0 g
II. Lutrol F 127 [1] .......................................20.0 g 20.0 g
III. Sodium hydroxide solution, 1 molar.................– 7.9 g
IV. Water.....................................................70.0 g 61.1 g
2. Manufacturing
Dissolve the solids (I) in water (IV), cool to about 6 °C, dissolve Lutrol F
127 (II) and adjust the pH value with the sodium hydroxide solution (III).
Maintain cool until all air bubbles escaped.
3. Properties of the gels
No. 1 No. 2
Viscosity 61,000 mPa · s 54,000 mPa · s
(Brookfield, 23 °C)
pH value (20 % in water) 2.2 4.6
4. Stability (14 days, 52 °C)
No. 1 No. 2
Viscosity 58,000 mPa · s 45,000 mPa · s
(Brookfield, 23 °C)
pH value (20 % in water) 1.9 2.7
Loss of available iodine 10.2% 8.0%
BASF Fine