Xpert

MRSA/SA
BC

Xpert MRSA/SA BC
®

Accurate Detection of MRSA and SA in Positive

Blood Culture Specimens in About an Hour

A better way.
In an era of escalating antimicrobial resistance and lack of new antibiotic discovery,
the most efficacious and timely method for S. aureus bacteremia detection and
antibiotic therapy with de-escalation are needed. The Xpert® MRSA/SA BC test,
in conjunction with an ID PharmD intervention, provides increased clinical and
economic benefits.”

Debra Goff, PharmD.

Infectious Disease Specialist
The Ohio State University Medical Center

the need the solution

Bloodstream infections are a major healthcare concern:
• Severe sepsis strikes 750,000 people annually in the
U.S., resulting in mortality rates of up to 200,000 per
year.1 Methicillin-resistant Staph aureus (MRSA) and
Staph aureus (SA) are the causative pathogen in up to
35% of severe sepsis cases.2
• Current culture-based lab testing methods for gram
positive blood culture bottles require an additional 18-48
hours for determination of MRSA or SA.
• Without timely results, clinicians often employ empiric
treatments, using costly and inadequate antimicrobials
that contribute to increased drug resistance.
On-demand molecular testing — an ideal solution:
• Accurate molecular detection of MRSA or SA from a
gram-positive blood culture sample in about an hour
• Simple test protocol can be run on all shifts to provide
results around-the-clock
• Provides clinicians actionable information when it is
most needed
• Easily integrates into your hospital’s bundle of
sepsis interventions
The Impact
A recent clinical study3 showed that using the Xpert® MRSA/SA BC test coupled with an infectious disease
pharmacist consultation resulted in:
• Switch to optimum antimicrobial therapy 1.7 days sooner
• Mean length of stay was reduced 6.2 days
• Mean hospital costs were $21,387 less per bacteremic patient

Impact on Patient management: “TEST AND TREAT”

4 to 36 hours additional 1-2 hrs additional 1-2 days

Patient Specimen
Presents Collected
with and Sent Blood Culture Positive
Septicemia for
Symptoms Testing

GeneXpert
MRSA/SA Optimize
Pathway with GeneXpert System BC Treat-
On-Demand ment
TAT < 1 hr

Optimize
Culture Treat-
Pathway with Traditional Testing
ment

COMPREHENSIVE APPROACH TO HAI Management & Control

Screening, Admissions, Diagnostic, ICU, Screening, ICU
ICU, Pre-Surgical Emergency Dept Microbiology Lab Hospital Ward Transplant Center

Xpert MRSA and
Xpert SA Nasal Complete
Admitted patients
colonized with
MRSA/SA increases
risk of infection of
themselves and others
Xpert MRSA/SA SSTI
Carriers of MRSA/SA
may result in skin &
soft tissue infections
Xpert MRSA/SA BC
Undiagnosed infections
can enter the blood
stream leading to sepsis
Xpert C. difficile/Epi Xpert vanA
Vancomycin treatment Prolonged treatment
reduces intestinal with vancomycin
floral exposing patient predisposes patient
to C. difficile to VRE
WORKFLOW:
3 Easy Steps
Total hands-on time: <1 Minute

1 2 3
Gently mix the sample Vortex and transfer Insert cartridge and
by hand, transfer a 50 uL the sample into start assay
aliquot to the elution S chamber
reagent vial using the
pipette provided

Xpert® MRSA/SA BC is a qualitative real-time PCR test for automated detection of S. aureus
and MRSA DNA directly from positive blood cultures
Catalog number

Xpert MRSA/SA BC (10 tests) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GXMRSASA-BC-10

Xpert SA Nasal Complete (10 tests) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GXSACOMP-10

Xpert MRSA (10 tests) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GXMRSA-100N-10
Xpert MRSA (120 tests) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GXMRSA-120
Xpert MRSA/SA SSTI (10 tests) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GXMRSA/SA-SSTI-10
Xpert C. difficile/Epi (10 tests) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GXCDIFF/EPI-10
Xpert C. difficile/Epi (120 tests) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GXCDIFF/EPI-120
Xpert vanA (10 tests) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GXVANA-10

References:
1. http://www.ihi.org/explore/Sepsis/Pages/default.aspx
2. Septic Shock; The Lancet; January 2005
3. Goff, D et al. An Antimicrobial Stewardship Program’s Impact with Rapid Polymerase Chain Reaction Methicillin-Resistant Staphylococcus aureus/S. aureus Blood Culture Test in
Patients with S. aureus Bacteremia. Clin.Infect. Dis. November 2010.

For In Vitro Diagnostic Use.

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