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Critical review on Naga Kalpas in Bhaishajyaratnavali

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IJEPP 2016, 2 (2), 59-71 Shobhnath et al

ISSN: 2455-5533

(www.ijepp.in)

Review Article

Critical review on Naga Kalpas in Bhaishajyaratnavali

Shobhnath Yadav1,Ashish Verma1,Dr. Galib2,B.J. Patgiri3,P.K. Prajapati4
1
PhD Scholar, 2Associate Prof., 3HOD, RS & BK, 4Director
IPGT & RA, Gujarat Ayurved University, Jamnagar-361008

Abstract

Lead is a soft ,malleable poor metal, also considered to be one of the heavy metal. Naga is one among metals (puti loha)
present in the earth‘s crust which is .0013% found and used in deregulation of metabolism cures disease and metabolic
disease characterized by of human body. The administration of Naga Bhasma in Ayurvedic classics also quote significant
information. Naga formulation are the unique compound herbo metalic formulations where bhasm is used as a major and
minor ingredient. Some research works has been published on critical review Naga kalpas in different literature but till date
no work has been found published on different percentage of Naga & Naga Bhasm in kalpas of Bhaisajyaratnavali. Its book
is mention D&C act 1940 ,First schedule (serial No-9) containing different composition of Naga and Naga Bhasma .The total
53 kalps contain Naga Bhasm& Naga compound. Most of the latest formulation was compiled in Bhaisajyaratnavali. These
formulation has been taken from original references books. Taking a note of this it has been decided to calculate percentage
of Naga Bhasm, anupan, dose, therapeutic indications in different formulation. Unfortunately most of the Naga formulations
are not found in the market. Hence Pharmaceutical firms may bring these unique dosage forms in to the market to supply the
health care needs of the community. It is interesting that Naga preparations are used in Ayurveda in different medical
conditions a part from madhumeha. This leaves a scope for further researches on different composition of Naga and their
indications in many literature. Because a lot of have query on the uses of Naga (Lead) and their toxicity at different levels.

Keywords: Naga references, Naga kalpas, Lead percentage, Incineration.

.
*Corresponding author:
Key words: Ethnobotanical knowledge, Akamba people, Ethnonomedicines, Plant products, Eastern Kenya, Ukambani region.
Shobhnath Yadav
Email. shobhnathbhuims@gmail.com
Q.C. In-charge, Dhanvantari Unit, GSFDC Ltd, Vadodara, Gujarat

Quick Response Code:

IJEPP|April-June 2016|Vol 2|Issue 2 Page 59

IJEPP 2016, 2 (2), 59-71 Shobhnath et al
INTRODUCTION
In the past decade there has been renewed attention
and interest in the use of traditional medicine
globally. The golden period of Rasa Shastra, an off
shoot of Ayurveda popular from medieval (8-
11century)) period, mostly deals with therapeutic
utilization of metals and minerals.i
Bhaisajyaratnavali are the classics book which
have popularize in all direction part of India
(North-South-West-East)compiled all formulation
from different classics available at that time so its
was planed to screen out About 4500 ` of
formulations are explained in Bhaisajyaratnavali
classical texts compiled on basis of
Rogadhikar(total -70 Rogadhikar) with
combination of Bhasmas along with herbal
ingredients. Total number of Naga containing
formulation in Bhaisajyaratnavali are 53 out of
4500 formulation in which 8 formulation indicate
used as prameha. Relevant literature
Bhaisajyaratnavali reviewed togather information
about Naga Kalpas. Careful review shows that
there are around 53 formulation contain Naga
bhasm along with different proportion which are
frequently used. A simple change in the method of
preparation and ingredients can bring a change in
the action, indication, and efficacy. Hence, it is the
need of the hour to critically analyze the
formulations and the rationality behind it. This may
be a guideline for further research to unravel
Ayurveda. In our classics, Naga Bhasma is depicted
as Pramehaghnaii. Apakwa Naga Bhasm causes
various diseases like in Kustha, gulma, Raju,
Pandu, Jwara, Tridosapokapiii, Roga, Mriytuiv,
Kshay, Kamalav, Kilas, Sandhishoola,
pakchavadha, Anaha, Amasshot, Avabahuka,shula
vi
Kandu, Anilsadavii etc. and remove these
unwanted effect given various text viii,ix,x,xi advise
for swarna Bhasm, haritaki and sita internali take
for three days and Rasahridaya Tantra use as Go
mutra, kutuki karvellakaxii. India accounts has
largest number of people 50.8 million suffering
from diabetes in the world. Hence it is the need of
the hour to search some alternative from other
systems of medicine like Ayurveda. Naga Kalpas
can be a better alternative from Ayurveda. Till date,
no scientific comprehensive review has been done
on Naga Kalpas. Hence this study is undertaken.
Naga Kalpas are formulations which possess Naga
Bhasma (Lead sulphide) as the major ingredient
along with the other herbal ingredients. xiii Some of
IJEPP|April-June 2016|Vol 2|Issue 2
the formulations have use Naga sindoor in place
Naga bhasm.
BACKGROUND
The external use of Naga bhasm is described in
Charak Samhita for treatment of Mandal kustha xiv
In Sushruta samhita use as Traptyadi Ghana xv as
mandal kustha Acharya Charaka further elucidates
that every object can be a medicine if used wisely
with a logical thought (Yukthi).xvi Considering this
fact, the three forms of natural materials herbal,
mineral, and animal origins were subjected to trials
and their therapeutic values were established. Due
to the toxic nature of the minerals and metals, they
were less used for the internal administration
compared to herbs. Naga is heavy metal one of the
issue the article JAMA( the Journal of the American
Medical Association) titled ―Lead, Mercury, and
Arsenic in US- and Indian-Manufactured Ayurvedic
Conversion of metals into suitable consumable
medicinal form is found in the preparation. Some
researchers have been carried out on individual
Naga Kalpas like Naga Bhasma prepared arka
kshira(latex)xviiand prepared two different media
parad and herbal xviii .Mercurial containing
compound or its compounds preserve their potency
indefinitely. When well protected from moisture
and heat, they preserve their potency for a period of
about 5years (D&C rule 1945 ,161B)xix .
MATERIALS AND METHOD
Important texts of Ayurveda commencing from
Brihtraya to Rasa Ratna Samucchaya (RRS) to
Rasatarangini (RT) Rasendra SaraSamgraha
(RSS),Rasaprakash Sudhakar and Bhaishajya
Ratnavali (BR),Rasayogasagar (RYS) etc have
been the sources for Naga Kalpas. BR being a
comprehensive source for Naga Kalp was the main
source and the other important formulations are
selected from other classics and enumerated
according to the method of preparation. Only the
formulations having as Naga are considered for the
study. Quantity of Naga bhasm in few formulations
is quotedas ―Sarva dravya samam Nagam‖ which
means 50% of the formulation will be Naga
Bhasma(Incinerated lead). In other formulations the
quantity is calculated in accordance with the solid
constituents, where in the ingredients like
decoctions(Kwatha), fresh juices (Swarasa), ghee
(Ghrita -clarified butter), and honey (Madhu) are
not taken into consideration.
Page 60
IJEPP 2016, 2 (2), 59-71 Shobhnath et al
Calculation is based on the raw ingredients taken
prior to the pharmaceutical processes.
Method of calculation
Percentage of NB =100×weight of NB/weight of
total solid ingredients (including NB). E.g., in
Drvadasayas (B.R-Vatraktadhikar: 27/53-57) total
weight of all ingredients mineral and herbal is
280gm out of which 10gm is NB..Percentage of NB
is 100×10 g/280 g = 3.57, i.e., Ardarak swarasa are
not considered for calculation.
RESEARCH WORK ON NĀGA BHASMA:
Nāga bhasma at 160 therapeutic equivalent dose
(TED) level was found to be safe in acute toxicity.
while nontoxic effect was observed in chronic
toxicity study at 5 TED level. One of the study
Naga bhasm prepared with parad and manahasila
significantly reduces blood sugar level. xx The
reduction of blood sugar showed by 90% patient
and 65% of the patient was reported, who were
consuming modern antidiabetic drug along with
Nāga bhasma; while, 50% of patients who were on
only Ṣaṣtipuṭa Nāga bhasma also showed a
reduction in blood sugar levels. This study can
prove to be a lead toward addition of the Bhasma as
an adjuvant to the synthetic drugs for the
management of diabetes mellitus.xxiIn a testicular
regenerative potential study of Nāga bhasma, it
was observed that the test drug when given
simultaneously with CdCl2 (Cadmium chloride)
showed marked prevention of testicular
degenerative effects of CdCl2 and when given alone
after 36 h of CdCl2administration, showed
noticeable regenerative potential on partially
degenerated testis. Nāga bhasma showed specific
regenerative effect on germinal epithelium of testis.
CdCl2 is toxic to testicular germinal epithelium and
its effects can be minimized by Nāga bhasma. At
higher doses, the drug is found very effective, thus
these findings are well collaborated with the
Ayurvedic concept of Vṛṣya property of Nāga
bhasma.xxii Acute toxicity study indicates LD 50 of
both test drugs is higher than 2000mg/kg. Naga
Bhasma prepared from Parada media and Vasa
media (in seven Puta) are toxic at TED X 5 and
TED X 10 dose level. However, both test drugs
produced mild adverse effect in Kidney and Liver
at TED dose level which indicates that Naga
Bhasma prepared in seven Puta should be avoided
in renal and hepatic impairment. Chronic toxicity
IJEPP|April-June 2016|Vol 2|Issue 2
study elaborates the classical claim that Naga
Bhasma (seven Puti) should not be used for
Rasayana purpose i.e. for long duration.
Experimental study shows that both sample of
Naga Bhasma have no hypoglycemic action but
possess moderate anti-hyperglycemic effect after
one hour and significant anti-hyperglycemic effect
compared to initial BSL. But this difference is
statically non –significant when compare in
between both the groups.xxiii
Vati Naga Kalp (Tablets)-
Vati is usually prepared with the combination of
kaustousadhi dravya, Churna, Bhasm, Sudha ,
rasoparasa, sadharanarasa, guda, sarkara,
Guggulu , jala, swarasa, mutra etc drug
combination . Vati is made in the shape of flat
circular mass hence it is similar to tablet.1
Churna Naga Kalpa (Powder mixtures)-
Churnas (powder mixtures) are prepared by
pounding the dry drugs and then sieving through a
fine cloth or sieves. Lauha Kalpa in Churna form
are prepared by adding the fine powder of the
herbal drugs to the Lauha Bhasma and triturated
(dry) until homogenous mixture is obtained: Table-
2.
Sneha form of Naga Kalp-
Sneha basically contain fatty material which
contain guru, sheet, sar, snigdha, mand sukshma,
mridu, drava having property. Medicated sneha i.e
ghrita or taila is prepared by mixing one part of
kalka (paste of drugs) four part of sneha and
sixteen part of liquid media. the dose of sneha is
one pala: Table-3.
Malhar & Paste Naga Kalp-
(Semisolid preparation)
Literally, Lehya refers to that which is consumed
by licking. It is a semisolid dosage form, prepared
by solidifying the decoctions, etc. primary liquid
dosage forms by boiling along with sugar-, jaggery-
like sweetening agents and after it attains proper
consistency fine powders of drugs (Prakshepa
Dravya), ghrita, and honey are added: Table-4.
Dhupan form of Naga Kalp-Micro organism ,pain,
found smell etc. produced in Vrana are treated by
Dhupan (medicinal fumigation) called Vrana
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IJEPP 2016, 2 (2), 59-71 Shobhnath et al
Dhupan . Same manner Dhupan is performed in
yoni, guda, nasa, sisna etc.: Table-5.
Varti form of Naga Kalp
Varti is a similar form of vati kalpana. Form
making varti medicine is modified into yavakrita
(long oval shape) solid form, then it called as Varti
Kalpana: Table-6.
Kupipakwa of Naga Kalp
(Incinerated material prepared in bear bottle)-
This term is composed of four words
kupi,pakva,rasa and ayana.A rasayana product
from parad, ganghaka,etc is prepared in a glass
bottle by applying mild, moderate and intense heat.
based on preparation method it is classified into
antardooma and bahirdhooma: Table-7.
DISCUSSION
Rasaushadhis (herbomineral formulations) are
being prescribed by Ayurvedic physicians since
long with are mention of toxicity. It is observed
that herb—mineral complexes are more stable and
more interactive compared to plain herbs as these
result in faster therapeutic action and have a longer
shelf life.xxiv Naga Kalpas are formulations which
are safe effective, and note worthy compound
formulations of Naga. Properties of Nāga bhasma
includes Uṣṇa Vīrya (hot in action), Tikta rasa
(bitter taste), cures Vātaja‑Kaphaja Prameha and
Udakameha (polyuria).xxv Most of kupipakwa
formulation Parad used as yogvahi properties.xxvi
Which makes it ideal to combine with other
metals/minerals to increase their potency and
therapeutic efficacy . Rasa sindhūra is a sublimated
product of Pārada and Gandhaka and also
possesses antidiabetic property . xxvii These results
indicate that Haridrā is a promising vehicle for the
prevention and amelioration of type 2 diabetesxxviii.
Vāgbhaṭa says that Haridrā is superior among
those which cure Prameha. xxix After careful
review of Naga Kalpas, it is found that unlike
popular understanding they all are not only
Khalviya preparations but can be classified based
on the methods of preparation into Vati kalp,
Churna Kalpa, Sneha kalpand . Vati, Bhasm,
Churna Kalpas are prepared by wet trituration
(Bhavana, impregnation) with liquid ingredients,
i.e., decoctions and herbal juices. In few
formulations, water is used as a media for
IJEPP|April-June 2016|Vol 2|Issue 2
Bhavana. Wet trituration (Toya Sannikarsha)
facilitates particle size reduction and
homogenization leading to modification of
properties (Gunantharadhana) of the end
product.In Bhaisajratnavali literature it contain
about 53 formulation in which Naga bhasm& its
ore, present various proportion (lower percentage
of Naga bhasma in yograjguggulu is .4 and
maximum percentage of Naga Bhasma in
Sinduradi lape is 33.3 % used in Rasayana & Pama
disease and 20% of Naga bhasma used in
Suchikabharanrasa. In some the formulation there
is not given the dose just like Sinduradi tail,
Vipretamalla tail, Vranarachasa tail
(1),Vranarachasa tail(2), Karchura tail,
Sindooradya tail, Sindooradi tail, Kustharachas
tail, Sathabindu tail, used as external application in
skin disease. In some of the formulation where not
used as anupan just like example in all external
application formulation. Total 3 formulation which
contain below than one percentage of Naga bhasm,
13 formulation contain 1to 5% of Naga Bhasm, 16
formulation contain 5to10% Naga Bhasm ,10 to
15% of Naga Bhasm found in 12 formulation,15 to
20% of Naga Bhasm found in 8 formulation and
last 20 to 40% Naga bhasm was found in two
formulation. Mehakunjarkesari &
Basantakusumakar rasa having a maximum dose 6
ratti in compare to other formulation. There are 3
formulation of Vati form,3 formulation of churna
form, used as prameha. In jwaradhikar different
tyes of dosage form used 7 vati
formulation,3churna formulation .In same way
3churna kalp used as Rajyakchma diseases. Total
nine Sneha form & one Malher formulation used in
skin disease as external application and one
formulation in the form of Varti used for Eye
disease. Ardarak swarasa used anupan in 9.4%of
formulation having kaphvata samak properties.
Honey used anupan form 37.73 %in Naga
formulation and have antidote of Naga bhasm. It
has been found that consumption of natural honey
reduces cardiovascular risk factors, particularly in
subjects with elevated risk factors.xxx Ghee is
resistant to free radical damage and is lactose free.
Scientific studies have indicated the ability of ghee
in supporting physical and mental performance.
Ghee also acts as anti‑ageing, nutritive for nerves
and brain cells.xxxi A comparative study of some
representative samples of Nāga Bhasm from
chemical and structural point of view showed that
the Nāga Bhasm samples were predominantly
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IJEPP 2016, 2 (2), 59-71 Shobhnath et al

Bhaisajya Ratnavalli (Siddhinandan Mishra), 2011, Chaukhambha Subharti Prakashan

Table-1 Formulation of Naga Bhasm prepared with vati form.(B.R)

Sr. No. Pag Formulation Slok No. Pb % Rogadhikar Anupan Dose References
e a
No.

1. 142 Kulbadhu 596-597 16.67 Jvaradhikar, Nasya ½- Rasayansar

Rasa- 2ratti Samagrha
Sannipatjwar,

Nasya

2. 180 Jvarari Rasa 1032-1033 11.11 Jvaradhikar. Ardarak 1ratti Bhasijyarat

navali
Jwara,Shoola swaras,

honey

3. 157 Trailokya 766-772 09.09 Jvaradhikar Narikel ½ Rasa Raj

Chintamani water ratti Sundar
Rasa Sannipat jwar

4. 132 Navjarebhsing 485-487 11.70 Jvaradhikar. Ardaraks 2ratti Rasedra

h Rasa waras& Chintamani
Navjwar,
honey
Grahniroga,

5. 139 Gadmurari 560 10.00 Jvaradhikar, Usna jala 2- Rasedra

Rasa 2Ratii Chintamani
Amajwar ,

6. 151 Rasa Rajendra 696-702 11.11 Jvaradhikar. Tulasipat 1ratti, Rasedra

ra Sar
All type of jwar swaras sangraha

7. 154 Sannipat 734-742 05.89 Jvaradhikar, Ardaraks 1ratti, Rasa Raj

Bhirava Rasa waras& Sundar
Jirnajwar,
honey
Sawas Kash

8. 285 Brihannripball 366-370 4.78 Grahniroga, Ardaraks 2ratti, Rasayansar

abh Rasa waras& sangraha
Agnimandya,Aji
rna,Arsha,Amaji honey
rna

9. 527 Yograjguggulu 102-113 0.4 Vatvyadhirogad Usna jala 4- Sa.M.Kh-7

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IJEPP 2016, 2 (2), 59-71 Shobhnath et al

hikar. 8ratti

Trodosghna,ras
ayana

10. 577 Drvadasayasa 53-57 3.57 Vatraktadhikar, Honey& 2ratti, Bhaishajya

Amavat,Mandag Ratnavali
ni,Mahakustha guduchi
swarasa

11. 602 Vatgajendrasi 81-87 6.45 Amavatrogadhik Milk 3ratti, Bhaishajya

ngh ar, Ratnavali

Amavat,

Chino

12. 656 Nageswar 87-89 8.33 Gulmarogadhik Tambula 2-4 Bhaishajya

Rasa ar, patra ratti, Ratnavali

Gulma,Pliha

13. 671 Sankar Vati 50-54 11.7 Hridrogadhikar, Usna jala 2ratti, Bhaishajya
Amavat, Ratnavali

jirnajwar
Prameha

14. 704 Vedavidya 79-83 5.89 Prameharogdhi Madhu 3 Bhaishajya

Vati kar in All &Amla ratti, Ratnavali
Prameha swaras

15. 707 Yogeswar 105-109 4.16 Prameharogdhi Honey 2ratti, Rasayansar

Rasa kar,Prameha,m sangraha
utrakuchha,Asm
ari

16. 708 Basantkusuma 114-119 10.34 Prameharogadh Honey, 1 Rasayansar

kar Rasa ikar,Prameha, ratti, sangraha
Medhya, Ghrita,

Sita,

Milk

17. 773 Shobhankush 55-56 16.67 Shotharogdhika Roganus 1-4 Bhaishajya

Rasa r, Jwar,sotha, ar( As ratti Ratnavali
per
Pandu,Vataj,Pit diseas)
taj, Kaphaj

18. 795 Rasarajendra 70-73 7.69 Vridhirogad Honey 1ratti Bhaishajya

Ratnavali
Hiker,Antrabrid

IJEPP|April-June 2016|Vol 2|Issue 2 Page 64

IJEPP 2016, 2 (2), 59-71 Shobhnath et al

hi

19. 796 Akadasayasa 82-84 3.44 Vridhirogadhika Honey 2ratti Bhaishajya

Rasa r, Ratnavali

Andkoshvridhi,
mutrakrichha

20. 103 Pradar Ripu 59 8.3 Pradarrogadhik Honey 6 ratti Yogaratnak

3 ar,prader ar

21. 103 Ratna 60-64 8.3 Pradarrogadhik Bala 1 ratti Bhaishajya

4 Prbhavatika ar,Balya,Rasaya Kwatha Ratnavali
n,

Prader

22. 106 Garbhapala 94-96 6.8 Grahanirogadhi Draksha 1-2 Baidhak

0 Rasa kar,Garbhinirog Kwatha ratti Chintamani
a

23. 106 Sutikahara 72-75 6.25 Sutikarogadhika Honey, 4-4 Rasayansar

9 Rasa r,Atisar, ratti a Samghra
Gandhap
Shoolhar rasarnis
wara

24. 111 Nilkantha 66-74 10.82 Rasanadhikar,K Honey 2 ratti Rasayansar

4 Rasa shaya roga, a Samghra
Grahniroga

,Rakta pitta

25. 111 Basanta 128-133 8.57 Prameha,Rasay Tambul 2ratti Rasayansar

8 Kusmakar ana swarasa a Samghra
Rasa(1)

26. 111 BasantaKusu 134-135 10.35 Rasayanadhikar Tambul 6-6 Bhaishajya

9 makar Rasa(2) ,Rasayan karm swarasa ratti Ratnavali

Table-2 Formulation of Naga Bhasm prepared with,Churna form.(B.R)

S Page Formulatio Slok No. Pb % Rogadhikar Anupana Dose References

r. No. n
N
o.

146
1. Suchikabhar 642-643 20.00 Jvaradhikar, Brahmaratha 5 mg , Rasayan
an Rasa use Sar

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IJEPP 2016, 2 (2), 59-71 Shobhnath et al

Sannipat jwar Samagrha

147
2. Suchikabhar 646-649 16.67 Jvaradhikar Brahmaratha 5 mg , RasayanSar
an Rasa- use Samagrha
Brihat Sannipat
jwar,Atisar,Visu
chika

163
3. Pratap 823-848 06.45 Jvaradhikar, Chitrak kwath 1 ratti Rasa
lankesh Manjari
Rasa Sannipatjwar

395
4. Raktpittakul 68-71 16.67 Raktapittadhika Yastimadhu 2ratti Yogaratnad
kandan Rasa r, kwath &honey hikar

Raktapitta

415
5. Chaykesari 91-100 4.35 Rajyakchma, Honey,Pippalich 2ratti, Rasayansar
Rasa(brihat) urn,Sarkarachun sangraha
Prameha,Medor a,Ardaraka
aga swarasa

422
6. Ratnagarbh 180-185 7.7 Rajyakchma, Pippalichurna& 1 ratti Rasayan sar
pottali sangraha
8tyes Maharoga Honey

425
7. Lakchmivila 215-218 4.54 Rajyakchma, Roganusar 1- Yogaratnad
sh Rasa 2ratti hikar
Pandu,Arsha,Sh
oola,Kustha

536
8. Navratnaraj 207-212 3.84 Vatvyadhirogad Honey,- 1 ratti Yogaratnak
mringak hikar, Pipper,guduchi ar
Rasa satva
20 types
Prameha

709
9. Mehakunjar 130-135 11.11 Prameharogadh Honey 6 ratti Bhaishajya
kesari Rasa ikar Ratnavali

Prameha,
Rasayan

776
10. Shpthsardul 96-98 11.11 Shotharogdhika Usnodaka 3-6 Bhaishajya
a Rasa r, Mutrakrichha, ratti Ratnavali
Udar roga

872
11. Manikya 126-134 3.8 Kustharogadhik Honey, 2ratti Rasendrach
rasa ar intamani
ghrita
Alltypes Kustha

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IJEPP 2016, 2 (2), 59-71 Shobhnath et al

100
12. Nainamritan 204-205 15.38 Netrarogadhika No anupan Extern Rasamanjar
4 jan r,Timir,Netrapat al use i
al,all types of
(Sudha eye diseas Churna
Naga) use by
salaka

113
13. Puspadhanv 70 20.00 Vajikarn Honey, 1- Yogaratnak
1 a Rasa Rogadhikar,Vaji 2ratti ar
karana Ghrita,

Sarkara,

Godugdha

Table-3 Formulation of Naga Bhasm prepared with Sneha(Tail) form.(B.R)

Sr. Page Formulation Slok Pb % Rogadhikar Anupan Dose References
No. No. No.

1. 807 Sinduradi 71-72 16.28 Granthaburdadhika No External Bhavprakash

tail(Nagsindoor) r, Gandmala anupan; use as per
require

2. 826 Vipretamalla tail 67-68 12.5 Vranashothadhikar No External Chakradatta

anupan use
(Nagsindoor) Galgand,

Pama

3. 826 Vranarachasa tail 69-71 4.02 Vranashothadhika, No External Bhaishajya

anupan use Ratnavali
(Nagsindoor) Nadivrana,
Vranamansvridhi,k
ustha

4. 827 Vranarachasa tail 72-76 0.53 Vranashothadhika No External Bhaishajya

anupan use Ratnavali
(Nagsindoor) Vatrakta,Kandu,
Mahaswatkustha

5. 839 Karchura tail 30 4.76 Nadivranadhikar, No External Bhavprakash

anupan use
(Nagsindoor) Nadivrana,Visarpa

6. 886 Sindooradya tail 270 7.2 Kustharogadhikar, No External Chakradatta

Pama anupan use
(Nagsindoor)

7. 887 Sindooradi tail 274- 4.76 Kustharogadhikar, No External Chakradatta

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IJEPP 2016, 2 (2), 59-71 Shobhnath et al

(Nagsindoor) 277 Kustha,Pama, anupan use

Eczema

8. 889 Kustharachas tail 285- 8.3 Kustharogadhikar,S No External Bhaishajya

289 witra, vatrakta, anupan use Ratnavali
(Nagsindoor) Pama

9. 889 Sathabindu tail 290- 1.49 Kustharogadhikar, No External Bhaishajya

291 Kustha anupan use Ratnavali
(Nagsindoor) ,Vicharckika

Table-4 Formulation of Naga Bhasm prepared with Malhar & Paste form.(B.R)

Sr. Page Formulation Slok Pb % Rogadhikar Anupan Dose References

No. No. No.

1. 862 Sinduradi lape 30 33.33 Kustharogadhikar, No anupan External Chakradatta

use
(Nagsindoor) Pama

2. 939 Naradi tail 78 25 Chudrarogadhikar, No anupan External Bhaishajya

Kesya ranjan use Ratnavali
(Sudha Naga)
(past)

Table-5 Formulation of Naga Bhasm prepared with Dhupan form.(B.R)

Sr. No. Page No. Formulation Slok Pb % Rogadhikar Anupan Dose References
No.

1 849 Paradadidhupa 19-21 2.48 Updansarogadhik No anupan Dhupa Bhaishajya

n ar, n use Ratnavali

(Nagsindoor) Updansvrana

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IJEPP 2016, 2 (2), 59-71 Shobhnath et al

Table-6 Formulation of Naga Bhasm prepared with Varti form (B.R)

Sr. No. Page No. Formulation Slok No. Pb % Rogadhikar Anupan Dose References

1 1004 Rasanjanadi 202-203 11.11 Netrarogadh No Exter Bhaishajya

Varti ikar, anupan nal Ratnavali
use
All types eye
diseas

Table-7 Formulation of Naga Bhasma prepared with Kupipakwa form (B.R)

Sr. No. Page No. Formulation Slok No. Pb % Rogadhikar Anupan Dose References

1 1119 Astavakra Rasa 136-140 0.97 Rasanadhikar, Roganus 1 Bhaishajya

Balipalit ar ratti Ratnavali
nasak

crystalline, i.e., mixture of PbO Pb3O4.xxxii Other
work on synthesis, characterization and
histopathological study of Nāga Bhasm showed
that Nāga Bhasm is nontoxic (6 mg/100 g/day),
while crude lead (6 mg/100 g/day) is highly
toxicxxxiii.
them available. On the basis classical references it
is concluded that Nāga Bhasma possesses
significant antidiabetic property and is a safe drug.
Thus, there is an urgent need to conduct research
on safety and efficacy of apart from antidiabetic
formulations of Nāga bhasma.

CONCLUSION

There are 53 formulations of Bhaisajyaratnavali REFERENCES

contain Naga bhasma out of 4500 formulation and
6 kalpas contain Naga Bhasma indicated for
Prameha. Total 7 dosage form was used as Vati,
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Kupipakwa rasayana of naga Formulation. Nāga
bhasma, is mainly useful in Vātaja‑Kaphaja
Prameha and should be used cautiously in Pittaja
type of Prameha. Amlaki, tulasiī, Gudūci and
Madhu enhance the antidiabetic action of Nāga
bhasma and also are helpful in preventing diabetic
Complications. Ardarak swarasa was used as
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samak properties.Honey was used as anupan
in37.73 % formulations and indicated as antidote
of Naga bhasma. Based on the method of
preparation, shelf life, pharmacological action,
indication varies. There are number of formulations
which are not available in the market and but suits
the present day healthcare demand. Hence
pharmaceutical houses can manufacture and market
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