Agitation refers to a state of hyperarousal, increased tension, and irritability that
can lead to confusion, hyperactivity, and overt hostility. Agitation can result from a toxic (poisons), metabolic, or infectious cause; brain injury; or a psychiatric disorder. It can also result from pain, fever, anxiety, drug use and withdrawal, hypersensitivity reactions, and various disorders. It can arise gradually or suddenly and last for minutes or months.Whether it’s mild or severe, agitation worsens with increased fever, pain, stress, or external stimuli. Agitation alone merely signals a change in the patient’s condition. However, it’s a useful indicator of a developing disorder. HISTORY Determine the severity of the patient’s agitation by examining the number and quality of agitation-induced behaviors, such as emotional lability, confusion, memory loss, hyperactivity, and hostility. Obtain a history from the patient or a family member, including diet and known allergies. Ask if the patient is being treated for any illnesses. Has he had any recent infections, trauma, stress, or changes in sleep patterns? Ask the patient about prescribed or over-the-counter drug use, including supplements and herbal medicines. Ask about alcohol intake. PHYSICAL ASSESSMENT Perform a complete physical examination. Check for signs of drug abuse, such as needle tracks and dilated pupils. Obtain baseline vital signs and neurologic status for future comparison.