4 Acetic Acid Glacials - 2 PDF

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 31.05.2010
1. Identification of the substance/mixture and of the company/undertaking

Product Information
Catalogue No.: 100063
Product name: Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
Use of the Reagent for analysis, Chemical production, Pharmaceutical production
Substance/Mixture and analysis
Company: Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0

Emergency telephone: Please contact the regional Merck representation in your country.
Responsible/issuing person: EQ-EPS * e-mail: prodsafe@merck.de
2. Hazards identification
GHS Classification
Flammable liquid, Category 3 H226: Flammable liquid and vapour.
Skin corrosion, Category 1A H314: Causes severe skin burns and eye damage.
EC Classification
R10
C; R35
For the full text of the R-phrases mentioned in this Section, see Section 16.
3. Composition/information on ingredients
Formula CH₃COOH C₂H₄O₂ (Hill)
CAS-No. 64-19-7
Index-No. 607-002-00-6
EC-No. 200-580-7
Molar mass 60,05 g/mol
4. First aid measures
After inhalation: fresh air. Call in physician.

After skin contact: wash off with plenty of water. Dab with polyethylene glycol 400. Immediately
remove contaminated clothing. Call a physician immediately.
After contact with eyes: Rinse with plenty of water keeping eyelids open, protecting the
unaffected eye (at least 10 minutes). Seek medical advice immediately!
After swallowing: make victim drink water (two glasses at the most), avoid vomiting (risk of
perforation!). Call a physician immediately. Do not attempt to neutralize.
5. Fire-fighting measures
Suitable extinguishing media

Water, Carbon dioxide (CO2), Foam, Dry powder
The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
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Safety Data Sheet

Product name: Acetic acid (glacial) 100% anhydrous for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
Specific hazards during fire fighting

Combustible material, Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air at elevated temperatures.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
Acetic acid vapours
Special protective equipment for fire-fighters
Do not stay in dangerous zone without self-contained breathing apparatus. In order to
avoid contact with skin, keep a safety distance and wear suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Cool closed containers
exposed to fire with water spray. Prevent fire extinguishing water from contaminating surface
water or the ground water system.
6. Accidental release measures
Personal precautions
Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation.
Environmental precautions
Do not empty into drains. Explosive properties
Methods for cleaning up
Take up with liquid-absorbent material (e.g. Chemizorb® ). Forward for disposal. Clean up
affected area.
7. Handling and storage

Handling
Advice on safe handling
Observe label precautions.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.
Storage
Further information on storage conditions
Keep away from heat and sources of ignition. Keep container tightly closed in a dry and well-
ventilated place.
Store at +15°C to +25°C.
8. Exposure controls/personal protection
Personal protective equipment

Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.
Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: filter E-(P2)
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Safety Data Sheet

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Hand protection
full contact:
Glove material: butyl-rubber
Glove thickness: 0,7 mm
Break through time: > 480 min
splash contact:
Glove material: natural latex
Glove thickness: 0,6 mm
Break through time: > 30 min
The protective gloves to be used must comply with the specifications of EC irective 89/686/EEC
and he resultant standard EN374, for example. KCL 898 Butoject® (full contact), KCL 706
Lapren® (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to
EN374 with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet and supplied by
us as well as to the purpose specified by us. When dissolving in or mixing with other substances
and under conditions deviating from those stated in EN374 please contact the supplier of CE-
approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Eye protection
Tightly fitting safety goggles
Protective measures
Protective suit
Hygiene measures
Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands
and face after working with substance.
9. Physical and chemical properties

Form liquid
Colour colourless
Odour stinging
pH 2,5
at 50 g/l
20 °C
Viscosity, dynamic 1,22 mPa.s

at 20 °C
Viscosity, kinematic 1,17 mm2/s

at 20 °C
Melting point 17 °C
Boiling point/boiling range 116 - 118 °C

at 1.013 hPa
Ignition temperature 485 °C
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Safety Data Sheet

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Flash point 39 °C
Method: c.c.
Oxidizing properties no data available
Flammability no data available
Lower explosion limit 4 %(V)
Upper explosion limit 19,9 %(V)
Vapour pressure 15,4 hPa

at 20 °C
Relative vapour density 2,07
Density 1,05 g/cm3

at 20 °C
Solubility/qualitative no data available
Water solubility 1.000 g/l

at 25 °C
Partition coefficient: n- log Pow: -0,17

octanol/water Method: (experimental)
(Lit.)
No bioaccumulation is to be expected (log Pow <1).
Evaporation rate no data available
Refractive Index 1,37

at 20 °C
10. Stability and reactivity
Conditions to avoid
Temperatures < 17 °C. Below melting point.
A range from approx. 15 Kelvin below the flash point is to be rated as critical. Warming.
Materials to avoid
Risk of explosion with:
Strong oxidizing agents, i.a., peroxi compounds, perchloric acid, chromosulfuric acid, nitrates,
warmth/heat, fuming sulfuric acid, phosphorus halides, hydrogen peroxide
Violent reactions possible with:
Metals, Iron, Zinc, magnesium, (generation of hydrogen), alkali hydroxides, nonmetallic halides,
ethanolamine, Acetic anhydride, Water, Aldehydes, Alcohols, halogen-halogen compounds,
chlorosulfonic acid, strong alkalis, Nitric acid
Hazardous decomposition products
in the event of fire: See chapter 5.
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Safety Data Sheet

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Further information
incompatible with:, various metals
Vapour/air-mixtures are explosive at intense warming.
11. Toxicological information

Acute oral toxicity
LD50 rat
Dose: 3.310 mg/kg
(RTECS)
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation
of the oesophagus and the stomach., Nausea, Vomiting, Pulmonary failure possible after
aspiration of vomit.
Acute inhalation toxicity
LCLO rat
Dose: 39,95 mg/l, 4 h
(RTECS)
LC50 rat
Dose: 11,4 mg/l, 4 h
(IUCLID)
Symptoms: Irritation symptoms in the respiratory tract., Pneumonia, bronchitis, Inhalation may
lead to the formation of oedemas in the respiratory tract., Symptoms may be delayed.
Acute dermal toxicity
LD50 rabbit
Dose: 1.060 mg/kg
(IUCLID)
Skin irritation
rabbit
Result: Causes burns.
(IUCLID)
Eye irritation
Causes severe burns. Risk of blindness! Risk of corneal clouding. Risk of perforation!
Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: negative
(National Toxicology Program)
Teratogenicity
Did not show teratogenic effects in animal experiments. (IUCLID)
Further information
Systemic effects:
Shortness of breath, gastric spasms, shock, Circulatory collapse, acidosis
Possible damages:
Damage of:
Kidney
Further data:
Handle in accordance with good industrial hygiene and safety practice.
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Safety Data Sheet

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12. Ecological information

Ecotoxicity
Toxicity to fish
LC50
Species: Lepomis macrochirus (Bluegill sunfish)
Dose: 75 mg/l
Exposure time: 96 h
(Lit.)
Toxicity to daphnia and other aquatic invertebrates.
EC5
Species: E.sulcatum
Dose: 78 mg/l
Exposure time: 72 h
neutral (maximum permissible toxic concentration) (Lit.)
EC50
Species: Daphnia magna (Water flea)
Dose: 47 mg/l
Exposure time: 24 h
(Lit.)
Toxicity to algae
IC5
Species: Scenedesmus quadricauda (Green algae)
Dose: 4.000 mg/l
Exposure time: 16 h
(maximum permissible toxic concentration) (Lit.)
Toxicity to bacteria
EC5
Species: Pseudomonas putida
Dose: 2.850 mg/l
Exposure time: 16 h
neutral (maximum permissible toxic concentration) (Lit.)
EC50
Species: Photobacterium phosphoreum
Dose: 11 mg/l
Exposure time: 15 min
microtox test (IUCLID)
Persistence and degradability
Biodegradability
Result: Readily biodegradable.
99 %
Exposure time: 30 d
Method: OECD Test Guideline 301D
(HSDB)
95 %
Exposure time: 5 d
Method: OECD Test Guideline 302B
Biochemical Oxygen Demand (BOD)
880 mg/g (5 d)
(Lit.)
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Safety Data Sheet

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Ratio BOD/ThBOD BOD5 76 %

(IUCLID)
Partition coefficient: n-octanol/water
log Pow: -0,17
Method: (experimental)
(Lit.)
No bioaccumulation is to be expected (log Pow <1).
Additional ecological information
Biological effects:
Harmfull effect on aquatic organisms. Harmful effect due to pH shift. Caustic even in diluted
form.
Further information on ecology
Do not allow to enter waters, waste water, or soil!
13. Disposal considerations

Product
Chemicals must be disposed of in compliance with the respective national regulations. Under
www.retrologistik.de you will find country- and substance-specific information as well as contact
partners.
Packaging
Merck product packaging must be disposed of in compliance with the country-specific
regulations or must be passed to a packaging return system. Under www.retrologistik.de you will
find special information on the respective national conditions as well as contact partners.
14. Transport information
ADR/RID
UN 2789 ACETIC ACID, GLACIAL, 8 (3), II
IATA
IMDG
EmS F-E S-C
The transport regulations re cited according to international regulations and in the form applicable
in Germany. Possible national deviations in other countries are not considered.
15. Regulatory information

GHS-Labelling
Hazard pictograms
Signal word
Danger
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Safety Data Sheet

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Hazard statements
H226: Flammable liquid and vapour.
H314: Causes severe skin burns and eye damage.
Precautionary statements
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301 + P330 + P331: IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
P307 + P310: IF exposed: Immediately call a POISON CENTER or doctor/physician.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Index-No. 607-002-00-6
Labelling according to EC Directives
Symbol(s): C Corrosive
R-phrase(s): 10-35 Flammable. Causes severe burns.

S-phrase(s): 23-26-45 Do not breathe vapour. In case of contact with eyes,
rinse immediately with plenty of water and seek medical
advice. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
EC-No. 200-580-7 EC Label
Reduced labelling (≤125 ml)
Symbol(s): C Corrosive
R-phrase(s): 10-35 Flammable. Causes severe burns.

S-phrase(s): 26-45 In case of contact with eyes, rinse immediately with plenty of water
and seek medical advice. In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
National legislation
Storage class VCI: 3 Flammable Liquids
Major Accident Hazard 96/82/EC Update: 2003
Legislation: Flammable.
6
Quantity 1: 5.000 t
Quantity 2: 50.000 t
Other regulations: Take note of Dir 94/33/EC on the protection of young people at
work.
16. Other information

Full text of R-phrases referred to under sections 2 and 3
R10 Flammable.
R35 Causes severe burns.
Regional representation: This information is given on the authorised Safety Data Sheet for
your country.
The information contained herein is based on the present state of our knowledge. It characterizes the product with
regard to the appropriate safety precautions. It does not represent a guarantee of the properties of the product.
Page 8 of 8

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SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 31.05.2010

1. Identification of the substance/mixture and of the company/undertaking

Company: Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0

4. First aid measures

After inhalation: fresh air. Call in physician.

Suitable extinguishing media

Catalogue No.: 100063

Specific hazards during fire fighting

6. Accidental release measures

7. Handling and storage

8. Exposure controls/personal protection

Personal protective equipment

Catalogue No.: 100063

9. Physical and chemical properties

Viscosity, dynamic 1,22 mPa.s

Viscosity, kinematic 1,17 mm2/s

Boiling point/boiling range 116 - 118 °C

Ignition temperature 485 °C

Catalogue No.: 100063

Oxidizing properties no data available

Flammability no data available

Lower explosion limit 4 %(V)

Upper explosion limit 19,9 %(V)

Vapour pressure 15,4 hPa

Relative vapour density 2,07

Density 1,05 g/cm3

Solubility/qualitative no data available

Water solubility 1.000 g/l

Partition coefficient: n- log Pow: -0,17

Refractive Index 1,37

10. Stability and reactivity

Catalogue No.: 100063

11. Toxicological information

Catalogue No.: 100063

12. Ecological information

Catalogue No.: 100063

Ratio BOD/ThBOD BOD5 76 %

13. Disposal considerations

14. Transport information

15. Regulatory information

Catalogue No.: 100063

R-phrase(s): 10-35 Flammable. Causes severe burns.

R-phrase(s): 10-35 Flammable. Causes severe burns.

16. Other information

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