Fever day 1
50%
Fever day 2 70%
Fever day 3 > 90%
False negative TT
• Obese patients
• Thin patients
• Not good technique
• During shock
Tourniquet test
Systolic + Diastolic = 5 mins.
2
WBC ≤ 5,000 cells/cumm.
• Early diagnosis
• Indicates: no fever within
the next 24 hours
• If DHF :
oEntering critical stage
oBeginning of plasma leakage
oIf severe : aware/ prevent
shock? Is possible
Duration of fever in DHF patients
4,595 DHF patients, QSNICH
Duration of fever %
(day)
2 2.16
3 10.07
4 41.01
5 30.94
6 11.51
7 2.16
>7 1.44
Prolonged shock
• > 10 hours untreated - Death!!!
• > 4 hours untreated
Liver failure- prognosis 50%
Liver + Renal failure - prognosis10%
3 organs failure (+respiratory
failure) – Prognosis is a miracle!!!
Natural course of DHF
Day 1 2 3 4 5 6 7 8 9
Shock
Fever
Pleural effusion,
Ascites
Hematocrit
• Early diagnosis of
dengue infections :
Tourniquet test and
CBC with follow-up
• Advise warning
signs of shock in
all patients with
suspected dengue
infections
Tourniquet test
CBC
Detection of shock : Difficult
Good consciousness
Diagnosis???
Management???
21.00 PM
Chest film
Problems :
• No baseline Hematocrit known
• Not done frequent enough
• Blood loss :
internal/ concealed bleeding
Hemolysis : thalassemia, G-6-PD
Ratio of Children : Adult Dengue
1997 - 2005
M 3 80
M +5%D 5 100-120
M +7%D 7 150
Pleural effusion,
Ascites
Hematocrit
WBC ≤5,000
Platelet count ≤100,000
Hct rising 20%
Albumin ≤3.5 gm%
Cholesterol ≤100 mg%
Professor Siripen Kalayanarooj
Monitoring parameters
clinical
• Infants
• Obese patients
• Prolonged shock
• Bleeding
• Encephalopathy
• Underlying diseases
Rate of IV Fluid in
Dengue Shock Syndrome
• Hct:
o Increase – use Dextran
o Decrease – Blood transfusion
• Electrolyte – Hypo Na, Hypo Ca
• Blood sugar - Hypoglycemia
• Blood gas - Acidosis
When not response to
conventional IV fluid treatment
• A – Acidosis (Prolonged
shock : LFT, BUN, Cr)
• S – Blood sugar
• C – Calcium (Na, K)
• B – Bleeding (Hct)
Albumin
50 USD/ 50 ml
(Not recommend because
often report of acute
pulmonary edema/ heart
failure)
Rate of IV Fluid in
Dengue Shock Syndrome
7 ml/kg/hr
7 ml/kg/hr(100-120 ml/hr)
8
8
6
6
1.5 ml/kg/hr (40 ml/hr) 3- 5 ml/kg/hr (80-120 ml/hr)
1.5 ml/kg/hr 3- 5 ml/kg/hr
4
4
2
2
Rate
0 Rate
00 6 12 18 24 30 36 42 48 Hours after
0 6 12 18 24 30 36 42 48 Hours after
leakage
Plt < 100,000 cells/cumm. leakage
HctPlt < 100,000 cells/cumm.
increase (Rate in adult)
Hct rising 10-20%
ICD obtained effusion
1860 ml =42 ml/kg
(maintained for 3 days)
Blood transfusion
Plt. 1 Unit = 50 ml
Recombinant factor VII
Reabsorption
Equilibrium
Start Stop
0 24 48 72 hours
Plt < 100,000 cells/cumm
Hct
Causes of death in DHF
Aug 07-Mar 08
• 32 cases:
o Adults 18 (56.25%)
o Children 14 (43.75%)
• Overweight: 19 (59.4%)
• Delayed Diagnosis: 22 (68.75%)
o Fluid overload 24 (75.0%) - IPD
o Prolonged shock 8 (25.0%) – OPD
o Massive bleeding (initially) - 0
Major causes of death in DHF
Bleeding
Conclusion
Cuba
Antwerp,
Nicaragua
Belgium
Vietnam
Thailand
Brazil
Venezuela
Malaysia
Europe
Latin America
Asia
Revised Dengue Classification
DENGUE ± Warning Signs SEVERE DENGUE
With
Without 1.Severe plasma leakage
WARNING 2.Severe haemorrhage
SIGNS 3.Severe organ impairment
Probable Dengue
Live in / travel to dengue Warning Signs* 1. Severe plasma leakage leading to
endemic area. Fever and 2 • Abdominal pain or tenderness • Shock (DSS)
of the following criteria: • Persistent vomiting • Fluid accumulation with
Nausea, vomiting
Rash
• Clinical fluid accumulation respiratory distress
Aches and pains • Mucosal bleed 2. Severe bleeding
Tourniquet test +ve • Lethargy; restlessness as evaluated by clinician
Leucopenia
• Liver enlargement >2cm 3. Severe organ involvement
Any warning sign
• Laboratory: Increase in HCT Liver: AST or ALT>=1000
Lab. confirmed dengue concurrent with rapid decrease CNS: Impaired consciousness
(important when no sign of plasma leakage) in platelet count Heart and other organs
* Requiring strict observation and medical intervention
Hotline DHF:
+6689-2045522 – M.D.
+6689-2042255 – GN.
• 2008 – 200+ cases
consulted and 90%
were saved
Outcome Measures