Phar.Dose Lec.

10 Defects of Tablet

Name of Defect Illustration Causes Remedy

Dry the granules
properly. Increase
Sticking Improperly dried or or change lubricant.
refers to the tablet improperly lubricated Reduce the amount
material adhering granules. Too much of binder or use a
to the die wall. binder. different type of
binder.
.
Separation of a tablet
into two or more Use tapered dies,
distinct horizontal i.e. upper part of
layers because of the die bore has an
Lamination
air–entrapment outward taper of 3°
is the separation of
during compression to 5°. Use pre-
a tablet into two or
and subsequent compression step.
more distinct
release on ejection. Reduce turret speed
horizontal layers.
The condition is and reduce the final
exaggerated by compression
higher speed of pressure.
turret
Use mild drying
Orange Peel It is surface defect
conditions, and use
appearance is resulting in the film
additional solvents
similar to that of an being rough and
to decrease
orange. nonglossy.
viscosity of solution.
Dry the granules
Chipping is
properly or increase
defined as the
Sticking on punch lubrication. Moisten
breaking of tablet
faces. Too dry the granules to
edges, while the
granules. Too much plasticize. Add
tablet leaves the
binding causes hygroscopic
press or during
chipping at bottom. substances.
subsequent
Optimize binding, or
handling.
use dry binders.
Twinning This could be
A defect wherein Drying is ineffective remedied by
two tablets are in the coating reducing spray rate
sticking together. process. and increasing pan
speed.
 Cracking It is observed as a
Small, fine cracks result of rapid
observed on the expansion of tablets
upper and lower due to air Reduce granule
central surface of entrapment, size. Add fines.
tablets, or very especially when deep Use tapered die.
rarely on the concave punches are Use special take-off
sidewall are used.
referred to as Large size of
Cracks granules.
Binding Usually due to
Sticking of the excessive amount of
Dry the granules
tablet to the die moisture in granules,
properly. Increase
and does not eject lack of lubrication
or change lubricant.
properly out of the and/or use of worn
die. dies.
Colored drug, whose
Use appropriate
color differs from the
colorants. Mix
Mottling color of excipients
properly and reduce
or the used for granulation
size if it is of a
unequal distribution of a tablet.
larger size to
of color on a tablet. Improperly mixed
prevent
dye, especially during
segregation.
‘Direct Compression’.
It is due to free
rotation of punches
which have some
engraving or
Use keying in
Double monogram on the
tooling, i.e. inset a
Impression punch faces. During
key alongside of the
having two his free travel, the
punch, so that it fits
engraving or punch rotates and at
the punch and
monogram on the this point, the punch
prevents punch
punch faces. may make a new
rotation.
impression on the
bottom of the tablet,
resulting in 'Double
Impression.

Tablet core Increase levels of

ingredients do not hydrophilic
Bridging promote good ingredients.
coating fills in the coating adhesion. Optimize levels of
letter or logo on the lubricants.
tablet