1.

High Incidence of Sepsis in the Adult Population

a. Many research report identifies that the rising prevalence of HAIs on a global level
will be one of the primary growth drivers for the global sepsis diagnostics market till
2021. Centres for Disease Control and Prevention (CDC) evaluation found more than
90% of adults and 70% of children who developed sepsis had a health condition that
may have put them at risk. This high growth of sepsis or mortality due to sepsis
causes the demand for the sepsis diagnosis equipment to increase.
2. Growing Incidence of Hospital-Acquired Infections
a. In the US, the incidence of septic shock and severe sepsis is high among the older
population who get admitted to hospitals for general surgery or another diagnosis
purpose. According to the studies, HAI among people who are admitted to hospitals
for the treatment of respiratory tract infection, urinary tract infection, and
bloodstream infection is very high. The HAIs can trigger sepsis particularly in people
who are already at risk, such as those with chronic diseases, like diabetes or who are
immune-compromised, such as under chemotherapy or don’t have a spleen
including very young population or very old population. According to Centre for
Disease Control and Prevention, on any given day in a hospital in the US, about one
among 25 hospital patients has at least one healthcare associated infection. Thus,
with the rising number of HAIs, there is rising demand for sepsis diagnostics driving
this market.
3. Increasing Number of Surgical Procedures
a. The surgical site infections (SSI) and pneumonia in hospitals are also driving the
prevalence of septicaemia. Like HAIs, SSIs are increasing in patients across US who
are, particularly, in an immune-compromised condition. The incidence of the disease
increase at the time of surgery for such patients. The need for monitoring devices
are thus very crucial for prevention and early detection of infections.
4. Rising Initiatives to Increase the Awareness and Drive the Adoption of Sepsis Diagnostic
Tests
a. The Government and the healthcare providers are educating patients and their
families about the early symptoms of severe infection and sepsis, and when to seek
care for an infection, especially those at higher risk. The World Sepsis Day (WSD), a
great opportunity to increase awareness about sepsis, is going to be held on Sept.
13. Also, an online survey conducted in May 2018 questioned over 2,000 adults
living in the United States about their knowledge of sepsis. The results showed that
65% of respondents had heard of sepsis, compared with only 44% in 2015. It is
reassuring to see that the awareness of sepsis has increased significantly over recent
years, from 19% in 2003 to 65% in 2018.
5. Funding for Sepsis-Related Research Activities
a. Hospital care expenditures in particular, which constitute the largest single
component of health care spending, grew 4.1 percent in 2014. Septicaemia was the
most expensive condition treated, accounting for $23.7 billion, or 6.2 percent of the
aggregate costs for all hospitalizations. However, sepsis received a very small
proportion of overall funding in both the UK and USA from 2008 to 2013. But, the
scenario is changing with more funds being allocated to sepsis related research.
6. High Cost of Automated Diagnostic Devices
a. There has been rise in the use of the electronic health record (EHR) systems allowing
the possibility of widespread sepsis surveillance using clinical criteria for concurrent
infection and organ dysfunction. Developing more accurate tracking methods to
 evaluate progress in preventing and treating patients with sepsis is often very costly.
But, a recent study showed that, in a 500-bed hospital with 5,100 annual high-risk
patients, T2MR technology and the T2Candida Panel could save as much as
$5,858,448 annually, due to decreased length-of-stay and reduced use of
unnecessary antimicrobial drugs.
7. Development of Rapid Diagnostic/POC Techniques for Early Sepsis Diagnosis
a. T2MR can quickly and accurately identify sepsis pathogens direct from whole blood
– without the need for a blood culture. It's the first and only detection method to
achieve this feat and dramatically reduces the time of detection by eliminating the
2-5 day blood culture process. It also increases sensitivity because there is no
reliance on blood culture which suffers from a sensitivity of 50-60%.
8. Evolution of Novel Biomarkers for Sepsis Diagnosis
a. The identification of new and useful biomarkers that serve diagnostic and prognostic
roles in sepsis has great potential to improve the bedside management of the
disease. The availability of high-throughput technologies such as transcriptomics,
proteomics and metabolomics provide robust frameworks for the discovery and
development of novel biomarkers. The biomarkers singly or more likely in
combination, may be able to identify patients with sepsis and at high risk for poor
outcomes with improved accuracy.