Anda di halaman 1dari 4

# BAB IV

4.1 Hasil

Ppm = ug/ml

= 500 mg/250 ml

## 4.1.3 Perhitungan Konsentrasi

Waktu Absorbansi Pengenceran Konsentrasi
y=0.0447x+0.0881
0.194=0.0447x + 0.0881
10 0.194 5x
x= 1.202 ppm
Konsentrasi = 1.202 x 5 = 6.010 ppm
y=0.0447x+0.0881
0.2.38=0.0447x + 0.0881
20 0.238 5x
x= 1.701 ppm
Konsentrasi = 1.701 x 5=8.507 ppm
y=0.0447x+0.0881
30 0.205 5x
0.205=0.0447x + 0.0881
x= 1.3269 ppm
Konsentrasi = 1.3269 x 5 =6.6345 ppm
y=0.0447x+0.0881
0.174=0.0447x + 0.0881
40 0.174 5x
x= 0.975ppm
Konsentrasi = 0.9750 x 5 =4.875 ppm
y=0.0447x+0.0881
0.138=0.0447x + 0.0881
50 0.138 5x
x= 0.5664 ppm
Konsentrasi = 0.5664 x 5 =2.8320 ppm
y=0.0447x+0.0881
0.11=0.0447x + 0.0881
60 0.110 5x
x= 0.24858 ppm
Konsentrasi = 0.24858 x 5 =1.24291 ppm
y=0.0447x+0.0881
0.106=0.0447x + 0.0881
70 0.106 5x
x= 0.20318 ppm
Konsentrasi = 0.20318 x 5 = 1.101589 ppm

## 4.1.4 Data Konsentrasi Per Satuan Waktu

Waktu (menit) Konsentrasi (ppm) Ln C
10 6.010 1.793
20 8.507 2.141
30 6.634 1.892
40 4.875 1.584
50 2.832 1.041
60 1.243 0.217
70 1.016 0.0158

## Kurva PCT peroral dalam satuan

Waktu
2.5

1.5
Kurva PCT peroral
1 dalam satuan Waktu

0.5

0
0 20 40 60 80
Kurva PCT peroral Tanpa menit 60
2.5

Tanpa menit 60

0.5

0
0 20 40 60 80

## 4.1.5 Nilai Parameter

Jika di dapatkan dari kurva diatas sebuah persamaan
Laju Eliminasi → Ln Ct =3.156 – 0.043x
Nilai Parameter Teoritis Praktikum
C0 D0 X F/ vd Ln Ct = 3.156 – 0.043x
10 mg x 0.49/0.25 L Ln C0 =3.156 – 0.043(0)
=19.6 ppm` Ln C0 = 3.156
C0 = 23.4765 ppm
K eliminasi k = Cl / Vd
Ln Ct = 3.156 – 0.043x
k = 10 ml/menit /250 ml
K eliminasi =0.043/menit
k = 0,04 / menit
T1/2 eliminasi T1/2 → 0.693/k = 0.693/0.04 T1/2 → 0.693/k = 0.693/0.043
=17.3286 menit =16.1197 menit
Vd 250 ml Vd = DoXF / Co
Vd = 10 mg x0.49 / 23.4765 µg/ml
Vd = 0.209 L = 209 ml
Cl 10 ml/menit Cl = k x Vd
Cl = 0,043 / menit x 425 ml
Cl = 18.275 /menit
AUC AUC = Co / k AUC = Co / k
AUC = 19.6/ 0.04/menit AUC =23.475 µg/ml / 0,043/menit
AUC = 490 µg.menit/ml AUC =545.96 µg.menit/ml
F Tidak diketahui 𝐹 𝐾𝑎 𝐷0
Cp =𝑉𝑑 (𝐾𝑎−𝑘)(e-kt- e-kat)
𝐹 0.23 𝑥 10 𝑚𝑔
6.63 ppm =0.25 (0.23−0.043)(e-0.043x30-

e-0.23x30)
𝐹 2.3
6.63 ppm =0.04675(0.274)

F =0.49
B D0 x F/ vd Ln Ct = 3.156 – 0.043x
10 mg x 0.49/0.25 L Ln C0 =3.156 – 0.043(0)
=19.6 ppm` Ln C0 = 3.156
C0 = 23.4765 ppm
β k = Cl / Vd
Ln Ct = 3.156 – 0.043x
k = 10 ml/menit /250 ml
K eliminasi =0.043/menit
k = 0,04 / menit
α Tidak Diketahui 𝑙𝑛 𝐶1′−𝑙𝑛 𝐶2′
Ka = 𝑡2−𝑡1
3.156−1.7
Ka = 10−0

Ka = 0.23
Persamaan Tidak diketahui Cp = 23.4765 (e-0.043t – e-0.23t)