waktu absorbansi cp ln cp eliminasi AUC

0 0 0 0 263.4234
5 0.0700 105.3694 4.6575 537.4442
10 0.0740 109.6083 4.6969 555.9896
15 0.0770 112.7875 4.7255 2621.7321
30 0.1940 236.7768 5.4671 2693.2644
45 0.0860 122.3252 4.8067 1826.9294
60 0.0850 121.2654 4.7980 1787.1893
75 0.0810 117.0265 4.7624 1699.7610
90 0.0740 109.6083 4.6969 3176.9772
120 0.0670 102.1902 4.6268 a 4.8430 126.8525 3018.0167
150 0.0640 99.0109 4.5952 b -0.0017 0.9983
r -0.9770
auc total 17917.3039
Konsentrasi(
μg/ml) Absorbansi Cp
0 0 a -0.0294
205.8 0.147 b 0.0009
308.4 0.162 r 0.9741
411.2 0.430
514.0 0.483
616.0 0.564
719.0 0.626

Kurva Paracetamol Kelompok I

250.0000

200.0000

150.0000
Kurva Pa racetamol Kelompok 3
Li near (Kurva Pa ra cetamol
Cp

100.0000 Kel ompok 3)

50.0000

0.0000
0 20 40 60 80 100 120 140 160
Waktu (s)
50.0000

0.0000
0 20 40 60 80 100 120 140 160
Waktu (s)
cp' cp res ln cp res distribusi cp" cp res"

9.8346 95.5348 4.5595 5.9952 89.5396

14.8261 94.7822 4.5516 5.8180 88.9643
19.8176 92.9699 4.5323 5.6407 87.3292
34.7922 201.9845 5.3082 a 6.1724 479.3340
49.7668 72.5583 4.2844 b -0.0354 0.9652
64.7414 56.5240 4.0347 r -0.9549
79.7160 37.3104 3.6193

M 126.8525 L 479.3340 N 90.8488

b 0.9983 a 0.9652 ka 0.9975

auc model 532.6193

ka (/menit) 0.9975
T maks (menit) 1.0021
α (/menit) 0.9652
K21(/menit) 100.3086
K12(/menit) 66.1600
Vds (ml) 1.1284
Vdss (ml) 1.8727
Vp (ml) 0.7443
Cl (ml/ menit) 1.1265
β (/menit) 0.9983
t ½ (jam) 0.0116
K (/menit) 0.9719
cp maks (mg/ml) 195.4290
Vd 1.1265

Kurva Baku Paracetamol

1
1
1
Absorbansi

0
0
0
0
0
0 100 200 300 400 500 600 700 800
Konsentrasi (ppm)

Kurva Ba ku Pa ra cetamol Linear (Kurva Baku Pa raceta mol )

 ln cp res"

4.4947 a 4.5092 90.8488

4.4882 b -0.0025 0.9975
4.4697 r -0.9631

Kurva Paracetamol Kelompok I

250

200

150
Kurva Paracetamol
Cp

Kel ompok 3
100 10; 102.1902

50

0
0 20 40 60 80 100 120 140 160
Waktu (s)
waktu absorbansi cp ln cp' cres ln cres
0 0 0
5 0.0700 105.3136 4.6569 125.7822 -20.4686
10 0.0740 109.5529 4.6964 124.7209 -15.1679
15 0.0770 112.7324 4.7250 123.6685 -10.9361
30 0.1940 236.7333 5.4669 120.5644 116.1689 4.7550
45 0.0860 122.271 4.8062 117.5382 4.7328 1.5545
60 0.0850 121.2111 4.7975 114.5879 6.6232 1.8906
75 0.0810 116.9718 4.7619 111.7117 5.2600 1.6601
90 0.0740 109.5529 4.6964
120 0.0670 102.1341 4.6263
150 0.0640 98.95457 4.5947

eliminasi distribusi
t ln cp reg t ln cres
90 4.6969132779 a 4.8430 30 4.7554192418
120 4.6268353986 b -0.0017 45 1.5658996055
150 4.5952304493 r -0.9770 60 1.8987419651
75 1.6704831409
β 0.0017
B 126.8525

Konsentra
si(μg/ml) Absorbansi Cp
0 0 a
205.6 0.147 b -0.0294
308.4 0.162 r 0.0009

411.2 0.430 0.9741

514.0 0.483
616.0 0.564
719.0 0.626
cp" cres" ln cres" AUC
263.2840
199.9216 220.3902 5.3954 537.1663
148.4913 163.6592 5.0978 555.7134
110.2916 121.2276 4.7977 2620.9927
45.1925 2692.5317
18.5178 1826.1157
7.5878 1786.3719
3.1091 1698.9354
3175.3052
3016.3298
58390.1375
AUC TOTAL 76562.8836
absorbsi
reg t ln cres" reg
a 5.5953 5 5.395146 a 5.6945
b -0.0595 10 5.097448 b -0.0598
r -0.7537 15 4.797216 r -0.7537

α 0.0595 Ka 0.0598
A 269.1649 C 297.2383

parameter hasil satuan

t1/2 eliminasi 408.9186 /menit
F 0.8
t max 16.7683 menit
auc 84348.3314 μg.menit/ml
cl 0.2419 /menit
vd area 142.7110 ml
cmax 113.5182 μg/ml
k12 0.0360 /menit
k21 0.3216 /menit
k 0.0003 /menit