Ishan Chadha*
Graduate Student Mentors: Carrie Trant and Gagan Kangovi #Faculty Mentor: Sangwoo Lee#
Materials and
Gel Permeation Chromatography
Research Objective
- Hydrogenate polyisoprene to poly(ethylene-alt-
Conclusions
propylene) (PEP)
Methods - Successful hydrogenation to synthesize poly(ethylene-
- Ni-Al catalyst was prepared
alt-propylene)
The interaction parameter for polymers determines their bond in PI was actually broken
Future Direction
ability to interact with other molecules in general. The - differential scanning calorimetry (DSC) was
used to find the melting temperatures of the
interaction parameter of a polymer can be evaluated from its
polymers
melting temperature. As one adds more of a certain polymer In the future, I plan to test the interaction parameters of
to a solution, depression in the melting temperature has been
dendrimers with different terminal groups in order to
observed. For this study, polyisoprene and poly(ethylene-alt- a H2
b design a dendrimer that functions as a polydentate
propylene), which is the hydrogenated version of
Ni-Al ligand. These dendrimers would need to be able to serve
polyisoprene, were each mixed in pyrene. After this, melting catalyst
temperatures of the different polymer mixtures were tested
+Citric
Acid
+Sodium as vehicles for drugs, notably bisphosphonates and
Bicarbonate
via differential scanning calorimetry. Using the measured teriparatide. The application that I plan on testing of this
Poly(1,4-isoprene) Poly(ethylene-alt-propylene)
melting temperatures, the interaction parameter of is as a countermeasure against space osteopenia. So far,
polyisoprene was observed to be higher than that of mimicking the conditions found in outer space has been
poly(ethylene-alt-propylene). Since polyisoprene has an b
particularly difficult. By utilizing the measure of the
Solution
interaction parameter that is much more favorable, one can a interaction parameter, one can understand the properties
Solution
predict that the double bond that hydrogenated in of dendrimers in a calcium deficient environment by
poly(ethylene-alt-propylene) contributed to pi-stacking and
using the melting temperature of the substance in
therefore a more interactive structure.
PEP (blue) vs. PI (orange) various circumstances rather than having to
2.5
experimentally observe the differences between the
Interaction Parameter
1.5
minuscule interactions that occur when a complex is
1
PEP
0
polymers with more favorable designs can be created. An 0.0023 0.00235 0.0024 0.00245 0.0025 0.00255 0.0026 M=
1/T (K-1 )
innovative example of this is designing dendrimers, in which
the molecules chosen for the terminal groups of dendrimers
characterize the use of the dendrimer. Some uses of
PEP (blue) vs. PI (orange) Volume Fraction vs. Interaction Parameter
dendrimers are drug delivery systems, filtration systems, and 160 2.5
References
Interaction Parameter
150 2
Melting Point ( )
145
purposed is by understanding their abilities to interact with 140 1.5
Tian, Yiwei, Booth, Jonathan, Meehan, Elizabeth, Jones, David, Li, Shu, & Andrews, Gavin. Construction of
135 PEP
PEP
Poly. (Series1)
various molecules. Also, relating the interaction of molecules
Expon. (Series1) Drug - Polymer Thermodynaic Phase Diagrams using Flory-Huggins Theory: Identifying the Relevance of
130 1
125 Poly. (Series2)
PI Expon. (Series 2)
PI Temperature and Drug Weight Fraction to Phase Separation within Solid Dispersions. Mol. Pharmaceutics
on the nanoscale level to melting temperature, a clearly 120
115
0.5
2013, 10, 236-248.
110 0
Lorenzo, A.T, Arnal, M.L, Miller, A.J, A. Boschetti-de-Fierro, & V. Abetz. Nucleation and Isothermal
observable property of materials, is a revolutionary method of 0.3 0.4 0.5 0.6 0.7 0.8 0.9 0 0.2 0.4 0.6 0.8 1
Crystallization of the Polyethylene Block within Diblock Copolymers containing Polystyrene and
Volume Fraction Volume Fraction
understanding the way in which matter behaves. Poly(ethylene-alt-propylene). Macromolecules 2007, 40, 5023-5037.