��6 / 2 0 1 6 ' E * - ' F , D / J G

1) itch recptor is mediated by:

a.A delta

B. B delta

C. A& b delta

D. C nocioereptor✔

2)rare lesion on lepramatous leprosy:💡

A.macule

B.papule

C. Vesicle✔

D. Nodule

E.crust

3) psoriasis:

a.inflammatry

B.infectious

C.proliferative

D. Inflammatory proliferative disease✔

4) cells not found in epidermis:

a)lymphocyte✔
 B.merkle

C.melanocyte

D.keratinocyte

e. Langerhans cell

5) Hensons disease sensation lost first:

a.temperature✔

b.pain

c.touch

d.pressure

e. Vibration

6) Kerion is;

a.Bacterial in fection

b.fungal infection that lead to tinea capits✔

C. Parasite infection

7) Duration of keratinization

a.21d

b.14d

c.28d✔

d.40d

8) Pitrysis vercicolor is disease of:

 a.midle age

b.adlosence✔

c.adult

d.female

E.male

9) sebacous secrete sebum via:

a.Holocrine mechanism✔

b.Exocrine mechanis�

c.Exocytosis

D.merocrine

1 0 ) t h e m o s t H y p e r v i t a m i n o s i s t o x i c i t y o f �v i t A i s r e l a t e d t o :
💡

a.retinol

B.retinoic acid 

C.B carotene

D.retinal

E.excessive intake of carrot

11) benign tumor:�

A.adenoma✔

B.sarcima

C.seminoma
 D.lymphoma

E. Melanoma

12) which of the following is STDs:

A.pediculosis✔

B.eczema

C.herpes zoozter

D tinea cruris

13) Iga all of the following except:

a.Can cross placenta✔

B.Cannot involve in complement activation

C.mucous membrane

D.body secretion

14) 25 Male devolop patch hair loss scalp.eye brow.beard dia

g n o s i s💡 :

a Alopicia eriata 

b.Androgenic alopcia

C.Vitiligo

15)Comorbidity in atopic dermatitis:

a.Cvs

B.Depressin
 C.Hyperactive syndrome

d.Food allregy✔

E. Diabetis

16)Male preseted with pailnless penile ulcer which investigat

ion u do using material from lesion confirm diagnosis:

a.VDRL

b.Dark light✔ microscopy�

C.Gram stain�

D . C u l t u r e o n T h a y e r m a r t i n m e d i a �gnorrea

g a r . chlamedia e . C u l t u r e o n c h o c h o l a t e a

17)Most common type of pemphigus:

A.pemphigus vegetans

B.pemphigus vulgaris✔

C.pemphgus foliacus

D.pemphigus erythrmatous

18)Which one from bone marrow

a.Lcs✔

b.Melanocyte

c . �K e r a t i n o c y t e

D. Merkle cell

E.dendrutc cell
19)Mast cell originated form bone marrow in association with
:

a.CD11

b.CD66

c.CD34✔

d.Cd43

)0 2 Herald patch is characteristic of : Pityriasis Rosea

a.Psoriasis

B.LP

c. P. versicolor

d.Tenia

e . N o n o f a b o v e ✔️

: A l l p r o l i f r a t i n g c e l l g o t h r o g h G 2 pha s e e n d i n ) 1 2

a.active mitosis

b. Postmitotic

c.Dna synthesis

d . r e s t i n g / p r e m i t o t i c ✔️

e. quisent phase

: K a r u s e e n d b l u p f o u n d i n💡 ) 2 2
 a.dermal papila of digit

b.orifice of hair follicle

c.vermillion of lip💡

d. Mechanoreceptor of weight bearing area deal with vibratio

n

e. deep dermis of weight bearing area for cold

Female vacation aboard presented with multiple �hyp 12 )3 2

opigmented patch cover by fine scale in back and chest �what
:e is most likely diagonsis

a.vitligo

b . p t r i a s i s v e r i c o l o r ✔️

c.p.alba

d.leprosy

:condylomata lata )42

primary syphilis .1

s e c o n d a r y s y p h i l i s ✔️ . 2

tertiary syphilis .3

: Arteriovenous shunt least site occur in ) 5 2

s c a l p ✔️ . 1

palm.2

sole.3

lip .4
 ear.4

;Asprine can cause the following ) 6 2

a . u r t i c u r i a ✔️

b.papular articuria

c.eczma

D.angiodema

Pt presented with papule flat top �violaceous cover by f ) 7 2

:ine scale whate is most likely diagnosis

a.psorasis

b . l i c n p l a n u s ✔️

C.ptrasis rosea

:impetigo contagiosm )82

A . h o n e y c r u s t ✔️

man with infected finger served sandwich that caused �v )92

omiting and diarrhoea to a customer, which of the following o
ragnism that most likely cause:💡

a.staphylococcus aureus💡

b. E coli

c. salmonellatyphimurium

d.vibrio vulnificus
 e. Vibrio parahaemolyticus

?? Elatic fiber specific protein )03

a . D i s m o s i n - i s o d i s m o s i n ✔️

b.Leucine &iso leucine

�c.phenylene

D.treptophan

:disease that cause alopecia if affect the scalp )1 3

a.psorasis

b . D L E ✔️

C.roseca

D.lichen planus

anchoring fibrills )2 3

a . C o l l a g e n 7 ✔️

Which of the following responsible of wound healing )3 3

m a c r o p h a g e ✔️ . 1

Nutrophil .2

Mast cell .3
infant presented with erythematous rash on his cheek mot )43
: her with bronchial asthma what the diagnosis

a.eczema

b . a t o p i c d e r m a t i t i s ✔️

C.alergic contact dermatitis

years old child presented with painfull erythematous 01 )53

vesicopapular lesion on one side of his back ,dignosis confirm
b y t z a n e k t e s t f r o m l e s i o n c o m p l i c a t i o n t h a t h a p p e n a t t his
age

a.renal failure

B.hepatic insufficiency

C.postherpatic neurolagia✔

D.infertilty

E.diabetis

36)Fillagarin,the protein of granular layer is detectable at :

a.7w

B.10w

C.15w✔

D.17w

E.29w

37)Atopic dermatitis:

a.has 2 phases: infantile/adult

 B.start in infant commonly at age of 1 year

C.usualy there is no family history of atopy

D.can be treated by topical meconazle

E . e m o l l ients are e s s e n t i a l f o r t h e a s s o c i a t e d d r y s k i n . ✔

3 8 ) F e m a l e p t w h o s e a g e w a s 2 8 yrs p r e s e n t e d w i t h f a t i g u e w e
akness &shortness of breath on effort she also suffering from
difficulty on swallowing she has atrophic epithelial changes o
n h e r t o n g u e & r b c 4 . 2 �1 0 6 H b 6 . 5 p c v 1 9 m c v 6 2

Which of the following investigation is approp riate for confir

ming the diagnosis?

A.red cell folate estimation

B.Serum v. B12

C.serum iron

D.serum transferin

E. Serum iron& serum transferin✔

39) The usual initiating event when systemic infection occurs

w i t h f u n g u s �💡

A. The pt to ingest it from meat

B. The pt to ingest it from Water

C. The pt acquired it from another person

D. Pt inhale it 

E. Pt contact with an animal

40) Which of the following about darkly pigmented races vs li
ghtly pigmented races is correct?💡

�a . T h e n u m b e r o f m e l a n o s o m s e i n m e l a n o c y t e a r e t h e s a m e

b. The individual melanosomse have same degree of melanizat

ion

C. The melanosomse are equal in size

D. They are equal number of melanocyte 

E. There is a faster rate of mekanosomse degrsdation

41) 25 yrs old female delivered full term baby followed by se

v e r e v a g i n a l b l e e d i n g w b c . 1 2 . 3 p l a t e l e t 2 8 �1 0 9 p t t 5 9 p t 2 1

A.factor 8 inhibitors

B. Vit k diff.�

C. Dic✔

D. ITP

E.von willebrand disease

43) in the dermoepidermal junction, which is true ?

A.there is no anchoring filaments in lamina lucida

B.lamina fibroreticularis lies above lamina densa

C.lamina fibroreticularis comprise of anchroning fibrill and el

astic microfibrills✔

D. B.vessels cross the DEJ to epidermis.

E.lamina lucida is an electron dense layer

44) Which staph Aures toxin responsible for the scalded skin
syndrome

A . toxic shock syndrome

B . exf

oliating toxin✔

scarlet fever C . e r y t h r o g e n i c �

D. Binary

E.panton valentine

4 5 ) T h e f o l l o w i n g a r e t h e largest c o n s t i t u e n t o f c e l l e n v l o p e

A.involucrin

B.plasmonigen activator type 2

C.loricrin✔

D. Anexin

E. electron dense particle

46)Natural killer cell are:

A.large granular lymphocytes✔

B.myelocyte

C.thymocytes

D.plasma cell

E.form of dendritic cell

47)Neutralisation of mucosal surface function of :

 A.igg1

B.igg3

C.iga✔

D.igm

E. Ige

48)The most effective tissue destruction& dysfunction is caus

ed by the following mechanism:💡

A.opsanization by antibody

B. opsanization by complement

C.lysis by mac 

D. Phagocytosis

E.adcc k. Cell

49)The function of PG/GAG in the dermis is:�

A.regulate water binding capacity✔

B interact with dermal dendrocyte

C.faciltate collagen vII bindingto the anchoring plaque

D.facilitate mast cell degranulation

E.regulate lymphocyte trafficking

50)Which of the following graft of most clinical application

A. Outograft✔

B.yngegraft
 C . allograft

D.xenogenic graft

E. All of above

51)Melanocyte dervied from :

A.bone marrow

B.neural crest✔

C.mesodermal precursors

D.endodermal precursors

E.yolk sac drevied

52)Which of the following about plectin is true:

A.links fillagrin to the plasma membrane

B.plectin is a member of plakin family✔

C.crosslinks protein in adherent junction

D.mutation result in junctional epidermolysis bullosa with pyl

oris atresia

E.plectin is a constituant protein of desmosome

53) Eccrine glands are found in all except:

A.axillae

B.palms

C.labia minora✔

D.scalp
 E.cutaneous lip

54) Amylodosis:

A.is an extracelluler protein deposition✔

B.structurally homogenous protein�

C.produced by plasma cell

D.usually composed of immunoglobin

E.its protein synyhesized by the liver

5 5 ) M a l i g n a n t h y p e r t h e r m i a i s c h r a c t e r i z e d b y : �💡

A.adverse reaction on exposure to halothane

B.heavy muscle contraction & rigidity

C.hypermetabolism & hyperthermia 

D.mutation in the gene encoding calcium releasing channel

E.muscle relaxant is a drug of choice

56)Free radicales cause allof the following except:

A.membrane lipid peroxi

dation

B.DNA fragmentation

C.enzymes denaturation

D.protein cross linking✔

E.vascular degeneration
 57) Acne vulgaris:

A.is a disease of sweat gland

B.decrease sebum production play an imp role in pathogenesi

s

C.apart from face it may involve the chest and shoulder ✔

D.although it appear with puperty,hormonal change has no rol

e

E.good prognosis when the normal proprionibacterium presen

t.

58)Which is the avarge duration of telogen in scalpe hair:

A.2-3 w

B. 2-3 w

c. 3 months✔

D. 6 months

E. 9 months

59)prophylaxis of cutenious leshmaniasis in endemic area:

A.antinsect with bed nets✔

B . p e n t o s t a m t a b s f o r �p r o p h y l a x i s

C.prophylaxis antibiotics

D.vaccine for c.leshmeniasis

E.work when sundown

60) the following is mainly cholinetgic:

 A.ecrrine gland✔

B.apocrine

C.errecter pilli muscle

D.blood vessles

E .sebaceous gland

61) sebum lipid that different from other body lipid in:💡

A.triglycetide

B.squalene 

C.fatty acid�

D.cholestrol

E.wax

62)Epstain barr virus causes which of the folowing cancers :

A.cervical ca

B.thyroid ca

C.hodgkins lymphoma✔

D.gastric ca

E.endometrial ca

63) The infection most often associated with candida albicans

is :

A.oral thrush✔

B.sinusitis
 C.pneumonia

D.meningitis

E.skin dermatitis

6 4 ) s c a b e i s : �💡

A.water wash disease 

B.water vector related disease�

C.unrelated to water

D.water born diease

65) hair from inner to outer layer:

A.medulla, cortex ,hair shaf cuticle irs cuticle, huxle layer,he

nele laye✔

B. ED.(7 (JF 'D.J'1'* /J

66)Anchoring filament originate at the haemod esmosome inse

rted into the :

A.desmosome

B.subbasal dense plate

C.lamina lucida

D.BP 180

e. Lamina densa✔

67)Keratohyline granule contain:

A.desmoplakin
 B.envoplakin and keratin 6

C.profilaggrin and loricrin✔

D.numerous golgi apparati

E. Involucrin

68) Permeability of skin to water depends largely on

A.gag

B . lipid coat✔

C . protein content

D. thickness of layers

E.glycolipids

6 9 ) R e l a s e o f f i l a g r i n �t o f o r m m a c r o m o l e c u l e o c c u r i n :

a,Granular layer✔

B.Cornial layer

C.Spinous layer

D.basal layer

E.germinativium�

70)thickest regi

on of dermis???

A.scalp

B.back✔
 c.palm�

d.sole

E.thigh

7 1 ) �C o m p o n e n t s o f d e s m o s o m e e x c e p :

A.desmoplakin

B.plakophillin

C.desmoglein

D.desmocollin

E.Connexon✔

72)Gap junction:

low molecule✔

73)tight junction except:

Has a role in heat loss✔

74)What of the following tumor markers will be released in th

e serum in a pt with prostatic ca:

A.beta HCG

B.alpha fetoprotein

C.CEA

D.PSA✔

E.CA-125
 75)Sweat glands

A . found only in the palms ,soles, axilla

B.in eccrine sweat glands.ducts open into hair follicles

C.apocrine sweat gland secretions is odourless✔

D.sweat contains salt 95%

E. Eccrine& apocrine sweat gland have the sam e size

76)sebaceous gland:

A.respond to chemical stimuli such as hormones 

B.respond to chilinergic neural activity,exclusively

C. respond to adernergic neural activity,exclusively

D.respond to both adrenergic and cholinergic stimuli

E.respond to the local release of cytokines from inflammation

77)A16 y girl presented to clinic complaining of generalized w

eakness O/E multiple purpura over her body, gingival swelling
with bleeding gum.lab tests revealed that she has anaemia w
hich is the most likely diagnosis:

A. Iron defficiency due to lack of absorption

B.vit B 12 def due to internsic factor

C.folic acid def due to lack of vit B 12

D.lack of nacin due to problem of tryptophan

E.vit c difficency✔
78) pt with constipation recieved laxative developed hyperpig
mented lesion on his thigh which the most likely cause :

A.vasculitis

B.fixed drug eruption✔

C.steven jonhson

79) causes of cancer:

UVR✔

80)mast cell take place in :

a.Autoimmune 

B.immediate degranulation when binding to ag✔

C.has MHC2 that presented ag to T cell

81) red color hair is due to:

A.presence of pheomelanin✔

B.presensce of eumelanin

C.decrease of tyrosinase enzyme activity..

82) stratum cornium:

A.Slightly premeable to water

B.fully differeniated cell✔

C.?
 D.?

83)Pitryasis rosea is:

A.self limiting disease✔

B.Chronic relapsing

C.Life threatening infection

D.caused by dermatophyte

E.topical steroid is the treatment of choice