Tabel 1.

Karakteristik 24 Penelitian yang Berpatisipasi dalam Analisis Gabungan

Jumlah Kasus
Sumber Mean Adenocarcinoma
Periode Data Ras Kulit Usia Adenocarcinoma With Squamous Mixed Clear Jumlah
Penelitian Lokasi Rekrutmen Matching Factors Histologi Putih, % Tahun‡ Endometrioid NOS Differentiation Serous Cell Cell Mucinous Kontrol
Penelitian Kohort
Breast Cancer 29 US 1979-1980 Birth year, cohort entry, Path 92.6 65.2 48 276 27 10 1 4 1,858
Detection clinics race, clinic
Demonstration
Project (BCDDP)
Cancer Prevention 21 US 1992 Birth year, cohort entry, Path/registry 98.7 68.9 205 270 18 30 2 9 16 2,431
Study II (CPS-II) states race, area
Nutrition Cohort
Canadian National Canada 1980-1985 Birth year, cohort entry, Registry 96.9 59.9 149 396 49 23 1 9 12 2,953
Breast race, area
Screening Study
(NBSS)
California Teachers California 1995-1996 Birth year, cohort entry, Registry 91.9 64.7 367 173 27 19 23 6 16 2,539
Study (CTS) race, area
Iowa Women’s Iowa 1986 Birth year, cohort entry, Registry 98.7 71.6 99 316 26 26 2 6 3 2,120
Health Study race, area
(IWHS)
Multiethnic Cohort Hawaii, 1993-1996 Birth year, cohort entry, Registry 28.1 65.6 235 187 26 29 10 13 6 2,341
(MEC) California race, area
Nurses’ Health 11 US 1976 Birth year, race Path 94.8 62.4 430§ 23 4 9 1,271
Study (NHS) states
NIH-AARP Diet 8 US areas 1995-1996 birth year, cohort entry, Registry 93.9 67.5 809 495 39 71 23 19 29 6,831
and Health race, area
Study (NIH-
AARP)
Netherlands Netherlands 1986 birth year, cohort entry Path/registry 100.0 69.6 98 182 43 5 14 3 766
Cohort Study
(NLCS)
Swedish Sweden 1987-1990 Birth year, cohort entry Registry 100.0 70.5 293 3 10 4 1 1,283
Mammography
Cohort (SMC)
Semua penelitian
kohort 61.0 66.4 2,440 2,588 281 227 61 90 90 24,393
Case-control studies
Alberta Canada 2002-2006 Usia ( ± 5 years) Path/registry 94.8 58.3 424 15 8 18 15 10 4 1,026
Australian National Australia 2005-2007 Usia (5-year group), Path 88.6 61.2 861 1 164 49 132 21 3 703
Endometrial state
Cancer Study
(ANECS)
Bay Area California 1996-1999 Age (5-year group), Registry 90.3 61.8 178 199 10 15 11 20 445
Women’s Health ethnicity
Study (BAWHS)
Connecticut Connecticut 2004-2009 Usia (5-year group) Path 93.2 61.5 502 22 5 35 23 9 9 627
Endometrial
Cancer Study
(CECS)
(bersambung ke halaman berikutnya)
 Tabel 1. Karakteristik 24 Penelitian yang Berpatisipasi dalam Analisis Gabungan

Jumlah Kasus
Sumber Mean Adenocarcinoma
Periode Data Ras Kulit Usia, Adenocarcinoma With Squamous Mixed Clear Jumlah
Penelitian Lokasi Rekrutmen Matching Factors Histologi† Putih, % Tahun‡ Endometrioid NOS Differentiation Serous Cell Cell Mucinous Kontrol
Estrogen, Diet, New Jersey 2001-2005 Usia (5-year group) Registry 90.1 62.8 292 96 9 26 6 4 3 464
Genetics, and
Endometrial
Cancer (EDGE)
Fred Hutchinson Washington 1994-2005 Usia (5-year group) Registry 95.5 59.7 463 260 35 35 20 3 6 847
Cancer Research
Center (FHCRC)
Hawaii Hawaii 1988-1993 Usia ( 2.5 years), Path/registry 29.1 62.5 93 192 19 4 3 2 3 335
Endometrial ethnicity
Cancer Study
(HAW)
Polish Endometrial Poland 2000-2003 Usia ( 5 years), site Path/slide 100.0 57.2 312 110 10 68 5 4 1,829
Cancer Study
(PECS)
Patient New York 1982-1998 Usia ( 5 years) Registry 97.4 62.9 72 327 33 19 5 8 2 504
Epidemiologic
Data System
(PEDS)
Shanghai China 1997-2004 Usia ( 5 years) Path/slide 0.0 54.6 997 60 7 15 3 8 2 1,205
Endometrial
Cancer Study
(SECS)
Turin Case Control Italy 1998-2008 — Path 100.0 60.9 180 12 4 9 3 10 2 266
Study (TURIN)
US Endometrial 5 US clinics 1987-1990 Usia ( 5 years), race, Path 93.1 58.8 18 224 47 11 1 7 10 303
Cancer Study telephone exchange
(US)
USC LA case- Los Angeles 1987-1993 Usia ( 5 years) Path 100.0 63.1 38 666 45 7 1 8 791
control (USC)
Women’s Insight Philadelphia 1999-2002 Usia ( 5 years), race Path 78.9 61.7 376 168 28 6 7 1,574
and Shared
Experience
(WISE)
Semua case-control 79.7 60.0 4,806 2,242 496 281 285 106 76 10,919

Pooled studies 85.4 63.9 7,246 4,830 777 508 346 196 166 35,312
Singkatan: AARP, American Association of Retired Persons; NIH, National Institutes of Health; NOS, not otherwise specified.
Berdasarkan wanita yang termasuk dalam analis gabungan (misalnya, setelah melakukan ekslusi pada wanita yang data faktor risikonya tidak ada).
†Path= tinjauan dari pathology report; slide = tinjauan dari pathology slides; registry= tipe histologi/kode yang dilaporkan oleh cancer registry.
‡Usia saat didiagnosis dan usia saat wawancara /tanggal kontrol.
§NHS mengkelompokkan endometrioid, adenocarcinoma NOS, dan mucinous tumors dalam satu kategori.
 Tabel 2. Karakteristik Wanita dalam Analisis Gabungan Berdasarkan Case – Control Status dan histologi

Kasus
Adenocarcinoma
Adenocarcinoma With Squamous
Endometrioid NOS Differentiation Serous Mixed Cell Clear Cell Mucinous Kontrol
(n 7,246) (n 4,830) (n 777) (n 508) (n 346) (n 196) (n 166) (n 35,312)

Variabel No. % No. % No. % No. % No. % No. % No. % No. %

Usia, tahun
Mean 61.9 64.1 61.8 66.5 62.4 65.6 64.6 64.3
SD 9.5 8.4 8.8 8.0 9.5 8.6 8.6 9.1
Ras
Putih 5,629 77.7 4,356 90.2 701 90.2 415 81.7 312 90.2 163 83.2 150 90.4 30,528 86.5
Hitam 154 2.1 103 2.1 13 1.7 44 8.7 10 2.9 9 4.6 5 3.0 1,360 3.9
Asia 1,165 16.1 256 5.3 28 3.6 25 4.9 9 2.6 11 5.6 9 5.4 2,270 6.4
Hawai/Kepulauan
Pasifik 21 0.3 39 0.8 5 0.6 1 0.5 257 0.7
Lainnyar† 277 3.8 76 1.6 30 3.9 24 4.7 15 4.3 12 6.1 2 1.2 897 2.5
Pasca Menopausel 5,768 79.6 4,246 87.9 648 83.4 471 92.7 177 90.3 294 85.0 135 81.3 29,513 83.6
2
BMI, kg/m 28.9 6.7 28.1 6.7 29.0 6.9 27.6 6.1 28.5 6.3 27.7 5.8 28.1 6.6 25.7 4.9
Mean
SD
Parous 5,951 82.1 3,867 80.1 584 75.2 425 83.7 279 80.6 165 84.2 130 78.3 30,719 87.0
Pernah menggunakan
menopausal hormone‡ 2,310 40.1 2,069 48.7 253 39.0 159 33.8 97 33.0 54 30.5 79 58.5 12,397 42.0
Pernah merokok§ 2,583 36.5 1,877 40.5 314 40.9 191 38.7 116 33.5 75 40.5 65 44.5 16,052 46.0
Singkatan: BMI, body mass index; SD, standard deviation.
Termasuk endometrioid carcinoma, mucinous dan adenocarcinoma not otherwise specified yang dikelompokkan menjadi satu (Nurses’ Health Study).
†Termasuk, Hispanic, lainnya, dan ras/etnis yang tidak diketahui.
‡Hanya terdiri dari wanita yang mengalami pasca menopause.
§Berdasarkan 23 penelitian yang memiliki data riwayat merokok (Bay Area Women’s Health Study tidak memiliki data riwayat merokok).
 Tabel 3. Hubungan antara Faktor Risiko Kanker Endometrium dan Histologi Spesifik Kanker Endometrium

Kasus

Adenocarcinoma With
Endometrioid Adenocarcinoma NOS Squamous Differentiation Serous Mixed Cell Clear Cell Mucinous

Jumlah No. of No. of No. of No. of No. of No. of No. of

Faktor Risiko kontrol Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI
BMI
kg/m2
25 18,400 2,428 1.00 1,914 1.00 260 1.00 208 1.00 122 1.00 74 1.00 67 1.00
25 - 30 10,986 2,163 1.57 1.46 to 1.68 1,332 1.31 1.21 to 1.42 223 1.41 1.17 to 1.71 149 1.11 0.89 to 1.38 104 1.27 0.96 to 1.68 60 1.29 0.91 to 1.83 43 1.13 0.76 to 1.67
30 - 35 4,078 1,319 2.56 2.35 to 2.80 830 2.41 2.19 to 2.67 145 2.32 1.86 to 2.89 94 1.73 1.34 to 2.25 65 1.71 1.23 to 2.37 42 2.46 1.65 to 3.68 31 2.10 1.35 to 3.28
35 - 40 1,255 753 4.75 4.22 to 5.34 412 4.05 3.52 to 4.66 82 4.18 3.15 to 5.54 32 1.80 1.20 to 2.68 33 2.79 1.83 to 4.25 10 1.94 0.98 to 3.87 17 3.36 1.90 to 5.96
$ 40 593 583 6.88 5.95 to 7.96 342 7.17 6.05 to 8.49 67 7.76 5.56 to 10.82 25 2.85 1.80 to 4.52 22 3.49 2.06 to 5.90 10 4.36 2.16 to 8.82 8 3.29 1.51 to 7.19
P trend .0001 .0001 .0001 .0001 .0001 .0001 .0001
BMI,
per 2 kg/m2 35,312 7,246 1.21 1.20 to 1.22 4,830 1.20 1.18 to 1.21 777 1.20 1.17 to 1.23 508 1.10 1.07 to 1.14 346 1.13 1.09 to 1.18 196 1.14 1.08 to 1.20 166 1.16 1.10 to 1.22
Usia menarke,
tahun
11 1,633 508 1.00 285 1.00 51 1.00 40 1.00 28 1.00 12 1.00 16 1.00
11-12 7,332 1,740 0.87 0.76 to 0.99 926 0.94 0.80 to 1.10 166 0.74 0.53 to 1.05 134 0.74 0.51 to 1.08 86 0.57 0.36 to 0.91 41 0.76 0.39 to 1.47 34 0.53 0.28 to 0.97
13-14 21,563 3,963 0.83 0.73 to 0.94 3,104 0.90 0.77 to 1.04 461 0.71 0.52 to 0.98 283 0.66 0.47 to 0.95 183 0.57 0.37 to 0.89 113 0.76 0.41 to 1.41 105 0.57 0.33 to 0.99
$ 15 4,784 1,035 0.67 0.58 to 0.78 515 0.77 0.65 to 0.92 99 0.59 0.41 to 0.86 51 0.48 0.31 to 0.75 49 0.50 0.30 to 0.84 30 0.83 0.41 to 1.69 11 0.32 0.14 to 0.70
P trend .0001 .002 .01 .001 .04 .81 .03
Paritas
0 4,593 1,295 1.00 963 1.00 193 1.00 83 1.00 67 1.00 31 1.00 36 1.00
1 4,528 1,271 0.73 0.65 to 0.81 621 0.81 0.71 to 0.91 107 0.54 0.41 to 0.70 74 1.00 0.72, 1.40 47 0.63 0.42 to 0.95 25 0.81 0.46 to 1.42 26 0.82 0.48 to 1.40
2 10,147 2,159 0.68 0.62 to 0.75 1,347 0.71 0.64 to 0.78 222 0.48 0.38 to 0.59 142 0.75 0.57 to 1.00 108 0.55 0.39 to 0.77 48 0.70 0.44 to 1.13 46 0.63 0.40 to 0.99
3 12,119 1,970 0.56 0.51 to 0.62 1,519 0.60 0.54 to 0.66 197 0.39 0.32 to 0.49 150 0.60 0.45 to 0.80 81 0.51 0.35 to 0.72 62 0.71 0.45 to 1.11 49 0.53 0.34 to 0.83
$4 3,925 551 0.42 0.37 to 0.47 380 0.41 0.36 to 0.48 58 0.25 0.18 to 0.35 59 0.55 0.38 to 0.78 43 0.54 0.35 to 0.84 30 0.73 0.43 to 1.24 9 0.30 0.14 to 0.65
P trend .0001 .0001 .0001 .0001 .0007 .19 .0002
Penggunaan
kontrasepsi oral
Tidak pernah 20,785 4,139 1.00 3,378 1.00 494 1.00 306 1.00 191 1.00 131 1.00 103 1.00
Pernah 14,527 3,107 0.78 0.73 to 0.84 1,452 0.67 0.62 to 0.73 283 0.64 0.53 to 0.78 202 0.87 0.70 to 1.07 155 0.54 0.40 to 0.72 65 0.66 0.46 to 0.94 63 0.65 0.44 to 0.95
Riwayat
merokok†
Tidak pernah 18,815 4,485 1.00 2,754 1.00 453 1.00 302 1.00 230 1.00 110 1.00 81 1.00
Dahulu 10,900 2,025 0.83 0.78 to 0.89 1,421 0.91 0.84 to 0.98 202 0.83 0.69 to 0.99 145 0.76 0.61, 0.94 82 0.62 0.47 to 0.81 47 0.78 0.54 to 1.11 57 1.14 0.80 to 1.62
Saat ini 5,152 558 0.61 0.55 to 0.68 456 0.64 0.57 to 0.71 112 0.88 0.70 to 1.10 46 0.66 0.48 to 0.91 34 0.53 0.36 to 0.78 28 1.13 0.73 to 1.73 8 0.41 0.19 to 0.85
Pack-years of
smoking‡
Tidak pernah 13,693 2,988 1.00 2,246 1.00 412 1.00 190 1.00 177 1.00 76 1.00 58 1.00
20 5,383 772 0.80 0.73 to 0.89 724 0.93 0.84 to 1.03 143 0.79 0.64 to 0.98 54 0.79 0.57 to 1.09 52 0.59 0.42 to 0.83 28 0.98 0.62 to 1.54 19 0.81 0.48 to 1.39
$ 20 3,594 465 0.68 0.60 to 0.77 544 0.71 0.64 to 0.80 100 0.80 0.63 to 1.02 46 0.83 0.59 to 1.17 23 0.49 0.31 to 0.78 17 0.82 0.47 to 1.41 14 0.77 0.42 to 1.41
P trend .0001 .0001 .02 .17 .0002 .50 .33
(bersambung ke halaman berikutnya)
 Tabel 3. Hubungan antara Faktor Risiko Kanker Endometrium dan Histologi Spesifik Kanker Endometrium

Kasus

Adenocarcinoma With
Endometrioid Adenocarcinoma NOS Squamous Differentiation Serous Mixed Cell Clear Cell Mucinous

Jumlah No. of No. of No. of No. of No. of No. of No. of

Faktor Risiko Kontrol Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI Cases OR 95% CI
Diabetes§
Tidak 26,575 4,967 1.00 3,100 1.00 453 1.00 314 1.00 158 1.00 122 1.00 109 1.00
Ya 2,077 929 1.28 1.16 to 1.42 417 1.25 1.10 to 1.43 56 1.04 0.76 to 1.41 63 1.33 0.98 to 1.81 41 1.93 1.30 to 2.85 19 1.23 0.73 to 2.09 13 1.37 0.73 to 2.55
Singkatan: NOS, not otherwise specified; OR, odds ratio.
Stratifikasi berdasarkan usia, penelitian, ras/etnis serta disesuaikan dengan indeks massa tubuh, usia menarke, paritas, penggunaan kontrasepsi oral, menopausal status, penggunaan menopausal hormone,
dan smoking status.
†Berdasarkan 23 penelitian yang disertai data riwayat merokok.
‡Berdasarkan 18 penelitian yang disertai data pack-years of smoking.
§Berdasarkan 19 penelitian yang disertai data riwayat diabetes.
 Tabel A2. Hubungan antara Faktor Risiko Kanker Endometrium dan Tumor Tipe I serta Tipe II Berdasarkan Desain Penelitian
Tipe I Tipe II

Kohort Case-Control Path Review Registry Kohort Case-Control Path Review Registry

Faktor Risiko OR 95% CI OR 95% CI OR 95% CI OR 95% CI OR 95% CI OR 95% CI OR 95% CI OR 95% CI
Indeks massa tubuh, kg/m2
25 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
25 - 30 1.32 1.23 to 1.43 1.60 1.48 to 1.73 1.53 1.40 to 1.66 1.40 1.31 to 1.50 1.14 0.86 to 1.52 1.19 0.95 to 1.48 1.08 0.84 to 1.40 1.24 0.98 to 1.57
30 - 35 2.44 2.23 to 2.67 2.61 2.36 to 2.88 2.45 2.19 to 2.74 2.56 2.35 to 2.78 1.76 1.25 to 2.47 1.72 1.32 to 2.23 1.55 1.13 to 2.12 1.90 1.44 to 2.50
35 - 40 4.15 3.65 to 4.72 4.84 4.20 to 5.58 4.45 3.76 to 5.26 4.46 3.98 to 5.00 2.22 1.37 to 3.61 2.15 1.48 to 3.11 2.21 1.42 to 3.45 2.12 1.43 to 3.16
$ 40 6.66 5.66 to 7.83 7.86 6.54 to 9.44 8.45 6.69 to 10.67 6.73 5.83 to 7.75 3.08 1.69 to 5.61 3.29 2.11 to 5.12 4.20 2.44 to 7.23 2.64 1.63 to 4.30
P trend .0001 .0001 .0001 .0001 .0001 .0001 .0001 .0001
Indeks massa tubuh, per
2
2 kg/m 1.20 1.18 to 1.21 1.22 1.20 to 1.23 1.21 1.19 to 1.23 1.20 1.19 to 1.22 1.12 1.08 to 1.17 1.12 1.08 to 1.15 1.13 1.08 to 1.17 1.11 1.08 to 1.15
Usia Menarke, tahun
11 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
11-12 0.90 0.78 to 1.04 0.88 0.75 to 1.03 0.90 0.74 to 1.09 0.88 0.77 to 1.00 0.62 0.40 to 0.97 0.72 0.48 to 1.07 0.67 0.40 to 1.11 0.67 0.46 to 0.96
13-14 0.87 0.75 to 0.99 0.83 0.71 to 0.96 0.82 0.68 to 0.97 0.86 0.76 to 0.97 0.52 0.34 to 0.79 0.71 0.49 to 1.03 0.68 0.42 to 1.10 0.58 0.41 to 0.81
$ 15 0.72 0.61 to 0.86 0.69 0.59 to 0.82 0.68 0.56 to 0.83 0.73 0.63 to 0.84 0.52 0.31 to 0.90 0.52 0.33 to 0.81 0.45 0.26 to 0.78 0.58 0.37 to 0.90
P trend .0002 .0001 .0001 .0001 0.01 .008 .008 .009
Paritas
0 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
1 0.80 0.71 to 0.90 0.70 0.59 to 0.76 0.64 0.56 to 0.74 0.79 0.71 to 0.88 1.06 0.69 to 1.61 0.72 0.52 to 1.01 0.67 0.45 to 0.98 0.98 0.69 to 1.40
2 0.77 0.70 to 0.85 0.57 0.51 to 0.63 0.56 0.49 to 0.63 0.73 0.67 to 0.80 0.84 0.59 to 1.21 0.57 0.43 to 0.76 0.51 0.37 to 0.72 0.80 0.60 to 1.07
3 0.63 0.57 to 0.69 0.48 0.43 to 0.54 0.46 0.40 to 0.52 0.61 0.56 to 0.67 0.65 0.46 to 0.93 0.50 0.38 to 0.67 0.46 0.32 to 0.65 0.64 0.48 to 0.85
$4 0.47 0.41 to 0.53 0.32 0.28 to 0.38 0.33 0.28 to 0.39 0.44 0.39 to 0.49 0.58 0.36 to 0.92 0.51 0.36 to 0.74 0.54 0.35 to 0.82 0.51 0.34 to 0.75
P trend .0001 .0001 .0001 .0001 .001 .0001 .0002 .0001
Penggunaan kontrasepsi
oral
Tidak pernah 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
Pernah 0.76 0.71 to 0.82 0.68 0.62 to 0.73 0.68 0.62 to 0.74 0.75 0.70 to 0.81 0.81 0.62 to 1.07 0.68 0.54 to 0.86 0.59 0.44 to 0.79 0.86 0.68 to 1.08
Riwayat merokok†
Tidak pernah 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
Dahulu 0.88 0.83 to 0.95 0.84 0.78 to 0.91 0.84 0.77 to 0.92 0.88 0.82 to 0.94 0.87 0.67 to 1.12 0.62 0.49 to 0.77 0.60 0.47 to 0.79 0.79 0.63 to 0.98
Saat ini 0.68 0.61 to 0.76 0.61 0.54 to 0.68 0.60 0.52 to 0.68 0.68 0.61 to 0.75 0.73 0.49 to 1.11 0.52 0.38 to 0.72 0.52 0.36 to 0.75 0.66 0.46 to 0.93
Diabetes‡
Tidak 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
Ya 1.21 1.06 to 1.38 1.31 1.18 to 1.47 1.34 1.18 to 1.52 1.24 1.10 to 1.39 1.15 0.73 to 1.82 1.76 1.31 to 2.37 1.53 1.05 to 2.24 1.55 1.13 to 2.14

Singkatan: OR, odds ratio.

Stratifikasi berdasarkan usia, penelitian, ras/etnis serta disesuaikan dengan indeks massa tubuh, usia menarke, paritas, penggunaan kontrasepsi oral, menopausal status, penggunaan menopausal hormone,
dan smoking status.
†Berdasarkan 23 penelitian yang disertai riwayat merokok
‡Berdasarkan 19 penelitian yang disertai riwayat diabetes