A patient usually does not exhibit symptoms of memory loss or other cognitive
impairments during stage one of Alzheimer’s disease. The only way the disease
can be detected during this stage is by a positron emission tomography (PET)
scan, which is an imaging test that studies how well the brain is working. As the
disease progresses into other stages, a patient will experience more changes in
their reasoning or thinking.
Patients with stage two Alzheimer’s disease still may not show symptoms, or
they may exhibit very mild cognitive impairment. In most cases, memory loss
associated with this stage is difficult to differentiate from the symptoms of
normal aging. A patient with stage two Alzheimer’s disease may still do well on
memory tests, and symptoms are unlikely to be picked up by medical
professionals yet. Stage two is characterized by small changes that do not
interfere with a patient’s ability to live on their own.
By stage three, a patient’s medical doctors and family members may begin to
notice memory and cognitive impairments. The three most common areas
affected during stage three Alzheimer’s disease are planning and organizing,
finding the right word to describe feelings during a conversation, and
remembering names of new places or people. A patient with stage three may
finally show signs of Alzheimer’s disease on memory and cognitive tests. During
this stage, it is common to lose personal possessions such as keys, money, and
other valuables.
During stage four Alzheimer’s disease, the symptoms that began to arise in
stage three start to get worse. A patient will often forget important details
about themselves, forget what month or time of year it is, have trouble locating
the date on a calendar or perform simple math equations, and can no longer
order from a menu or cook for themselves. It is recommended that patients in
stage four no longer drive and are protected from being taken advantage of
financially.
During stage five, patients often experience significant confusion resulting in the
inability to get dressed or recall simple details like their phone number. They
may still maintain a moderate amount of functionality and can usually bathe
and use the restroom by themselves unassisted. They may also still recall the
names of family members and details about their past, such as their youth and
childhood. A person with stage five Alzheimer’s disease may repeat themselves
or ask the same questions over and over again.
Has the person lost interest in friends, family, or home activities? YES NO 123
Does the person lack curiosity in topics that would usually have attracted her/his interest? YES NO 123
Has the person become less spontaneous and active for example, is she/he less likely to initiate or
YES NO 123
maintain conversation?
Has the person lost the motivation to act on their obligations or interests? YES NO 123
Is the person less affectionate and/or lacking in emotions when compared to her/his usual self? YES NO 123
Has the person developed sadness or appear to be in low spirits? Does he/she have episodes of
YES NO 123
tearfulness?
Has the person become less able to experience pleasure? YES NO 123
Has the person become discouraged about their future or feel that she/he is a failure? YES NO 123
Has the person become more anxious or worried about things that are routine (e.g. events, visits,
YES NO 123
etc.)?
Does the person feel very tense, having developed an inability to relax, or shakiness, or symptoms of
YES NO 123
panic?
This domain describes the ability to delay gratification and control behavior, impulses, oral
intake and/or changes in reward
Has the person become agitated, aggressive, irritable, or temperamental? YES NO 123
Has the person become more impulsive, seeming to act without considering things? YES NO 123
Does the person display sexually disinhibited or intrusive behaviour, such as touching
(themselves/others), hugging, groping, etc., in a manner that is out of character or may cause YES NO 123
offence?
Has the person become more easily frustrated or impatient? Does she/he have troubles coping with
YES NO 123
delays, or waiting for events or for their turn?
Does the person display a new recklessness or lack of judgement when driving (e.g. speeding, erratic
YES NO 123
swerving, abrupt lane changes, etc.)?
Has the person become more stubborn or rigid, i.e., uncharacteristically insistent on having their
YES NO 123
way, or unwilling/unable to see/hear other views?
Is there a change in eating behaviors (e.g., overeating, cramming the mouth, insistent on eating only
YES NO 123
specific foods, or eating the food in exactly the same order)?
Does the person no longer find food tasteful or enjoyable? Are they eating less? YES NO 123
Does the person hoard objects when she/he did not do so before? YES NO 123
Has the person developed simple repetitive behaviors or compulsions? YES NO 123
Has the person recently developed trouble regulating smoking, alcohol, drug intake or gambling, or
YES NO 123
started shoplifting?
This domain describes following societal norms and having social graces, tact, and empathy
Has the person become less concerned about how her/his words or actions affect others? Has she/he
YES NO 123
become insensitive to others feelings?
Has the person started talking openly about very personal or private matters not usually discussed in
YES NO 123
public?
Does the person say rude or crude things or make lewd sexual remarks that she/he would not have
YES NO 123
said before?
Does the person seem to lack the social judgement she/he previously had about what to say or how
YES NO 123
to behave in public or private?
Does the person now talk to strangers as if familiar, or intrude on their activities? YES NO 123
Has the person developed beliefs that they are in danger, or that others are planning to harm them or
YES NO 123
steal their belongings?
Has the person developed suspiciousness about the intentions or motives of other people? YES NO 123
Does she/he have unrealistic beliefs about her/his power, wealth or skills? YES NO 123
Does the person describe hearing voices or does she/he talk to imaginary people or spirits? YES NO 123
Does the person report or complain about, or act as if seeing things (e.g. people, animals or insects)
YES NO 123
that are not there, i.e., that are imaginary to others?