Nama Sari Utami

Nim 050217A090
Tugas Farmakokinetik

Soal
Suatu obat diberikan dengan suntikan iv bolus. Div = 50 mg, kepada subyek berat badan 60 kg. Sample
dari hasil analisa kadar disajikan pada tabel berikut :

Waktu (jamkadar obat darah (mg/L)

0.25 53.8
0.50 43.3
0.75 35.0
1.0 29.1
1.5 21.2
2.0 17.0
3.0 12.6
4.0 10.5
5.0 9.0
6.0 8.0
7.0 7.0

Hitung semua parameter model 2 kompartemen

Jawab
Waktu (jamkadar obat ln Cp (µg/ml)
0.25 53.8 3.985
0.50 43.3 3.768 Waktu Vs ln
0.75 35.0 3.555 4.500
1.0 29.1 3.371 4.000
1.5 21.2 3.054 3.500 f(x) = - 0.2870866177x + 3.6885509409
2.0 17.0 2.833 3.000 R² = 0.8978245159
3.0 12.6 2.534 2.500
4.0 10.5 2.351 2.000
5.0 9.0 2.197 1.500
6.0 8.0 2.079
1.000
7.0 7.0 1.946
0.500
0.000
0 1 2 3 4
Col umn E

Fase Eliminasi
T (jam) kadar obat ln Cp (µg/ml)
4.0 10.5 2.3513753 Fase Eliminasi Vs ln K
5.0 9.0 2.1972246 2.5
6.0 8.0 2.0794415 f(x) = - 0.133417836x + 2.8772859793
7.0 7.0 1.9459101 2 R² = 0.9972872857

1.5

1
 Fase Eliminasi Vs ln K
2.5
f(x) = - 0.133417836x + 2.8772859793
2 R² = 0.9972872857

1.5

a 2.8773 1

b -0.1334 jam⁻¹
0.5
slope ß 0.1334 jam⁻¹
intersep B 17.761 mg/L
0
t½ 5.195 jam 3.5 4.0 4.5 5.0 5.5
persamaan17,761 e
-0,1334 t
Col umn E
r 0.9973

Waktu (jamkadar obat kadar ekstraKadar Resiln Kadar Residual (mg/L)

0.25 53.8 17.178 36.622 3.601
0.50 43.3 16.615 26.685 3.284 4.000
0.75 35.0 16.070 18.930 2.941 3.500 f(x
1.0 29.1 15.543 13.557 2.607 R²
3.000
2.500
2.000

a 3.9392 1.500
b -1.3298 1.000
r 0.9997 0.500
slope a -1.3298 jam⁻¹ 0.000
intersep A 51.357 mg/L 0.2 0
a 1.3298 jam⁻¹
t½ 0.521 jam
Cs= 51,357 e-1.3298 t+17,761 e-0,1334t
AUC 171.760 mg.jam/L
Dosis 50 mg

Vs 0.723 L
Cl 0.291 L/jam
K21 0.441 jam⁻¹
K 0.402 jam⁻¹
K12 0.620 jam⁻¹
berat badan 60 kg. Sample darah diambil secara periodik selama 7 jam,

Waktu Vs ln

870866177x + 3.6885509409
245159

2 3 4 5 6 7 8
Col umn E Li near (Col umn E)

Fase Eliminasi Vs ln Kadar Obat

- 0.133417836x + 2.8772859793
9972872857
Fase Eliminasi Vs ln Kadar Obat

- 0.133417836x + 2.8772859793
9972872857

4.5 5.0 5.5 6.0 6.5 7.0 7.5

Col umn E Li near (Col umn E)

Kurva WaktuVs ln Kadar Residual

4.000
3.500 f(x) = - 1.3298314421x + 3.9392385271
3.000 R² = 0.9997451115

2.500
2.000
1.500
1.000
0.500
0.000
0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1.1
Col umn G Linea r (Col umn G)